Regeneration endothelial stem cells. Medical search. Frequent questions

It is well established that insulin-like growth factor (IGF) signaling is important for cell responses such as mitogenesis, cell growth, proliferation, angiogenesis, and differentiation. (wikipedia.org)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. (stemcellsportal.com)
Histological and immunohistochemical assessments revealed that CD146 + cells promoted bone regeneration and angiogenesis. (unair.ac.id)
Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
Regulation of pericyte function in angiogenesis and tissue regeneration: The role for T-cadherin. (aofoundation.org)
Khosrotehrani K , 2011 , 'Novel hierarchy of resident endothelial progenitors integral to skin wound angiogenesis' , in JOURNAL OF INVESTIGATIVE DERMATOLOGY , NATURE PUBLISHING GROUP , SPAIN, Barcelona , pp. (edu.au)
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. (koreamed.org)
During angiogenesis, actin-rich filopodia protrusions have been proposed to drive endothelial tip cell functions by translating guidance cues into directional migration and mediating new contacts during anastomosis. (biologists.com)
To investigate the structural organisation, dynamics and functional importance of F-actin in endothelial cells (ECs) during angiogenesis in vivo , we generated a transgenic zebrafish line expressing Lifeact-EGFP in ECs. (biologists.com)
As the cancer volume increases, the cancer may release angiogenesis factors, such as vascular endothelial growth factor (VEGF), which promote formation of new blood vessels that are required for further growth. (msdmanuals.com)
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. (lu.se)

The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. (molvis.org)
This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
PRP has proven to be an adequate extracellular matrix environment for mesenchymal stem cell proliferation and was also shown to promote vascularization when seeded with endothelial cells. (aofoundation.org)
Tissue regeneration requires expression of a large, unknown number of genes to initiate and maintain cellular processes such as proliferation, extracellular matrix synthesis, differentiation and migration. (oncotarget.com)
Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
BNP also stimulated the proliferation of WT1 + epicardium-derived cells but only in the hypoxic area of infarcted hearts. (elifesciences.org)
The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)
However, when the liver is severely damaged or hepatocyte proliferation is greatly inhibited, liver stem/progenitor cells (LSPCs) will contribute to the liver regeneration process. (ijbs.com)
Furthermore, BPC 157 has been shown to stimulate the proliferation and migration of various types of cells involved in tissue repair, including fibroblasts, endothelial cells, and stem cells. (marketingoutsourcing.es)
Inhibits proliferation and promotes osteogenic differentiation, while inhibiting adipogenic differentiation, of human amnion-derived mesenchymal stem cells (MSCs) and rabbit bone marrow-derived MSCs (Wu et al. (stemcell.com)
Decreased proliferation and Nanog expression in mouse embryonic stem (ES) cells, with increased erythroid differentiation (Chae et al. (stemcell.com)
The Hirschi Lab is broadly interested in endothelial cell differentiation, proliferation, specification and function during development. (hirschilabuva.com)
Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)

For example, an endothelial progenitor cell (EPC) is more specialized than an ESC, and an EC is more specialized than an EPC. (wikipedia.org)
Here we show that the impaired neovascularization in mice lacking eNOS is related to a defect in progenitor cell mobilization. (nih.gov)
Scholars@Duke publication: Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. (duke.edu)
Let me introduce you to another component within Bone Marrow Aspirate, the Endothelial Progenitor Cell. (sheinkopmd.com)

Important signaling factors for vasculogenesis are TGF-β, BMP4, and VEGF, all of which promote pluripotent stem cells to differentiate into mesoderm, endothelial progenitor cells, and then into mature endothelium. (wikipedia.org)
The recently disclosed plasticity properties of adult-derived stem cells, their ability to be reprogrammed by defined factors into pluripotent stem cells and the comprehension of "epi"-genetic mechanisms underlying stem cells differentiation process has opened unexpected avenues to attempt regeneration of tissues affected by degenerative disorders and prompted the birth of the new "regenerative medicine" concept. (mpi.nl)
Whilst differentiation of some lineage specific stem cells can be induced with a degree of certainty, a differentiation outcome of a population of pluripotent stem cells is less predictable. (justia.com)

