Regenerative important skeletal muscle proliferation and differentiation. Medical search. Frequent questions

Cellular and molecular regulation of muscle regeneration. (scielo.br)
Satellite cells are essential for skeletal muscle regeneration:the cell on the edge returns centre stage. (scielo.br)
Regeneration of skeletal muscle is accompanied by the dynamic remodeling of the MuSC niche to promote each step of the regeneration process in a specific manner. (leibniz-fli.de)
They selected this protein because it was among the most prominently affected proteins in skeletal muscle during aging and its level increases progressively with age as well as during regeneration. (leibniz-fli.de)
Therefore, medications that can prevent the progression of muscle atrophy or promote muscle regeneration are in high demand. (biomedcentral.com)
Considering that reinnervation of the TA muscle can occur even after UVFP through these anastomoses, it would be ideal if drugs that promote nerve regeneration could be used to treat UVFP. (biomedcentral.com)
Satellite cells (SCs), which are precursors of skeletal muscles, such as the TA muscle, play a key role in muscle homeostasis and regeneration. (biomedcentral.com)
SCs are normally in a quiescent state in adult muscles, and start proliferating during muscle regeneration in response to denervation. (biomedcentral.com)
2008 In addition to satellite cells recent studies have recognized an important part for fibro/adipogenic progenitors (FAPs) in muscle mass regeneration and its fatty degeneration (Joe et al. (scienceexhibitions.org)
In particular, her work has been focusing on the molecular mechanisms involved in the modulation of the peripheral synaptic transmission, skeletal muscle adaptation and regeneration in physiological and pathological conditions. (units.it)
The research activity of the group is focused on the identification of new strategies to improve skeletal muscle regeneration. (units.it)
Our current running hypothesis is that the positive growth factors produced by hESCs trigger injured muscle to initiate and maintain regeneration, the TGF-beta inhibitors produced by hESCs reduce the TGF-beta signaling, and the combination assures the robust regeneration of muscle. (ca.gov)
Preliminary data indicates the effects on regeneration of old muscle look very promising. (ca.gov)
Specifically, our data suggest that several other ligands of MAPK pathway secreted by hESCs are likely to enhance and rejuvenate the regeneration of old muscle tissue. (ca.gov)
We have submitted the several manuscripts on topics of enhanced tissue regeneration and we are preparing the manuscript that identifies hESC-based novel strategies for restoring high regenerative capacity to old muscle. (ca.gov)
Finally, our data suggest that muscle stem cells either do not accumulate DNA damage with age or can efficiently repair such damage, when activated for tissue regeneration. (ca.gov)
Among Ca 2+ -sensitive pathways, calcineurin is essential for myoblast differentiation and muscle regeneration. (biologists.com)
MSCs are ideal stem cells for tissues regeneration because of their excellent capacities for differentiation and proliferation. (researchassistantresume.com)
since bone tissue regeneration cannot effectively occur with out a bloodstream supply achieving the bone tissue defect angiogenesis CEP-28122 is certainly important for bone tissue regeneration in vivo [6-10]. (researchassistantresume.com)
Without dystrophin, muscles are susceptible to mechanical injury and undergo repeated cycles of necrosis and regeneration. (medscape.com)

During aging the regenerative capacity of skeletal muscle declines, in part due to reduced numbers of MuSCs, but also due to impaired MuSC functionality. (leibniz-fli.de)

Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
the entire adipogenic activity consists of a reduction in proliferation ability and upregulation of genes related to lipid generation and energy metabolism, as well as several genes associated with myogenesis. (bvsalud.org)
Activation of IL-4/IL-13 signaling promotes proliferation of FAPs to support myogenesis while inhibiting their differentiation into adipocytes. (scienceexhibitions.org)
Adult regenerative myogenesis is dependent on progenitor cells. (biologists.com)

