Regulate the gene. Medical search. Frequent questions

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Sen said the findings could have particular relevance if future research determines that mutations in exosome genes are linked to skin disorders or other diseases. (scitechdaily.com)
Once mutations in exosome complex genes are identified in either skin diseases or other diseases like pontocerebellar hypoplasia, it may be possible to design drugs targeting these defects. (scitechdaily.com)
Nevertheless, NDRG1 sequencing assay disclosed no mutations in the gene. (scirp.org)
A study found that many autistic children share a set of mutations that regulate/regulates genes known to influence communication among brain cells. (stackexchange.com)
So whether the verb REGULATE should agree with the noun phrase a set of mutations or the noun phrase mutations depends on which noun phrase is the understood Subject of the verb. (stackexchange.com)
People with rare mutations of genes in the leptin-signaling pathway (e.g., complete deficiencies of leptin or its receptor) have a very high likelihood of developing obesity. (cdc.gov)
Familial hypercholesterolemia (FH) can be caused by inherited changes (mutations) in the LDLR , APOB , and PCSK9 genes, which affect how your body regulates and removes cholesterol from your blood. (cdc.gov)
Genetic testing is available to check for mutations in these genes. (cdc.gov)
In very rare cases, a person can have two FH-causing mutations in both copies of the same gene, which results in a much more serious , rare form of FH called homozygous FH. (cdc.gov)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)

Summary of top hits from Gene Set Enrichment Analysis (GSEA) of ERβ ligand-responsive differentially expressed genes commonly regulated by E2 and LY treatments identified in RNAseq study. (figshare.com)
Among the components of this signaling pathway, we show that natriuretic peptide receptor 3 (Npr3) plays a pivotal role by differentially regulating two developmental programs through its dual function as clearance and signaling receptor. (gene-tools.com)
Furthermore, based on differentially expressed genes and WGCNA analyses, we found that the hypoxia signaling pathway was enriched under heat shock conditions. (biomedcentral.com)
Gene ontology annotation revealed a number of critical signalling pathways that were differentially expressed in cells treated with LA, including biological processes involved in establishment of cell polarity, molecular functions that regulate junctional structures, and cellular components associated with epithelial repair (cell leading edge, ruffle and apical junctional complex). (ecco-ibd.eu)

