Regulate roles nuclear localization signals. Medical search. Frequent questions

Integrin costimulatory signals modulate inflammatory gene expression, but the important control points between these pathways remain unresolved. (escholarship.org)
Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. (frontiersin.org)
Genes of the E(spl)-C and AS-C regulate neurogenesis and related differentiation pathways. (sdbonline.org)
Many signal transduction pathways are composed of modules that are remarkably conserved across species, such that lessons from different experimental model organisms have contributed to the understanding of molecular hierarchies that control signal communication in many cellular contexts. (biomedcentral.com)
The first step in the Wnt signal occurs when extracellular Wnt ligand binds Frizzled receptors on the cell surface, leading to the activation of several distinct transduction pathways (see Figure 1 ). (biomedcentral.com)
The intracellular protein Dishevelled is common to both canonical and non-canonical signaling pathways, raising the question of how this mysterious protein acts at the signal crossroads. (biomedcentral.com)
Wnt signals via canonical and non-canonical pathways. (biomedcentral.com)
The roles of the other proteins in the two pathways, and of the Dsh motifs, are discussed in the text. (biomedcentral.com)
Nevertheless, small is well known regarding the precise pathways regulated by HOXA7 that promote the success and development of granulosa cells. (cancerhugs.com)
Since glucocorticoids are essential for life, other cellular signaling pathways strongly regulate GR actions in many different ways, such as physical interaction via their effector transcription factors and epigenetic modifications including phosphorylation and acetylation. (brainimmune.com)
Traditionally, WNT signaling is usually classified into two large groups: the canonical WNT (or -catenin-dependent) and non-canonical WNT (or -catenin-independent) pathways. (icsv20.org)
It can reduce the sulfation of cell surface heparan sulfate proteoglycan (HSPG) and inhibit various growth factor receptor-mediated signaling pathways. (oncotarget.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
You will find now many opportunities to evaluate how SP acts in concert with other inhibitors of intracellular signaling pathways to modulate elements of viral biology. (mi-rna.com)
One can find now a lot of options to evaluate how SP acts in concert with other inhibitors of intracellular signaling pathways to modulate facets of viral biology. (vegfrinhibitors.com)
In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
Limb-girdle muscular dystrophy (LGMD) protein defects occur in several pathways involved in the biologic function of muscle and can be divided into groups based on cellular localization. (medscape.com)

These studies have revealed that 14-3-3 proteins can interact with the phosphorylated forms of their client proteins in response to certain signals, and that this binding finalizes the signaling event by enabling a change in the subcellular localization, protein stability or intrinsic enzymatic activity of the client, or by promoting an association between the client and other proteins. (elifesciences.org)
But it is becoming increasingly clear that protein subcellular localization can be extremely dynamic, allowing key proteins to play different roles in different compartments. (biomedcentral.com)
Furthermore, the subcellular localization of HOXA7 changed from nuclear to cytoplasmic during follicular maturation [13] predominantly. (cancerhugs.com)

