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  • teleost
  • Here, we characterize aspects of paired fin development in the paddlefish Polyodon spathula (a non-teleost actinopterygian) and catshark Scyliorhinus canicula (chondrichthyan) to explore aspects of this model in a broader phylogenetic context. (cloudfront.net)
  • endogenous
  • Our studies reveal a previously undetected competency window in which cells retain their intrinsic regenerative program, identify a novel endogenous role for Na V in regeneration, and show that modulation of sodium transport represents an exciting new approach to organ repair. (jneurosci.org)
  • thus, the refractory period represents an exciting opportunity to understand and learn to overcome endogenous time-dependent loss of regenerative ability. (biologists.org)
  • stages
  • The zebrafish fin is a relatively simple appendage that is easily manipulated to study multiple stages in epimorphic regeneration. (jove.com)
  • One gene identified from this screen disrupts a specific component of the extracellular matrix material Laminin, Laminin beta 1a, a factor that we find to be dispensable in uninjured adult animals but required for all stages fin regeneration. (prolekare.cz)
  • At the outset, the fundamentals of caudal fin architecture and the stages of epimorphic regeneration are described. (semanticscholar.org)
  • processes
  • Scientists can use RegenDB to analyze integrated functional genomic datasets of regenerative processes to identify conserved gene networks within and across species. (mdibl.org)
  • mesenchymal
  • The neonephrogenic zone in the adult kidney of the little skate resembles the embryonic metanephric kidney and contains stem cell-like mesenchymal cells, tips of the branching collecting duct system, and outgrowth of the arterial system. (asnjournals.org)
  • distal
  • The evolutionary origin of the autopod involved a loss of the fin-fold and associated dermal skeleton with a concomitant elaboration of the distal endoskeleton to form a wrist and digits. (cloudfront.net)
  • formation
  • Upon analyzing the effects of sex steroids and their inhibitors, we show that androgens induce and estrogens inhibit BT cluster formation in intact and regenerating pectoral fins. (biologists.org)
  • adult
  • Transcripts of the chromatin remodeler chd4a /Mi-2, the histone deacetylase hdac1 /HDAC1/2, the retinoblastoma-binding protein rbb4 /RBBP4/7, and the metastasis-associated antigen mta2 /MTA were specifically co-induced in the blastema during adult and embryonic fin regeneration, and these transcripts displayed a similar spatial and temporal expression patterns. (biomedcentral.com)
  • Here, we performed a large-scale, unbiased genetic screen for epithelial signaling deficiencies during the regeneration of amputated adult zebrafish fins, from which we identified several new mutants. (prolekare.cz)
  • Chen
  • In addition, isolated BTs have been observed in various areas, including the head, body and fins ( Chen and Arratia, 1996 ). (biologists.org)
  • developmental
  • Organ regenerative ability depends on the animal species and the developmental stage. (jove.com)
  • Developmental studies, primarily from teleosts and amniotes, suggest a model for appendage evolution in which a delay in the AER-to-fin-fold conversion fuelled endoskeletal expansion by prolonging the function of AER-mediated regulatory networks. (cloudfront.net)
  • ability
  • This groundbreaking work led to the co-founding of Novo Biosciences, Inc. (Bar Harbor, ME, USA), a regenerative medicine company devoted to accelerating our innate ability to heal. (mdibl.org)
  • cell
  • We propose that Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity. (biologists.org)