Drs. Martignetti and Adel Shalata, of the Ziv Medical Center Safed, Israel, and their team analized a large Israeli Arab family affected by autosomal-recessive morbid obesity and identified a truncating mutation in the gene that recently was found to encode CEP19, a ciliary protein. (eurekalert.org)
Activity-regulated cytoskeleton-associated protein predicts symptom response to cognitive behavioral therapy among individuals with first-episode psychosis. (nih.gov)
trnp: A conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression. (nih.gov)
In search of novel painkillers, researchers at Butantan Institute's Special Pain and Signaling Laboratory (LEDS) in São Paulo, Brazil, studied TRPV1, a sensory neuron receptor that captures noxious stimuli, including heat and the burning sensation conveyed by chili peppers, and discovered a potential pain insensitivity mutation in the gene that encodes this protein. (phys.org)
We have cloned and characterized the Dictyostelium discoideum repE gene, a homolog of the human xeroderma pigmentosum (XP) group E gene which encodes a UV-damaged DNA binding protein. (nih.gov)
In the present study, a 419 bp upstream sequence of the phycocyanin b subunit ( cpcB ) gene from Arthrospira platensis FACHB341 was fused with green fluorescent protein ( gfp ) gene, and a heterologous reporting system was built up to investigate the influence of light intensity on the expression of gfp gene, and the regulation function of different region of the upstream sequence of cpcB gene. (ejbiotechnology.info)
This protein also revealed a similarity to RP-2 , a gene activated in thymocytes undergoing programmed cell death. (aacrjournals.org)
For example, methylation of the DNA sequence of a gene may turn the gene off so it does not make a protein. (fapesp.br)
In the article, the authors recall that in the central nervous system the protein CREB1 normally binds to a section of the gene PKMzeta so that it expresses the protein of the same name. (fapesp.br)
The study showed, however, that hypermethylation of this piece of the gene resulted in significantly lower levels of the protein PKMzeta. (fapesp.br)
Several tests were conducted to see if methylation of the gene PKMzeta would lead to a drop in levels of the protein it produces, using drugs that interfere in DNA methylation and the gene-editing technique CRISPR. (fapesp.br)
In this case, alterations made to the gene PKMzeta prevented proper binding of the protein CREB1. (fapesp.br)
The results confirmed that the gene in question requires CREB1 to trigger production of the protein PKMzeta and that DNA methylation explains the drop in levels of the protein. (fapesp.br)
If the expression of other genes besides PKMzeta is affected by this pattern of DNA methylation, it must be particularly relevant to brain alterations possibly associated with pathologies, and the authors showed that the mechanism is not confined to the protein PKMzeta. (fapesp.br)
For instance, an amino acid protein called Stimulator of Interferon genes (STING) plays a critical role in modulating anti-cancer response. (asianscientist.com)
Researchers have known that a gene called surfeit 4 ( SURF4 ) produces its protein, SURF4, in higher quantities in such cancers. (asianscientist.com)
This protein binds to STING, preventing it from regulating cancer growth. (asianscientist.com)
But when the researchers injected SURF4 -suppressed cells in the tumors of lab rodents, the tumour growth was arrested, suggesting that suppressing levels of SURF4 protein can regulate leukemia progression. (asianscientist.com)
Genes involved in protein biosynthesis (RPL7), fatty acid oxidation (CPT1) and lipolysis (FABP4) were up regulated in fast and intermediate growing lambs in all studied tissues. (preprints.org)
Thus, it has evolved a protection mechanism against heat stress by increasing the expression of the gene coding for heat shock protein (HSP) 70 under elevated temperatures. (biomedcentral.com)
The recombinant protein GlyR2 was produced and was shown to bind in vitro to the cel5D and glyR2 promoter regions, suggesting that besides regulating its own expression, GlyR2 may regulate cel5D expression. (nottingham.ac.uk)
Cocaine- and amphetamine-regulated transcript, also known as CART, is a neuropeptide protein that in humans is encoded by the CARTPT gene. (wikipedia.org)
CMT type 1 is a disorder of peripheral myelination resulting from a mutation in the peripheral myelin protein-22 ( PMP22 ) gene. (medscape.com)
The drug, ARO-ANG3 (Arrowhead Pharmaceuticals), is a hepatocyte-targeted small interfering ribonucleic acid (siRNA) designed to silence expression of the angiopoietin-like protein 3 (ANGPTL3) gene. (medscape.com)
Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. (cdc.gov)
DNA-dependent protein kinase catalytic subunit (DNAPKcs) regulates non-homologous end joining (NHEJ) in DNA double strand break (DSB) repair. (cdc.gov)
Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function in regulating mtROS independent of the unfolded protein response. (lu.se)
Our results reveal a function of HSF proteins in regulating mtROS homeostasis that is independent of the unfolded protein response. (lu.se)

Incomplete dosage compensation, independent of DNA methylation, was found to be largely responsible for sexually dimorphic gene expression, with dosage compensation increasing throughout life. (ugent.be)
In conclusion, our results indicate that DNA methylation regulates neurodevelopmental gene expression dynamics through steering transcription factor activity, but does not explain sexually dimorphic gene expression patterns in zebra finch telencephalon. (ugent.be)

