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RegenerationMuscle DevelopmentNerve RegenerationLiver RegenerationMyoD ProteinMyoblastsMyogeninMyogenic Regulatory Factor 5Bone RegenerationCell DifferentiationMuscle, SkeletalMyoblasts, SkeletalMusclesMyogenic Regulatory FactorsSatellite Cells, Skeletal MuscleGuided Tissue RegenerationPAX7 Transcription FactorGene Expression Regulation, DevelopmentalMuscle Fibers, SkeletalExtremitiesStem CellsMuscle ProteinsSomitesPlanariansHepatectomyMEF2 Transcription FactorsCells, CulturedNotophthalmus viridescensAxonsDesminSalamandridaeCell FusionPaired Box Transcription FactorsSignal TransductionCell LineAmbystoma mexicanumCobra Cardiotoxin ProteinsCell ProliferationZebrafishChick EmbryoNerve CrushMesodermGene Expression RegulationTranscription FactorsZebrafish ProteinsIn Situ HybridizationRNA, MessengerMuscle CellsAnimal FinsImmunohistochemistryMice, Inbred C57BLWound HealingTissue EngineeringFibroblast Growth Factor 6Tissue ScaffoldsTime FactorsCardiotoxinsTailDNA-Binding ProteinsMolecular Sequence DataCell LineageMyostatinSpinal Cord RegenerationSciatic NerveEmbryo, NonmammalianTrans-ActivatorsHomeodomain ProteinsAnimals, Genetically ModifiedAxotomyMyosin Heavy ChainsWnt ProteinsMice, KnockoutBase SequenceMice, TransgenicPeripheral NervesModels, BiologicalSchwann CellsHeadCell DivisionRegenerative MedicineCreatine KinaseHepatocytesGene ExpressionTurbellariaLiverTranscription, GeneticUrodelaMorphogenesisStem Cell TransplantationPeripheral Nerve InjuriesBiocompatible MaterialsNotochordTransfectionReverse Transcriptase Polymerase Chain ReactionLimb BudsMuscular DiseasesDisease Models, AnimalNeuritesUp-RegulationSpinal Cord Injuries
SkeletalTissueProgenitor cellsRegenerativeMyogenicMyofiber regenerationDifferentiationAngiogenesisStemMacrophageRegulationVitroEmbryonicDisruptsMyofibersRegulateAffectsTherapeuticPromotesExpressionMechanismsWoundTissuesNicheDevelopmentResearchersExperimentsCellularMolecularProcessInjuryGrowthEffectsHumanFactor
Skeletal21
  • Myogenesis is the formation of skeletal muscular tissue, particularly during embryonic development. (wikipedia.org)
  • To test whether complete removal of skeletal muscle tissue affects the spatiotemporal relationship between myogenesis and angiogenesis during regeneration, subthreshold volumetric muscle loss was created with a biopsy punch (diameter, 2 mm) through the center of the gluteus maximus (GM) in adult mice. (biomedcentral.com)
  • Following punch biopsy of adult skeletal muscle, regenerating microvessels span the wound and become perfused with blood prior to myofiber regeneration. (biomedcentral.com)
  • Skeletal muscle regeneration is regulated by coordinated activation of multiple signaling pathways. (elifesciences.org)
  • However, the role of individual arms of the UPR in skeletal muscle regeneration remain less understood. (elifesciences.org)
  • Myofiber-specific ablation of IRE1α or XBP1 in mice diminishes skeletal muscle regeneration that is accompanied with reduced number of satellite cells. (elifesciences.org)
  • Finally, targeted ablation of IRE1α also reduces Notch signaling, abundance of satellite cells, and skeletal muscle regeneration in the mdx mice, a model of Duchenne muscular dystrophy. (elifesciences.org)
  • The genetic pathways that regulate the establishment of skeletal muscle in the embryo have been studied extensively, and many of the genes that govern muscle stem cell maintenance and commitment are redeployed during adult homeostasis and regeneration. (pasteur.fr)
  • The changes of FGF-6 expression in regeneration and repair process after exercise-induced muscle damage indicate that FGF-6 is closely related to skeletal muscle regeneration and repair. (uwi.edu)
  • To investigate the changes of fibroblast growth factor (FGF)-6 expression in the regeneration and repair process after exercise-induced muscle damage (EIMD) and the relationship with skeletal muscle regeneration and repair. (uwi.edu)
  • Satellite cells are essential for skeletal muscle regeneration:the cell on the edge returns centre stage. (scielo.br)
