• Clonal hematopoiesis of indeterminate potential, or CHIP, is a common aging-related phenomenon in which hematopoietic stem cells (HSCs) or other early blood cell progenitors contribute to the formation of a genetically distinct subpopulation of blood cells. (wikipedia.org)
  • DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. (haematologica.org)
  • The cyclin-dependent kinase inhibitor, p21 cip1/waf1 (p21), maintains hematopoietic stem cell quiescence, and we evaluated its role in the regenerative response of neural tissue after ischemic injury using the mice deficient in p21. (rupress.org)
  • The hematopoietic system is well established as a paradigm for the study of cellular hierarchies, their disruption in disease and therapeutic use in regenerative medicine. (ox.ac.uk)
  • The application of these new single cell methods to investigate the hematopoietic system has led to paradigm shifts in our understanding of cellular heterogeneity in hematopoiesis and how this is disrupted in disease. (ox.ac.uk)
  • In this review, we summarize how single cell techniques have been applied to the analysis of hematopoietic stem/progenitor cells in normal and malignant hematopoiesis, with a particular focus on recent advances in single-cell genomics, including how these might be utilized for clinical application. (ox.ac.uk)
  • Hematopoietic stem cells are pivotal in maintaining the body's blood cell supply, and their versatility makes them invaluable in both medical treatments and scientific research related to blood disorders and regenerative medicine. (thenoveldifference.com)
  • The hematopoietic system is the most regenerative mammalian tissue. (digs-bb.de)
  • Applications that emphasize all types of heart, blood and hematopoietic regenerative medicine and stem cell science will be reviewed in BBHV. (nih.gov)
  • Under the mentorship of Professor Hiromitsu Nakauchi at the University of Tokyo, an international leader in hematopoiesis, I developed allele-specific anti-human leukocyte antigen (HLA) monoclonal antibodies for severe GVHD caused by HLA-mismatched hematopoietic stem cell transplantation (Nakauchi et al. (stanford.edu)
  • Atta-ur-Rahman, Shazia Anjum , " Frontiers in Stem Cell and Regenerative Medicine Research ", Bentham Science Publishers (2017). (eurekaselect.com)
  • The Regenerative Medicine (RM) field requires a new type of researcher, well-trained in fundamental RM concepts and methods, able to integrate human biology and engineered systems with awareness of challenges involved in advancing basic research, regulatory science, and clinical translation. (wakehealth.edu)
  • The Wake Forest Institute of Regenerative Medicine (WFIRM) has a unique infrastructure that provides facilities and expertise for translational studies, from basic preclinical findings all the way through Phase 2 clinical trials. (wakehealth.edu)
  • The overall goal of our T32 pre-doctoral training program, "Studies in Translational Regenerative Medicine", is to develop the next generation of multidisciplinary trained research scientists and engineers, who will lead new diverse research teams designing solutions to real-world health problems and advance the RM field. (wakehealth.edu)
  • 9 Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. (jci.org)
  • Thus, decryption of stem cell activation programs offers valuable insights for immune regenerative medicine. (bvsalud.org)
  • They can also be manipulated for regenerative medicine and gene therapy applications. (thenoveldifference.com)
  • Progenitor cells are being explored for various therapeutic applications, including tissue engineering and regenerative medicine. (thenoveldifference.com)
  • Our study provides a useful framework for future investigation of human developmental hematopoiesis in the context of blood pathologies and regenerative medicine. (unibg.it)
  • The findings could have important implications for regenerative medicine and cancer therapies, says Wange Lu, Ph.D., assistant professor of biochemistry and molecular biology at the Keck School of Medicine of USC, and the principal investigator on the study. (phys.org)
  • Researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC analyzed sections of the forebrain in animal model embryos to investigate Ryk's function in vivo. (phys.org)
  • This study will help in our efforts to produce nerve cells from embryonic stem cells, and may lead to the development of new strategies for the repair of the nervous system, using protein or small molecule therapeutic agents," says Martin Pera, Ph.D., director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC. (phys.org)