While ERRγ deletion did not fully recapitulate the transcriptional alterations observed in postmortem tissue, it caused reductions in genes involved in synaptic and mitochondrial function and autophagy. (nature.com)
Further evidence suggests that during PD progression, transcriptional programs for the expression of genes involved in mitochondrial structure and function are disrupted 11 . (nature.com)
in fact, these genes are targets of the transcriptional coactivator and master regulator of transcription of mitochondrial genes peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) 12 . (nature.com)
14 ). It is important to identify the transcription factors involved in regulation of these genes to reveal potential avenues for modulating transcriptional programs that could be dysfunctional in PD. (nature.com)
Notably, a nucleus-resident actin (R62D NLS ) also regulates SRF's transcriptional activity. (jneurosci.org)
In Pseudomonas the osmotic regulation of neuraminidase production was dependent upon algR1 and algR2, genes involved in the transcriptional activation of algD, which is responsible for the mucoid phenotype of Pseudomonas and pathognomonic for chronic infection in CF. Under the hyperosmolar conditions postulated to exist in the CF lung, nanA is likely to be expressed to facilitate the initial adherence of Pseudomonas to the respiratory tract. (jci.org)
Although some of these genes are controlled by specific transcriptional programs, very little is known about their post-transcriptional regulation. (iric.ca)
The expression of key molecules of β-cell function including Insulin, Pdx1, Gck, Glut2, and Insrβ was down-regulated in Chl1 -silenced cells at transcriptional and translational levels. (lu.se)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)

But, as yet largely unnoticed is that the European Commission is considering whether the gene-editing of plants and animals, for example in agriculture, be exempted from regulation or even falls outside the scope of EU law governing genetically modified organisms (GMOs). (theecologist.org)
Senior author Ramin Shiekhattar is a professor in two programs at Wistar, the gene expression and regulation program and molecular and cellular oncogenesis program. (sciencedaily.com)
The PVG-RT1(av1) strain had significantly more T-cell influx than both DA and PVG, suggesting regulation both by MHC and non-MHC genes. (nih.gov)
In addition to regulation of cytoplasmic cytoskeletal dynamics, a little appreciated property of actin signaling is modulation of gene expression so far only reported for non-neuronal cells. (jneurosci.org)
The regulation of the neuraminidase gene nanA was examined in Pseudomonas and as cloned and expressed in Escherichia coli. (jci.org)
Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans . (elifesciences.org)
Yet the molecular basis of the differential regulation of latent and lytic gene expression by epigenetics is unclear. (cam.ac.uk)
Transcription and expression regulation of some individual cel genes (cel5A, cel5I, cel5D and cel44O) of Clostridium cellulolyticum were investigated. (nottingham.ac.uk)
Similarly to the cip-cel operon, cel5A and cel5I expressions are regulated by a carbon catabolite repression mechanism, whereas cel44O and cel5D expressions do not seem to be submitted to this regulation. (nottingham.ac.uk)
CART expression is regulated by several peripheral peptide hormones involved in appetite regulation, including leptin, cholecystokinin and ghrelin, with CART and cholecystokinin having synergistic effects on appetite regulation. (wikipedia.org)
Here, we found that the MNB1 (mannose-binding-lectin 1) gene is involved in the regulation of Fe-deficiency stress response in Arabidopsis thaliana . (biomedcentral.com)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)
A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)

Our analysis revealed that DNA methylation regulates expression of this gene, which plays a role in several pathologies," said Deborah Schechtman , last author of the article and a professor at the University of São Paulo's Institute of Chemistry (IQ-USP) in Brazil. (fapesp.br)
DNA methylation regulates transcripti. (ugent.be)

In Brachypodium distachyon, the BdCathB gene that encodes a Cathepsin B-like thiol-protease, orthologous to the wheat Al21 and barley HvCathB, is highly induced in germinating seeds and its expression is regulated by transcription factors (TFs) encoded by genes BdGa-myb and BdDof24, orthologous to the barley HvGamyb and BPBF-HvDof24, respectively. (upm.es)

Melo-Hanchuk TD, Kobarg J. Polyglutamylase activity of tubulin tyrosine ligase-like 4 is negatively regulated by the never in mitosis gene A family kinase never in mitosis gene A -related kinase 5. (wjgnet.com)
Together, our findings show that the MNB1 gene negatively controls the Fe-deficiency response in Arabidopsis via modulating reactive oxygen species (ROS) levels and the ROS-mediated signaling pathway, thereby affecting the expression of Fe uptake- and translocation-related genes. (biomedcentral.com)

