• While many proteins adopt a regular 3D shape, it is now accepted that large sections of many proteins termed intrinsically disordered regions (IDRs) have no fixed shape. (leeds.ac.uk)
  • Intrinsically disordered regions (IDRs), are ubiquitous stretches of protein that do not adopt a stable structure, are a major class of protein structure found in all living organisms and viruses, and, are predicted to be present in around a third of eukaryotic proteins. (leeds.ac.uk)
  • Amino acid substitution scoring matrices specific to intrinsically disordered regions in proteins. (bvsalud.org)
  • MNA Region One November 18 Programs Post-Traumatic Stress Disorder: Trauma and Survival and The Nurse's Role in Suicide Prevention: Shifting the Perspective from Despair to Hope location changes! (massnurses.org)
  • Generalized Anxiety disorder, substance abuse, post-traumatic stress disorder and alcohol abuse accounted for 7.6%, 5.5%, 2.4% and 1.7% of psychiatric disorders respectively. (who.int)
  • On the other hand, the diagnosis of depression, post-traumatic stress disorder, HIV could be distressing enough to cause symptoms generalized anxiety disorder, alcohol and substance such as fear, depressed mood, feeling of guilt, abuse/dependence modules. (who.int)
  • However, limited reimbursement and the high cost of availing of bleeding disorder treatment facilities may hinder the market growth in the forecast period. (giiresearch.com)
  • Most pineal region tumors are germ cell tumors. (msdmanuals.com)
  • Pineal region tumors tend to occur during childhood but can occur at any age. (msdmanuals.com)
  • Diagnosis of pineal region tumors is by MRI and tissue biopsy. (msdmanuals.com)
  • Prognosis for and treatment of pineal region tumors depend on tumor histology. (msdmanuals.com)
  • Mental and neurological disorders in the elderly, such as Alzheimer's disease, other dementias, and depression, contribute significantly to the burden of noncommunicable diseases. (paho.org)
  • Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by psychiatric and neurological features. (biomedcentral.com)
  • The market for mental wellness will be driven by the increased prevalence of mental illnesses/disorders, such as depression, anxiety, eating disorders, and others, as a result of busy lifestyles, poor diets, a lack of physical activity, and excessive work hours in today's society. (researchandmarkets.com)
  • A team from the Kansas University Medical Center, London School of Hygiene and Tropical Medicine, Pakistan Human Development Research Foundation, Texas A&M University, University of Liverpool, and WHO Regional Office for the Eastern Mediterranean conducted a systematic review and meta-analysis of primary studies within the Eastern Mediterranean Region aimed at synthesizing the prevalence of specific common mental disorders. (who.int)
  • This course provides an overview of opioid use disorder and the use of harm reduction strategies as a public health approach to mitigate the risk and stigma associated with opioid use. (arizona.edu)
  • This course consists of 5 modules that provide an overview of opioid use disorder and the use of harm reduction strategies to mitigate the risk and stigma associated with opioid use. (arizona.edu)
  • In this module, we will explain opioid use disorder in the context of the social-ecological model, describe the social determinants of health and mental health factors that influence opioid use disorder, and describe the root causes of the current opioid crisis in the United States. (arizona.edu)
  • This course aims to expand foundational knowledge for using non-pharmacological approaches when caring for infants with Neonatal Abstinence Syndrome (NAS) and working with mothers with Opioid Use Disorder (OUD) in hospital settings. (arizona.edu)
  • It's money that can - and should - be channeled to programs and services that have proved to reduce overdose deaths and help people with opioid use disorder achieve recovery. (pewtrusts.org)
  • That's a start, but by itself it's not enough to ensure that current and future leaders will use the money to make meaningful and sustained progress on opioid use disorder. (pewtrusts.org)
  • IDRs and their order-disorder transitions regulate diverse functional proteins (and thus cellular processes) incl. (leeds.ac.uk)
  • However, widely used substitution scoring matrices, such as BLOSUM series, have been developed using aligned blocks that are mostly devoid of disordered regions in proteins . (bvsalud.org)
  • Hence, these substitution-scoring matrices are mostly inappropriate for homology searches involving proteins enriched with disordered regions as the disordered regions have distinct amino acid compositional bias , and therefore expected to have undergone amino acid substitutions that are distinct from those in the ordered regions. (bvsalud.org)