  • These studies are very important for regenerative medicine and drug discovery for therapy of neurodegenerative diseases. (phys.org)
  • Basic studies blood, heart and vascular cells and tissues: "Omics", stem cell biology and regenerative medicine (including hematopoiesis and cardiac differentiation), cell lineage and cell fate studies. (nih.gov)
  • BBHV and Integrative Vascular Physiology and Pathology (IVPP) have shared interests in using stem cells and in regenerative medicine. (nih.gov)
  • Continuing a commitment to advance medicine through forward-thinking approaches and groundbreaking discoveries, the Icahn School of Medicine at Mount Sinai is announcing the creation of the Institute for Regenerative Medicine to foster innovative research into new pathways to cure a host of diseases from leukemia to Alzheimer's disease, breast cancer, and airway diseases-;with the promise of improving medical care, quality of life, and longevity for all patients. (mybestmedicine.com)
  • The Institute will advance and coordinate research and training in broad areas of regenerative biology and medicine across the basic science and clinical departments at Mount Sinai, and will encompass three centers that each focus on a subset of diseases and disorders. (mybestmedicine.com)
  • The Institute for Regenerative Medicine is dedicated to making transformations in how we treat regenerative diseases that impact millions of lives. (mybestmedicine.com)
  • Clinicians, scientists, and researchers from across Mount Sinai will continue to leverage expertise and discoveries in human biology and regenerative medicine, rapidly translating our findings to improve care and treatment for some of the most crippling developmental and degenerative conditions that impact our patients. (mybestmedicine.com)
  • By using innovative research techniques including cell cultures, animal models, and human tissue studies, the scientists are seeking new insights into the workings of the nervous system, identifying new ways to prevent and treat brain disorders-;and ultimately transforming the field of regenerative medicine for these devastating illnesses. (mybestmedicine.com)
  • The future of regenerative medicine for brain disorders lies in understanding how the brain develops and maintains itself throughout life,' said the Center's Director, Nan Yang, PhD, Associate Professor of Neuroscience at Icahn Mount Sinai. (mybestmedicine.com)
  • The remarkable progress of regenerative medicine in the last few years indicates promise for the use of stem cells in the treatment of ophthalmic disorders. (biomedcentral.com)
  • 15 Cellularized scaffolds: new clothes for cardiac regenerative medicine. (vinastemcelllab.com)
  • The Developmental Haematopoiesis Group aims to learn from the embryo how HSCs are specified and how their self-renewal and differentiation into functional end cells is controlled, and apply this knowledge for the purpose of regenerative medicine. (ox.ac.uk)
  • The BMMNCs fraction is an extensive source of cells that can be used in regenerative medicine and tissue engineering technologies. (synthesit.ru)
  • Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. (ca.gov)
  • For this work, scientists have combined adult stem cells with a repurposed drug that improves healing to create a novel bioengineered scaffold that could someday lead to a new treatment for chronic diabetic ulcers," said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. (ipscell.com)
  • Nearly 70 years ago, Professor Charles Leblond led McGill in regenerative medicine with the first report of mammalian stem cells. (mcgill.ca)
  • Since this 1954 discovery, the regenerative medicine field has advanced remarkably with an expectation that regenerative medicine research and applications are predicted to reach $100 billion worldwide in the next quarter century. (mcgill.ca)
  • Together, this comprehensive delineation of mammalian cell differentiation trajectories in vivo represents a baseline for understanding the effects of gene mutations during development, as well as a roadmap for the optimization of in vitro differentiation protocols for regenerative medicine. (nih.gov)
  • Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)
  • The Scientific Directors of the Center are Ya-Wen Chen, PhD, Assistant Professor of Otolaryngology and Cell, Developmental and Regenerative Biology, and Elena Ezhkova, PhD, Professor of Cell, Developmental and Regenerative Biology and Dermatology. (mybestmedicine.com)
  • Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. (ipscell.com)
  • The establishment of a clonal population may occur when a stem or progenitor cell acquires one or more somatic mutations that give it a competitive advantage in hematopoiesis over the stem/progenitor cells without these mutations. (wikipedia.org)
