Regulated genes encoding mirnas micro rna that regulates. Medical search. Frequent questions

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
This type of RNA is called a messenger RNA ( mRNA ), as it serves as a messenger between DNA and the ribosomes, molecular machines that read mRNA sequences and use them to build proteins. (khanacademy.org)
The binding of miRNA- protein complexes to mRNA causes translation inhibition or destabilisation of target transcripts. (ukessays.com)
1) This is resulting in the downregulation of the protein encoded by mRNA. (ukessays.com)
The present study aimed to screen and explore the key circRNA/microRNA (miRNA or miR)/mRNA interactions in head and neck squamous cell carcinoma (HNSCC) using bioinformatics. (spandidos-publications.com)
Circular RNAs (circRNAs) are closed, long, non-coding RNAs that are formed via direct reverse splicing of precursor mRNA that function by regulating RNA transcription and protein production, as well as sponging miRNAs ( 4 ). (spandidos-publications.com)
Notably, previous studies revealed that circRNAs participate in cancer pathogenesis by sponging miRNAs that target mRNA and circRNAs exhibit potential as predictive biomarkers and therapeutic targets for cancer treatment ( 5 , 6 ). (spandidos-publications.com)
In addition, a previous study demonstrated that circRNA/miRNA/mRNA networks are involved in the development and progression of multiple types of malignancy ( 7 ). (spandidos-publications.com)
Thus, further investigations into the specific molecular mechanisms underlying circRNA/miRNA/mRNA regulation are required to aid discovery of effective therapeutic targets. (spandidos-publications.com)
Messenger RNA, or mRNA , transfers information held in genes to the ribosome, where cellular proteins are made. (nih.gov)
Transfer RNA, or tRNA , decodes the genetic information held in the mRNA and helps add amino acids to a growing protein chain. (nih.gov)
MicroRNA, or miRNA , is a tiny piece of cellular RNA that regulates protein production by binding to mRNA and blocking its ability to function. (nih.gov)
Sometimes mRNA localizes to a specific region of the cell, where the protein it encodes does its task. (nih.gov)
Here, the mRNA that encodes a protein involved in cell movement moves to the leading edge of a migrating cell. (nih.gov)
Small nuclear RNA, or snRNA , teams up with a host of proteins to form the spliceosome, a complex that snips out extraneous segments of mRNA to make a fully functional molecule that can then code for a protein. (nih.gov)
The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
The mature miRNA is then loaded onto an Argonaute protein (Ago2 in humans) where it then interacts with and regulates the mRNA target. (biomedcentral.com)
MicroRNAs (miRNAs) are short non-coding RNAs, typically 21-23 nucleotides long, that function in post-transcriptional gene regulation typically through translation inhibition and/or mRNA degradation ( 1 ). (amegroups.org)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

The KSHV-encoded proteins are shown in red. (frontiersin.org)
By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
Note that by convention gene names are italicized and the proteins they make are not. (cancerquest.org)
The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)
Mechanisms involved in epigenetic changes include DNA methylation, changes to chromatin structure facilitated by modification of histone proteins and changes to chromatin structure modified by noncoding RNAs. (evolutamente.it)
These RNAs are involved in the fundamental process of translation, when the information in our genes is decoded and used to produce proteins. (nih.gov)
Long intervening noncoding RNA, or lincRNA , appears to function as a scaffold for coordinating the activities of proteins that regulate gene activities. (nih.gov)
MiRNA expression is frequently altered during cancer development, associated with dysregulated expression of a plethora of different miRNAs, their biogenesis or processing proteins, such as DROSHA and DICER1 ( 1 ). (amegroups.org)

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
MiRNAs bind the 3' untranslated region (3'UTR) of target mRNAs. (ukessays.com)
A molecular regulatory network consisting of three circRNAs, seven miRNAs and seven mRNAs was constructed, resulting in identification of two signaling axes, hsa_circ_0035431/hsa‑miR‑940/fucosyltransferase 6 (FUT6) and hsa_circ_0035431/hsa‑miR‑940/cingulin‑like 1 (CGNL1). (spandidos-publications.com)

Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)
Still other RNA molecules, such as tiny microRNAs ( miRNAs ), act as regulators of other genes, and new types of non-protein-coding RNAs are being discovered all the time. (khanacademy.org)
MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
MicroRNAs (miRNAs) are short non-coding RNAs that have been termed "master regulators of the genome" given their significance in post-transcriptional gene regulation, and roles in a multitude of normal and disease processes. (amegroups.org)
Since their discovery in Caenorhabditis elegans , miRNAs have been extensively investigated as master regulators of gene expression in a variety of animal, plant, and human models. (amegroups.org)
MicroRNAs, a key class of gene expression regulators, have emerged as crucial players in various biological processes such as cellular proliferation and differentia-tion, development and apoptosis. (123dok.net)
Colorectal cancer Core tip: MicroRNAs (miRNAs), a key class of gene ex-pression regulators, have emerged as crucial players in various biological processes such as cellular prolifera-tion and differentiaprolifera-tion, development and apoptosis. (123dok.net)

Circular RNAs (circRNAs) are molecular sponges that are involved in regulation of multiple types of cancer. (spandidos-publications.com)
MicroRNAs (miRNAs or miRs) are involved in the post-transcriptional regulation of gene expression via complete or partial base pairing with the 3′untranslated region of target genes ( 3 ). (spandidos-publications.com)
Organization and complexity of life is built from the utilization of basic metabolites, followed by the introduction of biochemical and epigenetic regulation of genes. (evolutamente.it)
The current updated understanding of the term epigenetics describe cellular processes that affect medium to long-term readability and accessibility of the genome that would determine changes in the regulation and structure during gene expression that is outside of the direct changes made to the DNA sequence. (evolutamente.it)
Collectively, these results suggest an important function for let-7 family miRNAs in regulation of human neuronal development and raise implications for understanding the complex molecular etiology of neurodevelopmental disorders, such as T21, where let-7c gene dosage is increased. (nih.gov)
The objective of this study is to identify microRNAs-small, non-coding RNAs that help control gene expression-that contribute to the regulation of new blood vessel formation. (ca.gov)
These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)
The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)
Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)

A chromosome may contain tens of thousands of genes , each providing instructions on how to make a particular product needed by the cell. (khanacademy.org)
Let-7c is encoded on chromosome 21 in humans and therefore may be overexpressed in human brains in Trisomy 21 (T21), a complex neurodevelopmental disorder. (nih.gov)
Using a combination of miRNA hairpin predictions and co-mapping with miRBase entries, we identified a highly conserved cluster of miRNA genes on the X chromosome in the tammar and a total of 94 other predicted miRNA producing genes. (biomedcentral.com)
Twenty-two of the pairs, chromosome numbers 1 to 22, the autosomes, are normally homologous (identical in size, shape, and position and number of genes). (msdmanuals.com)
the smaller Y chromosome carries genes that initiate male sex differentiation, as well as a few other genes. (msdmanuals.com)
The genes that occupy the same locus on each chromosome of a pair (one inherited from the mother and one from the father) are called alleles. (msdmanuals.com)
A chromosome contains many genes. (msdmanuals.com)

The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
Moreover, we found that these differentially expressed exosomal miRNAs connect osteogenic differentiation to processes such as axon guidance, MAPK signaling, and Wnt signaling. (hindawi.com)
This study confirms that alterations in the expression of exosomal miRNAs can promote osteogenic differentiation of ADSCs, which also provides the foundation for further research on the regulatory functions of exosomal miRNAs in the context of ADSC osteogenesis. (hindawi.com)
Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. (ukessays.com)
The let-7 family of miRNAs has been shown to regulate neuronal differentiation, neural subtype specification, and synapse formation in animal models. (nih.gov)

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. (cancerindex.org)
Annotated database entry including the location and sequence of the mature miRNA sequence. (cancerindex.org)

DNA and RNA are polymers (in the case of DNA, often very long polymers), and are made up of monomers known as nucleotides . (khanacademy.org)

These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
Global DNA hypermethylation have been observed in subjects with chronic epilepsy, with the involvement of genes associated with calcium signaling, DNA binding and transcription, programmed cell death and synaptic transmission [6, 7]. (evolutamente.it)
Following a complex process of miRNA transcription, processing, and nuclear export, miRNAs are further processed by the RNaseIII enzyme, Dicer, and its cofactor TRBP. (biomedcentral.com)