Gene-editing is a form of genetic engineering. (theecologist.org)
Many of these techniques can be used to insert genes from an unrelated species into a plant or animal as traditional genetic engineering does and the resulting products, with their novel genes would be regarded as GMOs. (theecologist.org)
Traditional' genetic engineering involves the random insertion of genes (or genetic sequences) into an organism's genome. (theecologist.org)
Proponents tell us that gene-editing is far more precise than the genetic engineering techniques we are familiar with. (theecologist.org)
Although we detected no genetic alteration in the coding sequences, one of four rhabdomyosarcoma cell lines examined had completely lost expression of this gene. (aacrjournals.org)
The researchers found common genetic variations in or near 35 genes that may be associated with the condition. (medlineplus.gov)
[ 1 ] Its genetic spectrum spans more than 80 genes. (medscape.com)

A new study shows that an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells is also a target for certain monoamine oxidase inhibitors used to treat depression. (sciencedaily.com)
In 2005, professor Ramin Shiekhattar, Ph.D., at The Wistar Institute and his colleagues reported details about an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells. (sciencedaily.com)
We present a hitherto unappreciated cross talk of actin signaling with gene expression governing neuronal motility. (jneurosci.org)
Conversely, actin signaling regulates neuronal SRF-mediated gene expression. (jneurosci.org)
Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription. (jneurosci.org)
In the mammalian brain, alternative pre-mRNA splicing is a fundamental mechanism that modifies neuronal function dynamically where secretion of different splice variants regulates neurogenesis, development, pathfinding, maintenance, migration, and synaptogenesis. (aging-us.com)

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development. (nih.gov)
Thus, allelic differences in Vra4, harboring the Ciita gene, was found to regulate expression of the invariant chain at the mRNA level, with a much smaller effect exerted by the MHC locus itself. (nih.gov)
The repE gene is not expressed by mitotically dividing cells, and repE mRNA is first detected during the aggregation phase of development when the cells have ceased dividing and replicating genomic DNA. (nih.gov)
NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay. (iric.ca)
Transcripts of both TF genes increase during germination and treatments with abscisic acid (ABA) or paclobutrazol (PAC, an inhibitor of GA bio-synthesis) decrease mRNA expression of BdGamyb but do not affect that of BdDof24. (upm.es)
In presenting the data, Raal explained that ARO-ANG3, which is administered subcutaneously, inhibits and degrades ANGPTL3 mRNA, leading to "deep and durable silencing of the ANGPTL3 gene, while avoiding off-target effects. (medscape.com)

To identify candidate genes, we will make selections using the newly available canine genome sequence, as well as the more detailed human genome sequence. (akcchf.org)
The aim of present study was to link the gene expression profile of selected candidate genes with blood profile, growth performance and carcass traits of Barki lambs. (preprints.org)

Results showed that the upstream sequence of cpcB gene could drive the expression of gfp gene in Synechococcus sp. (ejbiotechnology.info)
To understand the mechanism, the researchers used epigenetics, the science of how environmental stimuli activate or inhibit gene expression without altering the DNA sequence. (fapesp.br)
This represses target genes with a sequence complementary to the tRF-3 in the 3' UTR . (bvsalud.org)
Therefore, Dicer-independent tRF-3s, generated upon tRNA overexpression, repress genes post-transcriptionally through an Argonaute-GW182 containing RISC via sequence matches with target mRNAs. (bvsalud.org)

However, the pathway downstream NDRG1, involving p21 and c8/18, regulating cell cycle progression and DNA synthesis is unfunctional. (scirp.org)
These findings indicate that TLR3 prevents the progression of lens fibrosis by targeting the Jagged-1/Notch signaling pathway to regulate LEC proliferation, migration, invasion and TGF-β2-induced EMT. (researchsquare.com)
Pusan National University scientists have discovered that SURF4, a novel gene, can help regulate leukemia progression. (asianscientist.com)
Researchers from the Pusan National University in South Korea have found that a gene called SURF4 can help regulate progression of leukemia, a type of blood cancer. (asianscientist.com)