In this paper, we discuss the current available information about the role that different phenotypes of macrophages plays after injury and during the remodelling phase in different tissue types, with particular attention to the skeletal muscle. (hindawi.com)
More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. (nature.com)
Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
Glutamine is regarded as the most abundant amino acid in the body, is mainly synthesized in skeletal muscle 10 , and muscle tissue is the most important site for Gln storage 11 . (nature.com)
Adipose-derived stem cells (ADSCs) that are enriched in adipose tissue with multilineage differentiation potential have become an important tool in therapeutic research and tissue engineering. (bvsalud.org)
If, for example, damage to the muscle occurs because of an injury, MuSCs start to divide very quickly and replace the damaged muscle tissue. (leibniz-fli.de)
These results demonstrate that Lkb1 plays an important role in maintaining body weight, liver and adipose tissue function, blood glucose homeostasis and survival in adult mice. (omicsdi.org)
In this study, we focused on three mostly endeavoured applications in bone, skeletal muscle and skin tissue engineering. (sharif.ir)
Skeletal muscle is a target tissue for anabolic steroids. (frontiersin.org)
2010 However reflecting their adipogenic potential FAPs can also give rise to ectopic adipocytes that accumulate in degenerating muscle tissue (Uezumi et al. (scienceexhibitions.org)
Muscle injury results in quick activation of the innate immune system which exerts pleiotropic effects on regenerating muscle mass (Brunelli and Rovere-Querini 2008 Tidball and Villalta 2010 Within minutes of injury neutrophils infiltrate hurt skeletal muscle mass and launch tissue-damaging reactive molecules which exacerbate muscle mass damage (Tidball 1995 This initial burst of security damage caused by the innate immune system is followed by a wave of reparative macrophages. (scienceexhibitions.org)
With ageing, skeletal muscle undergoes a severe reduction in tissue mass, leading to a decrease in strength (sarcopenia). (units.it)
Our work is at the stage of understanding the molecular mechanisms by which the aging of the regenerative potential of organ stem cells can be reversed by particular human embryonic factors that are capable of neutralizing the affects of aged niches on tissue regenerative capacity. (ca.gov)
Thus, the use of hESC-produced pro-regenerative factors for boosting the regenerative capacity of organ stem cells is likely to yield healthy, young tissue. (ca.gov)
Regenerative medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects. (biomedcentral.com)
Initial studies indicate an immense potential for cell based strategies to enhance current orthopaedic approaches in skeletal tissue reconstruction. (openorthopaedicsjournal.com)
A number of traditional therapeutic approaches to repair skeletal tissue have been developed and hypothesised, but they have all presented with a variety of shortcomings. (openorthopaedicsjournal.com)
This method aims to regenerate rather than repair skeletal tissue defects. (openorthopaedicsjournal.com)
The research in Dr. Vorp's lab focuses on the biomechanics, "mechanopathobiology," regenerative medicine, and tissue engineering of tubular tissues and organs, predominantly the vasculature. (pitt.edu)
Bone tissue marrow-derived mesenchymal stem cells (BMSCs) are widely used in regenerative medicine in light of their ability to differentiate along the chondrogenic and osteogenic lineages. (researchassistantresume.com)
A prior study within a rabbit calvarial defect model additional revealed that there is seductive spatial and temporal relationship between newly produced blood vessels and further skeletal bone tissue development [12]. (researchassistantresume.com)

To determine their possible roles in tissues and satellite cells in vitro, their expression pattern was examined in tissues from 40-day-old chickens and in satellite cells from the breast muscles of 1-week-old and 2-week-old chickens using RT-PCR and immunocytochemistry analyses. (scielo.br)
Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
Here, we describe isolation of primary ADSCs from ovine embryonic fat tail tissues that displayed high self-renewal capacity, multilineage differentiation and excellent adipogenic ability. (bvsalud.org)
Explanation of use of a protocol termed "Autologous Regenerative Matrix" (ARM) is explained for guided, percutaneous placement into damaged tendinous tissues. (journalofprolotherapy.com)
GDF11 regulates essential cell differentiation and proliferation responses and is expressed in numerous tissues, including the skin, heart, skeletal muscle , and developing nervous system . (fightaging.org)
MSCs have been isolated from various tissues such as bone marrow (BM), umbilical cord blood, skeletal muscle and brain. (biomedcentral.com)
What was surprising is that administering these inhibitors to the whole animal appears to reduce TGF-beta levels in the whole animal, suggesting some kind of feed-back and perhaps effects on other tissues as well as muscle. (ca.gov)
The poor performance of stem cells in an aged organ, such as skeletal muscle, is caused by the changes in regulatory pathways such as Notch, MAPK and TGF‐β, where old differentiated tissues and blood circulation inhibit the regenerative performance of organ stem cells. (ca.gov)
In clinical practice, these involve the life-long immunosuppression of the organ transplantation patients, the creation of the supporting environment for engineered tissues in the mended organ, the unsolved issues of cell survival and differentiation of the cell-based therapy, and the selection and development of vectors for gene therapy. (biomedcentral.com)
It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)

