• PNS injuries initiate transcriptional reprograming in both Schwann cells and sensory neurons that promotes regeneration. (biorxiv.org)
  • While the factors that initiate the transcriptional reprograming in Schwann cells are well characterized, the full range of stimuli that initiate this reprograming in sensory neurons remain elusive. (biorxiv.org)
  • By profiling sensory ganglia at single-cell resolution we show that this demyelination induces transcriptional reprogramming preferably in proprioceptive and Aβ RA-LTMR neurons. (biorxiv.org)
  • Transcriptional reprograming is assumed to be a cell autonomous response of sensory neurons to mechanical axonal injury. (biorxiv.org)
  • By identifying similar reprograming in non-injured, demyelinated neurons, our study suggests that this reprograming represents a non-cell autonomous transcriptional response of sensory neurons to the loss of axon-Schwann cell interactions. (biorxiv.org)
  • Schwann cell loss results in transcriptional reprograming in specific sensory neurons. (biorxiv.org)
  • The intermediate cell layer is highly proliferative and, therefore, provides for rapid cell regeneration in response to injury or infection of the organ or tube in which it resides. (wikipedia.org)
  • In this Review, we discuss recent work that reveals the changes in white matter with ageing and neurodegenerative disease, how this relates to microglia dynamics during myelin damage and regeneration, and factors that influence the regenerative functions of microglia. (nature.com)
  • In addition, we found that in the presence of LIF, MDLS could replace feeder cells to maintain the undifferentiated state of OG2-mES cells (Oct4-GFP reporter gene mouse embryonic stem cell line), and the MDLS-expanded OG2-mES cells showed an elevated expression levels of pluripotency markers in vitro. (biomedcentral.com)
  • The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. (nature.com)
  • These mice also showed anxiolytic modulation in the elevated plus maze and open field tests, and increased adult neurogenesis, as evidenced by double staining of BrdU and neural progenitor/neuronal markers. (biomedcentral.com)
  • The aim of this current study was to elucidate if and to what extent pancreas-resident mesenchymal stromal cells (MSCs) with adipogenic progenitor potential differ from the corresponding stromal-type cells of the inguinal white adipose tissue (iWAT). (bvsalud.org)
  • Dr. Rajaguru Aradhya and Jagla, K., "Insulin-dependent Non-canonical Activation of Notch in Drosophila: A Story of Notch-Induced Muscle Stem Cell Proliferation", in Notch Signaling in Embryology and Cancer: Molecular Biology of Notch Signaling, vol. 1227, J. Reichrath and Reichrath, S., Eds. (amrita.edu)
  • A recorded presentation on 'CRISPR and Human Genome Editing: Progress & Opportunities' by Jennifer Doudna, Li Ka Shing Chancellor's Chair Professor in the Department of Chemistry and the Department of Molecular and Cell Biology, University of California, Berkeley, USA, is available to watch . (royalsociety.org)
  • In 1988 he moved to the MRC National Institute for Medical Research, becoming Head of the Division of Stem Cell Biology and Developmental Genetics in 1993. (royalsociety.org)
  • He has had long-standing interests in the biology of stem cells, in how genes work in the context of embryo development, and how decisions of cell fate are made. (royalsociety.org)
  • Major themes of his current work include sex determination, development of the nervous system and pituitary, and the biology of stem cells within these systems. (royalsociety.org)
  • He has received the Louis Jeantet Prize for Medicine (1995), the Amory Prize (1996), the Feldberg Foundation Prize (2008), the Waddington Medal of the British Society for Developmental Biology (2010), the ISSCR Public Service Award (2021), and the Genetics Society Medal (2022). (royalsociety.org)
  • Learning and memory modulate cell proliferation, neurogenesis, and survival throughout postnatal life. (ibe-unesco.org)
  • Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain. (nature.com)
  • The results showed that the EPS isolated from L. plantarum JY039 effectively improved the adhesion rate of L. paracasei JY062 to Caco-2 cells (1.8 times) and promoted the proliferation of L. paracasei JY062. (bvsalud.org)
  • Fuchs, E. The tortoise and the hair: slow-cycling cells in the stem cell race. (nature.com)
  • However, one of the bottlenecks in the stem cell therapy is that stem cells tend to differentiate into other types of cells during culture in vitro. (biomedcentral.com)
  • 6 Center for Stem Cell & Regenerative Medicine, The University of Texas Health Science Center of Houston, TX 77030, USA. (oaepublish.com)
  • Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)