  • We, therefore, developed a novel series of substitution scoring matrices referred to as EDSSMat by exclusively considering the substitution frequencies of amino acids in the disordered regions of the eukaryotic proteins . (bvsalud.org)
  • The newly developed matrices were tested for their ability to detect homologs of proteins enriched with disordered regions by means of SSEARCH tool. (bvsalud.org)
  • The results unequivocally demonstrate that EDSSMat matrices detect more number of homologs than the widely used BLOSUM, PAM and other standard matrices, indicating their utility value for homology searches of intrinsically disordered proteins . (bvsalud.org)
  • But it had taken doctors in Dubbo seven years to diagnose Liam with an eating disorder - something he thinks he began to show symptoms of when he was only 10 years old. (canberratimes.com.au)
  • Many disorders have been described, with signs and symptoms that vary widely between specific disorders. (wikipedia.org)
  • Although "nervous breakdown" is not rigorously defined, surveys of laypersons suggest that the term refers to a specific acute time-limited reactive disorder involving symptoms such as anxiety or depression, usually precipitated by external stressors. (wikipedia.org)
  • Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases (such as Krabbe disease), including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses as well as peroxisome disorders such as X-linked adrenoleukodystrophy. (medscape.com)
  • PHILADELPHIA - The U.S. Department of Labor's Occupational Safety and Health Administration today announced a campaign to raise awareness about the hazards likely to cause musculoskeletal disorders among health care workers responsible for patient care. (osha.gov)
  • Future studies should investigate gene-by-environment interactions and employ functional imaging to understand how salience network structure translates to psychiatric disorder risk. (nature.com)
  • A mental disorder, also referred to as a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. (wikipedia.org)
  • The prevalence of a psychiatric disorder was 22.1% out of whom 5.0% had more than one psychiatric diagnosis. (who.int)
  • Major depression was the most common (11%) psychiatric disorder. (who.int)
  • 5 developing a psychiatric disorder. (who.int)
  • Independent studies indicate that functional differences in salience processing in these brain regions are associated with several neuropsychiatric disorders and their progression 11 . (nature.com)
  • Copy-number variants, a type of genomic rearrangements, has been suggested to contribute significantly to phenotypic diversity and disease susceptibility in many neurodevelopmental disorders. (harvard.edu)
  • Neurodevelopmental disorders include, i.a. attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability, of which onset occurs early in the developmental period. (wikipedia.org)
  • Memory and neurodevelopmental disorders: neglected condition. (lninstitute.org)
  • MDAM provides one-on-one peer support, a variety of support groups, as well as give presentations in workplaces, non-profit groups or in schools about mood disorders. (moodmb.ca)
  • This is a "coffee and conversation" support group for women experiencing mood disorders, low mood, or the frustrations and concerns of Covid-19. (moodmb.ca)
  • The Mood Disorders Association of Manitoba offices are located on original lands of the Anishinaabe, Cree, Oji-Cree, Dakota, and Dene Peoples, and on the homeland of the Métis Nation. (moodmb.ca)
  • Lithium Beyond Bipolar Mood Disorders: A Hope or Hype? (psychiatrist.com)
  • Chronic physical conditions and mental disorders were identified using International Classification of Diseases, 9th Revision, Clinical Modification codes. (cdc.gov)
  • Such disorders may be diagnosed by a mental health professional, usually a clinical psychologist or psychiatrist. (wikipedia.org)
  • Most international clinical documents use the term mental "disorder", while "illness" is also common. (wikipedia.org)
  • These disorders are characterized by clinical, biochemical, and genetic heterogeneity. (medscape.com)
  • This book is based on the most common pelvic disorders encountered in clinical practice and provides practitioners with key treatments to aid with patient care and recovery. (barralinstitute.com)
  • Articles in this series have a focus on preclinical and clinical empirical studies of these emerging rare disorders. (biomedcentral.com)
  • Lysosomal storage diseases describe a heterogeneous group of dozens of rare inherited disorders characterized by the accumulation of undigested or partially digested macromolecules, which ultimately results in cellular dysfunction and clinical abnormalities. (medscape.com)
