Regulate cellular chromatin. Medical search. Frequent questions

In the human genome, C-myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on enhancer box sequences (E-boxes). (wikipedia.org)
A new study led by University of Maryland physicists sheds light on the cellular processes that regulate genes. (phys.org)
They dynamically regulate the expression of genes, transposable elements, and higher-order chromatin structures. (pasteur.fr)
Our results show that all 6 candidates regulate the expression of germline genes. (pasteur.fr)
Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence. (nih.gov)
In the context of DNA damage, p53 is thought to be a decision-making transcription factor that selectively activates genes as part of specific gene expression programmes to determine cellular outcomes. (nih.gov)
Chromatin is the molecular apparatus that packages DNA into a smaller volume so it can fit into the cell and physically regulates how genes are expressed. (science20.com)
The finding fits with accumulating evidence that damage to chromatin regulatory genes is a common feature of various psychiatric and neurodevelopmental disorders. (science20.com)
By combining the mutational data from this and related studies on schizophrenia, the authors found that "chromatin regulation" was the most common description for genes that had damaging mutations. (science20.com)
PTFs also enable other transcription factors, histone modifiers, and nucleosome remodeling complexes to alter the chromatin state and promote gene expression of silenced genes. (cytoskeleton.com)
The transcription factors Oct4, Sox2, and Klf4 were found to trigger endogenous expression of pluripotent genes [2] and were identified as PTFs due to their ability to access closed chromatin [3] . (cytoskeleton.com)
To isolate possible mechanisms underlying these structural and functional changes, we used whole-genome RNA sequencing and found prominent dopamine-induced enrichment of genes containing the CCCTC-binding factor (CTCF) motif, suggesting involvement of chromatin restructuring in the nucleus. (jneurosci.org)
Such three-dimensional organization of chromosomes into spatially distinct domains sheds light on how complex genomes might set specific transcriptional programs to regulate genes individually or as groups of genes. (biomedcentral.com)
Polycomb Group (PcG) of proteins compact chromatin keeping genes in a repressed state. (chicagobiomedicalconsortium.org)
PCR2 targets genes that are developmentally regulated and catalyzes di- and histone tri-methylation, resulting in chromatin compaction and gene repression. (chicagobiomedicalconsortium.org)
Several genes involved in different aspects of stem cell activation are being studied, including some that transduce initial signals, and others that regulate self-renewal and differentiation. (chicagobiomedicalconsortium.org)
The laboratory uses CRISPR/Cas9-based screening approaches to identify genes that modulate cellular sensitivity to radiotherapy and chemotherapy. (cancer.gov)
Background: Bivalent chromatin domains consisting of the activating histone 3 lysine 4 trimethylation (H3K4me3) and repressive histone 3 lysine 27 trimethylation (H3K27me3) histone modifications are enriched at developmental genes that are repressed in embryonic stem cells but active during differentiation. (researchgate.net)
Here we show that bivalent domains and chromosome architecture for bivalent genes are dynamically regulated during the cell cycle in human pluripotent cells. (researchgate.net)
Transcriptional activity is regulated by DNA binding transcription factors, but these typically act in more than one cell lineage activating different subsets of target genes in each. (edu.au)
Chromatin packing has an influence on what genes are transcribed by making specific locations accessible, now we know that it also influences how the gene is going to be transcribed. (embl.org)
Disturbance of this process alters the activity of many genes and disrupts several cellular processes, which could explain the diverse signs and symptoms of Coffin-Siris syndrome. (medlineplus.gov)
Research suggests that the SOX11 gene, another gene associated with Coffin-Siris syndrome, is one of many genes regulated by SWI/SNF complexes. (medlineplus.gov)
TFs being expressed and the downstream differentiation target been established as candidates to regulate both pluripotency and genes being shut off [11]. (lu.se)