Their fate is regulated by the expression of various transcription factors, including paired box 7 (Pax7) and myogenic differentiation (MyoD) [ 6 ]. (biomedcentral.com)
The close association of FAPs with regenerating muscle mass fibers along with their manifestation of factors that influence myogenic differentiation such as IL-6 and IGF-1 suggests that these stromal cells may perform a supportive part in myogenic differentiation (Joe et BV-6 al. (scienceexhibitions.org)
Using synchronized cultures of C2C12 myoblasts to model these divergent programs, we show that p8 (also known as Nupr1 ), a G1-induced gene, negatively regulates the cell cycle and promotes myogenic differentiation. (biologists.com)

The function and mechanisms of the novel circCHRNG in muscle satellite cell proliferation were explored using CCK-8 assay, Western blot, qPCR, and dual-luciferase reporter assay. (bvsalud.org)
Notably, a novel circRNA, termed circRNA CHRNG, acts as a miR-133 sponge to promote skeletal muscle satellite cell proliferation. (bvsalud.org)
A single, early local administration of high-dose bFGF prevented atrophic changes in the thyroarytenoid muscles by activating satellite cell proliferation and reforming neuromuscular junctions. (biomedcentral.com)

2008 For instance autocrine Notch signaling regulates the activation and proliferation of satellite cells (Bjornson et al. (scienceexhibitions.org)

In this study, we identified important regulators that trigger ovine adipocyte differentiation, main biological pathways involved in adipogenesis as well as the evolutionarily conserved genes governing adipogenic process across species. (bvsalud.org)

Muscles have an enormous ability to regenerate, however this decreases during aging. (leibniz-fli.de)
Skeletal muscle has a remarkable ability to regenerate that depends on muscle stem cells (MuSCs) - also termed satellite cells. (leibniz-fli.de)

Upon increasing culture times in chicken´s primary skeletal muscle satellite cells, SULF1 and SULF2 expression in 1-week-old chickens was significantly higher than in 2-week-old chickens, suggesting that sulfatases play a key role in satellite cell development. (scielo.br)
Proliferating, BrdU-positive cells in muscle sections were detected with immunohistochemistry indicating different cell types and decreasing proliferation with age. (nature.com)
Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
KEGG results showed that DEcircRNAs were enriched in muscle contraction, the regulation of cell proliferation, and the AMPK, insulin, and PI3K-Akt signaling pathways. (bvsalud.org)
Intrinsic changes in muscle stem cells (MuSCs) alter their proteome in addition to changes in the stem cell niche. (leibniz-fli.de)
By investigating the interplay between changes in the proteome of MuSCs and in their niche, the study published in Cell Reports provides a better understanding of how muscle stem cells are affected during aging. (leibniz-fli.de)
In the next step, we focused on the proteins that were significantly affected in both old and geriatric MuSCs and found evidence that they play an important role in metabolic processes and protein homeostasis, as well as influence the communication with the stem cell niche. (leibniz-fli.de)
To investigate which cell types contribute most to the MuSC niche remodeling during aging, single-cell RNA sequencing data from adult skeletal muscle were combined with the proteomic data. (leibniz-fli.de)
We were able to assign the majority of ECM proteins that are altered in aging skeletal muscle to at least one distinct cell type," reports Dr. Julia von Maltzahn, research group leader at FLI. (leibniz-fli.de)
Skeletal muscle progenitors (satellite cells), murine cell line and immortalized human myoblasts are studied in vitro to identify, in a controlled environment, the pathways regulating the regenerative potential of the skeletal muscle. (units.it)
Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
Cell proliferation is a very important physiological effect for low power laser irradiation (LPLI) used in clinical practice. (biomedcentral.com)
However, the mechanisms of cell proliferation induced by LPLI are poorly understood. (biomedcentral.com)
Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
Research has shown the importance of growth factors in guiding and modulating the differentiation of MSCs in order to obtain the required cell type. (openorthopaedicsjournal.com)
2014-Present Professor Liv Hospital (Ulus) Regenerative Medicine Stem Cell Production Center Istanbul- Turkey. (livhospital.com)
1 Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. (jci.org)
What we thought we knew and understood about muscle cell physiology and hypertrophy has been turned upside down through blood flow restriction research. (pensummed.pro)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)
Channels typically cluster into crystalline structures known as gap junction plaques where they act to exchange numerous small molecules important in cell signalling [ 1 ]. (biomedcentral.com)
The results showed that quercetin significantly enhanced the cell proliferation osteogenic differentiation and angiogenic factor secretion of rBMSCs in a dose-dependent manner with a concentration of 2 μM achieving the best stimulatory effect. (researchassistantresume.com)
In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)