  • Psychiatric and substance use disorders may be clinical interview which enables researchers to associated with unsafe sexual practices and needle make diagnosis of psychiatric disorders, and sharing which increases the likelihood of HIV consists of 16 modules, each representing a transmission thereby worsening disease diagnostic category. (who.int)
  • To estimate and forecast the market size of global bleeding disorders treatment market from 2022 to 2027 and growth rate until 2027. (giiresearch.com)
  • Magnetic resonance imaging of brain of child with autism spectrum disorder infected with Baylisascaris procyonis roundworms, Washington, USA, 2022. (cdc.gov)
  • Using provincial health data from two periods -- January 2017 to February 2020 and March 2020 to August 2022 -- researchers calculated and compared the expected and observed rates of eating disorder-related hospital visits for various age groups. (ctvnews.ca)
  • According to a recent study, in 2020 those disorders increased by 15.3% in children and adults 30 and younger. (networkofcare.org)
  • In addition, I identified 19 novel functional cis-regulatory enhancers in Autism Spectrum Disorders. (harvard.edu)
  • Prevalence of functional gastrointestinal disorders in Italian children living in different regions: analysis of the difference and the role of diet. (qxmd.com)
  • Functional Gastrointestinal Disorders (FGIDs) are common in pediatric age. (qxmd.com)
  • The most frequent disorders were functional constipation, functional dyspepsia, and abdominal migraine. (qxmd.com)
  • Functional characterization of the identified regions found relationships between methylation at these loci and nearby genetic variation contributing to chronic painful TMD and with gene expression of proximal genes. (iasp-pain.org)
  • To test this, the authors overlaid these lesion locations on a map of the brain known as the connectome -a structural map of region to region connectivity derived from functional MRI data. (scientificamerican.com)
  • Previous genetic studies focused on analyses of the protein-coding regions in the genomes of Autism Spectrum Disorder affected individuals whereas the relationship between the non-coding regions and Autism Spectrum Disorder development was largely unexplored. (harvard.edu)
  • Mental disorders and psychoactive substance-related disorders are highly prevalent throughout the world and are major contributors to morbidity, disability, and premature mortality. (paho.org)
  • Pathological dissociation is a trans-diagnostic phenomenon, highly prevalent in dissociative disorders and in trauma-related disorders, including depersonalization/derealization disorder (DDD), dissociative identity disorder (DID), posttraumatic stress disorder (PTSD), and borderline personality disorder (BPD) [ 1 , 5 ]. (springer.com)
  • I have OCD (obsessive compulsive disorder) that contributes a little bit. (networkofcare.org)
  • a diagnosis of] eating disorder didn't really come up," Liam said. (canberratimes.com.au)
  • M50.920 is a valid billable ICD-10 diagnosis code for Unspecified cervical disc disorder, mid-cervical region, unspecified level . (icd10coded.com)
  • The pediatric treatment program for eating disorders at the Children's Hospital of Eastern Ontario (CHEO) could use that money. (globalnews.ca)
  • In 2013, mental disorders contributed to 5.6% of the total disease burden in the EMR (1894 DALYS/100,000 population): 2519 DALYS/100,000 (2590/100,000 males, 2426/100,000 females) in high-income. (lu.se)
  • Common mental disorders are leading contributors to the global burden of disease and the economic cost due to ill health and loss of productivity, which is estimated at US$ 16.3 trillion globally. (who.int)
  • Mental and substance use disorders are the main causes of non-fatal burden of disease in the Eastern Mediterranean Region. (who.int)
  • By Disorder - TheDepression segment dominated the market in 2021 since depression is a key factor in the overall global burden of disease and a primary cause of disability worldwide. (researchandmarkets.com)
  • The global bleeding disorders treatment market is segmented into drug type, disease type, distribution channel, end user, regional distribution, and competitive landscape. (giiresearch.com)
  • To classify and forecast global bleeding disorders treatment market based on drug type, disease type, distribution channel, end user, and regional distribution. (giiresearch.com)
  • Historically, disorders of taste and smell have been difficult to diagnose and treat, often because of a lack of knowledge and understanding of these senses and their disease states. (medscape.com)
  • There is no evidence that you have a seizure disorder or that you experienced a stroke, TIA or movement disorder such as Parkinson's disease. (mywabashvalley.com)
  • In general, transplantation yields the best results when performed early in the course of the disease (ie, in an asymptomatic affected sibling of a child with a lysosomal storage disorder), in centers with experience in performing transplantations to treat inherited metabolic disorders, and in patients healthy enough to tolerate the conditioning and transplantation regimen. (medscape.com)