The first to be discovered was its capability to drive cell proliferation (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation, and stem cell self-renewal. (wikipedia.org)
The laboratory is particularly interested in studying how specific DNA sequences, DNA binding proteins, and chromatin. (rochester.edu)
How the proteins that regulate these processes function in the context of chromatin and its dynamic architectures is an intensive field of study. (rockefeller.edu)
Over the past decade, genome-wide assays and new imaging approaches have enabled a greater understanding of how access to the genome is regulated by nucleosomes and associated proteins. (rockefeller.edu)
For example, alkaline vacuole/lysosome are deficient in autophagy, Golgi pH regulates its ability to glycosylate proteins and failure to maintain endosomal pH perturbs with its ability to recycle receptors to the Plasma membrane or, the trans-Golgi. (upstate.edu)
Sirtuins, comprising a group of evolutionarily conserved nicotinamide adenine dinucleotide (NAD+) -dependent proteins, beneficially regulate lifespan and cellular senescence. (fightaging.org)
1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
Maria Karayiorgou, MD, professor of psychiatry and Joseph Gogos, MD, PhD, professor of physiology and cellular biophysics and of neuroscience, and their team sequenced the "exome"-the region of the human genome that codes for proteins-of 231 schizophrenia patients and their unaffected parents. (science20.com)
Michael Hendzel (right) co-led a study that revealed the gel-like nature of chromatin, the complex package of DNA and proteins contained within the nucleus of our cells. (ualberta.ca)
University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid? (ualberta.ca)
Right now, all of our understanding of gene regulation is largely based on the assumption of freely moving proteins that find DNA and whose accessibility is only regulated by the blocking of that movement. (ualberta.ca)
All of our chromosomes are made from chromatin, which is half histone (or structural) proteins and half DNA, organized into long strings with bead-like structures (nucleosomes) on them. (ualberta.ca)
Furthermore, since the CTCF induced loops regulate the inclusion of exons that tend to be coding for proteins associated with cellular stress response - it might help in understanding how cells respond to stress. (embl.org)
RATIONALE: Post-translational modification of histone proteins are major mechanisms that modify chromatin structure and regulate gene expression in eukaryotes. (cdc.gov)

Here we identify extensive transcriptional changes that occur during murine astrocyte maturation in vivo that are accompanied by chromatin remodelling at enhancer elements. (nature.com)
Culturing astrocytes in a three-dimensional matrix containing FGF2 induces expression of Rorb , Dbx2 and Lhx2 and improves astrocyte maturity based on transcriptional and chromatin profiles. (nature.com)
Therefore, extrinsic signals orchestrate the expression of multiple intrinsic regulators, which in turn induce in a modular manner the transcriptional and chromatin changes underlying astrocyte maturation. (nature.com)
Identifying the relevant transcriptional regulatory pathways in these neurons has been a priority, yet such attempts have been stymied due to their low abundance and the rich cellular diversity of the ARC. (biorxiv.org)
The Reinberg lab studies the processes shaping chromatin structure and the transcriptional outcome establishing cellular identity. (chicagobiomedicalconsortium.org)
Pioneer transcription factors are able to recognise and bind their motif sequences in inaccessible or closed chromatin, and their ability to achieve this is required to establish new regulatory elements and transcriptional networks during development and cellular reprogramming. (nih.gov)
Activation of histone acetyltransferase (HAT) or inhibition of histone deacetylases (HDAC) is generally believed to allow chromatin to assume a more open state, permitting transcriptional activity. (cdc.gov)

The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation. (rochester.edu)
Additionally, RAD18 functions beyond DNA repair and may regulate many other key biological processes, such as chromatin strengthening, cell survival/death, stemness, and differentiation. (nature.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
In this study, we investigated how higher-order chromatin structure modulates differential expression of the human INK4b-ARF-INK4a locus during progenitor cell differentiation, cellular ageing and senescence of cancer cells. (biomedcentral.com)
Developmentally regulated EZH2 levels are one of the factors that can determine the higher order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control. (biomedcentral.com)
Expression of the INK4b-ARF-INKa locus during cellular ageing and differentiation . (biomedcentral.com)
During the cellular differentiation process, cellular metabolism alters as the cell prepares for ongoing changes. (nih.gov)
However, each differentiation method has a different impact on cellular metabolic changes. (nih.gov)
Further Chromatin immunoprecipitation (ChIP) analysis confirmed that the KLF2 and active epigenetic marks (H3K27Ac and H3K4me3) were upregulated in the promoter region ATG7 during OB differentiation. (nih.gov)
These results provide evidence that the involvement of mitophagy is crucial during OB differentiation, and KLF2 critically regulates it. (nih.gov)
Such approaches might thus help to unravel the nature and dynamics of epigenomes during cellular differentiation at the molecular level. (biomedcentral.com)
Cellular RNA methylation level can have profound impacts on normal cell differentiation and cancer cell proliferation. (chicagobiomedicalconsortium.org)
Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. (researchgate.net)
This protein is involved in different signaling pathways and in basic cellular functions, such as DNA repair, cell growth, differentiation, apoptosis, and tumor suppression. (medscape.com)