Hematopoietic stem cells (HSCs) reside in association with bone marrow (BM) sinusoidal vessels in vivo, but the function of BM endothelial cells (ECs) in regulating hematopoiesis is unclear. (duke.edu)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
In addition to the restoration of the liver parenchymal tissue by hepatocytes or/and LSPCs, or in some cases bone marrow (BM) derived cells, such as hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), the wound healing after injury in terms of angiopoiesis by liver sinusoidal endothelial cells (LSECs) or/and sinusoidal endothelial progenitor cells (SEPCs) is another important aspect taking place during regeneration. (ijbs.com)
Circulating endothelial progenitor cells, which are involved in healing blood vessels, and hematopoietic stem cells, which produce various healing growth factors, were significantly increased as compared to pre-treatment values. (cellmedicine.com)
Given that both endothelial progenitor cells and hematopoietic stem cells are involved in acceleration of tissue regeneration and healing, it may be possible that Stem-Kine could improve outcomes in conditions ranging from diabetes to heart failure, to neurodegenerative conditions. (cellmedicine.com)

Not only is VEGF critical for mesoderm cells to become an EC, but also for EPCs to differentiate into mature endothelium. (wikipedia.org)
Mice deficient in eNOS (Nos3(-/-)) show reduced vascular endothelial growth factor (VEGF)-induced mobilization of endothelial progenitor cells (EPCs) and increased mortality after myelosuppression. (nih.gov)
Enhanced expression of IL-6, IGF-1, TGF-β, and VEGF has also been observed in LC treated BMSCc+ groups, suggested the cardiac differentiation of BMSCc+, and can be utilized in tissue engineering for cardiac cell therapy. (techscience.com)
YAP expression increased following laser exposure, in accordance with vascular endothelial growth factor (VEGF) expression. (molvis.org)

ACTR covers - Neuroregeneration, Soft Tissue Repair, Cartilage/Tendon and Bone/Ligament Regeneration as well as competence centers for molecular biology, miRNA analysis, polymer synthesis, bioprinting, preclinical in vivo facilities incl. (icgeb.org)
now reveal that differentiation of USCs generates ECs with robust endothelial function in vitro and endothelial potential in vivo, thereby suggesting this approach as a non-invasive, simple, and low-cost method [5] to produce sufficient autologous ECs for applications in tissue-engineered vascular regeneration or the repair of endothelial dysfunction [6]. (stemcellsportal.com)
Melero-Martin JM , Khan ZA , Picard A , In vivo vasculogenic potential of human blood-derived endothelial progenitor cells . (avma.org)
Rabbit artificial SF endothelial grafts were transplanted in a DMEK surgery into a rabbit in vivo model. (arvojournals.org)
and with mechanical properties that allowed its use in a DMEK surgery, proving its in vivo functionality in a rabbit model of endothelial dysfunction. (arvojournals.org)
The effect of CD146 on SHED-mediated bone regeneration in vivo remains unknown. (unair.ac.id)
Zong C, Bronckaers A, Vande Velde G, Willems G, Cadenas de Llano-Pérula M. (2022) In Vivo Micro-Computerized Tomography Tracking of Human Periodontal Ligament Stem Cells Labeled with Gold Nanocomplexes. (uhasselt.be)
Bone regeneration was assessed via in vivo computed tomography (CT), ex vivo micro-CT and histology. (biomedcentral.com)
Traditional cell delivery methods involve direct seeding and attachment of MSC on biomaterial scaffolds before in vivo transplantation [ 26 ]. (biomedcentral.com)
However, this method may not be optimal for the delivery of cell spheroids where the 3D structure, essential to maximize their in vivo effects, is lost by direct seeding. (biomedcentral.com)

In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. (nii.ac.jp)
Damage to ECs is catastrophic and induces endothelial cell dysfunction. (koreamed.org)
Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. (koreamed.org)
Induces upregulation of the pluripotency network genes (Klf4, Klf2, Nanog, Oct4, Myc, Sox2) and epigenetic-associated proteins (Dnmt3a, Mbd3) in mouse ES cells, and inhibits retinoic acid-induced differentiation (Adamo et al. (stemcell.com)

There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. (techscience.com)
However, MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory effects. (techscience.com)
Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)
This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. (cancerindex.org)
We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. (cancerindex.org)
In a matrigel invasion assay, interferon-gamma, a specific inhibitor of eotaxin-related homing, significantly reduced the transmigration of PC-3 cells, under co-cultured condition with MSCs, in a dose-dependent manner (P (cancerindex.org)
It seems that in fracture repair, the synergistic effect of EPCs and MSCs is crucial for complete bone regeneration. (sheinkopmd.com)
We have been able to demonstrate not just viability, but also that our transportation, processing and cryopreservation methods maintain these properties in the mesenchymal stem cells (MSCs) found in your baby's umbilical cord tissue. (cells4life.com)
Umbilical cord tissue samples processed and stored by Cells4Life contain MSCs that can be isolated and expanded into billions of cells. (cells4life.com)
MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)