  • Alternatively, clonal hematopoiesis may arise without a driving mutation, through mechanisms such as neutral drift in the stem cell population. (wikipedia.org)
  • Clonal hematopoiesis may occur in people who are completely healthy but has also been found in people with hematologic diseases. (wikipedia.org)
  • The incidence of clonal hematopoiesis has been found to rise dramatically with age. (wikipedia.org)
  • Recent studies have demonstrated that less than 1% of the population under age 40 but approximately 10-20% of the population over age 70 has observable clonal hematopoiesis. (wikipedia.org)
  • Having clonal hematopoiesis has been linked to a more than 10-fold increased risk of developing a blood cancer, though the overall likelihood is still low. (wikipedia.org)
  • Clonal hematopoiesis does not typically give rise to noticeable symptoms, but does lead to increased risk of cardiovascular disease. (wikipedia.org)
  • Patients with solid tumors or lymphoma and clonal hematopoiesis have been shown to have an inferior outcome. (wikipedia.org)
  • The first major evidence for the existence of prevalent clonal hematopoiesis in healthy people was put forth in the 1990s. (wikipedia.org)
  • The combination of these two ideas, that clonal hematopoiesis might be common in the elderly population and that AML evolves from pre-leukemic populations, led to the hypothesis that malignancy-associated mutations could also contribute to asymptomatic clonal hematopoiesis in healthy individuals. (wikipedia.org)
  • This view gained mechanistic support in 2012 when it was found a number of the women who showed evidence for clonal hematopoiesis through X-inactivation skew also had mutations in the hematologic-malignancy-associated gene TET2. (wikipedia.org)
  • In combination, these studies have demonstrated the widespread incidence of clonal hematopoiesis in the healthy adult population and have stimulated further efforts to broaden our understanding of clonal hematopoiesis in health and disease. (wikipedia.org)
  • These findings offer a comprehensive resource for TET-dependent transcriptional regulation of human hematopoiesis and shed light on the potential mechanisms by which TET deficiency contributes to clonal hematopoiesis and malignancies. (stanford.edu)
  • However, recent work has shown that post-transplant hematopoiesis differs significantly from native hematopoiesis. (digs-bb.de)
  • Using our fate mapping and proliferation reporter mouse models, we recently investigated how native hematopoiesis responds to systemic inflammation or blood loss (Munz et al. (digs-bb.de)
  • Mouse models for fate mapping and proliferation tracking allow investigating the contribution of HSC to native hematopoiesis. (digs-bb.de)
  • We are investigating native hematopoiesis following mutations that either reduce genome replication fidelity or predispose to leukemia development. (digs-bb.de)
  • We reveal that Fli-1 activity is essential for HSCs during regenerative hematopoiesis. (bvsalud.org)
  • By interacting with interferon and interleukin in our body, Synthesit contributes to the hematopoiesis and enhances our immunity. (synthesit-world.com)
  • Chaga birch mushroom has very strong regenerative activity, enhances hematopoiesis, removes radionuclides and toxins from the body, improves the function of the gastrointestinal tract and is used as an additional therapy in malignant neoplasms, those of an oncological character. (phyto-gelios.com)
  • 1. Myelogram changes in the experimental and control groups indicate that prolonged oral taking of the SYNTHESIT® Iron not only enhances hematopoiesis, but also increases its reparative processes in the red bone marrow due to an increase in the number of mononuclear (stem) cells. (synthesit.ru)
  • Harnessing the potential of adult cardiac stem cells: lessons from haematopoiesis, the embryo and the niche. (ox.ac.uk)
  • The differential diagnosis for brain meningioma includes dural metastasis (with breast and prostate cancer being the most common primary malignancies), hemangiopericytoma, granulomatous disease (including sarcoidosis and tuberculosis), idiopathic hypertrophic pachymeningitis, extramedullary hematopoiesis, hemangioma, and dura/venous sinuses. (medscape.com)
  • In inflammation, Synthesit activates the regenerative potential of macrophages and regulatory T-cells, gently regulating the immune system and inhibiting cytokine storm in SARS. (synthesit-world.com)
  • This regenerative ability ensures a constant supply of blood cells throughout an individual's lifetime. (thenoveldifference.com)
  • Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
  • Single cell analysis of normal and leukemic hematopoiesis. (ox.ac.uk)
  • Traditional approaches to study hematopoiesis involve purification of cell populations based on a small number of surface markers. (ox.ac.uk)
  • Hematopoiesis is the process of blood cell formation. (thenoveldifference.com)
  • 4 Maintenance of hematopoiesis: role of early b cell factor 2 matthias kieslinger. (vinastemcelllab.com)
  • Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets. (ox.ac.uk)
  • Endothelium-restricted deletion of c-Maf disrupts liver sinusoidal development, aberrantly expands postnatal liver hematopoiesis, promotes excessive postnatal sinusoidal proliferation, and aggravates liver pro-fibrotic sensitivity to chemical insult. (bvsalud.org)
  • The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis. (ox.ac.uk)
  • During regenerative conditions, Fli-1 presets and enables propagation of niche-derived Notch1 signaling. (bvsalud.org)
  • Our goal is to understand how blood formation proceeds in mammals, which factors govern and control this and how dysregulation of hematopoiesis leads to disease. (digs-bb.de)
  • Iron is a most important trace element, which is contained in over 100 enzymes in human body and participates in breathing, hematopoiesis, immunobiological processes and oxidation-reduction processes. (farmakom.ua)
  • Research is aimed at developing novel treatments using neuroprotective and regenerative strategies. (biomedcentral.com)
  • For the analysis and modeling of our experimental data, we collaborate with theoretical scientists to achieve a more quantitative interpretation of native haematopoiesis. (digs-bb.de)
  • Clonal hematopoiesis of indeterminate potential, or CHIP, is a common aging-related phenomenon in which hematopoietic stem cells (HSCs) or other early blood cell progenitors contribute to the formation of a genetically distinct subpopulation of blood cells. (wikipedia.org)
  • Alternatively, clonal hematopoiesis may arise without a driving mutation, through mechanisms such as neutral drift in the stem cell population. (wikipedia.org)
  • Clonal hematopoiesis may occur in people who are completely healthy but has also been found in people with hematologic diseases. (wikipedia.org)
  • The incidence of clonal hematopoiesis has been found to rise dramatically with age. (wikipedia.org)
  • Recent studies have demonstrated that less than 1% of the population under age 40 but approximately 10-20% of the population over age 70 has observable clonal hematopoiesis. (wikipedia.org)
  • Having clonal hematopoiesis has been linked to a more than 10-fold increased risk of developing a blood cancer, though the overall likelihood is still low. (wikipedia.org)
  • Clonal hematopoiesis does not typically give rise to noticeable symptoms, but does lead to increased risk of cardiovascular disease. (wikipedia.org)
  • Patients with solid tumors or lymphoma and clonal hematopoiesis have been shown to have an inferior outcome. (wikipedia.org)
  • The first major evidence for the existence of prevalent clonal hematopoiesis in healthy people was put forth in the 1990s. (wikipedia.org)
  • The combination of these two ideas, that clonal hematopoiesis might be common in the elderly population and that AML evolves from pre-leukemic populations, led to the hypothesis that malignancy-associated mutations could also contribute to asymptomatic clonal hematopoiesis in healthy individuals. (wikipedia.org)
  • This view gained mechanistic support in 2012 when it was found a number of the women who showed evidence for clonal hematopoiesis through X-inactivation skew also had mutations in the hematologic-malignancy-associated gene TET2. (wikipedia.org)
  • In combination, these studies have demonstrated the widespread incidence of clonal hematopoiesis in the healthy adult population and have stimulated further efforts to broaden our understanding of clonal hematopoiesis in health and disease. (wikipedia.org)
  • Research in the Laboratory of Molecular Hematopoiesis, led by Dr. Cynthia E. Dunbar, focuses on understanding the process of hematopoiesis in humans and in animal models that closely predict biology and disease in humans. (nih.gov)
  • Our research interests span basic laboratory studies through pioneering clinical trials focusing on stem cell biology and hematopoiesis-the development and differentiation of bone marrow stem cells into multiple types of blood cells. (nih.gov)
  • Dr. Cheng's laboratory is working on human stem cell biology and engineering, and their applications in regenerative medicine for curing blood diseases. (nih.gov)