  • The advent of anti-retroviral therapy (ART) has significantly reduced the mortality of the disease, thereby transforming it to a chronic disorder, with significant co-morbid psychiatric sequalae. (who.int)
  • To analyze and forecast the market size of global bleeding disorders treatment market from 2017 to 2021. (giiresearch.com)
  • Autism Spectrum Disorders have a strong genetic basis. (harvard.edu)
  • I systematically evaluated the effect of copy-number variations in the non-coding regions of Autism Spectrum Disorder genomes. (harvard.edu)
  • By combining the chromosomal interaction information and the expression quantitative trait loci data, I found that Autism Spectrum Disorder specific copy-number variations were enriched in the non-coding regions, especially in the enhancer regions. (harvard.edu)
  • With the existence of large, well-characterized sample sets and the explosion of high-throughput methods in genetics there are numerous new genetic and genomic disorders that are being identified in autism. (biomedcentral.com)
  • Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, speech and motor impairments, epilepsy, abnormal sleep, and phenotypic overlap with autism. (biomedcentral.com)
  • Human genetic and genomic studies have supported a strong causal role of SHANK3 deficiency in autism spectrum disorder (ASD). (biomedcentral.com)
  • The Eastern Mediterranean Region (EMR) is witnessing an increase in chronic disorders, including mental illness. (lu.se)
  • This meta-analysis has shown that the prevalence of common mental disorders in the Eastern Mediterranean Region is higher than the global rates and highlights the need for increasing investment to scale up mental health services for effective treatment coverage in the Region. (who.int)
  • The global bleeding disorders treatment market is projected to witness a steady CAGR during the forecast period, 2023-2027. (giiresearch.com)
  • Conserved RBPs harbour defined repetitive motifs within disordered regions, which display striking evolutionary expansion. (nature.com)
  • In this study, we investigated the association between mental health disorders and chronic physical conditions among children, and we assessed whether having mental disorders is associated with increased health care costs for children with chronic physical conditions, using Medical Expenditure Panel Survey data from 2008 through 2013. (cdc.gov)
  • We used logistic regression to assess the relationship between mental disorders and chronic physical conditions, and we used generalized linear models with gamma distribution and log link to estimate direct medical costs. (cdc.gov)
  • Temporomandibular disorders (TMDs), collectively representing one of the most common chronic pain conditions, have a substantial genetic component, but genetic variation alone has not fully explained the heritability of TMD risk. (iasp-pain.org)
  • We've actually not been able to treat somebody with a mild, moderate or even moderately severe eating disorder in the Ottawa region in the past two years," she said. (globalnews.ca)
  • Among adults with severe and moderate affective, anxiety, and substance use disorders, the median treatment gap is 73.5% for the Region of the Americas, 47.2% for North America, and 77.9% for Latin America and the Caribbean (LAC). (paho.org)
  • A previous study led by Toulany and published in 2021 in the Journal of Adolescent Health showed that the first 10 months of the pandemic saw an overall 66 per cent increase in ER visits and a 37 per cent hike in hospital admissions for eating disorders among children and adults in Ontario. (ctvnews.ca)
  • This training is brought to you by the Western Region Public Health Training Center in collaboration with Sonoran Prevention Works, a comprehensive harm reduction organization based in Arizona that combines direct service, legislative advocacy, and capacity building to create stronger, healthier communities for people made vulnerable by substance use. (arizona.edu)
  • While the precise neurobiological underpinnings of dissociation remain elusive, neuroimaging studies in disorders, characterized by high dissociation (e.g., depersonalization/derealization disorder (DDD), dissociative identity disorder (DID), dissociative subtype of posttraumatic stress disorder (D-PTSD)), have provided valuable insight into brain alterations possibly underlying dissociation. (springer.com)
  • In the Region, depression continues to be the leading mental health disorder, and is twice as frequent in women as in men. (paho.org)
  • Psychiatric disorders are common in PLWHA, with major depression being the commonest. (who.int)
  • The stigma, social exclusion, and discrimination that occur around people with mental disorders compound the situation. (paho.org)
