Regulate specific. Medical search. Frequent questions

The exon junction complex (EJC) deposited on spliced mRNAs, plays a central role in the post-transcriptional gene regulation and specific gene expression. (nature.com)
These observations strongly suggest the implication of EJC in fine-tuning of specific gene expression in different cellular contexts. (nature.com)
Qu W , Jin H , Chen B , Liu J , Li R , Guo W , Tian H , . CPEB3 regulates neuron-specific alternative splicing and involves neurogenesis gene expression. (aging-us.com)
In conclusion, our results indicate that DNA methylation regulates neurodevelopmental gene expression dynamics through steering transcription factor activity, but does not explain sexually dimorphic gene expression patterns in zebra finch telencephalon. (ugent.be)
MicroRNAs are a kind of small noncoding RNAs, which are involved in the posttranscriptional regulation of gene expression by binding the translation section and lead to either mRNA degradation or translational inhibition and have been found to regulate crucial biological processes, including proliferation, differentiation, and apoptosis [ 10 - 12 ]. (hindawi.com)
In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. (jneurosci.org)
Conversely, actin signaling regulates neuronal SRF-mediated gene expression. (jneurosci.org)
DNA methylation regulates eukaryotic gene expression and is extensively reprogrammed during animal development. (ista.ac.at)
Here we report a distinctive gene-targeted RNA-directed DNA methylation (RdDM) activity in the Arabidopsis thaliana male sexual lineage that regulates gene expression in meiocytes. (ista.ac.at)
Our results establish a regulatory paradigm in which de novo methylation creates a cell-lineage-specific epigenetic signature that controls gene expression and contributes to cellular function in flowering plants. (ista.ac.at)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)

DNA methylation regulates transcripti. (ugent.be)
Sexual-lineage-specific DNA methylation regulates meiosis in Arabidopsis," Nature Genetics , vol. 50, no. 1. (ista.ac.at)

Using both new and existing data, we propose to identify regions of the PWD genome that contain genes regulating the frequency of Addison's disease. (akcchf.org)
However, whether developmental methylation reprogramming during the sporophytic life cycle of flowering plants regulates genes is presently unknown. (ista.ac.at)
However, little is known about the specific genes involved in motion sickness because few studies have been done to identify them. (medlineplus.gov)
Additional research will be necessary to confirm the association between variations in specific genes and motion sickness susceptibility. (medlineplus.gov)
Neuronal activation promotes expression of an immediate early gene (IEG) program comprised primarily of activity-dependent transcription factors , which are thought to regulate a second set of late response genes (LRGs). (bvsalud.org)
Yeast-form-specific genes identified in Histoplasma capsulatum function in calcium/calmodulin signaling pathways and sulphur metabolism. (cdc.gov)

In the mammalian brain, alternative pre-mRNA splicing is a fundamental mechanism that modifies neuronal function dynamically where secretion of different splice variants regulates neurogenesis, development, pathfinding, maintenance, migration, and synaptogenesis. (aging-us.com)
Sequence-specific RNA-Binding Protein CPEB3 has distinctive isoform-distinct biochemical interactions and neuronal development assembly roles. (aging-us.com)
Here we show that Cul3 is essential to regulate neuronal migration and, therefore, constitutive Cul3 heterozygous mutant mice display cortical lamination abnormalities. (nature.com)
At the molecular level, we found that Cul3 controls neuronal migration by tightly regulating the amount of Plastin3 (Pls3), a previously unrecognized player of neural migration. (nature.com)
Here, we show that Cul3 is required during brain development to regulate neuronal migration and thus precisely assemble the cerebral cortex. (nature.com)
Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function and guide enduring plasticity. (bvsalud.org)

Furthermore, we found that Pls3 cell-autonomously regulates cell migration by regulating actin cytoskeleton organization, and its levels are inversely proportional to neural migration speed. (nature.com)
Notably, a nucleus-resident actin (R62D NLS ) also regulates SRF's transcriptional activity. (jneurosci.org)

Here, we show that FGF is Glycosylphosphatidylinositol-anchored to the producing cell surface and that this modification both inhibits free FGF secretion and activates target-specific bidirectional FGF-FGFR signaling through cytonemes. (biorxiv.org)
The secretion of testosterone is regulated by luteinizing hormone (LH), and is subject to negative feedback via the pituitary and hypothalamus. (cdc.gov)
Its synthesis and secretion are regulated by estrogen. (cdc.gov)

Moreover, experiments with the luciferase activity analysis of truncated apoM promoters could demonstrate that a regulatory region (from-1580 to −1575 bp (−GGTCA-)) upstream of the transcriptional start site of apoM gene was essential for the basal transcriptional activity that regulated by the ER-α. (lu.se)