  • Considering his services to the advancement of knowledge, particularly in regenerative medicine and stem cell science, AKU​ honoured Professor Lalani as the Khatija and Mohan Manji Dhrolia Endowed Chair​ in Stem Cell Biology and Regenerative Medicine in 2021. (aku.edu)
  • Dr. David Bodine, Ph.D. is Chief of the Genetics and Molecular Biology Branch and Head of the Hematopoiesis Section at the National Human Genome Research Institute (NHGRI). (nih.gov)
  • Being the first adult stem cell in the history of regenerative medicine, basic biology of HSC is well documented. (nebraska.edu)
  • He is an international leader in childhood lymphomas and leukemias, stem cell transplantation, developmental therapeutics, experimental hematopoiesis and immunology and stem cell biology and regenerative therapy. (westchestermedicalcenter.org)
  • Basic studies blood, heart and vascular cells and tissues: "Omics", stem cell biology and regenerative medicine (including hematopoiesis and cardiac differentiation), cell lineage and cell fate studies. (nih.gov)
  • However more than 50 years after the first successful hematopoietic transplant and two decades after the prospective isolation of HSC large gaps in knowledge hamper both our understanding of basic HSC biology and their clinical (-)-Blebbistcitin use in regenerative medicine. (bio-cavagnou.info)
  • The stem cell and regenerative medicine field lost a great one this week with the passing of Susan Solomon. (ipscell.com)
  • Regenerative cellular therapies for neurologic diseases. (nih.gov)
  • 10. Bone Marrow Micro-Environment in Normal and Deranged Hematopoiesis: Opportunities for Regenerative Medicine and Therapies. (nih.gov)
  • We have ideas for novel applications of gene and cell therapies particularly to correct inborn errors of immunity and hematopoiesis (e.g., sickle cell disease and beta-thalassemia). (nih.gov)
  • Indeed hematopoietic transplants are used to treat both hematopoietic and non-hematopoietic disorders and to reconstitute hematopoiesis after cancer therapies of a variety of solid tumors. (bio-cavagnou.info)
  • Working with the research group led by Prof. Vijay G. Sankaran of Boston Children's Hospital and the Broad Institute, Rajiv K. Khajuria, a doctoral student at Charité's Berlin-Brandenburg School for Regenerative Therapies, studied the molecular processes involved in the differentiation of stem cells and their development into mature blood cells. (charite.de)
  • One of the Hematopoiesis Section's research objectives is to understand the epigenetic changes that accompany red cell differentiation, including how the erythroid epigenetic profiles differ from the profiles in cells from other lineages. (nih.gov)
  • The establishment of a clonal population may occur when a stem or progenitor cell acquires one or more somatic mutations that give it a competitive advantage in hematopoiesis over the stem/progenitor cells without these mutations. (wikipedia.org)
  • The liver has a high regenerative capacity that involves stem/progenitor cells when the proliferation of hepatocytes is impaired. (jci.org)
  • Thus, our data suggest an important role for IL-3 in early human hematopoiesis by supporting the endothelial to hematopoietic transition of hemato-endothelial progenitor cells and highlight the potential of a hemanoid-based model to study human hematopoietic development. (haematologica.org)
  • The Institute for Regenerative Medicine will host a virtual edition of our annual retreat on Tuesday, January 26, 2021 from 1 PM to 5 PM . This year, we plan to focus on collaborations: how have IRM researchers recently partnered on exciting projects and how can we foster new team science efforts. (upenn.edu)
  • The neonatal mouse cerebellum is a powerful model system to uncover regenerative responses due to its high regenerative potential. (nih.gov)
  • Hematopoiesis occurs throughout life, and dysfunction of these processes can result in bone marrow failure or leukemia. (nih.gov)
  • IL-6 family members contribute to host defense through the stimulation of acute-phase signaling, hematopoiesis, immune reactions, and regenerative processes. (aai.org)
  • It is during the recovery period that tissue self-renewal takes place, their regenerative activity increases, restorative hematopoiesis processes intensify: the body is rejuvenated. (dryfasting.info)
  • Both cells' lineages are connected to each other in the bone niche and work together to maintain bone homeostasis, sustaining in particular the osteogenesis, osteoclastogenesis, and hematopoiesis processes. (encyclopedia.pub)