Our studies show that after being secreted into the extracellular matrix, CCN5 binds to the α6β1 integrins of the cells leading to inhibition of the PI3K-AKT signaling pathway. (ku.edu)
Many cell fate decisions in higher animals are based on intercellular communication governed by the Notch signaling pathway. (sdbonline.org)
Now, in Journal of Biology [ 1 ], Sergei Sokol and colleagues show that the Dishevelled (Dsh) protein of the Wnt signaling pathway can shuttle in and out of the nucleus (see 'The bottom line' box for a summary of the work and 'Background' for further explanations and definitions). (biomedcentral.com)
Studies of the Wnt pathway provide a wonderful example of how researchers from different fields have contributed to a detailed understanding of a key signal transduction pathway [ 2 ]. (biomedcentral.com)
The Wnt signaling machinery is tightly regulated, and disruption of components of the signaling pathway have been implicated in diseases including cancer [ 2 , 4 ]. (biomedcentral.com)
Frizzled receptors can also initiate an independent ' non-canonical ' Wnt pathway that diverges to regulate complex developmental events involved in planar cell polarity and convergent extension movements during embryo development, via small GTPases and the JNK kinase. (biomedcentral.com)
Moreover, Tip60 apparently is required for the proper activation of the UV-induced JNK-signaling pathway, thereby ensuring an efficient response to DNA damage and apoptosis induction. (uni-marburg.de)
Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]. (cancerindex.org)
The cyclic AMP-dependent protein kinase A signaling pathway plays a major role in regulating plant infection from the rice blast fungus and or are both necessary for development of spores and appressoria by and play roles in cell wall differentiation, regulating melanin pigmentation and cell surface hydrophobicity during spore formation. (bio2009.org)
functions downstream of the cAMP/PKA signaling pathway and are novel transcriptional regulators associated with 192203-60-4 cellular differentiation during flower infection from the rice blast fungus. (bio2009.org)
Recently, we reported that MoRic8 interacts with MagB and functions upstream of the cAMP/PKA pathway to regulate multiple phases of infection-related morphogenesis in [56]. (bio2009.org)
However, downstream targets of the cAMP/PKA pathway are not well analyzed in and and are regulated by the cAMP/PKA pathway. (bio2009.org)
Based on this work I won a fellowship from the Korean Federation of Science and Technology Societies to investigate the subcellular localisation of maize auxin biosynthesis at Dankook University in Seoul which lead to a publication that showed for the first time that both steps of the TAA/YUC pathway of auxin biosynthesis can be ER-localised. (brookes.ac.uk)
Hence, this review is supposed to serve as a refresher of the existing understanding about the physiologic and pathogenic assignments of WNT/-catenin signaling pathway, also to put together potential therapeutic possibilities by concentrating on the canonical WNT pathway. (icsv20.org)
A fuller picture of the WNT signaling pathway surfaced when T-cell aspect/lymphocyte enhancer aspect (TCF/LEF) transcription elements had been defined as WNT nuclear effectors 9, 10 and Frizzleds (FZDs) had been defined as WNT obligate receptors 11, working as well as co-receptors, such as for example low-density lipoprotein-receptor-related proteins (LRPs)/Arrow 12. (icsv20.org)
WNT palmitoylation is vital for WNT signaling and it is completed by PORC, an ardent ER-localized O-acyltransferase and extremely conserved element of the WNT pathway 32, 33. (icsv20.org)
Dysregulation of WNT signaling pathway is normally associated with several human illnesses 17-27. (icsv20.org)
Biologically, the canonical WNT/-catenin signaling pathway usually plays crucial functions in regulating cell fate, proliferation and survival, while the non-canonical WNT signaling is usually more associated with differentiation, cell polarity and migration 25-27. (icsv20.org)
An important anti-tumor mechanism of hSulf-1 operates by decreasing downstream AKT signaling pathway activity and inhibiting the nuclear import of CDK4. (oncotarget.com)

Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. (wikipedia.org)
EGF signaling takes on a significant part in cell differentiation and development [16]. (cancerhugs.com)
Nuclear aspect-κB (NF-κB) includes a category of transcription elements that play vital roles in irritation immunity cell proliferation differentiation and success (7). (scienceexhibitions.org)
In normal human tissues, hSulf-1 is stably expressed, and it plays important roles in cell proliferation and differentiation [ 1 , 2 ]. (oncotarget.com)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)

STAT1 homodimers are involved in type II interferon signalling, and bind to the GAS (Interferon-Gamma Activated Sequence) promoter to induce expression of interferon stimulated genes (ISG). (wikipedia.org)
Other examples of Drosophila gene complexes include the Antennapedia complex (ANTP-C), the bithorax complex (BX-C) and the achaete-scute complex (AS-C). The hallmark of all these gene complexes, including the E(spl)-C is that within any complex the genes are evolutionarily related and jointly regulated. (sdbonline.org)
It seems that the expansion of numbers of genes evolving by duplication to handle the ever increasing complexities of neurogenesis, has been matched by a similar expansion of genes, also by duplication, to suppress or regulate neurogenesis. (sdbonline.org)
Developmental signals received by the Notch receptor cause Suppressor of Hairless (Su[H]) to mediate transcription of target genes. (sdbonline.org)
Various genes regulating cellular and subcellular metal distribution have been identified and characterized. (frontiersin.org)
TDP-43 regulates RNA metabolism, trafficking, and localization of thousands of target genes. (nature.com)
Our results showed the roles of PpHDZs on root formation, which is helpful to better understand the classification and function of peach HD-Zip genes. (biomedcentral.com)
The formation and growth of adventitious root is the key to cutting propagation, which is regulated by genes. (biomedcentral.com)
olycomb group proteins are subunits of PcG complex 1 and 2 and other complexes and regulate the transcription of developmental regulators, which include Hox genes. (gabasignaling.com)
Germline mutations in the NOTCH1 , NOTCH2 and NOTCH3 genes cause Adams-Oliver syndrome, Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, respectively ( 4 ), and DLL4-NOTCH3 signaling in human vascular organoids induces basement membrane thickening and drives vasculopathy in the diabetic microenvironment ( 5 ). (spandidos-publications.com)
By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
The genes were found to have overlapping functions in regulating post-embryonic growth and meristem maintenance. (plantae.org)
Fasting signals are relayed by various intracellular enzymes, such as kinases, phosphatases, acetyltransferases, and deacetylases, which affect the transcriptional activity of transcription factors and transcriptional coactivators for gluconeogenic genes. (e-enm.org)