Here, we review the ongoing development of accessibility measurements, we summarize the different molecular and structural mechanisms that shape the accessibility landscape, and we detail the many important biological functions that are linked to chromatin accessibility. (rockefeller.edu)
They have complementary skills in the fields of molecular and cellular virology, immunology, and physiopathology of infectious diseases. (europa.eu)
Here, we used a chromatin immunoprecipitation assay to study the molecular mechanism responsible for this expression pattern. (aacrjournals.org)
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian. (uib.no)
Dr. Maity obtained his Ph.D. in Cellular and Molecular Biology from the Life Science and Biotechnology department at Jadavpur University, India in 2017, where he studied the DNA damage repair protein WRN and autophagy. (nih.gov)
Dr. Jyoitirindra Maity has focused on cellular and molecular biology in rare disease models and cancer and stem cell modeling throughout his career. (nih.gov)

Access to DNA is a prerequisite to the execution of essential cellular processes that include transcription, replication, chromosomal segregation, and DNA repair. (rockefeller.edu)
Additional mechanisms that may control DNA accessibility in vivo include chromatin compaction and phase separation - processes that are beginning to be understood. (rockefeller.edu)
These enzymatic activities indicate that SIRT6 is closely related to cellular biological processes, such as DNA repair, genome stability, inflammation, and metabolic homeostasis . (fightaging.org)
It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. (mdpi.com)
The mechanisms used by certain viruses to dysregulate the host cell through manipulation of epigenetic processes and the role of cellular cofactors such as BRD4 that are known to be involved in epigenetic regulation of host cell pathways will also be covered. (mdpi.com)
PcG silencers bind and coordinately regulate INK4b and INK4a , but not ARF , during a variety of physiological processes. (biomedcentral.com)
Lamin B1 regulates many cellular processes such as DNA replication, chromatin organization, and senescence. (raredis.org)
Discovering this novel mechanism that regulates RNA splicing is relevant basic knowledge and adds to the functional roles that chromatin structure plays in gene regulation - from development to disease processes. (embl.org)
Biotin-dependent carboxylases have essential roles in the intracellular processes by which nutritive material is converted into cellular components, a process defined as intermediary metabolism. (medscape.com)

In terms of genome stability, SIRT6 enhances DNA repair and maintains telomere integrity by regulating DNA repair and chromatin-associated factors, such as PARP1 , DDB2 , SNF2H and WRN . (fightaging.org)
This new understanding of the physical properties of chromatin challenges that idea, and could lead to a more accurate understanding of how the genome is encoded and decoded. (ualberta.ca)
Chromatin carries epigenetic information by molding the genome into transcriptionally active or repressed inheritable domains. (chicagobiomedicalconsortium.org)
Here, we present whole-genome chromatin immunoprecipitation followed by high-throughput DNA sequencing (ChIP-seq) analyses of a wide variety of histone markers in the brain, heart, and liver of early human embryos shortly after their formation. (researchgate.net)
We discovered that CCCTC binding factor (CTCF) - a protein that can create chromatin loops between two distant sites in the genome - regulates which exons get included in the RNA by forming a loop. (embl.org)

Inside the nucleus of a cell, the chromatin fibre interacts with itself to condense into a chromosome. (ualberta.ca)
Below we discuss mechanisms in the form of pioneer transcription factors, histone modifications, and recently identified actin-dependent mechanisms that regulate chromosome accessibility and gene regulation during cellular reprogramming. (cytoskeleton.com)