I am molecular and cellular biologist with expertise in virus and microRNAs. (researchgate.net)
These alterations can take the form of epigenetic modifications, point mutations, translocations, amplifications or deletions and modify gene functions in ways that deregulate cellular signalling pathways leading to the cancer phenotype. (bmj.com)
RNA is best known as a messenger that carries genetic information, but this versatile molecule is involved in many other essential cellular functions, as well. (nih.gov)
Its discovery made it a 'celebrity' in the RNA world because it was the first time researchers had found evidence that RNA could act as a catalyst that controls and directs cellular functions. (nih.gov)
Research on these and other RNAs has led scientists to a broader understanding of RNA's critical role in many important cellular processes and of how impairments in these processes can lead to disease. (nih.gov)
This review integrates the literature on EBV-miRNAs, cellular miRNAs, and miRNA signatures to guide future research, while acknowledging challenges in the selection and clinical implementation of relevant miRNA biomarkers and signatures. (amegroups.org)

MicroRNAs are ~22-25 nucleotide non-coding RNAs. (ukessays.com)

Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed on differentially expressed genes (DEGs). (spandidos-publications.com)

This progression from DNA to RNA to protein is called the " central dogma " of molecular biology. (khanacademy.org)
Of the 30,000 or so genes that are currently thought to exist in the human genome , there is a small subset that seems to be particularly important in the prevention, development, and progression of cancer. (cancerquest.org)
In cancer, dysregulation of miRNAs can facilitate disease progression and therapeutic resistance, affecting tumour-suppressors and oncogenes. (amegroups.org)
These miRNA alterations are potential diagnostic and prognostic biomarkers when assessing patient disease progression or guiding clinical management. (amegroups.org)

Rationale: Formation and remodeling of the vasculature during development and disease involves a highly conserved and precisely regulated network of attractants and repellants. (ca.gov)
Methods and Results: We show that the highly conserved microRNA family encoding miR-10 regulates the behavior of endothelial cells during angiogenesis by positively titrating pro-angiogenic signaling. (ca.gov)
We examined each of these small RNA classes with respect to the newly assembled tammar wallaby genome for gene and repeat features, salient features that define their canonical sequences, and the constitution of both highly conserved and species-specific members. (biomedcentral.com)

For instance, some genes specify ribosomal RNAs ( rRNAs ), which serve as structural components of ribosomes, or transfer RNAs ( tRNAs ), cloverleaf-shaped RNA molecules that bring amino acids to the ribosome for protein synthesis. (khanacademy.org)
A segment of siRNA (red) guides a 'slicer' protein (multi-colored twists and corkscrews) to the target RNA molecules. (nih.gov)
Many RNA molecules need to be cut, pasted, trimmed or chemically modified before they can function. (nih.gov)
M1 RNA helps clip tRNAs in bacteria so that these molecules can decode genetic information. (nih.gov)
Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)

Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)

Because of their ability to target and inactivate specific segments of RNA, siRNAs have also become a powerful research tool for learning more about how genes function. (nih.gov)

Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
A better understanding of the function of miRNAs is pro-viding new insights into the molecular basis of human pathologies, and new biomarkers for disease diagnosis and therapy. (123dok.net)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)

10 Genes that, when activated, contribute to the carcinogenesis are generally termed proto-oncogenes. (bmj.com)
The mutated forms of these genes are referred to as oncogenes. (bmj.com)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
The normal versions of genes in the first group are called proto-oncogenes. (cancerquest.org)
The mutated or otherwise damaged versions of these genes are called oncogenes. (cancerquest.org)
We have two copies of each gene and for oncogenes, a single defective copy is enough to cause a cell to divide. (cancerquest.org)
Numerous genes have been identified as proto-oncogenes. (cancerquest.org)
Some proto-oncogenes work to regulate cell death. (cancerquest.org)
As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)

Advances in miRNA profiling techniques have highlighted the significance of both EBV- and human genome-encoded miRNAs in the pathogenesis of NPC. (amegroups.org)

A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)