  • Satellite cells and skeletal muscle regeneration . (inrs.ca)
  • MicroRNA-1/206(miRNA-1/206) is specifically expressed in skeletal muscle and play a critical role in myogenesis. (biomedcentral.com)
  • Low-intensity pulsed ultrasound (LIPUS, a form of mechanical stimulation) can promote skeletal muscle functional repair, but a lack of mechanistic understanding of its relationship and tissue regeneration limits progress in this field. (ijbs.com)
  • We investigated the hypothesis that specific energy levels of LIPUS mediates skeletal muscle regeneration by modulating the inflammatory microenvironment. (ijbs.com)
  • LIPUS at intensity of 60mW/cm 2 could significantly promoted skeletal muscle regeneration through shifting macrophage phenotype from M1 to M2. (ijbs.com)
  • Its role in skeletal muscle regeneration and myogenesis has been well documented. (biomedcentral.com)
  • Research in the Tidball lab is directed toward understanding processes that regulate skeletal muscle wasting and regeneration. (ucla.edu)
  • Exploring the mechanisms through which the immune system can modulate skeletal muscle wasting, injury, regeneration and growth is a particular focus of the lab. (ucla.edu)
  • Skeletal muscle regeneration is ensured by satellite cells (SC), which upon activation undergo self-renewal and myogenesis. (unifi.it)
  • Global inactivation of Dio2 gene impairs skeletal muscle (SKM) differentiation and regeneration in response to muscle injury. (deiodinase.org)
Tissue20
  • It is unknown whether the spatiotemporal coupling between myofiber and microvascular regeneration persists when muscle tissue is completely removed and local guidance cues are lost. (biomedcentral.com)
  • The loss of residual guidance cues with complete tissue removal disrupts the spatiotemporal correspondence between microvascular and myofiber regeneration. (biomedcentral.com)
  • The manuscript evaluated an under appreciated aspect of tissue regeneration which is the need to synthesize and assemble huge amounts of contractile machinery and supporting structures and metabolic enzymes. (elifesciences.org)
  • The findings shed new light on mechanisms of regeneration of healthy myofibers after severe tissue injury and suggest interplay between these fibers and muscle satellite cells though mechanisms remain to be elucidated. (elifesciences.org)
  • Tissue and organ regeneration proceed in a coordinated manner to restore proper function after trauma. (pasteur.fr)
  • Future identification of this activity will improve our understanding of embryonic versus adult regulation of tissue regeneration suggesting novel strategies for organ rejuvenation. (ca.gov)
  • Specifically, our data suggest that several other ligands of MAPK pathway secreted by hESCs are likely to enhance and rejuvenate the regeneration of old muscle tissue. (ca.gov)
  • We have submitted the several manuscripts on topics of enhanced tissue regeneration and we are preparing the manuscript that identifies hESC-based novel strategies for restoring high regenerative capacity to old muscle. (ca.gov)
  • Finally, our data suggest that muscle stem cells either do not accumulate DNA damage with age or can efficiently repair such damage, when activated for tissue regeneration. (ca.gov)
  • Our plan is to develop further these projects that cross-fertilize each other and have a main theme of enhancing and rejuvenating tissue regeneration. (ca.gov)
  • Therefore, identification of factors that can promote tissue regeneration and mitigate inflammation could be key to restoring wound healing after composite tissue injury. (usuhs.edu)
  • One such factor that may directly affect both inflammation and tissue regeneration in response to these multi-tissue injuries may be Vitamin D. Beyond traditional roles, the pleiotropic and localized actions of Vitamin D are increasingly being recognized in most aspects of wound healing in complex tissue injuries - e.g., regulation of inflammation, myogenesis, fracture callus mineralization and remodeling. (usuhs.edu)