EPCs can be defined as bone marrow-derived precursor cells with the ability to differentiate into endothelial cells and to participate in the formation of new blood vessels. (sheinkopmd.com)
Our results demonstrated that these immature cells have a natural capacity to differentiate into endothelial cells in infarcted hearts. (elifesciences.org)

It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. (cancerindex.org)
The majority of epithelial cells are therefore short-lived, in contrast to a limited number of long-lived stem cells in the base of the crypts. (nature.com)
The lung is a complex organ composed of many types of epithelial cells, immune cells, endothelial cells and stromal cells. (stemcell.com)
The alveolar epithelium is lined with type I and II alveolar epithelial cells (AECs). (stemcell.com)

One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)

There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
This interaction triggers a cascade of cellular events that ultimately lead to the activation of various signaling pathways involved in tissue repair and regeneration. (marketingoutsourcing.es)
The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. (koreamed.org)
However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)
Endothelial cell specialization is associated with suppression of cell growth, but how signaling pathways that control endothelial cell cycle and fate are coordinated was not known. (hirschilabuva.com)

These findings indicate that eNOS expressed by bone marrow stromal cells influences recruitment of stem and progenitor cells. (nih.gov)
The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
Merckx G, Hosseinkhani B, Kuypers S, Deville S, Irobi J, Nelissen I, Michiels L, Lambrichts I, Bronckaers A. (2020) Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles. (uhasselt.be)
Herrmann M, Stanic B, Hildebrand M, Alini M, Verrier S. In Vitro Simulation of the Early Proinflammatory Phase in Fracture Healing Reveals Strong Immunomodulatory Effects of CD146-positive Mesenchymal Stromal Cells. (aofoundation.org)
Regeneration requires stromal Rspo3, which is present at increased levels upon injury and reprograms Lgr5 − but Lgr4 + differentiated cells. (nature.com)
In contrast, depletion of stromal Rspo3 impairs crypt regeneration, even upon mild injury. (nature.com)
We have shown that in the stomach, stem cell homeostasis is regulated by Wnt and Rspo secreted by stromal myofibroblasts 11 . (nature.com)
This Rspo3-driven regeneration program is supported by injury-induced stromal remodeling, and is essential for epithelial recovery. (nature.com)
Recent advances in isolating epithelial progenitor cells and stromal cells, as well as defining niche factors important for lung development, have led to the establishment of an in vitro 3D lung culture system: pulmonary (lung) organoids. (stemcell.com)
Recent progress isolating lung epithelial progenitor and stromal cells, as well as defining stem cell niche factors that are important for lung development, has led to the establishment of an in vitro three-dimensional (3D) culture system: lung organoids 2 , also known as airway organoids or pulmonary organoids. (stemcell.com)
Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). (biomedcentral.com)

Ongoing studies are further investigating underlying regulatory mechanisms, the role of endothelial cell cycle state in lymphatic specification, and the role of dysregulated of endothelial cell cycle state in vascular malformations and diseases. (hirschilabuva.com)

Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
BALB/c mice were treated with total body irradiation (TBI) and then infused with C57Bl6-derived endothelial progenitor cells (EPCs) to augment endogenous BM EC activity. (duke.edu)

They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
Within this tissue stem cells differentiate into fibroblasts, epithelial and endothelial cells as well as melanocytes. (oncotarget.com)

Through them, the cells modify their microenvironment and the behavior of neighboring cells. (frontiersin.org)

Embryonic stem cells isolation primarily requires the consent of donors and can include the killing of fertilized eggs. (techscience.com)
In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. (justia.com)
Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
culturing a stem cell in the presence of an embryonic cell and/or extracellular medium of an embryonic cell, under conditions that induce differentiation of the stem cell. (justia.com)
Hematopoietic stem and progenitor cells (HSPCs) that are essential for establishment and maintenance of the adult blood system are generated during embryonic definitive hematopoiesis. (hirschilabuva.com)
1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)
3,4 The zygote and cells derived from the first two cellular divisions constitute the most primitive cells (totipotent cells) that are capable of forming the embryo and the embryonic annexes (e.g. placenta, amniotic membranes etc). (bvsalud.org)