  • The disorder most often starts in young adulthood, but can also occur in children and adolescents. (psychologytoday.com)
  • When looking at all of the published lesion cases for a given condition-say parkinsonism-researchers see that the lesions that cause this condition don't occur in just one region. (scientificamerican.com)
  • The lesions did not all occur in the same region, and surprisingly most were not in the substantia nigra. (scientificamerican.com)
  • Studies have shown that psychiatric disorders occur and charts. (who.int)
  • Nordgaard, J & Henriksen, MG 2016, ' Self-disorders: A promising Candidate for Early Detection ', Scandinavian Journal of Child and Adolescent Psychiatry and Psychology , bind 4, nr. 1, s. 12-13. (regsj.dk)
  • does not have a seizure disorder and did not suffer a stroke after a medical episode last week. (mywabashvalley.com)
  • Iodine deficiency disorders in the region Eastern, Central and Southern Africa : proceedings of a symposium held in Gaborone (Botswana, 20 November 1986 / edited by F. van der Haar and F. P. Kavishe. (who.int)
  • Iodine deficiency disorders (IDDs) refer to a wide range of health problems associated with iodine deficiency1 in a population. (who.int)
  • Iodine deficiency disorder is a public health problem in populations where the median urine iodine is less than 100 µg/l or where more than 5% of children aged 6 to 12 years have goitre. (who.int)
  • In 1990, World Health Assembly Resolution WHA43.2 endorsed the goal of eliminating IDD as a public health problem.3 In 1993, WHO, UNICEF and the International Council for the Control of Iodine Deficiency Disorders (ICCIDD) recommended universal salt iodization as the main strategy to achieve elimination of IDD.4 In high-risk areas, iodized oil is recommended for the most vulnerable groups such as pregnant women and young children. (who.int)
  • Consequently, in 2005 and 2007, the World Health Assembly resolutions WHA58.24 and WHA60.21 on sustaining the elimination of iodine deficiency disorders called on countries to establish multidisciplinary national coalitions to monitor the state of iodine nutrition every three years and to report progress to the World Health Assembly. (who.int)
  • Elimination of iodine deficiency disorders will improve children's cognitive development, reduce stillbirths and reduce stunting. (who.int)
  • 3 Resolution WHA43.2, The prevention and control of iodine deficiency disorder s . (who.int)
  • Females had a greater proportion of burden due to mental disorders than did males of equivalent ages, except for those under 15 years of age. (lu.se)
  • I was suffering from an eating disorder for a really long time without knowing what it was, and I had no concept and I had no understanding or knowledge that males could get eating disorders - it was always something that was associated with women," Liam said. (canberratimes.com.au)
  • The authors of this report discuss bipolar mood disorder and the associated cardiovascular morbidity and mortality. (psychiatrist.com)
  • For a mental state to be classified as a disorder, it generally needs to cause dysfunction. (wikipedia.org)
  • In 2013, the American Psychiatric Association (APA) redefined mental disorders in the DSM-5 as "a syndrome characterized by clinically significant disturbance in an individual's cognition, emotion regulation, or behavior that reflects a dysfunction in the psychological, biological, or developmental processes underlying mental functioning. (wikipedia.org)
  • Because approximately 80% of taste disorders are truly smell disorders, much of this article focuses on the sense of smell and its dysfunction, with additional discussion of taste and related disorders. (medscape.com)
  • The pandemic, with its double whammy of isolation and fear of getting sick, changed the way many people related to their bodies and contributed to a rise in eating disorders for kids and young adults. (networkofcare.org)
  • The study, published Tuesday in the Canadian Medical Association Journal, also showed that ER visits for eating disorders were 13 per cent higher than expected among young adults between the ages of 18 and 26. (ctvnews.ca)
  • Toulany said there aren't enough hospital beds for adults with eating disorders and they sometimes end up on wards for other medical issues so their eating disorder may not be coded as such in health data. (ctvnews.ca)
  • Within our cancer and blood disorders program, our team of specialists and subspecialists work both together and independently to treat kids and young adults facing a wide variety of serious conditions, all within a single health system. (childrensmn.org)
  • This is the first study to quantify the burden of mental disorders in the EMR. (lu.se)
  • The burden of mental disorders in EMR increased from 1726 DALYs/100,000 in 1990 to 1912 DALYs/100,000 in 2013 (10.8% increase). (lu.se)
