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  • gene expression
  • NP receptor type A (NPRA) gene expression was positively correlated to mRNA levels of PPARγ coactivator-1α (PGC1A) and several oxidative phosphorylation (OXPHOS) genes in human skeletal muscle. (jci.org)
  • In human myotubes, NP induced PGC-1α and mitochondrial OXPHOS gene expression in a cyclic GMP-dependent manner. (jci.org)
  • This study aimed to investigate the effect of Jieduquyuziyin prescription (JP)-treated rat serum on the gene expression of MeCP2 in Jurkat T cells and its role in the pathogenesis of SLE. (sivb.org)
  • Increases in muscle protein synthesis occurring in response to resistance training can be attributed to pre-translational (increase in mRNA abundance) mechanisms [ 7 ], as muscle-specific gene expression is up-regulated in order to provide an ample supply of mRNA template to meet translational (increases in protein synthesis/unit of mRNA) demands. (biomedcentral.com)
  • microRNAs (miRNAs) are a group of highly conversed noncoding RNAs that regulate many biological processes by governing target gene expression [ 10 ]. (ijbs.com)
  • In contrast to counterparts from young subject's muscle, the satellite cells from aged muscle exhibit the gene expression pattern which favours oxidative damage, altered turnover of cytoskeleton, activation of FOXO-dependent atrophy programs, suppressed myotube formation, and impairment of [Ca.sup.2+]-mediated signaling [25-27, 29, (thefreelibrary.com)
  • M.A.Q. Saddiqui and colleagues found that HEXIM1 blocks gene expression that is required for muscle regeneration after injury. (eurekalert.org)
  • We are particularly interested in the role of some membrane proteins including TNF-α converting enzyme (TACE) and integrins in regulating muscle gene expression. (uth.edu)
  • 2000). While there are many factors regulating this process, from gene expression to hormones and other growth factors, the two necessities for hypertrophy are some form of increased muscular tension, damage, or stress (Goldberg. (blogspot.com)
  • insulin
  • Such intrinsic aging seems unavoidable, since it is caused simply by utilizing (over a particular period of time) the physiological signaling pathways necessary for cell function and survival, for example, the mTOR pathway, IGF/insulin pathway or Reactive Oxygen species (ROS)-specific signal transduction [ 1 , 7 - 12 ]. (pubmedcentralcanada.ca)
  • As a consequence of lower MEF2C binding on their enhancer region, the transcription of miR-1 and miR-133a is reduced, leading to decreased levels of their mature forms in muscle, after insulin treatment. (wikipedia.org)
  • Altered activation of PI3K and SREBP-1c may explain the defective regulation of miR-1 and miR-133a expression in response to insulin in muscle of type 2 diabetic patients. (wikipedia.org)
  • In human subjects, fructose consumption is positively associated with dyslipidemia, insulin resistance, and obesity [ 6 , 7 ]. (hindawi.com)
  • regulation
  • Crist CG, Montarras D, Pallafacchina G, Rocancourt D, Cumano A, Conway SJ, Buckingham M (2009) Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression. (springer.com)
  • This perspective analyzes the current literature on regulation of organ stem cells by their young versus old niches and suggests that determinants of healthy and prolonged life might be under a combinatorial control of cell cycle check point proteins and mitogens, which need to be tightly balanced in order to promote tissue regeneration without tumor formation. (pubmedcentralcanada.ca)
  • These findings suggest a crucial role for the HEXIM1/P-TEFb pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases. (jci.org)
  • Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. (amedeo.com)
  • regenerate
  • On the other hand, diseased or injured muscle has the capacity to regenerate leading to recovery of muscle mass and function. (uth.edu)
  • 2017
  • 2017). Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways. (uth.edu)
  • attenuate
  • Although pharmacologic approaches are being investigated as alternative methods to increase or attenuate declines in muscle mass [ 9 ] few, if any, countermeasures are superior to resistance exercise. (hindawi.com)
  • proliferate
  • These cells, called bulge stem cells (BSCs) or hair follicle stem cells (HFSCs), are normally slow-cycling but can be stimulated to proliferate in response to injury or to certain growth stimuli. (medsci.org)
  • Accumulated evidence has confirmed that the initiation of a new hair cycle relies on the activation of quiescent stem cells to proliferate and differentiate in response to signals from the dermal papilla (DP). (medsci.org)
  • In response to muscle damage or under increased workload these cells activate, migrate into damaged sites, proliferate, and fuse with existing myofibers or with each other to form new myofibers, whereas a small portion of these cells returns into quiescence [11, (thefreelibrary.com)
  • promotes
  • Here, we show that miR-206 promotes skeletal muscle regeneration in response to injury. (jci.org)
  • Clearance duced dysregulation of cytogenesis, proliferation, and in- of senescent cells delays the induction of various geri- flammation in multiple TSCs, and discuss functional atric pathologies, supporting the concept that the similarities of microRNAs across different types of TSCs SASP promotes aging in a non-cell-autonomous in aging. (deepdyve.com)