Medina RJ , Barber CL , Sabatier F , Endothelial progenitors: a consensus statement on nomenclature . (avma.org)
This has been studied mainly in the small intestine, where different cell types such as enterocyte progenitors 4 , more differentiated secretory Bmi1 + cells 3 , or even fully differentiated Paneth cells can repopulate crypts upon injury. (nature.com)
Hirschi KK, Dejana E. Resident Endothelial Progenitors Make Themselves at Home. (hirschilabuva.com)

Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)
In vitro functional analysis of Na, K-ATPase pump activity revealed that sTECE had significantly high pump function compared to SKPs or control 3T3 cells. (elsevierpure.com)

Understanding this process can lead to further research in vascular regeneration. (wikipedia.org)
Overall, the authors provide substantial evidence that non-invasively collected USCs represent an exciting new source of autologous ECs for applications in tissue-engineered vascular regeneration or repair of endothelial dysfunction. (stemcellsportal.com)

Autophagy was recognized early in the pathogenesis of endothelial dysfunction. (koreamed.org)

Objective: Stem cells from human exfoliated deciduous teeth (SHED) have bone regeneration ability and potential therapeutic applications. (unair.ac.id)
Results: Bone regeneration was observed upon transplantation with CD146 + and heterogeneous populations of SHED, with significantly higher bone regeneration observed with CD146 + cells. (unair.ac.id)
Bone regeneration was higher in the CD146 − group than in the control group, but significantly lower than that in the other transplant groups at 4 and 8 weeks. (unair.ac.id)
Conclusion: Transplantation of CD146 + SHED into bone defects may be useful for bone regeneration. (unair.ac.id)
The aim of this study was to compare the potential of human BMSC cultured as 2D monolayers or 3D spheroids encapsulated in constructs of 3D-printed poly-L-lactide-co-trimethylene carbonate scaffolds and modified human platelet lysate hydrogels (PLATMC-HPLG) for bone regeneration. (biomedcentral.com)

ESCs will eventually produce endothelial cells (ECs), which create the thin-walled endothelium that lines the inner surface of blood vessels and lymphatic vessels. (wikipedia.org)
Endothelial cells can be found throughout the whole vascular system and they also play a vital role in the movement of white blood cells ECs were first thought to arise from extraembryonic tissues because blood vessels were observed in the avian and mammalian embryos. (wikipedia.org)
When vasculogenesis occurs the cells transform into different versions throughout the process to eventually become the earliest blood vessels. (wikipedia.org)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
One project in the lab focuses on the communication among cells of the neurovascular unit, a collection of cells that make up the blood-brain barrier (BBB), a unique characteristic of blood vessels in the brain. (dcu.ie)
It may well be that the Endothelial Progenitor Cells are responsible for new blood vessels and a resultant favorable environment. (sheinkopmd.com)
This promotes the formation of new connective tissue, blood vessels, and other components necessary for tissue regeneration. (marketingoutsourcing.es)

Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)
For more on the massive potential of urine-derived stem cells and their regenerative applications, stay tuned to the Stem Cells Portal ! (stemcellsportal.com)
Urine-derived stem cells: A novel and versatile progenitor source for cell-based therapy and regenerative medicine. (stemcellsportal.com)
The Stem Cells Portal provides coverage of the latest research, clinical applications, policies, and developments in the stem cell and regenerative medicine fields. (stemcellsportal.com)
For this work, scientists have combined adult stem cells with a repurposed drug that improves healing to create a novel bioengineered scaffold that could someday lead to a new treatment for chronic diabetic ulcers," said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. (ipscell.com)
Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. (ipscell.com)
Endothelial Cell Development and Its Application to Regenerative Medicine. (hirschilabuva.com)
Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)

Can we reprogram cancer cells or their niche to stop them? (ipscell.com)

In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
In the multicellular theory, each tumor type is associated with a specific differentiated cell of origin within the salivary gland unit. (medscape.com)

In the bone field we study cell based therapies using hypertrophic bone marrow or adipose derived MSC and iPS derived MSC. (icgeb.org)

Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. (koreamed.org)
The lab also uses human stem cell culture models to study the regulation of human endothelial cell differentiation and specification, and to study the functional roles of endothelial cells in regulating tissue-resident stem cells. (hirschilabuva.com)
Regulation of endothelial cell differentiation and specification. (hirschilabuva.com)

More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
The recent EMBO workshop 'Spinal cord development and regeneration' held in Sitges, a pleasant Spanish Mediterranean town, highlighted the spinal cord as a complex and accessible model system in which to analyse neural circuit formation and repair. (biologists.com)
Facial skin may therefore be an accessible autologous source of neural crest derived cells. (elsevierpure.com)