  • However, the limited amount of stem cells and their tendency to undergo spontaneous differentiation upon extended propagation in vitro restrict their practical application. (biomedcentral.com)
  • Furthermore, MDLS could promote teratoma formation and enhanced differentiation potential of P19 cells in vivo. (biomedcentral.com)
  • In 2001, Kevin M. Godfrey and David J.P. Barker published the article "Fetal Programming and Adult Health" in Public Health Nutrition, where they identified the significance of maternal nutrition during pregnancy to healthy offspring development. (asu.edu)
  • Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders. (nature.com)
  • Lipofuscin, which accumulates most prominently in brain and cardiac cells, is one such 'age pigment. (extropy.org)
  • His main scientific contributions in the last 10 years relate to antigen presentation in dendritic cells and immunotherapy. (euroacadti.eu)
  • Dr. Aradhya aims to understand molecular aspects regulating the development of mesodermal derivatives both in Drosophila and mammalian counterparts. (amrita.edu)
  • Since 2000 PA is the group leader of the Cell Death Research & Therapy lab, at the Department of Cellular & Molecular Medicine of the KU Leuven, and in 2008 she became Full Professor at the same Institution. (euroacadti.eu)
  • To help achieve this, the cells of transitional epithelium are connected by tight junctions, or virtually impenetrable junctions that seal together to the cellular membranes of neighboring cells. (wikipedia.org)
  • Decreased intracellular drug concentration, enhanced function of cell processing active products, enhanced repair ability of cellular DNA damage, and blockage of related apoptosis pathways play an important role in it. (eurekaselect.com)
  • Fate mapping analysis reveals that adult microglia derive from primitive macrophages. (nature.com)
  • Morris, R. J. & Potten, C. S. Highly persistent label-retaining cells in the hair follicles of mice and their fate following induction of anagen. (nature.com)
  • Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. (nature.com)
  • It is expressed in ESCs, embryonic germ (EG) cells and embryonic carcinoma (EC) cells and essential for early embryonic development [ 14 , 15 ]. (biomedcentral.com)
  • Prior to the PhD he also worked in the laboratory of Dr. Maneesha Inamdar, JNCASR, India, where he worked on the characterization of pericardial cells in Drosophila Melanogaster. (amrita.edu)
  • His research has been focusing on the characterization of the natural immune responses towards malignant cells. (euroacadti.eu)
  • Schwann cells, the main glial cell in the peripheral nervous system (PNS), ensheath bundles of small unmyelinated axons or form myelin on larger axons. (biorxiv.org)
  • Platinum drugs are a class of chemotherapeutic drugs that affect the cell cycle, and the main site of action is the DNA of cells, which are common chemotherapeutic drugs in clinical practice. (eurekaselect.com)
  • PA started her own research group in 1996 with a focus on mechanisms of cancer cell death induced by irradiation. (euroacadti.eu)
  • Roy H. Hamilton , A Professor of Neurology in the Perelman School of Medicine, studies the characteristics and limits of functional neuroplasticity in the adult human brain, including how the brain reorganizes itself in response to injury and the brain's potential for reorganization in order to speed rehabilitation using noninvasive electrical or magnetic brain stimulation. (upenn.edu)
  • Blanca E. Himes , An Associate Professor of Biostatistics, Epidemiology, and Informatics in the Perelman School of Medicine, studies asthma pathogenesis and treatment using biomedical informatics approaches, including genome-wide association studies of asthma and related traits as a lead investigator and as part of large collaborations. (upenn.edu)
  • Taku Kambayashi , A Professor of Pathology and Laboratory Medicine in the Perelman School of Medicine, studies signal transduction pathways employed by cells involved in fundamental immunological processes and in immune-related disorders, especially the mechanistic underpinnings of these processes to identify novel targets for therapeutic intervention or for diagnostic/prognostic value. (upenn.edu)
  • Beth Linker , the Samuel H. Preston Associate Professor and chair of history and sociology of science in the School of Arts and Sciences, studies the history of science and medicine, disability, healthcare policy, and gender, including research on rehabilitation and on postural abnormalities in early 20th century America. (upenn.edu)
  • After an EMBO fellowship in Paris he established his independent laboratory in 1982 at the MRC Mammalian Development Unit, UCL, directed by Anne McLaren. (royalsociety.org)
  • Matthew Albert is Director of Research INSERM and Head of the Laboratory of Dendritic Cell Immunobiology at the Institut Pasteur, Paris, leading a team in the area of dendritic cell immunobiology and tumor immunity. (euroacadti.eu)