E3 ubiquitin ligases regulate cellular protein composition by providing target recognition and specificity to the ubiquitin-dependent proteasomal degradation pathway 12 . (nature.com)
At the molecular level, Cul3 regulates cytoskeletal and adhesion protein abundance in mouse embryos. (nature.com)
The COOH-terminal A168-170 region of the giant sarcomeric protein titin interacts with muscle-specific RING finger-1 (MURF-1). (rupress.org)
These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns. (nih.gov)
Calcium-regulated heat stable protein 1 (CARHSP1) also known as calcium-regulated heat-stable protein of 24 kDa (CRHSP-24) is a protein that in humans is encoded by the CARHSP1 gene. (wikipedia.org)
Here, we show that structurally distinct N-glycans regulate an extracellular protein complex involved in the patterning of somatosensory dendrites in Caenorhabditis elegans. (elsevierpure.com)
Specifically, aman-2/Golgi alpha-mannosidase II, a conserved key enzyme in the biosynthesis of specific N-glycans, regulates the activity of the Menorin adhesion complex without obviously affecting the protein stability and localization of its components. (elsevierpure.com)
Calcium-dependent signaling pathways and heat shock protein expression regulate dimorphism in Paracoccidioides brasiliensis and have broad implications for other pathogens. (cdc.gov)

This specific phenotype also was caused by the expression of titin A168-170. (rupress.org)
Our study also shows that activation of Sirt1 with resveratrol exerts its antioxidant effect by regulating the expression of PGC-1α. (frontiersin.org)

Studies also show that Sirt1 regulates apoptosis through other pathways, such as the anti-inflammatory pathway of NF-κB acetylation and the regulation of AMPK in autophagy ( 6 , 7 ). (frontiersin.org)
These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)

Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. (nih.gov)

Policy-level experts perceive the private sector as market-driven and poorly regulated. (who.int)

With the applications of an electrophoresis mobility shift assay and a chromatin immunoprecipitation assay, we could successfully identify a specific ER-α binding element in the apoM promoter region. (lu.se)

Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2. (nih.gov)

Within those large regions we propose to identify the specific DNA sequence variants that are associated with Addison's. (akcchf.org)

Resveratrol (RSV) is a kind of polyphenol, a plant secondary metabolite extracted from wine, grain, fruit, root, etc., which has a protective effect on cardiovascular and nervous system diseases by regulating anti-inflammatory and anti-oxidation processes. (frontiersin.org)
Here we establish that DIP-α and its interacting partners Dpr6 and Dpr10 regulate multiple processes, including arborization within layers, synapse number, layer specificity, and cell survival. (nih.gov)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)

Moreover, distinct types of N-glycans on specific N-glycosylation sites regulate DMA-1/LRR-TM receptor function, which, together with three other extracellular proteins, forms the Menorin adhesion complex. (elsevierpure.com)
In summary, specific N-glycan structures regulate dendrite patterning by coordinating the activity of an extracellular adhesion complex, suggesting that the molecular diversity of N-glycans can contribute to developmental specificity in the nervous system. (elsevierpure.com)

This note analyses the competitiveness of different segments of the telecommunications markets in the five countries (United States, United Kingdom, Australia, New Zealand, and Chile) shows that those countries that have relied on a proper balance between antitrust and sector-specific regulation have, on the whole, more competitive telecom markets. (ssrn.com)
There, the balance between antitrust and sector-specific regulation matters much less than the fact that prices have in many instances been set below costs with the result that the potential for competition in the provision of fixed local services does not exist. (ssrn.com)
The XBee Explorer Regulated takes care of the 3.3V regulation, signal conditioning, and basic activity indicators (Power, RSSI and DIN/DOUT activity LEDs). (sparkfun.com)
Bitcoin-specific regulation is one step closer to a reality in New York. (vox.com)
According to the Ontario Ministry of Agriculture, Food, and Rural Affairs (OMAFRA), "Products produced and sold within the same province are not regulated by this regulation unless they are using the new federal organic logo. (organiccouncil.ca)

Without establishing PELs, OSHA promulgated standards in 1974 to regulate the industrial use of 13 chemicals identified as potential occupational carcinogens. (cdc.gov)

Specific sections of the law regulate perfluoroalkyl and polyfluoroalkyl substances (PFAS) and two heavy metals (lead and cadmium) in a wide range of products with details as listed below. (sgs.com)

It proposes to leverage the Australian financial services framework to regulate digital asset platforms to ensure consistent oversight and safeguards for consumers. (treasury.gov.au)

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development. (nih.gov)

These data strongly suggest that the immune system naturally drives antibody glycosylation in an antigen-specific manner and highlights a promising means by which next-generation therapeutics and vaccines can harness the antiviral activity of the innate immune system via directed alterations in antibody glycosylation in vivo. (harvard.edu)
An intricate system regulates complement activity. (medscape.com)

The government seeks views from interested parties on the proposed framework for regulating digital asset platforms. (treasury.gov.au)
Most jurisdictions have established a specific regulatory framework based on the structure and operation of captives. (iii.org)
3 Consisting of an overarching framework and four specific policies on engagement with nongovernmental organizations, private sector entities, philanthropic foundations and academic institutions. (who.int)

However, conflicting results indicate the clinical use of β-TCP for bone repair remains questionable in several specific experiment models. (frontiersin.org)

Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. (lu.se)

Furthermore, these senescence phenotypes appear to be independent of insulin signaling and manifest in an organ-specific manner. (bioone.org)

The prevalence and similarities of these signaling filopodia suggest that the polarized target-specific morphogen exchange through filopodial contacts is an evolutionarily conserved signaling mechanism. (biorxiv.org)
Notably, CPEB3 partially modulated differential gene splicing enhanced in the modulation of neural development, neuron cycle, neurotrophin, synapse, and specific development pathway, implying an alternative splicing regulatory mechanism associated with neurogenesis. (aging-us.com)
Compared with the prior art, the functions of mould regulating and mould locking are organically combined by the utility model, the toggle rod mechanism is reserved, the movement feature of ''slow-fast-slow'' and the amplification effect of force are ensured to be implemented. (google.com)
An mould locking oil cylinder is integrated on the mould regulating device, by directly locking mould using the mould locking oil cylinder, feature of bad mould locking precision of the toggle rod mechanism is avoided, the mould locking force has high repeating precision, and the stability of the mould locking is reliable. (google.com)

Transcriptome-wide RNA-seq studies revealed that ASAP and PSAP complexes regulate distinct alternative splicing events both in EJC-independent and EJC-dependent manner. (nature.com)
Additionally, distinct vaccine regimens induced different antigen-specific IgG glycosylation profiles, suggesting that antibody glycosylation is not only programmable but can be manipulated via the delivery of distinct inflammatory signals during B cell priming. (harvard.edu)

Understanding how signals might inform cells of their positional identity, directionality, and interactions and organize these functions in diverse tissue-specific patterns is critical to understanding morphogenesis. (biorxiv.org)

The discrete tissue-specific organization of morphogen signaling is known to be dependent on the ability of signal-receiving cells to selectively sense and respond to a specific signal 3 . (biorxiv.org)
While some examples will be given here, a rescue organization or foster care provider should check the specific state and city laws where they are located. (animallaw.info)

The US state of Minnesota has approved measures to regulate PFAS and heavy metals in a wide variety of products. (sgs.com)

DIP and Dpr proteins are expressed in a synaptic layer-specific fashion in the visual system. (nih.gov)
How interactions between these proteins regulate layer-specific synaptic circuitry is not known. (nih.gov)

In response to a string of recent natural disasters, USDA's Animal and Plant Health Inspection Service published a rule in December making it mandatory that all dealers, exhibitors, intermediate handlers, carriers, research facilities, and other entities regulated by the agency under the Animal Welfare Act have an emergency or contingency plan-the better to save the lives of employees and animals in the event of an emergency or natural disaster. (awionline.org)

2016. "Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination. (harvard.edu)
The many different applications of the Internet of Things (IoT), the new business models that IoT enables, and the issues involved in securing and regulating these were a big topic at last week's Techonomy 2016 conference . (pcmag.com)

When the animals were adults, two injections of toxin caused the specific cell population to die within 48 hours, impairing the mouse's ability to eat and resulting in acute anorexia. (scienceblog.com)
We asked: (1) How do cytonemes recognize a specific target cell and form signaling contacts? (biorxiv.org)
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. (nih.gov)

Here, we show that antibody glycosylation is determined in an antigen- and pathogen-specific manner during HIV infection. (harvard.edu)

The approach in general could also eventually lead to specific destruction of cells in other kinds of diseases. (scienceblog.com)
Samples are needed from healthy dogs and dogs affected by specific diseases. (akcchf.org)

According to the Canadian Food Inspection Agency (CFIA), any agricultural product that is labelled organic is regulated by the CFIA. (organiccouncil.ca)

How are captive insurance companies regulated? (iii.org)

One good example is New Mexico, where CPMs are regulated and licensed by the Department of Health. (ourbodiesourselves.org)

This generalizes to: how do we deliver regulated financial products to people in an industry sector that manages risk and is risk-averse? (milliman.com)

These were programs that not only were purpose-built but, because of that, you could easily evaluate them and assess their accuracy for a specific task. (medscape.com)

We used RNA-seq to analyze CPEB3-regulated alternative splicing on control and CPEB3-overexpressing cells. (aging-us.com)
Government should support specific alternative internal and external sources of expertise. (bristol.ac.uk)

Chemicals and Drugs5

Phenomena and Processes1

Information Science1

Gene expression11

Methylation regulates2

Genes6

Neuronal6

Actin2

Secretion3

Transcriptional activity1

Protein8

Expression2

Pathways2

Cerebral cortex1

Poorly1

Chromatin1

Inhibition1

Variants1

Processes3

Adhesion2

Regulation5

Chemicals1

Substances1

Safeguards1

Interacts1

Activity2

Framework3

Results indicate1

Phosphorylation1

Insulin1

Mechanism4

Distinct2

Patterns1

Organization2

Measures1

Proteins2

Entities1

20162

Cell3

Show1

Diseases2

Product1

Companies1

Department1

Products1

Programs1

Alternative2