Various signaling pathways control the behavior of endothelial cells, but their post-transcriptional dose-titration by miRNAs is poorly understood. (ca.gov)
What pathways are this gene/protein implicaed in? (cancerindex.org)
In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)

These genetic alterations result in either activation or inactivation of specific gene functions that contribute to the process of carcinogenesis. (bmj.com)

Objective: To identify miRNAs that regulate angiogenesis. (ca.gov)
Conclusions: Our study provides insights into how FLT1 and VEGF receptor-2 signaling is titrated in a miRNA-mediated manner and establishes miR-10 as a potential new target for the selective modulation of angiogenesis. (ca.gov)

A diagram showing the major cancer genes for some cancers. (cancerquest.org)
ALL cancers have lots of additional changes, the so-called 'passenger' mutations, that may contribute to the cancer, but are not the main genes. (cancerquest.org)
Altered expression of this gene has been observed in multiple human cancers. (cancerindex.org)

Ribosomal RNA, or rRNA , is a part of the ribosome that plays a direct role in linking protein building blocks called amino acids. (nih.gov)

Approximately 30-60 % of the human genome, regulated by miRNAs. (ukessays.com)
As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs). (biomedcentral.com)
Mapping all miRNAs to the tammar genome and comparing target genes among tammar, mouse and human, we identified 163 conserved target genes. (biomedcentral.com)
This study encompasses the first analyses of the major classes of small RNAs for the newly completed tammar genome, validates preliminary annotations using deep sequencing and computational approaches, and provides a foundation for future work on tammar-specific as well as conserved, but previously unknown small RNA progenitors and targets identified herein. (biomedcentral.com)

The genes in the second group are called tumor suppressors. (cancerquest.org)

Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)
Based on the consistent expression patterns associated with patient survival outcomes and in tumors vs. normal lung tissues, 10 miRNAs were considered to be putatively tumor suppressive and 4 miRNAs were deemed as oncogenic in lung cancer. (cdc.gov)

For the current study, we performed transcriptome and small RNA sequencing to profile gene expression in SB-induced HCCs in an attempt to clarify the genetic element(s) contributing to tumorigenesis. (prolekarniky.cz)

In this review, we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis. (123dok.net)

The scientist who made this discovery, Sidney Altman, won a Nobel Prize in 1989 along with Thomas Cech, who independently uncovered evidence for catalytic activity in RNA when he discovered a self-splicing RNA molecule. (nih.gov)
A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
A gene is a segment of DNA that provides the code to construct a protein or RNA molecule. (msdmanuals.com)

Many genes encode protein products, meaning that they specify the sequence of amino acids used to build a particular protein. (khanacademy.org)
Importantly, not all genes encode protein products. (khanacademy.org)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)

Genes are contained in chromosomes in the cell nucleus and mitochondria. (msdmanuals.com)
The 23rd pair, the sex chromosomes (X and Y), determines a person's sex as well as containing other functional genes. (msdmanuals.com)
Genes are arranged linearly along the DNA of chromosomes. (msdmanuals.com)
Each gene has a specific location (locus), which is typically the same on each of the 2 homologous chromosomes. (msdmanuals.com)
Some genes occur in multiple copies that may be next to each other or in different locations in the same or different chromosomes. (msdmanuals.com)

Scientists have uncovered hundreds of miRNAs in humans, and they estimate that miRNAs regulate more than half of our protein-coding genes. (nih.gov)
Humans have about 20,000 to 23,000 genes depending on how a gene is defined. (msdmanuals.com)

Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)

Non-coding RNA, including microRNA (miRNA) serves critical regulatory functions in the developing brain. (nih.gov)

Common features in epilepsy can now be explained by epigenetic mechanisms including DNA methylation, histone modifications, chromatin remodelling and non-coding RNAs. (evolutamente.it)

Current research links mutated DNA sequences in genes that encode neurotransmitter receptors or ion channels in hereditary or generalized epilepsies [4]. (evolutamente.it)