When skeletal muscle is injured due to physical or chemical insult, a pool of self-renewing muscle stem cells residing within the skeletal muscles, called satellite cells, can give rise to differentiated myofibers to repair injured muscle ( Charge & Rudinicki, 2004 Chargé SBP, Rudnicki MA. (scielo.br)
Günther S, Kim J, Kostin S, Lepper C, Fan CM, Braun T. Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. (scielo.br)
Intro The regenerative response of skeletal muscle mass to ICAM4 injury is dependent within the quiescent populace of skeletal muscle mass stem cells termed the satellite cells which reside beneath the basal lamina of each myofiber (Brack and Rando 2012 Wang and Rudnicki 2012 Upon injury these quiescent satellite cells become triggered and undergo proliferation providing rise to myogenic progenitors (MPs) that ultimately differentiate into mature myofibers. (scienceexhibitions.org)
The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)

The microporous structure and high surface-area-to-volume ratio of nanofibers are favourable for the adhesion, proliferation, and differentiation of cells. (sharif.ir)
MSCs were characterized for plastic adhesion, surface markers, proliferation and differentiation capacity. (biomedcentral.com)

GO and KEGG analyses showed that DEcircRNAs were enriched in multiple pathways associated with muscle development, such as the PI3K-Akt and AMPK signaling pathways. (bvsalud.org)
These data indicated that quercetin could promote the proliferation osteogenic differentiation and angiogenic factor secretion of rBMSCs in vitro partially through the ERK CEP-28122 and p38 signaling pathways. (researchassistantresume.com)

This study aimed to identify circRNAs related to sheep skeletal muscle development and explore their roles in myoblast proliferation. (bvsalud.org)
In addition, we propose that circCHRNG acts as a miR-133 sponge to upregulate the expression levels of SRF and MEF2A, thereby promoting myoblast proliferation. (bvsalud.org)
Stephane Koenig ABSTRACT Ca 2+ signaling plays a key role during human myoblast differentiation. (biologists.com)
Our results showed that miR-195 and miR-497 were upregulated during muscle development and myoblast differentiation. (biologists.com)

For instance it has been proposed that classically triggered (M1) macrophages infiltrate early to facilitate the clearance of necrotic debris whereas alternatively triggered (M2) macrophages infiltrate later on to assist with muscle growth (Arnold et al. (scienceexhibitions.org)

Bober E, Franz T, Arnold HH, Gruss P, Tremblay P. Pax-3 is required for the development of limb muscles:a possible role for the migration of dermomyotomal muscle progenitor cells. (scielo.br)
2009 potentially reflecting the reduced secretion of myogenic growth element IGF-1 by these cells (Wynes and Riches 2003 While these studies demonstrate a facilitative part of innate immune cells in muscle mass regrowth after injury a direct molecular link between the innate immune system and muscle mass progenitor biology remains to be founded. (scienceexhibitions.org)
There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)

After several rounds of proliferation, most SCs differentiate into myoblasts, which fuse to form new myofibers [ 5 ]. (biomedcentral.com)