  • Findings from this review suggest that careful monitoring and/or supplementation of Vitamin D may be critical for wound regeneration in composite tissue injuries. (usuhs.edu)
  • Despite being made of the same polypropylene material as conventional flat meshes, the dynamic behavior of the 3D scaffold that moves in tune with inguinal movements proves that modifying the design and kinetic attitude turns the biological response into tissue regeneration. (unica.it)
  • The results achieved with ProFlor likely demonstrate that modifying the two-dimensional design of hernia meshes into a 3D outline and arranging the device to respond to kinetic stresses turns a conventional regressive foreign body response into advanced probiotic tissue regeneration. (unica.it)
  • To mimic myogenesis, the researchers relied on a key ingredient in their specially formulated bioink: insulin-like growth factor-1 (IGF-1), a hormone with a molecular structure similar to insulin that, along with growth hormone, is vital for normal bone and tissue growth and development. (newatlas.com)
  • After six weeks, the mice that received the constructs with sustained-release IGF-1 showed the most muscle tissue regeneration. (newatlas.com)
  • The sustained release of IGF-1 facilitates the maturation and alignment of muscle cells, which is a crucial step in muscle tissue repair and regeneration," said Ali Khademhosseini, corresponding author of the study. (newatlas.com)
  • Initial studies have primarily focused on the canonical Hippo pathway, which governs organ development, tissue regeneration, and tumorigenesis. (bvsalud.org)
  • Myogenesis is the process by which muscle tissue is formed during embryonic development and in certain regenerative processes in adults. (affiab.com)
Progenitor cells1
  • Adult regenerative myogenesis is dependent on progenitor cells. (biologists.com)
Regenerative1
  • While responses of adult stem cells are regulated extrinsically and age‐specifically, our work recently published puts forward experimental evidence suggesting that embryonic cells have an intrinsic youthful barrier to aging and produce soluble pro‐regenerative proteins that signal the MAPK pathway for rejuvenating myogenesis. (ca.gov)
Myogenic1
  • Fibroblast growth factor (FGF)-6, accumulated almost exclusively in the myogenic lineage, possesses important functions in myogenesis. (uwi.edu)
Myofiber regeneration2
  • Whether microvascular regeneration and myofiber regeneration following injury may proceed sequentially has not been resolved. (biomedcentral.com)
  • Therefore, as an alternative approach to test the interdependence of microvascular and myofiber regeneration following acute injury, a punch biopsy (diameter, 2 mm) was performed through the mouse gluteus maximus (GM) muscle. (biomedcentral.com)
Differentiation3
  • Injection of FGF-6 recombinant protein into damaged mouse muscle can induce cyclin D1 mRNA and differentiation markers, including Cdkl1, MHC I and Tn1, which results in the acceleration of muscle regeneration. (biolegend.com)
  • However, introducing fEVs to induce proliferation, and then nEVs to promote differentiation, substantially improved the muscle regeneration of these animals, bringing them nearly to the levels of young mice. (lifespan.io)
  • Among Ca 2+ -sensitive pathways, calcineurin is essential for myoblast differentiation and muscle regeneration. (biologists.com)
Angiogenesis2
  • Established models of injury have used myotoxins and physical trauma to demonstrate the concurrence of myogenesis and angiogenesis during regeneration. (biomedcentral.com)
  • We conclude that angiogenesis precedes myogenesis during regeneration following subthreshold volumetric muscle loss. (biomedcentral.com)
Stem4
Macrophage1
  • RvD1 had minimal direct impact on in vitro myogenesis but directly suppressed myokine production and stimulated macrophage phagocytosis, showing that SPMs can modulate both infiltrating myeloid and resident muscle cell populations. (jci.org)
Regulation2
  • Cellular and molecular regulation of muscle regeneration. (scielo.br)