  • Dr Lo Celso's work focuses on the dynamic processes underlying healthy and malignant haematopoiesis, using an interdisciplinary approach that combines advanced intravital microscopy, computational image analysis, flow cytometry and mathematical modelling. (imperial.ac.uk)
  • Severely immunodeficient mice engrafted with functional human cells and tissues, known as 'humanized' mice, facilitate progress in studies of human haematopoiesis, immunity, gene therapy, infectious diseases, cancer and regenerative medicine. (nature.com)
  • Applications that emphasize all types of heart, blood and hematopoietic regenerative medicine and stem cell science will be reviewed in BBHV. (nih.gov)
  • Interestingly, the regenerative potential of the cerebellum decreases once development ends, despite the presence of NEP-like cells in the adult cerebellum that respond to cerebellar injury by increasing their numbers. (nih.gov)
  • Intriguingly HSC location changes during development with hematopoiesis shifting from the yolk sac and aorta-gonad-mesonephros region to the placenta fetal liver and bone marrow.1 In adult life HSC remain in dynamic contact with bone marrow niches and can also be found in extramedullary sites such as spleen liver and blood at various levels in response to stress or experimental stimuli. (bio-cavagnou.info)
  • He served the University as the first Global Dean of Research and Graduate Studies for eight years and transitioned from this position in 2016 to lead the development of the AKU Centre for Regenerative Medicine and Stem Cell Research as the Founding Director - a role that he held till March 2022. (aku.edu)
  • I am now head of the Lymphoid Tissue Regeneration Lab at the Clem Jones Centre for Regenerative Medicine. (edu.au)
  • Fig. 2: Regenerative and mixed lineages in primary tumors. (nature.com)
  • Since their discovery, HSC have been the focus of intensive research, and have proven invaluable clinically to restore hematopoiesis following inadvertent radiation exposure and following radio/chemotherapy to eliminate hematologic tumors. (nih.gov)
  • Hematology results were consistent with chemical-related methemoglobinemia and regenerative anemia. (nih.gov)
  • 8 Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden. (nih.gov)
  • 1 While embryonic macrophages and nucleated red blood cells are generated early in development in the first wave of primitive hematopoiesis, lymphoid cells, definitive erythro-myeloid progenitors and long-term repopulating HSC are only generated at later stages by the definitive hematopoietic program. (haematologica.org)
  • The goal of this review is to provide the reader with a brief glimpse into the remarkable potential HSC possess, and to highlight their tremendous value as therapeutics in regenerative medicine. (nih.gov)
  • This model provides unique predictive insights into human hematopoiesis and blood diseases. (nih.gov)
  • For over thirty years, our research group has utilized the rhesus macaque transplantation model to study hematopoiesis and the immune system. (nih.gov)
  • Previous research studies have evaluated the influence of gut microbes on the function of immune cells, but little had been known about their influence on the production of immune cells, a process known as hematopoiesis. (cedars-sinai.org)
  • This work provides important clues about the role of gut microbes in supporting a healthy immune system that is capable of providing efficient protection from infection,' said Helen Goodridge, PhD , collaborating author, assistant professor in the Department of Biomedical Sciences and a research scientist in the Regenerative Medicine Institute. (cedars-sinai.org)
  • Under the mentorship of Professor Hiromitsu Nakauchi at the University of Tokyo, an international leader in hematopoiesis, I developed allele-specific anti-human leukocyte antigen (HLA) monoclonal antibodies for severe GVHD caused by HLA-mismatched hematopoietic stem cell transplantation (Nakauchi et al. (stanford.edu)
  • The Hematopoiesis Section is currently employing genomic technologies to determine whether deletions involving RP genes or their regulatory sequences are the cause of DBA in the 30% of patients without a molecular diagnosis. (nih.gov)
  • One of objectives is to understand genetic and epigenetic regulation of cell fate determination in hematopoiesis. (nih.gov)
  • The clinical potential of pluripotent stem cells for use in regenerative medicine will be realized only when the process by which tissues are generated from these cells is significantly more efficient and controlled than is currently the case. (ca.gov)
  • Een grote uitdaging in het veld van stamcelonderzoek is om grote hoeveelheden van deze zeldzame cellen te genereren in vitro voor onderzoek en klinisch gebruik. (hubrecht.eu)
