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  • efficacy of adoptive
  • We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred. (nih.gov)
  • effectiveness
  • 2) Adjuvant therapy also refers to a treatment that is given in addition to a standard treatment regimen to increase its effectiveness. (themmrf.org)
  • transplantation
  • The preferred preparative regimen for specific diseases and the approaches to prevention of the other major complications of hematopoietic cell transplantation (eg, graft-versus-host disease) are discussed separately. (uptodate.com)
  • treatment
  • The treatment is one of several forms of adoptive immunotherapy now under intense study at several medical centers. (webmd.com)
  • Immunotherapy is the treatment of disease by activating or suppressing the immune system . (wikipedia.org)
  • Randomized controlled studies in different cancers resulting in significant increase in survival and disease free period have been reported and its efficacy is enhanced by 20-30% when cell-based immunotherapy is combined with conventional treatment methods. (wikipedia.org)
  • One of the oldest forms of cancer immunotherapy is the use of BCG vaccine , which was originally to vaccinate against tuberculosis and later was found to be useful in the treatment of bladder cancer . (wikipedia.org)
  • Investigators will determine in human brain tumor cells and in an animal model whether a genetically modified "immunotherapy" more effectively targets brain tumor, decreases its recurrence, and minimizes treatment complications. (dana.org)
  • Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional. (greenmedinfo.com)
  • Here we report that while exogenous administration of LPS was able to enhance adoptively transferred CD8 + T cells' tumor destruction, LPS treatment alone did not replace individual components of the tripartite ACT regimen, or obviate TBI. (springer.com)
  • Collectively, our results identify how and when to administer TLR agonists to augment T cell-based immunotherapy in the absence or presence of host preconditioning for treatment of advanced malignancies. (springer.com)
  • cell therapy
  • These cells can be expanded rapidly ex vivo to use them for adoptive cell therapy (ACT). (hindawi.com)
  • One of three reduced intensity conditioning regimens predetermined at each institutional center of the Childhood, Adolescent and Young Adult Lymphoma Cell Therapy Consortium (LCTC) will be utilized for related or matched unrelated adult donor allogeneic transplant followed by donor LMP specific CTL infusion for three doses post AlloSCT. (clinicaltrials.gov)
  • Adoptive cell therapy (ACT) in a lymphoreplete host. (nih.gov)
  • researchers
  • By combining adoptive immunotherapy with Yervoy, the researchers hope to deliver a potent one-two punch to late-stage melanoma, no matter how extensively the cancer has spread through the body. (webmd.com)
  • In recent years, immunotherapy has become of great interest to researchers, clinicians and pharmaceutical companies , particularly in its promise to treat various forms of cancer . (wikipedia.org)
  • overcome
  • The best way to sequence and combine these agents with existing regimens and how to overcome the problem of drug resistance represent new challenges in this rapidly developing field. (onclive.com)