Peripherin is thought to play a role in neurite elongation during development and axonal regeneration after injury, but its exact function is unknown. (wikipedia.org)
Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances their migration and axonal regeneration after rat spinal cord injury. (okano-lab.com)
Our studies also show that these NPs have differential requirements for LIF and ciliary neurotrophic factor (CNTF) and for epidermal growth factor (EGF), fibroblast growth factor (FGF-2) and platelet-derived growth factor (PDGF) for their propagation in vitro. (karger.com)
EnSCs synthesize and discharge several growth factors including transforming growth factor-α (TGFα), epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I). IGF-I, TGFα, epidermal growth factor receptor (EGFR), basic fibroblast growth factor (bFGF), and platelet derived growth factor-β (PDGFβ) receptor expression in epithelial cells are upregulated during expeditious growth in the proliferative stage. (samploon.com)
Cytokines2
Our studies have shown that these changes in neuropeptide expression are triggered by the induction of cytokines of the gp130 family, including leukemia inhibitory factor (LIF) and IL-6, and by the reduction of the target-derived trophic factor nerve growth factor (NGF) all of which occur after transection of sympathetic axons. (case.edu)
Although the expression of MHC class I and II molecules can be upregulated by MSC exposure to inflammatory cytokines interferon-gamma (IFN- γ ) and tumor necrosis factor-alpha (TNF- α ), they are still unable to induce an immunological response [ 18 ]. (hindawi.com)
Epithelial cells1
Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. (okano-lab.com)
Transplantation1
Cortical plasticity induced by inhibitory neuron transplantation. (ca.gov)
Platelet-derive1
In contrast, regulation of breast cancer CSCs (BCSCs) occurs by CD44 standard splice isoform (CD44s)-activated platelet-derived growth factor receptor b (PDGFRb)/signal transducer and activator of transcription 3 (STAT3), forkhead box C1 (FOXC1)-activated sonic hedgehog (SHH), and sphingosine-1-phosphate (S1P)/S1PR3-activated NOTCH pathways [ 10 - 13 ] . (oaepublish.com)
Cellular2
An unusual cellular factor potentiates protein-DNA complex assembly between Oct-1 and Vmw65. (mcmaster.ca)
Tumor necrosis element (TNF-), a pleiotropic cytokine exerting both inhibitory and stimulatory effects on diverse cellular processes, is a key regulator of immunological reactions.9 It has been reported that CML stem/progenitor cells (CML-SPCs) create TNF- at higher levels inside a kinase-independent style. (ppbhg.org)
MSCs2
MSCs are actively being investigated for the repair and regeneration of both osteochondral and other musculoskeletal tissues, such as tendon/ligament and meniscus. (biomedcentral.com)
Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (stemcellslab.net)
Pleiotropic1
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (abcam.com)
Proteins2
Previous research has established that, when a peripheral neuron's axon is severed, it decreases its synthesis of a number of proteins involved in neurotransmission and increases its synthesis of other proteins involved in regeneration. (case.edu)
EMSCs also have the high capacity proliferation, multidirectional differentiation that is indicative for the potentiality for tissue regeneration. (samploon.com)
Clinical applications of our research involves wound healing, cardiac tissue regeneration, ocular disease, and cancer imaging and therapy. (stanford.edu)
Tumor1
In contrast, no method created a significant inhibitory effect of hypothetic pulsed vector magnetic potential field on tumor cells. (saferemr.com)
Liver2
The root of the plant has qualities that aid in bile stimulation, liver cell regeneration as well as in supporting healthy uric acid levels. (lifeseasons.com)
Natural static magnetic field-induced apoptosis in liver cancer cell Different cell types require different factors like rotary frequency and treatment time to induce apoptosis. (saferemr.com)
Peripheral3
The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration , J Neuroinflammation , (2022) 19(1):179. (case.edu)
The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration. (case.edu)
Variable spatial magnetic field influences peripheral nerve regeneration in rats Strong spatial alternating magnetic field exerts positive effect on peripheral nerve regeneration. (saferemr.com)
Bone1
While some signals are mitogenic and proosteogenic, others function to inhibit osteogenesis and increase bone resorption, and it appears that a well-controlled, delicate balance of inflammatory factors is necessary for proper fracture repair [ 3 - 6 ]. (hindawi.com)
Differentiation4
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. (ca.gov)
Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. (ca.gov)
In this primer, we describe the key features of Hes factors and detail their roles in some representative processes of embryogenesis: namely, in the development of the nervous and digestive systems, two well-characterized processes, where Hes1 (and Hes3 and Hes5 in the nervous system) regulates cell proliferation and differentiation, and in the process of somite segmentation, where Hes7 functions as a biological clock. (biologists.com)
Acute1
The cancer stem cell (CSC) paradigm emerged from investigating a subpopulation of less-differentiated CD34+/CD38- cells possessing stem cell-like renewal ability and robust malignant-initiating capacity in acute myeloid leukemia (AML) [ 1 ] . (oaepublish.com)
Essential1
Leukemia inhibitory factor (LIF), Hepatocyte growth factor (HGF) and stem-cell factor (SCF) have the essential contribution in endometrial regeneration. (samploon.com)
Transcription factors1
Finally, we show that LIF increases the expression of the core transcription factors: Klf4, Fbx15, Nanog, Sox2 and c-Myc. (karger.com)
Trophic1
Recent mechanistic insights into the trophic activities of these cells point to ultimate regulation by nitric oxide, nuclear factor-kB, and indoleamine, among other signaling pathways. (biomedcentral.com)
Modulate1
That is accomplished by transferring factors that modulate different metabolic and signaling pathways. (frontiersin.org)
Occur2
We have found that alterations in gp130 cytokine signaling play a role in the deficit in regeneration known to occur in diabetes. (case.edu)
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. (ca.gov)
In vitro screening of exogenous factors for human neural stem/progenitor cell proliferation using measurement of total ATP content in viable cells. (okano-lab.com)
Effects1
There is no conclusion in the Executive Summary on whether the Committee determined that possible health effects of EMF are established for childhood leukemia and exist for genotoxicity, for neurological effects, for brain tumors, male fertility, fetal and neonatal effects or other key areas of research. (bioinitiative.org)
Cancer2
However, the role of PTEN alterations in north Indian breast cancer has not been explored especially in defining a group with distinct histological factors. (cancerindex.org)
In the current times where dissipated lifestyle and other counting factors such as dietary, physical, mental mismanagements, drug administration intoxicifications in the form of chemotherapies and chemical toxicities are adding up to the cumulative risk of cancer occurrence, consumption of Nutraculture™ Phycocyanin™ is essentially required. (nutraculture.com)
Response1
Soluble suppressor activity obtained from allopregnant mouse decidua that blocks the cytolytic effector response to IL-2 is related to transforming growth factor-beta. (mcmaster.ca)
Repair1
however, prolonged inflammation is inhibitory for fracture repair. (hindawi.com)
Expression1
Retinal neuroprotection by hypoxic preconditioning is independent of hypoxia-inducible factor-1α expression in photoreceptors. (hslu.ch)
Function1
We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)