Using both new and existing data, we propose to identify regions of the PWD genome that contain genes regulating the frequency of Addison's disease. (akcchf.org)
As such, LUNA plays a key role in efficient latency-associated viral gene expression and carriage of viral genome during latent carriage. (cam.ac.uk)
Through cloning of functional p53-binding sites (p53-tagged sites) from the human genome, we isolated a novel gene inducible by wild-type p53. (aacrjournals.org)

In a piece of work carried out by the Carbohydrate Metabolism Research Team of the Institute of Agrobiotechnology, the discovery has been made of the way in which the glgS gene (now renamed as the "surface composition regulator", scoR) acts in bacteria and how the mechanisms involved in bacterial infection can be altered by manipulating this gene, which indirectly affects glycogen production. (europa.eu)

Notably, CPEB3 partially modulated differential gene splicing enhanced in the modulation of neural development, neuron cycle, neurotrophin, synapse, and specific development pathway, implying an alternative splicing regulatory mechanism associated with neurogenesis. (aging-us.com)
Notably, HSP genes, which function as molecular chaperones, play an important role in heat shock response. (biomedcentral.com)

In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. (jneurosci.org)

Considering the diversity of microtubule polyglutamylation and the existence of many non-tubulin substrates, it is important to understand how the effector enzymes, the tubulin ligase-like (TTLL) proteins, are regulated. (wjgnet.com)

While the authors highlight how synergism between DNMT3A1 and TET1 helps to regulate both the epigenome and gene expression, they also note that their findings emphasize how the interplay between DNA methylation and histone modifications regulates gene expression, rather than one epigenetic mechanism predominating. (epigenie.com)
However, other viral genes are expressed during latency and this is correlated with activatory epigenetic modifications at latent gene promoters. (cam.ac.uk)
An epigenetic technique often used by researchers is gene silencing by DNA methylation, in which methyl groups are added to a specific section of a gene to prevent its transcription. (fapesp.br)

We demonstrate that deletion of ERRγ from DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial gene expression and number, that partial deficiency of ERRγ hastens synuclein-mediated toxicity, and that ERRγ overexpression reduces inclusion load and delays synuclein-mediated cell loss. (nature.com)
CPEB3 overexpression had insignificant effects on gene expression in HT22 cells. (aging-us.com)

Because the primary role of the enzyme is to repress sets of related genes, many other areas of potential influence for the monoamine oxidase inhibitors are possible too, according to Shiekhattar. (sciencedaily.com)
Called a deacetylase, this enzyme removes acetyl groups from histones to repress gene expression. (sciencedaily.com)
We show that endogenous 18 nucleotide tRFs derived from the 3' ends of tRNAs (tRF-3) post-transcriptionally repress genes in HEK293T cells in culture . (bvsalud.org)

We used RNA-seq to analyze CPEB3-regulated alternative splicing on control and CPEB3-overexpressing cells. (aging-us.com)
One would be to analyze other genes affected by this process of DNA methylation that inhibits CREB1 binding, with the aim of seeing what role they play in the organism, as well as their possible association with diseases. (fapesp.br)
To analyze benzene-caused aberrant gene expression, we examined differential gene expression by microarray analysis of peripheral mononuclear blood cells from seven workers diagnosed with benzene poisoning and seven matched controls. (cdc.gov)

New research data from scientists at USC San Diego suggests that the human exosome maintains progenitor cell function, functioning as a surveillance system in cells to regulate the normal turnover of RNAs as well as to destroy RNAs with errors in them. (scitechdaily.com)

Interestingly, we also show that LUNA interacts with the hematopoietic transcription factor GATA-2, which has previously been shown to bind to a number of latency-associated gene promoters, and that this interaction is dependent on the deSUMOylase domain of LUNA. (cam.ac.uk)

The data indicate that potential developmental roles for XP-related genes can be profitably studied in this system. (nih.gov)
These genes play a wide variety of roles in the body: some are involved in eye and ear development, and others in the formation of otoliths, which are tiny structures in the inner ear that are involved in sensing gravity and movement. (medlineplus.gov)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
RNA-seq demonstrates that endogenous target genes are specifically decreased upon tRF-3 induction. (bvsalud.org)