The machine learning technique known as 'random forests' applied to genomic data profiling histone modifications by means of chromatin immunoprecipitation and sequencing (ChIP-Seq) has recently allowed the prediction of Hi-C matrices and TAD borders [ 7 ]. (biomedcentral.com)

The Goodell Lab focuses on the basic mechanisms that regulate hematopoietic stem (HSC) cells, and how their mis-regulation leads to leukemia development. (chicagobiomedicalconsortium.org)

Here we generated AgRP neuron-specific transcriptomic and chromatin accessibility profiles during opposing states of fasting-induced hunger and leptin-induced hunger suppression. (biorxiv.org)
Here we reveal that the pluripotency-associated pioneer factor OCT4 binds inaccessible chromatin to shape the chromatin accessibility, transcription factor co-binding and regulatory potential of thousands of distal regulatory elements in mouse embryonic stem cells, demonstrating that its pioneering activity is a feature of normal pluripotency, and not just reprogramming. (nih.gov)
ZHBTC4 and Brg1fl/fl mouse embryonic stem cells were used to ablate OCT4 and BRG1 expression respectively, followed by ATAC-seq, ChIP-seq or RNA-seq to examine their contribution towards chromatin accessibility, transcription factor occupancy, and gene expression. (nih.gov)
Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. (joplink.net)
DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (joplink.net)

In B cells, Myc acts as a classical oncogene by regulating a number of pro-proliferative and anti-apoptotic pathways, this also includes tuning of BCR signaling and CD40 signaling in regulation of microRNAs (miR-29, miR-150, miR-17-92). (wikipedia.org)
These multiple layers of regulation enable p53 to execute cellular responses that are appropriate for specific cellular states and environmental conditions. (nih.gov)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
A clinical implication of this finding is the possibility of using the number and severity of mutations involved in chromatin regulation as a way to identify children at risk of developing schizophrenia and other neurodevelopmental disorders," said Dr. Gogos. (science20.com)
Down regulation of EZH2 causes release of the ~35 kb repressive chromatin loop and induction of both INK4a and INK4b , whereas ARF expression remains unaltered. (biomedcentral.com)
Our findings propose epigenetic regulation of chromatin landscape as a critical factor in the rapid astrocyte response to dopamine. (jneurosci.org)
The TLKs play a key role in chromatin assembly through the regulation of the ASF1 histone chaperones and mutations in TLK2 have been implicated in a distinct neurodevelopmental disorder characterized by microcephaly and intellectual disability. (cancer.gov)
More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)

Cellular senescence, which recently has gained broad attention, is thought to be an important player in the onset and development of diabetic nephropathy. (hindawi.com)
In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)
Moreover, we highlight the potential therapeutic targets of cellular senescence in diabetic nephropathy and provide important clues for clinical strategies. (hindawi.com)
Recently, the emerging role of cellular senescence in DN has attracted a broad attention. (hindawi.com)
In the present review, we will focus on the role of cellular senescence and its related mechanisms in DN. (hindawi.com)
Furthermore, we will explore the potential therapeutic targets of cellular senescence and provide important clues for clinical strategies in the management of DN. (hindawi.com)
Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)
Of all the sirtuins, SIRT6 seems the least likely to fall into this category, given that it is known to influence cellular senescence , transposon activation , and DNA repair , rather than the more usual package of stress response mechanisms. (fightaging.org)
These functions can influence cellular senescence and aging-related diseases, including CVDs, cancer, and neurodegenerative diseases. (fightaging.org)

For example, RAD18 plays a vital role in regulating the DNA stability of embryonic stem cells and cellular homeostasis in highly prolific cells [ 6 ]. (nature.com)
Together these observations reveal a distinct requirement for the chromatin remodelling factor BRG1 in shaping the pioneering activity of OCT4 and regulating the pluripotency network in embryonic stem cells. (nih.gov)

Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)

The accessible chromatin formed at OCT4 binding sites relies on the chromatin remodelling factor BRG1, which is recruited to these sites by OCT4. (nih.gov)
The occupancy of BRG1 is then required to support OCT4/SOX2 co-binding and normal expression of the pluripotency-associated transcriptome, and this reliance on BRG1 reflects OCT4 binding dynamics during cellular reprograming and early mouse development. (nih.gov)
Background: Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal and pluripotency. (lu.se)

