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  • mesoderm
  • The organizer secretes Chordin and Frizbee, diffusible antagonizers of BMP4 and Wnt-8, to establish a gradient of activity (not concentration) of BMP-4 and Wnt8 activity in the mesoderm. (studentreader.com)
  • Goosecoid
  • We find that removal of the morphological shield does not remove all goosecoid- and floating head-expressing cells, suggesting that the morphological shield does not comprise the entire organizer region. (zfin.org)
  • proteins
  • Homeodomain proteins play vital roles in the embryonic development of both vertebrates and invertebrates and may have roles in simpler animals as well. (sunyorange.edu)
  • Although most of these secreted factors bind to and antagonize the activity of Wnt and/or BMP proteins produced by non-organizer cells, these factors do not repress Wnt or BMP transcription, and are therefore not sufficient to exclude Wnt and BMP expression from the organizer. (biologists.org)
  • This helix-turn-helix (HTH) motif is only about 20 amino acids long and other parts of HTH proteins control the binding of the HTH region only at specific sites on the DNA molecule. (sunyorange.edu)
  • adjacent
  • Organizers, which comprise groups of cells with the ability to instruct adjacent cells into specific states, represent a key principle in developmental biology. (biologists.org)
  • Through retroviral insertional mutagenesis and chemical mutagenesis experiments in zebrafish, we have isolated mutations that cause abnormal hindbrain organization and a failure of the midbrain-hindbrain boundary (MHB) to form, a region that acts as an organizer for the adjacent brain regions. (zfin.org)
  • gene
  • A section of the text deals with differential regulation of gene expression in an ontogenetic causal network, attending to the structure of the genome and the functional peculiarities of enhancer and repressor regulatory regions that modulate gene transcription. (frontiersin.org)
  • Depending of the activity status of the transcription promoter region found next to each gene in the genome, a number of copies of the corresponding mRNA are produced, which sort out of the cell nucleus, and associate to polyribosomes in the cytoplasm. (frontiersin.org)
  • species
  • It has been found that the prolongation in the preimplantation period in the ferret is not accompanied by inhibition of mitosis or activity in nucleolus organizing regions of inner cell mass cells as occurs in species having an obligatory delay of implantation (obligate embryonic diapause). (deepdyve.com)
  • genome
  • Cytogenetic study on the activity of the ferret embryonic genome before implantation Isakova, G. 2010-06-04 00:00:00 A cytogenetic study of the activity of the embryonic genome in ferret (Mustela putorius) blastocysts during ∼6 days after their transition from the oviduct to the uterus has been carried out. (deepdyve.com)
  • experiments
  • The experiments which finally led to the discovery of the phenomena which are now designated as "organizer-effect" were prompted by a question which actually goes back to the beginnings of developmental mechanics, indeed to the beginnings of the history of evolution in general. (nobelprize.org)
  • The fate of the organizer is not altered in these experiments and the transplanted tissue differentiates as chordamesoderm, forming the notochord of the ectopic axis. (biologists.org)
  • Chordin
  • Studies on Chordin, Cerberus, Frzb-1, and Crescent have contributed to the current realization that growth factor antagonists secreted into the extracellular space mediate the formation of embryonic signaling gradients. (hhmi.org)
  • molecular
  • Using MAPK activation as a molecular marker, Lambert and Nagy have suggested that the fourth micromere descendant of the D macromere, 4d, functions as the embryonic axis organizer in the polychaete Hydroides ( Lambert and Nagy, 2003 ). (biologists.org)
  • regulation
  • A region of the Xwnt8 promoter containing four consensus homeodomain-binding sites was identified and this region mediated repression by Gsc and activation by VP16-Gsc, consistent with direct transcriptional regulation of Xwnt8 by Gsc. (biologists.org)
  • Embryonic self-regulation. (hhmi.org)