Therefore the most ideal induction method would simultaneously promote the osteogenic differentiation of BMSCs and enhance the manifestation of angiogenic factors. (researchassistantresume.com)

The main interest of her research activity is the nerve-muscle communication and the skeletal muscle physiology, including muscle plasticity and impact of ageing on the neuromuscular system. (units.it)
The results of the proposed research will advance the understanding of important aspects of the neuromuscular physiology such as the modulation of the neuromuscular transmission and the skeletal muscle plasticity. (units.it)

Gros J, Manceau M, Thomé V, Marcelle C. A common somitic origin for embryonic muscle progenitors and satellite cells. (scielo.br)

CS with underlying muscle was stained for apoptosis, proliferation, monocytes and blood vessels. (biomedcentral.com)
Histology analysis of extracted CS detected limited proliferation and approximately 10 % prevalence of apoptosis in transplanted mADSC. (biomedcentral.com)

Cellular and molecular mechanisms regulating skeletal muscle development. (scielo.br)
The objective of this study was to elucidate the effects of early bFGF administration on the thyroarytenoid muscle after RLN transection and to investigate the underlying mechanisms. (biomedcentral.com)
However, the pathophysiological mechanisms underlying this muscle syndrome and its relationship with plasma level of androgens are not completely understood. (frontiersin.org)
Additionally, our data in progress suggest that muscle and brain age by similar molecular mechanisms and thus, therapeutic strategies for rejuvenating muscle repair might be applicable to the restoration of neurogenesis in aged brain. (ca.gov)
then we review the studies on the molecular mechanisms of LPLI-induced proliferation since January 1999, which will serve as a reference for the researchers in this field. (biomedcentral.com)
Understanding their mechanisms may lead to the development of microRNA cocktails that can potentially be used in regenerative cardiology. (archivesofmedicalscience.com)

Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiation of cellular signaling. (biomedcentral.com)

Currently, there is increasing interest on the anabolic properties of testosterone for therapeutic use in muscle diseases including sarcopenia. (frontiersin.org)

These multipotent cells with innate self-renewal capacity can be in vitro expanded without losing their differentiation potential. (biomedcentral.com)

When an adequate number of cells (ASCs 10 × 10 6 and BM-MSCs 3 × 10 6 , because of their low rate of proliferation) was reached, two skin wounds were surgically induced in each animal. (biomedcentral.com)
For instance ASCs show a higher proliferative capacity and retain differentiation potential for a longer period in culture compared with human BM-MSCs. (biomedcentral.com)

E-cigarettes reduce lung function, reduce cardiac muscle function, and increase inflammation. (wikipedia.org)
These complex events involve three overlapping phases: inflammation, proliferation and remodelling [ 1 - 4 ]. (biomedcentral.com)

The interaction with the niche is critical to provide MuSCs with the proper cues for self-renewal, proliferation and differentiation. (leibniz-fli.de)

Myoblasts retain skeletal muscle properties and couple only sporadically to resident cardiomyocytes precluding synchronized contraction as mechanism of benefit (8). (escardio.org)
Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)

MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. (scielo.br)
The proliferation and differentiation of satellite cells are regulated by a number of extracellular signals ( Wang & Rudnicki, 2012 Wang YX, Rudnicki MA. (scielo.br)
Satellite cells, the engines of muscle repair. (scielo.br)
Isolation and culture of individual myofibers and their satellite cells from adult skeletal muscle. (scielo.br)
Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. (scielo.br)
Muscle samples were collected and myogenic cells were isolated and cultivated. (nature.com)
Immunohistochemistry indicated that bFGF significantly increased the number of satellite cells in the thyroarytenoid muscle up to day 14 and that of neuromuscular junctions on days 28 and 56. (biomedcentral.com)
Several types of adenosine receptors have been detected in developing and differentiated skeletal muscle cells, but little is known about the functional outcome of AR modulation on muscle AChRs. (units.it)
We confirmed that typical growth factor signaling was in fact occurring in muscle cells exposed to hESC produced factors, and that hESCs produce a TGF-beta antagonist. (ca.gov)
In the next reporting period we will re-confirm that the levels of candidate proteins from the 500 antibody array actually are very highly produced by hESCs and that the signals from these proteins are perceived by regenerating muscle cells. (ca.gov)
The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)
12 Furthermore, the simplicity of harvesting has made fat one of the most important sources for such cells. (jcadonline.com)