The STAT protein can be dephosphorylated by nuclear phosphatases, which leads to inactivation of STAT and subsequent transport out of the nucleus by an exportin-RanGTP complex. (wikipedia.org)
FAK signaling facilitated TNF-α-induced, mitogen-activated protein kinase activation, and, surprisingly, FAK inhibition resulted in the loss of the GATA4 transcription factor required for TNF-α-induced VCAM-1 production. (escholarship.org)
Structure-function analysis of the Dishevelled (Dsh) protein in frog embryos has defined sequences that regulate Dsh nuclear localization, which proves critical for Wnt signaling. (biomedcentral.com)
The degradation of β-catenin is regulated by interaction with a number of proteins including Axin , glycogen synthase kinase 3 (GSK3) and the adenomatous polyposis coli protein (APC). (biomedcentral.com)
TDP-43 is a highly conserved, ubiquitously expressed, multifunctional nucleic acid-binding protein composed of two RNA recognition motifs (RRM), nuclear localization (NLS) and export signals (NES), and a carboxy-terminal glycine rich region. (nature.com)
Rgs1, a regulator of G-protein signaling, interacts with all the three G subunits and functions as a negative regulator of G-proteins in [52]. (bio2009.org)
which encodes a putative G-protein-coupled receptor may be involved in regulating Mac pc1 activities, because is required for surface acknowledgement and virulence and exogenous cAMP restores appressorium formation and pathogenicity in deletion mutants [55]. (bio2009.org)
Our results show that class XI myosins play specific roles in the reproduction and intracellular movement of TMV in association with the dynamic endoplasmic reticulum network, whereas class VIII myosins support the specific targeting of the viral movement protein to plasmodesmata and thus the cell-to-cell movement of the virus. (prelekara.sk)
Scmh1 encodes a protein with quite a few characteristic domains, including the malignant brain tumor domains, the professional line, glutamine, serine, and threonine rich domains, the N terminal and C terminal putative nuclear localization sig nals, as well as Scm polyhomeotic l mbt domain, also designated as the SAM domain. (gabasignaling.com)
Scmh1 encodes a protein with many characteristic domains, as well as the malignant brain tumor domains, the pro line, glutamine, serine, and threonine wealthy domains, the N terminal and C terminal putative nuclear localization sig nals, plus the Scm polyhomeotic l mbt domain, also designated since the SAM domain. (gabasignaling.com)
TDP-43 is a predominantly nuclear protein, with much known about its nuclear roles in DNA and RNA binding, and regulation of transcription and translation. (edu.au)
In line with a more complex picture, multiple isoforms of the protein likely exist and non-centrosomal sites of localisation have been reported. (springer.com)
Here I pursued my scientific interests in subcellular protein localisation, bioinformatics, and mathematical modelling. (brookes.ac.uk)
My additional independent research on ER localisation and splicing in auxin biosynthesis showed for the first time ER-localisation for an auxin biosynthetic protein. (brookes.ac.uk)
Tonicity-responsive enhancer-binding protein (TonEBP), which is also known as nuclear factor of activated T cells 5 (NFAT5), was discovered 20 years ago as a transcriptional regulator of the cellular response to hypertonic (hyperosmotic salinity) stress in the renal medulla. (nature.com)
Non-canonical WNT signaling can also activate calcium flux and kinase cascades, including protein kinase C (PKC), calcium/calmodulin-dependent protein kinase II (CaMKII) and JUN N-terminal kinase (JNK), leading to the activation of AP1- and NFAT-regulated gene expression 25-27. (icsv20.org)
Posttranslational protein S-palmitoylation regulates the localization and function of its target proteins involved in diverse cellular processes including meiosis. (life-science-alliance.org)
A role of Akr1 S-palmitoylating the nuclear fusion protein Tht1 to function in karyogamy is identified. (life-science-alliance.org)
In this study, we found that hSulf-1 overexpression in melanoma cells can inhibit cell proliferation and induce cell cycle arrest and apoptosis by decreasing the protein kinase B (AKT) phosphorylation and limiting CDK4 nuclear import. (oncotarget.com)
Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)
To understand the functions of CRYAA and how these are regulated, protein-protein interactions need to be investigated. (molvis.org)
Protein arginine methyltransferases (PRMTs) were recently added to the list of enzymes that are critical for regulating transcription in hepatic gluconeogenesis. (e-enm.org)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)