  • It is known that the pathogenic properties of glioma cells and the response of glioma towards platinum-based drugs are strongly influenced by non-coding RNAs, particularly, by microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). (eurekaselect.com)
  • Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. (nature.com)
  • Moreover, MDLS significantly promoted the self-renewal capacity of P19 cells. (biomedcentral.com)
  • As a low degree of adipogenesis was also observed in pMSCs of diabetes-susceptible mice, we conclude that the development of pancreatic steatosis has to be induced by other factors not related to cell-autonomous transcriptomic changes and miRNA-based signals. (bvsalud.org)
  • Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. (nature.com)
  • Neurons are the building blocks of the brain, the cells most responsible for the ability to process and learn information. (ibe-unesco.org)
  • In the mid-1980s, neuroscientists studying the mechanics of how memory is encoded in the brain began to develop techniques precisely analogous to those used in medicine to create 3-dimensional images of tissue structure - but in this case, on the nanoscale as opposed to the macro-scale images produced from serial, uni-dimensional x-rays of tissue with Computerized Tomographic Scanning (CT-Scanning). (chronopause.com)
  • Recently, the lab of Dr. P. Agostinis documented that immunogenic cell death mediated by ER stress can be harnessed to develop novel and clinically relevant, next-generation dendritic cell-based immunotherapies for brain tumors. (euroacadti.eu)
  • Dr. Allison is a leader in the field of immunology, particularly in developing ways to help the immune system recognize and destroy cancer cells. (euroacadti.eu)
  • Pancreatic steatosis associates with ß-cell failure and may participate in the development of type-2-diabetes. (bvsalud.org)
  • He is also very active in both public engagement and policy work, notably around stem cells, genetics, human embryo and animal research, and in ways science is regulated and disseminated. (royalsociety.org)
  • He is also Leader of the Dendritic Cells (DC) Antigen Presentation research group. (euroacadti.eu)
  • PA group is currently developing new anticancer vaccines based on the concept of immunogenic cell death and exploring the crosstalk between angiogenesis and antitumor immunity in melanoma. (euroacadti.eu)
  • Bjorksten determined that this insoluble material, which could occupy as much as as 30% to 40% of the volume of non-dividing cells in aged animals, consisted largely of cross linked molecules of lipids and proteins. (extropy.org)
  • These function in the packaging and transport of proteins, such as keratin, to the superficial cell layer. (wikipedia.org)
  • These connections allow for communication to tell the cells to expand or contract. (wikipedia.org)
  • This tissue consists of multiple layers of epithelial cells which can contract and expand in order to adapt to the degree of distension needed. (wikipedia.org)
  • When the organ or tube is stretched (such as when the bladder is filled with urine), the tissue compresses and the cells become stretched. (wikipedia.org)
  • Transitional epithelium is made up of three types of cell layers: basal, intermediate, and superficial. (wikipedia.org)
  • They currently study angiogenesis and lymphatic vessels particularly in malignant tumors, focusing on the growth factor-receptor signaling and growth factor-mediated endothelial cell reprogramming. (euroacadti.eu)
  • Rosenberg B, Vancamp L, Krigas T. Inhibition of cell division in escherichia coli by electrolysis products from a platinum electrode. (eurekaselect.com)
  • Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases. (biomedcentral.com)
  • Colony formation assay, sphere-forming ability assay, alkaline phosphatase (AP) activity assay and teratoma-formation assay were used to assess the role of modaline sulfate (MDLS) in promoting self-renewal and reinforcing pluripotency of P19 cells. (biomedcentral.com)
  • D) Quantitative real-time RT-PCR for tdo mRNA expression in adult liver. (biomedcentral.com)
  • Octamer-binding transcription factor-4 (Oct4), a transcription factor belongs to the POU transcription factor family Class V, is fundamental for maintaining self-renewal ability and pluripotency of stem cells. (biomedcentral.com)
  • Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. (nature.com)
  • In 1901, the famous pathologist Karl Weigert noted that lymphoid cells were present in the muscle and other tissues of persons with this affliction. (medscape.com)
  • The cells in the superficial layer of the transitional epithelium are highly differentiated, allowing for maintenance of this barrier membrane. (wikipedia.org)