  • ZIP4 Promotes Muscle Wasting and Cachexia in Mice with Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells. (uth.edu)
  • lipid
  • Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: an exploratory study. (nih.gov)
  • Cardiac
  • Cardiac natriuretic peptides (NP) are major activators of human fat cell lipolysis and have recently been shown to control brown fat thermogenesis. (jci.org)
  • Striated muscle (skeletal and cardiac muscle) undergoes remodeling, either positive or negative, in response to physiological and pathological stress. (uth.edu)
  • 3. Signaling mechanism of cardiac muscle adaptation to mechanical stress. (uth.edu)
  • We study the mechanotransduction mechanism that mediates cardiac muscle response to overloading with the purpose of identifying ways to prevent the maladaptation specifically without blocking adaptation. (uth.edu)
  • progenitor cells
  • Old differentiated cells lose their functionality while stem and progenitor cells dedicated to generating new differentiated cells lose their regenerative capacity [ 5 , 6 ]. (pubmedcentralcanada.ca)
  • also known as Bmp13 and CDMP-2) as a regen- lating abilities of hematopoietic stem/progenitor cells erative factor secreted by young MSCs [21, (deepdyve.com)
  • Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development. (amedeo.com)
  • developmental
  • We further demonstrate that a TGFβ-Lox feedback loop between the MCT and myofibers maintains the dynamic developmental homeostasis between muscle components while also regulating MCT organization. (biologists.org)
  • stimulates
  • Neurogenic atrophy, which has a similar effect, is muscle atrophy resulting from damage to the nerve which stimulates the muscle, causing a shriveling around otherwise healthy limbs. (wikipedia.org)
  • Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin. (amedeo.com)
  • mice
  • An undefined youthful environment, i.e. heterochronic parabiosis, where aged mice are exposed to young blood circulation, was demonstrated to enhance endogenous regeneration in muscle and liver [ 14 , 19 ]. (pubmedcentralcanada.ca)
  • In humans, inactivating mutations in the TH transporter MCT8 cause the Allan-Herndon-Dudley syndrome, characterized by severe neuromuscular symptoms and an abnormal TH serum profile, which is fully replicated in Mct8 knockout mice and Mct8/Oatp1c1 double-knockout (M/O DKO) mice. (eur.nl)
  • In M/O DKO mice, we observed a strongly reduced number of differentiated SCs, suggesting an impaired stem cell function. (eur.nl)
  • Moreover, M/O DKO mice and mice lacking both transporters exclusively in SCs showed impaired skeletal muscle regeneration. (eur.nl)
  • Comparing and contrasting the molecular mechanisms controlling BAT growth and development in mice and humans will increase our understanding or how human BAT is developed and may identify potential therapeutic targets to increase EE. (biomedcentral.com)
  • Mice fed a diet high in SFAs developed alterations in the walls of the heart and heartbeat that are characteristic cardiomyopathy symptoms in humans. (eurekalert.org)
  • In this issue of the Journal of Clinical Investigation , researchers at the State University of New York Downstate Medical Center in Brooklyn report that HEXIM1, a protein that regulates gene transcription, is important for skeletal muscle regeneration in mice. (eurekalert.org)
  • Mice with a 50% reduction in HEXIM1 exhibited greater muscle mass and function after injury compared to mice with a normal amount of the gene. (eurekalert.org)
  • p38ß MAPK Mediates ULK1-dkepedent induction of autophagy in skeletal Muscle of tumor-bearing mice. (uth.edu)
  • important
  • Nutrients are one of the most important epigenetic factors to affect skeletal muscle development. (ijbs.com)
  • Findings from this study will contribute to the understanding of how cholesterol/CAV-1/caveolae regulates aspects of the cell membrane important to cell adhesion, substrate sensing, and microenvironment interaction. (springer.com)
  • This protein, which preferentially binds to a DNA consensus site (CANNTG) called an E-box, has been shown in both myogenic (C2C12) and nonmyogenic cell lines to be highly important in controlling the transcription of differentiation-specific genes ( Berkes and Tapscott, 2005 ). (rupress.org)
  • receptor
  • In this issue of the Journal of Clinical Investigation researchers led by George Miller at the New York University School of Medicine report that pancreatic cancer is driven by activation of a pro-inflammatory cell surface receptor known as TLR7. (eurekalert.org)
  • transcription
  • Although this scenario has yet to be demonstrated in satellite cells, it is most likely that analogous mechanisms would occur, and if so, it is possible that MyoD could be involved in inducing transcription from either Cdc6 or MCM2 in these cells after leaving quiescence. (rupress.org)
  • activate
  • When stem cells were induced to differentiate toward a hair fate in a co-culture system, Lef1 was notably up-regulated and accumulated in the nucleus, appearing to activate the target protein c-myc and jagged1. (medsci.org)