Evidently, CCN5-mediated restoration of ER-α and its downstream signaling cascades renders the TNBC cells sensitive to tamoxifen. (ku.edu)
In addition to its canonical roles as a cytoplasmic kinase downstream of integrin and growth factor receptor signaling, recent studies revealed new aspects of FAK action in the nucleus. (molcells.org)
Moreover, the EGF-induced KGN proliferation was abrogated, and the activation of downstream signaling was diminished when HOXA7 was knocked down. (cancerhugs.com)

NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. (spandidos-publications.com)
Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. (spandidos-publications.com)
Non-canonical WNT signaling can be initiated by WNT conversation with Frizzled receptors, or RYK and ROR receptor tyrosine kinases, and regulates small GTPases (such as RhoA, Rac and Cdc42) in DVL-dependent manner. (icsv20.org)

To identify underlying mechanisms, we studied the intracellular localization of Tip60 and Mdm2. (uni-marburg.de)

We found that the tricarboxylic acid cycle-associated enzyme α-ketoglutarate (α-KG) dehydrogenase (KGDH) entered the nucleus, where it interacted with various JMJs to regulate α-KG-dependent histone demethylations by JMJs, and thus controlled genome-wide gene expression in plants. (bvsalud.org)
Phosphorylation-resistant site mutations in PIF7 result in increased nuclear localization and shade-induced gene expression, and consequently augment hypocotyl elongation. (elifesciences.org)
Eukaryotic 5'-3' mRNA decay plays important roles during development and in response to stress, regulating gene expression post-transcriptionally. (uoa.gr)
Membrane-spanning proteins often function as receptors involved in recognition and cell adhesion, whereas nuclear proteins frequently play a role in regulating gene expression and transcription. (biomedcentral.com)
such studies have defined the molecules that ensure signals initiated at the cell surface are efficiently transmitted to the cell nucleus, where they often result in the induction of a specific gene-expression program. (biomedcentral.com)
Polycomb-group (PcG) proteins are part of an epigenetic memory system that regulates global gene expression throughout development in multicellular eukaryotes (Butenko and Ohad, 2011). (plantae.org)

These studies reveal new developmental and anti-inflammatory roles for kinase-inhibited FAK in limiting VCAM-1 production via nuclear localization and promotion of GATA4 turnover. (escholarship.org)
The two most important issues are proper subcellular traffic and targeting to the PM, and regulated endocytosis in response to physiological, developmental, or stress signals. (uoa.gr)

This leads to stabilization and nuclear localization of FOXO3A resulting in transcriptional activation of the cyclin-dependent kinase inhibitor P27KIP1. (ku.edu)

However, the mechanism through which phosphorylation regulates the activity of PIF7 is unclear. (elifesciences.org)
CTNNB1 phosphorylation regulates insulin internalization. (proteopedia.org)

NA has central roles in metal nutrition and metal homeostasis of flowering plants. (bvsalud.org)
Different subcellular compartments are suggested to be linked through complex retrograde signaling networks to regulate cellular metal homeostasis. (frontiersin.org)
Glucocorticoids, steroid hormones secreted from the adrenal cortex, play essential roles in the maintenance of internal homeostasis by influencing virtually all organs and tissues. (brainimmune.com)
Glucocorticoids are steroid hormones secreted from the zona fasciculata of the adrenal cortex, and play numerous important roles in the maintenance of internal homeostasis by influencing activities of virtually all organs and tissues, such as the brain, liver, skeletal muscles and the immune-related organs and cells [1]. (brainimmune.com)

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)

These findings established a new paradigm of FAK signaling from cellular adhesions to the nucleus. (molcells.org)
Although physiological stimuli for controlling FAK nuclear localization have not been completely characterized, FAK shuttles from focal adhesions to the nucleus to directly convey extracellular signals. (molcells.org)
In binding assays, ORA59 and RAP2.3 interacted in the nucleus and showed ethylene-dependent nuclear localization. (figshare.com)
As this localization pattern was not observed when GFP-CLF was expressed alone, PWO1 appears to recruit CLF to its target sites in the nucleus. (plantae.org)