  • In this study, we investigated the roles of these two miRNAs in myogenesis and analyzed their transcriptional regulation. (biologists.com)
Vitro1
  • The reprogrammed muscle precursor cells contributed to muscle regeneration in vitro and in vivo and were unequivocally distinguished because of the lineage marking method. (ca.gov)
Embryonic1
Disrupts1
  • A lack of c-Met disrupts secondary myogenesis and-as in LBX1-prevents the formation of limb musculature. (wikipedia.org)
Myofibers1
  • During muscle regeneration, it has been shown that FGF-6 can be released from necrotic myofibers and be sequestered by basal laminae. (biolegend.com)
Regulate1
Affects1
  • Other NIH-funded investigations in our lab explore epigenetic mechanisms through which an anti-aging protein called Klotho affects myogenesis and muscle regeneration in neonatal and aging muscle. (ucla.edu)
Therapeutic1
  • Muscle regeneration declines with aging and myopathies, and reprogramming of differentiated muscle cells to their progenitors can serve as a robust source of therapeutic cells. (ca.gov)
Promotes1
  • Collectively, our experiments suggest that the IRE1α-mediated signaling promotes muscle regeneration through augmenting the proliferation of satellite cells in a cell non-autonomous manner. (elifesciences.org)
Expression2
Mechanisms1
Wound2
  • Myogenesis into the wound was apparent by 14 dpi and traversed the wound by 21 dpi. (biomedcentral.com)
  • Aside from the direct effects of inflammation on myogenesis and osteogenesis, frank muscle loss has been shown to directly impair fracture union and ultimately contribute to failed wound regeneration. (usuhs.edu)
Tissues1
  • It continues to be expressed in adult muscle tissues, contributing to muscle maintenance and regeneration. (affiab.com)
Niche1
  • However, there are some important distinctions between prenatal development and regeneration - in the context of the cells, niche, anatomy and the regulatory genes employed. (pasteur.fr)
Development2
Researchers1
  • However, the researchers discovered that, if fEVs were given early on, and then nEVs were delivered later, significant muscle regeneration could be induced in this construct. (lifespan.io)
Experiments1
  • We also found a surprising increase in insulin production by hESCs and are integrating that result with ongoing regeneration experiments. (ca.gov)
Cellular2
  • In these models, efferocytosis removes cellular debris while basal laminae persist to provide guidance during myofiber and microvessel regeneration. (biomedcentral.com)
  • Our team is working on the molecular and cellular actors involved in human muscle regeneration , in muscle ageing and in muscular dystrophies including oculopharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). (institut-myologie.org)
Molecular1
  • To understand the function of SFRP1 and miRNA-1/206 in swine myogenesis, we first predicted the targets of miRNA-1/206 with the TargetScan and PicTar programs, and analyzed the molecular characterization of the porcine SFRP1 gene. (biomedcentral.com)
Process1
Injury1
  • Regeneration into the void was evaluated through 21 days post-injury (dpi). (biomedcentral.com)
Growth2
  • Our current running hypothesis is that the positive growth factors produced by hESCs trigger injured muscle to initiate and maintain regeneration, the TGF-beta inhibitors produced by hESCs reduce the TGF-beta signaling, and the combination assures the robust regeneration of muscle. (ca.gov)
  • In addition we will analyze the effect on regeneration of administering the growth factors that we found in Aim 2, both alone and in combination with the inhibitors of TGF-beta. (ca.gov)
Effects2
Human1
  • In addition to this, we are currently studying cross-talk between the muscle and its extracellular matrix, throughout the muscle as well as specifically at the myotendinous junction, in human models of regeneration and overload. (regionh.dk)
Factor1
  • Myf5 is considered to be the earliest expressed regulatory factor gene in myogenesis. (wikipedia.org)