  • The incidence or severity of splenic hematopoiesis and pigmentation (hemosiderin) increased with dose at the 7-week interim evaluations and at the end of thestudies. (nih.gov)
  • The Hematopoiesis Section participates in a consortium known as VISION (Validated Systematic IntegratiON of hematopoietic epigenomes) whose goal is to define the epigenetic changes that occur during erythropoiesis. (nih.gov)
  • In contrast, metastases are enriched for key endoderm and lung-specifying transcription factors, SOX2 and SOX9 , and recapitulate more primitive transcriptional programs spanning stem-like to regenerative pulmonary epithelial progenitor states. (nature.com)
  • While their ability to repopulate the entire hematopoietic system would already guarantee HSC a valuable place in regenerative medicine, the finding that hematopoietic chimerism can induce immunological tolerance to solid organs and correct autoimmune diseases has dramatically broadened their clinical utility. (nih.gov)
  • We have emphasized about the promise in use of the HSC in regenerative medicine in various preclinical and clinical set-up. (nebraska.edu)
  • Dr Abbas Shafiee is a tissue engineering & regenerative medicine scientist interested in translational cell-based and tissue engineering strategies to treat human diseases. (edu.au)
  • Here we show that human primary lung adenocarcinomas are characterized by the emergence of regenerative cell types, typically seen in response to lung injury, and by striking infidelity among transcription factors specifying most alveolar and bronchial epithelial lineages. (nature.com)
  • Myelodysplasia encompasses a heterogenous group of disorders that result in ineffective hematopoiesis. (medscape.com)
  • Bone marrow failure in myelodysplasia syndrome is due to ineffective hematopoiesis (related to excessive apoptosis) rather than a lack of hematopoiesis. (medscape.com)
  • However, macrocytosis is not just a feature of regenerative anaemias since non-regenerative anaemias associated with FeLV infection or myelodysplasia can be associated with macrocytosis (Shimoda, et al 2000, Weiss 2006b). (vin.com)
  • This regenerative potential has traditionally been attributed to the replicative capabilities of mature hepatocytes and cholangiocytes, though emerging evidence suggests that other resident liver cell types such as progenitors, liver sinusoidal endothelial cells, and hepatic stellate cells respond to liver injury and contribute to repair. (jci.org)
  • These findings provide support for the view that prolonged maintenance of CML marrow cells in long-term culture may allow molecular characterization of both the BCR-genotype and clonality status of cells with in vivo regenerative potential. (ashpublications.org)
  • Study investigators from the Regenerative Medicine Institute at Cedars-Sinai collaborated with the Mount Sinai School of Medicine and lead institution - the California Institute of Technology. (cedars-sinai.org)
  • Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, 391 Technology Way, Winston-Salem, NC 27157-1083, United States. (nih.gov)
  • In cats the majority of anaemias are non-regenerative in contrast to the dog. (vin.com)
  • in addition, the space of Disse may also serve as a stem cell niche during fetal hematopoiesis and constitute a niche for stellate cells in adults. (jci.org)
  • I completed my PhD studies in stem cells and hematopoiesis at the Australian National University. (edu.au)
  • i, Neurofilament staining showed numerous punctae and irregularly shaped structures consistent with disorganized and regenerative axons mixed with the Schwann cells. (ipscell.com)
  • BBHV and Integrative Vascular Physiology and Pathology (IVPP) have shared interests in using stem cells and in regenerative medicine. (nih.gov)
  • Understanding how stem cells age and identifying intervention strategies to maintain stem cell regenerative capacity will lead to new therapeutic approaches for maintaining our health as we age. (idibell.cat)
  • The latest researches on regenerative medicine show that stem cells appear to be excellently suited for healing the brain better than other existing therapy. (infinityclinic.com)
  • They could also be isolated again and engrafted into a second recipient-an important test of their regenerative capacity. (nih.gov)
  • Karen Christman and Marianna Alperin discuss the newest discoveries and cutting-edge techniques for pro-regenerative biomaterials for heart and skeletal muscle with applications to cardiovascular disease and pelvic floor disorders. (uctv.tv)
  • Harnessing genetics to understand personalized cancer care and regenerative medicine. (jax.org)