Landmark discovery of the physical state of complex DNA and protein "packages"-called chromatin-in a cell's nucleus could lead to better understanding of diseases such as cancer. (ualberta.ca)
They show for the first time the functional impact of the 3D structure of chromatin - the tightly-packed structure that the long DNA thread adopts to fit into the cell's nucleus - on the RNA-regulating splicing mechanism. (embl.org)

HIV persistence may arise from ongoing residual virus replication and/or from latently-infected cells defined as the cellular reservoir in which long-lived resting memory CD4+ T cells harbouring an integrated but transcriptionally silent provirus represent the largest pool in the blood (Chomont et al. (europa.eu)
The chromatin fibre also supports gene expression and replication of chromosomal DNA. (ualberta.ca)

Integration of the massive amounts of epigenomic data, including DNA methylation and histone modifications, thus represents a major hurdle for understanding how chromatin organization governs cell identity epigenetically. (biomedcentral.com)

This allows it to regulate global chromatin structure via histone acetylation. (wikipedia.org)
In this closed state, chromatin structure becomes an obstacle for eukaryotic transcription by impeding the interaction of RNA polymerase machinery and most transcription factors (TFs). (cytoskeleton.com)
Their cell lineage-specific effects are governed by chromatin structure. (edu.au)
Our paper shows how loops in the 3D structure of chromatin have an effect on RNA splicing. (embl.org)
In our study, we found that differences in chromatin structure across individuals correlate with in- or exclusion of a specific exon. (embl.org)
There's a lot of research surrounding chromatin structure because we don't fully understand how its structure and function are related. (embl.org)
The structure of chromatin can be changed (remodeled) to alter how tightly regions of DNA are packaged. (medlineplus.gov)
Biotin is also important for cell signaling, gene expression, and chromatin structure. (medscape.com)
Biotin's role in chromatin nucleic structure is based on its modulating effect on histones, the building blocks for chromatin. (medscape.com)
CBP has significant histone acetyltransferase activity and "opens" the chromatin structure so that transcription factors can enter and regulate gene expression. (medscape.com)
You will study the structure of DNA and chromatin, and develop an understanding for how the expression of genetic information is regulated. (lu.se)

An essential feature of this pioneering activity is the transition from inaccessible chromatin to a nucleosome-depleted and accessible chromatin state typical of normal regulatory elements, and this is believed to facilitate further transcription factor binding events. (nih.gov)
One such dependent process is regulating transcription factor NF-α-B, which is important in preventing cell death. (medscape.com)

Autophagy is a cytoplasmic conserved catabolic phenomenon to maintain cellular homeostasis. (nih.gov)
WRN critically regulates autophagy in various cellular stresses, including starvation, endoplasmic reticulum (ER) stress conditions to rescue the cell, and basal situations to restore proper cellular function. (nih.gov)

Specifically, we discuss how the interaction of p53 with DNA and chromatin affects gene expression, and how p53 post-translational modifications, its temporal expression dynamics and its interactions with chromatin regulators and transcription factors influence cell fate. (nih.gov)

The essential roles of SIRT6 in regulating chromatin and nuclear-cytoplasmic signaling pathways important for cellular homeostasis have been well characterized. (fightaging.org)
In addition, SIRT6 maintains an appropriate inflammatory response by regulating the TNF-α and NF-κB signaling pathways. (fightaging.org)

Therefore, our genetic screen has identified new regulators of key cellular states. (pasteur.fr)
In addition, mutual antagonism between two of these and other master regulators have been shown to regulate lineage determination. (lu.se)

Bivalent promoters are defined by the presence of both activating (H3K4me3) and repressive (H3K27me3) chromatin marks. (researchgate.net)

A developmental role for the chromatin-regulating CoREST complex in the cnidarian Nematostella vectensis. (uib.no)

CTCF binding to promoter sites bidirectionally regulates gene transcription and depends on activation of poly-ADP-ribose polymerase 1 (PARP1). (jneurosci.org)