Search miRCancer for miR-107 associations with cancer and associated genes. (cancerindex.org)
Therefore, miRNAs could consider as cancer targets. (ukessays.com)
Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. (ukessays.com)
The understanding of miRNA has increased over the past 10 years, and particularly the involvement of miRNAs in cancer. (ukessays.com)
A greater understanding of miRNA could possibly lead to better diagnostic and treatment of cancer. (ukessays.com)
These 12 genes are located at a region, which is frequently deleted in cancer. (ukessays.com)
The larger the gene name, the more frequently that gene is defective in that cancer type. (cancerquest.org)
These genes have been found to be either malfunctioning or non-functioning in many different kinds of cancer. (cancerquest.org)
The ability to regulate blood vessel growth is important for treating many diseases, including cancer. (ca.gov)
Scientists are also harnessing RNA as a research tool and as the basis for new therapies for infections, cancer and other conditions. (nih.gov)
These clinical evaluations demonstrate the importance and potential of further miRNA research for clinical use, especially in the diagnosis and treatment of cancer. (amegroups.org)
Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
From the list of genes that were targeted by the 73 diagnostic miRNAs, DGKE and WDR47 had significant associations with responses to both systemic therapies and radiotherapy in lung cancer. (cdc.gov)
Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)

piRNAs help ensure the integrity of the important pool of DNA that gets transmitted to future generations by blocking roving genetic elements that can jump into genes and cause mutations. (nih.gov)

As miRNAs proposed to control the expression up to one third of all genes and possibly utilised as diagnostic and prognostic marker for many genetic based diseases. (ukessays.com)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
FUT6 and CGNL1 were downregulated in HNSCC compared with adjacent healthy tissue and the expression levels of these genes were associated with tumor stage. (spandidos-publications.com)
Widespread changes to gene expression have been observed in epileptogenesis where genes are either turned on, or turned off. (evolutamente.it)
Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)
DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)

Small nucleolar RNA, or snoRNA , identifies the rRNA targets for the addition of a chemical group or for rearrangement. (nih.gov)

These miRNAs have been implicated in critical NPC processes such as epithelial-to-mesenchymal transition (EMT) and metastasis, while further promoting chemoresistance and radioresistance. (amegroups.org)

DNA and RNA structure and function. (khanacademy.org)
Piwi-interacting RNA, or piRNA , is largely restricted to egg and sperm cells, unlike siRNA and miRNA, which function in many cell types. (nih.gov)

HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
miR-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting VEGF Signaling. (ca.gov)
More than 8,000 lincRNAs are encoded in human DNA. (nih.gov)
An additional nine genes were identified in tammar that do not have an orthologous miRNA target in human and likely represent novel miRNA-regulated genes in the tammar. (biomedcentral.com)
Similarly, miRNA-based therapeutics are also in development for the treatment of a variety of human diseases. (amegroups.org)

Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)

Some viruses use RNA, not DNA, as their genetic material, but aren't technically considered to be alive (since they cannot reproduce without help from a host). (khanacademy.org)
Genetic experiments in zebrafish revealed that miR-10 functions, in part, by directly regulating the level of a protein called FLT1, which inhibits the behavior of endothelial cells that promotes new blood vessel growth. (ca.gov)

In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

MiRNA signatures derived from profiling data and bioinformatics/statistical analyses may be particularly useful for the diagnosis of NPC, as well as the stratification of patients into clinically relevant groups to guide treatment selection. (amegroups.org)

Organisms1

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes11

Information Science2

MRNA19

Proteins8

MRNAs3

Regulators7

Regulation9

Chromosome7

Differentiation6

Mature miRNA2

Nucleotides1

Transcription3

Cellular6

Nucleotide1

Differentially expressed1

Progression4

Highly conserved3

Molecules5

Roles1

SiRNAs1

Biomarkers3

Oncogenes10

Pathogenesis1

Cell Proliferation1

Pathways3

Alterations1

Angiogenesis2

Cancers3

Ribosome1

Genome4

Tumor suppressors1

Oncogenic2

Transcriptome1

Carcinogenesis1

Molecule3

Protein products4

Chromosomes5

Humans2

Assays1

Regulatory functions1

Epigenetic1

Receptors1

Cancer16

Mutations1

Diagnostic1

Expression5

Targets1

Processes1

Function2

Human5

Inflammation1

Genetic2

Target1

Analyses1