Our previous studies showed that Gln had the potential to increase muscle fiber size in piglets 16 , but the mechanism was not clear. (nature.com)
As a result, SVF has attracted substantial attention for its potential use in regenerative medicine in various fields, including internal medicine, 13-15 orthopedics, 16 plastic and general surgery, 17-19 and wound healing. (jcadonline.com)

The function of pannexins in bone and cartilage is beginning to be uncovered, but more research is needed to determine the role of pannexins in bone development, adult bone mass and skeletal homeostasis. (biomedcentral.com)

The manipulation of blood flow in conjunction with skeletal muscle contraction has helped us with the physiological understanding of muscle fatigue, blood pressure reflexes, and metabolism in humans. (pensummed.pro)

Significant loss of muscle mass may occur in cachexia and sarcopenia, which are major causes of mortality and disability. (mdpi.com)
Sarcopenia, the age-related loss of skeletal muscle mass and function, is becoming more prevalent as the lifespan continues to increase in most populations. (frontiersin.org)
Testosterone concentrations decline as age increase, suggesting that low plasma testosterone levels can cause or accelerate muscle- and age-related diseases, as sarcopenia. (frontiersin.org)
This age-related decline in skeletal muscle mass and strength generation, the primary function of skeletal muscle mass, is known as sarcopenia ( 2 , 3 ). (frontiersin.org)
Indeed, most of the intrinsic as well as extrinsic (systemic) muscle changes that occur with age are believed to be involved in the development of sarcopenia ( 5 , 6 ). (frontiersin.org)
The term sarcopenia was first proposed in 1989 by Irwin Rosenberg to describe a multifactorial syndrome that occurs with age and results in loss of skeletal muscle mass and function ( 3 , 4 ). (frontiersin.org)

BFRT exercise alters acute physiological stressors such as local muscle oxygen availability and vascular shear stress which may lead to adaptations that are not easily attained with conventional training. (pensummed.pro)

We previously reported that local administration of bFGF 1 month after recurrent laryngeal nerve (RLN) paralysis compensated for atrophy of the thyroarytenoid muscle. (biomedcentral.com)
As increased neuromuscular junctions are expected to maintain myofiber volume, bFGF administration may prevent thyroarytenoid muscle atrophy in the mid to long term. (biomedcentral.com)
These treatments provide only static adjustment to the larynx, and their effects may be limited by the remaining hoarseness due to progressive atrophy of the paralyzed thyroarytenoid (TA) muscle. (biomedcentral.com)

Various approaches can be used for the fabrication of the three-dimensional scaffolds for the regenerative medicine applications. (sharif.ir)
Research on regenerative medicine using basic fibroblast growth factor (bFGF) has recently advanced in the field of laryngology. (biomedcentral.com)
The basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family and is a key protein in regenerative medicine. (biomedcentral.com)
Efforts focusing on rejuvenation would expect an alternative, if not a better, accomplishment in the regenerative medicine. (biomedcentral.com)
Nevertheless, there are clues that are noticeable in current undertaking of systems biology and regenerative medicine research. (biomedcentral.com)
Blood flow restriction is becoming a new modality in the world of Regenerative Medicine, Sports Medicine, and performance enhancement. (pensummed.pro)

Cartilage heals very poorly, owing to the lack of intrinsic regenerative capacity of the chondrocytes and its poor vascular supply. (openorthopaedicsjournal.com)
The initial appeal for BFRT training was driven by studies demonstrating rapid increases in muscle size, strength, and endurance capacity, even when notably low intensities and resistances, which would typically be incapable of stimulating change in healthy populations, were used. (pensummed.pro)
The initial appeal for BFR training (BFRT) was driven by studies demonstrating rapid increases in muscle size, strength, and endurance capacity, even when notably low intensities and resistances were utilized. (pensummed.pro)

Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)

Such lack of clarity can be attributed to difficulty in isolating the individual events responsible for alterations in skeletal muscle, most of which occur simultaneously, among the multiple age-associated changes and co-morbidities associated with advanced age. (frontiersin.org)