  • Among EMR countries, Palestine had the largest burden of mental disorders. (lu.se)
  • Nearly all EMR countries had a higher mental disorder burden compared to the global level. (lu.se)
  • Moreover, our results showing the accelerating burden of mental health are alarming as the region is seeing an increased level of instability. (lu.se)
  • Indeed, mental health problems, if not properly addressed, will lead to an increased burden of diseases in the region. (lu.se)
  • This burden is greater than the global average in almost all countries of this region and it is expected to rise. (who.int)
  • Factors such as the rise in the patient population base, increased healthcare expenditure by the public and private players, and growing disposable income for middle-class families drive the global bleeding disorders treatment market. (giiresearch.com)
  • The ongoing research and development activities and the increased focus of pharmaceutical companies on recombinant products are expected to create lucrative growth opportunities for the global bleeding disorders treatment market in the next five years. (giiresearch.com)
  • North America is expected to dominate the global bleeding disorders treatment market in the forecast period. (giiresearch.com)
  • The compatibility of the population of all age groups in the United States for prophylaxis treatment is driving the market demand in the region. (giiresearch.com)
  • To identify dominant region or segment in the global bleeding disorders treatment market. (giiresearch.com)
  • To identify drivers and challenges for global bleeding disorders treatment market. (giiresearch.com)
  • To examine competitive developments such as expansions, new product launches, mergers & acquisitions, etc., in Global bleeding disorders treatment market. (giiresearch.com)
  • To identify and analyze the profile of leading players operating in Global bleeding disorders treatment market. (giiresearch.com)
  • To identify key sustainable strategies adopted by market players in Global bleeding disorders treatment market. (giiresearch.com)
  • Liam needed specialised eating disorder treatment and this simply wasn't available in Dubbo. (canberratimes.com.au)
  • Liam Manning hopes other young people don't have to struggle to find eating disorder treatment, like he did growing up in Dubbo. (canberratimes.com.au)
  • WATCH: In part two of our series on the wait for eating disorder treatment in Canada, Vassy Kapelos speaks with top doctors about what the federal government needs to do to deal with the issue before it's too late. (globalnews.ca)
  • Dr. Blake Woodside has been at the helm of Toronto General Hospital's eating disorder treatment program for two decades. (globalnews.ca)
  • Woodside has long advocated for the federal government to implement national wait-time standards for eating disorders, in order to push provinces to direct funding to treatment. (globalnews.ca)
  • There's absolutely no registry that shows the numbers that are out there and how many young people are getting eating disorders, or needing treatment or where the funding should go or what the treatment outcomes are - any of that," she said. (globalnews.ca)
  • The findings may help with predicting treatment efficacy and identifying treatment biomarkers in these disorders. (psychiatrist.com)
  • Various brain disorders may alter behavior in ways that result in behaviors judged by society as antisocial or outright criminal. (lninstitute.org)
  • I am excited to be back in my region and also bring support and Mental Health resources for the community. (moodmb.ca)
  • Mental disorders may also be referred to as mental health conditions. (wikipedia.org)
  • A mental disorder is one aspect of mental health. (wikipedia.org)
  • Conclusions: The study reinforces the evidence of the association between pesticide poisoning and mental health disorders. (who.int)
  • Mental health disorders increase the risk for other diseases and contribute to unintentional and intentional injury. (paho.org)
  • Median public spending on mental health across the Region is a mere 2.0% of the health budget, and over 60% of this is allocated to psychiatric hospitals. (paho.org)
  • This statistic presents the rate of new mental health disorder cases per 1,000 strength in the British Royal Navy from 2007/08 to 2018/19. (statista.com)
  • A retrospective meta-analysis of magnetic resonance imaging voxel-based morphometry studies proposed that reduced gray matter volumes in the dorsal anterior cingulate and the left and right anterior insular cortex-areas that constitute hub nodes of the salience network-represent a common substrate for major psychiatric disorders. (nature.com)
  • hypothesized that lower GM of this network represents a common neurobiological substrate for psychiatric disorders 1 . (nature.com)