Plant/ crop productivity effected by the environmental strains such as water deficit condition (drought), Low temperature (cold), salt and High temperature (heat) these stresses disturb the signal transduction of gene regulatory systems of plants. (scielo.br)
The most appropriate therapeutic technique may possibly in the end call for combination therapies of signal transduction modulators. (mi-rna.com)
Probably the most proper therapeutic method may perhaps in the end call for mixture therapies of signal transduction modulators. (vegfrinhibitors.com)
MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)

Patients with triple negative breast cancer (TNBC), where the cancer cells do not express nuclear hormone receptors and human epidermal growth factor receptor 2 (HER2), have worse survival rate compared to the patients with luminal subtypes of cancer. (ku.edu)
Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)

Here, we show that overexpression of dcap-1 in neurons of worms is sufficient to increase lifespan through the function of the insulin/IGF-like signaling and its effector DAF-16/FOXO transcription factor. (uoa.gr)

2015. C9ORF72 expression and cellular localization over mouse development, Acta neuropathologica communications, 3:59, 1-11. (edu.au)

We show that nuclear targeting is regulated by environmental signals and that KGDH is enriched at thousands of loci in Arabidopsis thaliana. (bvsalud.org)
Octadecanoid-responsive arabidopsis 59 (ORA59) is an ethylene response factor (ERF) transcription factor and has been suggested to integrate ethylene and jasmonic acid signaling and regulate resistance to necrotrophic pathogens. (figshare.com)
Finding that PWO1 belongs to a small gene family ( PWO1 - 3 ) in Arabidopsis, and that the members of this family had almost identical expression patterns, the authors conducted a mutant analysis to compare their roles. (plantae.org)
PWWP-DOMAIN INTERACTOR OF POLYCOMBS1 interacts with Polycomb-group proteins and histones and regulates Arabidopsis flowering and development. (plantae.org)

Nuclear FAK promotes p53 and GATA4 degradation via ubiquitination, resulting in enhanced cell proliferation and reduced inflammatory responses. (molcells.org)
Wnt signaling regulates cell proliferation, cell polarity and cell-fate determination. (biomedcentral.com)
This differential localization indicated that HOXA7 underwent cell type- and stage-specific adjustments during ovarian folliculogenesis, which most likely led to the rules of granulosa cell proliferation. (cancerhugs.com)
One important mechanism of carcinogenesis is uncontrolled cell proliferation caused by the excessive activation of cell proliferation signals. (oncotarget.com)

Much research has focused on elucidating the roles each of these domains play in regulating different STAT isoforms. (wikipedia.org)
This thesis characterized the expression pattern and cellular localisation of the three reported mouse isoforms of C9ORF72 in cell culture and in vivo, and demonstrated that C9ORF72 was present in synaptosomes and within actin-rich structures of neurons. (edu.au)
In this review, we summarize recent findings regarding the roles of PRMT isoforms in the control of fuel metabolism, with emphasis on glucose metabolism. (e-enm.org)

Also, we found that the CCN5-induced PI3K-AKT inactivation leads to stabilization and nuclear accumulation of P27KIP1 resulting in cell cycle arrest of TNBC cells. (ku.edu)
Here, we show that shade light induces the de-phosphorylation and nuclear accumulation of PIF7. (elifesciences.org)

Notch signaling dysregulation is involved in a variety of pathologies, including cancer and non-cancerous diseases. (spandidos-publications.com)

Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively. (escholarship.org)
These transcription factors are known as masters regulators because its single transcript regulate more than one gene, in this context the regulon word is fascinating more in compass of transcription factors. (scielo.br)

Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic transcription. (bvsalud.org)

Interestingly, nuclear translocation of FAK becomes prominent in kinase-inhibited conditions such as in de-adhesion and pharmacological FAK inhibition, while a small fraction of nuclear FAK is observed a normal growth condition. (molcells.org)

During growth, development and disease, extracellular signals are communicated, or transduced, into the cell and in such a way as to elicit a particular cellular response. (biomedcentral.com)

Originally, STAT proteins were described as latent cytoplasmic transcription factors as phosphorylation was thought to be required for nuclear retention. (wikipedia.org)
In this review, roles of nuclear FAK in regulating transcription factors will be discussed. (molcells.org)
HD-Zips (Homeodomain-Leucine Zippers) are a class of plant-specific transcription factors that play multiple roles in plant growth and development. (biomedcentral.com)
In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)