Furthermore, Gln serves as a precursor for the synthesis of arginine, which is indispensable for the optimal growth of neonatal piglets 14 and plays important roles in essential metabolic pathways 15 . (nature.com)

Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena, Germany, discovered reasons for the regenerative decline during aging. (leibniz-fli.de)

Anti-inflammatory effects are likely important in the observed benefits from upregulation of GDF11 in old animals. (fightaging.org)

We have developed methods that allow us to measure thousands of proteins in both, skeletal muscles as well as freshly isolated MuSCs," reports Dr. Svenja Schüler, who led the study as part of her PhD thesis in the Ori lab. (leibniz-fli.de)
The analysis of the skeletal muscle proteome revealed close to two hundred extracellular or secreted proteins affected by aging. (leibniz-fli.de)
In 2010 beginning of 2011, we have approached the identification and characterization of the proteins that are produced by hESCs and have the rejuvenating and pro-regenerative activity on adult muscle. (ca.gov)
Recently, the signaling proteins involved in LPLI-induced proliferation merit special attention, some of which are regulated by mitochondrial signaling. (biomedcentral.com)

Some studies have shown that GDF11 can reverse age-related dysfunction in muscle, nervous and cardiovascular systems. (fightaging.org)
The incorporation of BFRT exercise into the training of strength-and endurance-trained athletes has recently been shown to provide additive training effects that augment skeletal muscle and cardiovascular adaptations. (pensummed.pro)

This study elucidated effects of glutamine (Gln) supplementation on the cellular muscle development of LBW and normal birth weight (NBW) piglets. (nature.com)
Clinical studies of androgen supplementation in age-related diseases and muscle wasting are a focus of emerging interest ( 11 ). (frontiersin.org)

High levels are associated with muscle hypertrophy, whereas low levels are epidemiologically associated with metabolic syndrome and diabetes, which negatively impact muscle functions. (frontiersin.org)
It has been generally accepted that muscle hypertrophy requires high-intensity training utilizing loads of at least 70% of 1-repetition max or lower loads until failure. (pensummed.pro)
However, there is mounting evidence that now supports low-load resistance training (20-40%RM) combined with blood flow restriction can similarly induce muscle hypertrophy and strength gains. (pensummed.pro)

We observed a temporarily increased intramuscular availability of free Gln that could have influenced cellular processes in skeletal muscle. (nature.com)
Studies targeted at establishing such effects at cellular level and their correlations with in vivo models, will broaden our understanding of the roles played by androgens on skeletal muscle function in elderly. (frontiersin.org)

In this project, the group intends to investigate the nature and the role of adenosine and AR signalling pathways on the two isoforms of muscle AChRs: the embryonic (g-AChR) regulating synaptogenesis and muscle development and the adult (e-AChR) with a role in nerve-muscle communication. (units.it)
He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
More recently, genetic and pharmacologic studies revealed the role of connexins, and in particular Cx43, in the differentiation and function of all bone types. (biomedcentral.com)
We describe here the current knowledge on the role of connexins and pannexins on skeletal health and disease. (biomedcentral.com)

Anatomy64

Organisms14

Diseases14

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes59

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Health Care1

Regeneration20

Aging the regenerative capacity1

Myogenesis4

Tissue21

Tissues10

Myogenic differentiation3

Satellite cell proliferation3

Regulates1

Adipocyte differentiation1

Ability to regenerate2

Cell23

Stem8

Adhesion2

Signaling pathways2

Myoblast4

Macrophages1

Progenitor3

Differentiate1

Angiogenic1

Plasticity2

Progenitors1

Apoptosis2

Mechanisms6

Promotes1

Therapeutic1

Vitro1

MSCs2

Inflammation2

Self-renewal1

Cardiomyocytes2

Cells12

Potential2

Homeostasis1

Contraction1

Sarcopenia6

Physiological1

Atrophy3

Medicine6

Capacity3

Protein1

Alterations1

Precursor1

Decline1

Upregulation1

Proteins4

Cardiovascular2

Supplementation2

Hypertrophy3

Cellular2

Role4