Previously, fields such as biochemistry operated under the assumption that chromatin and other elements of the nucleus operated in a liquid state, Hendzel said. (ualberta.ca)
In the case of chromatin, it's about scaling this principle down to the level of the cell nucleus, because it is all connected. (ualberta.ca)

We show that astrocyte maturation is promoted by extrinsic signals that induce multiple transcription factors that act largely independently to regulate distinct gene expression modules that together promote a mature astrocytic phenotype. (nature.com)

In a study published in the journal Cell , the research team, led by Professor Michael Hendzel of the Faculty of Medicine & Dentistry and collaborator Jeffrey Hansen from Colorado State University, found that chromatin is neither a solid nor a liquid, but something more like a gel. (ualberta.ca)
This subset of transcription factors, known as pioneer transcription factors (PTFs), possess the ability to engage closed chromatin that is not accessible by other types of transcription factors, establish gene expression, and elicit cell reprogramming. (cytoskeleton.com)
The lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and development of hematologic malignancies. (chicagobiomedicalconsortium.org)
We are currently investigating the function of chromatin modifiers during embryonic development, in adult stem cell populations and in cancer, and modelling chromatin-based intellectual disability to discover ameliorating treatments. (edu.au)

Defects in the cellular response to DNA damage underlie rare diseases associated with cancer predisposition and are exploitable vulnerabilities for cancer therapy. (cancer.gov)

Thus, we are particularly interested in the function of chromatin modifiers, including the MYST family of histone acetyltransferases. (edu.au)

We further identify a novel role for the gut microbiome in regulating systemic coagulation response by limiting megakaryocyte proliferation and platelet turnover via the Sh2b3-Mpl axis. (rockefeller.edu)
The vacuolar ATPase (V-ATPase) is a highly conserved rotary motor proton pump that plays an essential role in cellular housekeeping functions. (upstate.edu)
Cellular factors which play role in host defense mechanisms against HIV were identified and their role in HIV induced inflammation was established. (europa.eu)
The tumour suppressor p53 has a central role in the response to cellular stress. (nih.gov)

The multidisciplinary consortium modelled and quantified the dynamics and mechanisms of epigenetic modulation at the cellular and organismal level. (ucl.ac.uk)

Expectedly, these chromatin marks are indispensable for mammalian development and alterations often lead to diseases such as cancer. (pasteur.fr)

The enzyme's proton pumping function is regulated by a unique process called "reversible disassembly", wherein V 1 dissociates from V o in a for example nutrient dependent manner. (upstate.edu)

In the repressed state, the PRC-binding regions are in close proximity, while the intervening chromatin harbouring ARF loops out. (biomedcentral.com)

Chromatin modification is therefore a crucial cellular activity. (science20.com)
TLK activity is regulated by the DNA damage response and their depletion provokes innate immune signaling and enhances cellular sensitivity to DNA damaging agents. (cancer.gov)

Accordingly, the expression of human HMGCS2 is down-regulated in 90% of Myc-dependent colon and rectum tumors. (aacrjournals.org)
In addition, it is also down-regulated in 80% of small intestine Myc-independent tumors. (aacrjournals.org)

Such computational approaches reinforce the idea of a linkage between epigenetically marked chromatin domains and their segregation into distinct compartments at the megabase scale or topological domains at a higher resolution. (biomedcentral.com)

EvoChromo: towards a synthesis of chromatin biology and evolution. (uib.no)

Anatomy11

Organisms3

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes29

Information Science2

Genes24

Proteins15

Transcriptional7

Differentiation14

Molecular7

Processes9

Genome5

Chromosome2

Immunoprecipitation1

Mechanisms that regulate1

Accessibility5

Regulation8

Senescence9

Embryonic stem2

Metabolic1

Oct43

Cell's nucleus2

Replication2

Organization1

Structure11

Transcription factor2

Autophagy2

Modifications1

Pathways2

Regulators2

Repressive1

Developmental1

CTCF1

NUCLEUS2

Astrocyte1

Cell4

Underlie1

Modifiers1

Role4

Dynamics1

Mammalian1

Function1

Loops1

Activity2

Tumors2

Segregation1

Synthesis1