With additional insight into genes regulating body weight, more targeted treatments may be on the horizon. (cdc.gov)

Variants in blood pressure genes and the risk of Accardi R, Rubino R, Scalise M et col . (2011). (who.int)

In short," said George L. Sen, PhD, assistant professor of medicine and cellular and molecular medicine, "the exosome functions as a surveillance system in cells to regulate the normal turnover of RNAs as well as to destroy RNAs with errors in them. (scitechdaily.com)
In addition, gene set enrichment analysis (GSEA) was performed to identify possible molecular signatures that associate with Chl1 expression silencing. (lu.se)
[ 4 ] Gene discovery has been revolutionized by new high-throughput molecular technologies. (medscape.com)

However, a strong association between DNA methylation and age-dependent gene expression was found for various transcription factors (i.e. (ugent.be)
Inability of 50 Hz magnetic fields to regulate PKC- and Ca(2+)-dependent gene expression in Jurkat cells med. (emf-portal.org)

Starting with gene discovery in a single family with morbid obesity, these studies led to the identification a gene that seems to be fundamental to regulating nutritional status," says one of the senior authors, Dr. John Martignetti of the Icahn School of Medicine at Mount Sinai in New York City. (eurekalert.org)
T. Okuda and H. Kondoh, "Identification of New Genes ndr2 and ndr3 Which Are Related to Ndr1/RTP/Drg1 but Show Distinct Tissue Specificity and Response to Nmyc," Biochemical and Biophysical Research Communications, Vol. 266, No. 1, 1999, pp. 208-215. (scirp.org)

In the vertebrate CNS, HB9/MNR2 transcription factors are specifically expressed in all somatic motoneurons and are necessary to distinguish motoneurons from interneurons, in part by repressing interneuron-specific gene expression. (jneurosci.org)
On the basis of recent vertebrate studies, the HB9/MNR2 gene family is a prime candidate for a general determinant of somatic motoneuron cell type. (jneurosci.org)
Thus, vertebrate HB9/MNR2 genes are expressed specifically in somatic motoneurons and are essential for distinguishing motoneuron/interneuron cell types. (jneurosci.org)

In terms of mechanism, the functional gain and loss experiments of human LEC show that TLR3 regulates the proliferation, migration, invasion of LEC and EMT induced by TGF-β2 by targeting the Jagged-1/Notch signaling pathway to affect the development of fibrotic cataract. (researchsquare.com)
Using a combination of MO-based knockdowns, pharmacological inhibitors and rescue assays we demonstrate that Npr3 cooperate with guanylate cyclase natriuretic peptide receptor 1 (Npr1) and natriuretic peptides (Nppa/Nppc) to regulate NC and CP formation, pointing at a broad requirement of this signaling pathway in early embryogenesis. (gene-tools.com)

Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and pressure, ventricular hypertrophy, fat metabolism, and long bone growth. (gene-tools.com)

Here we report the characterization of two benzene-regulated genes. (cdc.gov)

Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are targets for the transcription factor estrogen-related receptor gamma ( Esrrg /ERRγ). (nature.com)

N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)

This researcher, who is of Iranian origin, has studied the mechanism of the action of the glgS gene in bacteria and in various Salmonella species, which in certain cases can cause diseases and acute symptoms in humans. (europa.eu)

Next, they used the CRISPR/Cas9 gene editing technique to create mice with the mutation K710N, which they had previously found to reduce the receptor's reaction to capsaicin in cells. (phys.org)
The study, conducted by researchers at Ohio State UniversityMedical Center, Columbus, and published in GeneExpression (11:251- 62, 2004), found Super CitriMaxup-regulated more than 90 genes, while it had no affect on genes considered tobe indicators of toxicity in the body. (naturalproductsinsider.com)
In addition, we found 48 and 47 genes that were upregulated and downregulated by HSF1 in response to heat shock, respectively. (biomedcentral.com)
Twenty-two genes were found up-regulated and 18 down-regulated in benzene patients compared with controls. (cdc.gov)
About 60-80% of people with FH have a mutation found in one of these three genes. (cdc.gov)