The C terminal putative nuclear localization signal domain acts also as an interaction do primary for geminin. (gabasignaling.com)

FAK inhibition also triggered FAK nuclear localization. (escholarship.org)

Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)
Finally, based on these mechanisms, we discuss treatments that could increase the survival of older people, not simply by inhibiting the virus, but by restoring patients' ability to clear the infection and effectively regulate immune responses. (aging-us.com)

Moreover, bZIP52 in rice is a negative regulator in cold signaling [ 16 ]. (biomedcentral.com)

Nuclear localization sequences and conserved domains of the MoSom1 and MoCdtf1 proteins are crucial for 192203-60-4 his or her biological function. (bio2009.org)

Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. (escholarship.org)
The bZIP gene family has important roles in various biological processes, including development and stress responses. (biomedcentral.com)

regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. (proteopedia.org)

The initial case for the participation of WNT signaling in individual cancers was produced when the hereditary cancers symptoms termed familial adenomatous polyposis (FAP) gene item, adenomatous polyposis coli (APC) 13, 14, was discovered to connect to -catenin 15, 16, and was afterwards shown to enjoy a critical function in managing -catenin proteins stability. (icsv20.org)

The microenvironment of dystrophic muscles consists of turned on immune system cell infiltrates and up-regulated inflammatory gene appearance (6). (scienceexhibitions.org)

We further confirmed that hSulf-1 overexpression can inhibit AKT phosphorylation and CDK4 nuclear localization and retard the growth of melanoma xenograft tumors in nude mice. (oncotarget.com)

The gaseous plant hormone ethylene is a key signaling molecule regulating plant growth, development, and defense against pathogens. (figshare.com)
The analysis of transcriptome data of the leaves in C. paliurus revealed the bZIP gene family was one of the most abundant TFs in this organism that regulate leaf development [ 26 ]. (biomedcentral.com)
In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

Su(H) is shown to be the transmitter of Notch signaling to malpha, m4 and m2 . (sdbonline.org)
Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)
However, Notch signaling is inactivated in small‑cell lung cancer and squamous cell carcinomas. (spandidos-publications.com)
The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)

The lipid the different parts of WNTs are necessary for effective signaling, including WNT proteins secretion 30, 31. (icsv20.org)

In both and Flo8 interacts with Efg1, a homolog of the Phd1/Sok2 and StuA proteins that regulate morphogenesis of and FoStuA, GcStuA and MoStu1 (Mstu1), have recently been recognized [29]C[31]. (bio2009.org)
These results suggest that ORA59 physically interacts with RAP2.3 and that this interaction is important for the regulatory roles of ORA59 in ethylene responses. (figshare.com)

Here, we review progress in the understanding of different subcellular metal transport components in plants and discuss the prospects of regulating cellular metabolism and strategies to develop biofortified crop plants. (frontiersin.org)

More specifically, we summarize the roles of four PRMTs: PRMT1, PRMT 4, PRMT 5, and PRMT 6, in the control of hepatic gluconeogenesis through specific regulation of FoxO1- and CREB-dependent transcriptional events. (e-enm.org)

Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)
Evidence suggests that TDP-43 is also important for neurite outgrowth, remodelling and can regulate many components of the neuronal cytoskeleton. (edu.au)

Both the N-terminal and SH2 domains mediate homo or heterodimer formation, while the coiled-coil domain functions partially as a nuclear localization signal (NLS). (wikipedia.org)

Geminin types a Cdt1 geminin complicated that regulates Cdt1, which initiates DNA replication licensing. (gabasignaling.com)

Anatomy26

Organisms20

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes65

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Pathways17

Subcellular localization3

Pathway19

Differentiation5

Genes14

Protein23

Downstream3

Canonical3

Intracellular1

Gene expression6

Developmental2

Cyclin-depend1

Phosphorylation regulates2

Homeostasis4

Cascades2

Nucleus4

Transduction4

Receptor3

Effector1

Cellular localization1

Arabidopsis4

Proliferation4

Isoforms3

Accumulation2

Dysregulation1

Regulators2

Histones1

Translocation1

Extracellular signals1

Transcription factors4

Putative1

Inhibition1

Mechanisms2

Regulator1

Sequences1

Important roles2

Mitosis1

Cancers1

Inflammatory1

Overexpression1

Development3

Notch4

Secretion1

Interacts2

Metabolism1

Regulation1

Cytoskeleton2

Functions1

Replication1