Moreover, qRT-PCR verified the CPEB3-modulated transcription of neurogenesis genes LCN2 and NAV2, synaptogenesis gene CYLD, as well as neural development gene JADE1. (aging-us.com)

T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)

Silencing of Chl1 gene expression has been previously reported to reduce insulin secretion. (lu.se)

In the body's scheme for safely storing genes away until needed, DNA is tightly looped around the histones, kept secure by enzymes similar to the ones studied by the Wistar team until made accessible by the activity of other enzymes responsible for gene expression. (sciencedaily.com)

This gene is shown to be present not only in humans and mice but also in the simplest known single-cell animal. (eurekalert.org)
There has been a lot in the news recently about the ethics of gene editing in humans. (theecologist.org)
The repE gene maps to chromosome 4 and it is the first gene identified in Dictyostelium that is homologous to those involved in nucleotide excision repair and their related XP diseases in humans. (nih.gov)

More significantly, Super CitriMaxup-regulated an entire family of genes involved in the signaling activity ofserotonin, a brain chemical that affects sleep patterns, moods and appetite. (naturalproductsinsider.com)

A new studyfound InterHealth Nutraceuticals ( www.InterHealthUSA.com ) Super CitriMax®increases the activity of genes involved with carbohydrate and fat metabolism,as well as appetite control. (naturalproductsinsider.com)
Finally, we show that the deSUMOylase activity of LUNA is required for the establishment and/or maintenance of an open chromatin configuration around latency-associated gene promoters. (cam.ac.uk)
CART is released in response to repeated dopamine release in the nucleus accumbens, and may regulate the activity of neurons in this area. (wikipedia.org)

In addition, MHC and Vra4 congenic strains on these backgrounds were studied to give information on MHC and non-MHC gene contribution. (nih.gov)

Gene-editing techniques may perhaps be more precise at the level and point where the DNA is altered but how this altered DNA might affect interactions with other genes and processes within the cell is largely unknown. (theecologist.org)
Tight junctions (TJs) located at the apical lateral region of adjacent intestinal epithelial cells are largely responsible for regulating the intestinal mucosal barrier. (ecco-ibd.eu)

A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)

Laser-captured microdissected (LCM) DAergic neurons from postmortem tissue of patients with Lewy-pathology revealed a deficiency in expression for nuclear-encoded genes involved in mitochondrial respiration and function 12 . (nature.com)

This resulted in over-expression of NDRG1, which in turn markedly up regulated two differentiation markers of the prostate tissue, p21 and cytokeratin 8/18. (scirp.org)
This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. (cdc.gov)

In conclusion, the current study providing an evidence for the im-portance of co-expression of these genes in main body tissues linked with growth performance of Barki lambs. (preprints.org)

To find SURF4 protein's role in leukaemia, the Pusan researchers compared the expression levels of SURF4 gene among leukaemia patients. (asianscientist.com)

CRISPR is becoming well known in scientific circles as it's a particularly efficient method of gene-editing. (theecologist.org)

From these results, it is evident that not all heat-inducible genes were triggered simultaneously in response to heat shock stress. (biomedcentral.com)

Mutations11

Differentially4

Protein28

Sexually dimorphic gene expression2

Transcriptional11

Regulation14

Methylation regulates2

Encodes1

Negatively2

Genetic7

Neuronal6

MRNA6

Candidate genes2

Sequence4

Progression4

Genome3

Regulator1

Notably2

Modulates1

Proteins1

Epigenetic3

Overexpression2

Repress3

Analyze3

Suggests1

Interacts1

Roles2

Endogenous2

Treatments1

Variants1

Molecular3

Dependent2

Identification2

Vertebrate3

Pathway2

Physiological1

Characterization1

Transcription factor1

Cellular1

Mechanism1

Found5

Neural1

Proliferation1

Secretion1

Enzymes1

Humans3

Significantly1

Activity3

Strains1

Largely2

Novel gene1

Neurons1

Markers2

Body1

Researchers1

CRISPR1

Inducible1