Reporting in STEM CELLS Translational Medicine , Liu et al. (stemcellsportal.com)
STEM CELLS Translational Medicine 2018;7:686-698. (stemcellsportal.com)
The Center for Improvement of Human Functioning International (CIHFI) was lead author on a peer reviewed study published in the Journal of Translational Medicine http://www.translational-medicine.com/content/pdf/1479-5876-8-34.pdf describing how Stem-Kine, a commercially available nutritional supplement, significantly elevated levels of two types of stem cells in circulation. (cellmedicine.com)
Stem Cells Translational Medicine , 6 (3), 788-798. (elsevierpure.com)

Endothelial stem cells (ESCs) are one of three types of stem cells found in bone marrow. (wikipedia.org)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
Objective: the aim of this study was to conduct a literature review of the types of stem cells of dental origin and their applications in Dentistry. (bvsalud.org)

These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)
On the other hand, the "exosome vesicle " is an extracellular particle released from the endosomal compartment of most eukaryotic cells. (frontiersin.org)
The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)
Cells within the body release extracellular vesicles (EVs) that can contain genetic material and signalling molecules. (dcu.ie)
AQP4 operates in complex with the potassium channel Kir4.1, and their cell surface expression is mediated through the dystrophin-associated protein complex (DAPC) and the extracellular matrix. (dcu.ie)
Hereby we focus on the use of extracellular vesicles derived from dental pulp stem cells, a project with dr. (uhasselt.be)
It often has multiple types of cells mirroring their counterpart in the body along with constituents of native extracellular matrix (ECM) and is typically miniature or micro-scale in size. (stemcell.com)
BTE aims to combine the cellular ( osteogenic cells), extracellular ( osteoconductive scaffolds) and/or molecular elements ( osteoinductive growth factors) required for bone healing [ 2 ]. (biomedcentral.com)

SF artificial endothelial grafts showed the characteristic endothelial markers: zonula occludens (ZO-1) and Na + /K + ATPase. (arvojournals.org)
Histologic analysis showed that the SF artificial endothelial graft was attached and integrated on the surface of the corneal stroma without a significant inflammatory reaction, and rabbit CECs consisted in a monolayer that showed their characteristic markers ZO-1 and Na + /K + ATPase, suggesting proper intercellular junctions and cellular pump function. (arvojournals.org)
During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
Expression of major corneal endothelial markers were confirmed by Reverse transcription polymerase chain reaction (RT-PCR) and quantitative Real time polymerase chain reaction (qRT-PCR).Western blots confirmed the expression of Na, K-ATPase protein, the major functional marker of corneal endothelial cells. (elsevierpure.com)

Stem cells (SCs) are undifferentiated cells with self-renewal ability and capacity to differentiate into specialized cell types. (bvsalud.org)

Anterior segment optical coherence tomography revealed the SF graft as a fully integrated component in the corneal tissue, displaying a similar corneal thickness and endothelial cell count when compared with its healthy contralateral cornea. (arvojournals.org)

Heterogeneous populations of SHED and CD146 + and CD146 − cells were transplanted into bone defects generated in the skulls of immunodeficient mice. (unair.ac.id)

CD146, a cell adhesion protein expressed by vascular endothelial cells, is involved in osteoblastic differentiation of stem cells. (unair.ac.id)
The present invention relates to methods of inducing differentiation of stem cells. (justia.com)
Differentiation of stem cells is known be triggered by various growth factors and regulatory molecules. (justia.com)
Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)

2020, Cell Research . (ipscell.com)
Cell Rep. 2020. (hirschilabuva.com)

Regeneration of the vascular and myocardial tissues is considered a primary endpoint to limit the consequences of acute and chronic ischemic heart disorders. (mpi.nl)
Collagen is a major component of connective tissues and BPC 157 promotes collagen production, which helps in tissue repair and regeneration. (marketingoutsourcing.es)
This process is essential for delivering oxygen and nutrients to injured tissues, facilitating their healing and regeneration. (marketingoutsourcing.es)
Vascular perfusion is required for all tissues in the body to provide nutrients and oxygen, remove waste products, maintain fluid homeostasis, and traffic immune cells. (hirschilabuva.com)
ASCs are present in a number of posnatal tissues and are responsible for normal tissue renewal as well as for regeneration and healing after injuries. (bvsalud.org)
Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)

Urine-derived Stem Cells: An Exciting New Source of Autologous Endothelial Cells? (stemcellsportal.com)
As a means to generate sufficient autologous ECs, researchers from the laboratory of Yuanyuan Zhang (Wake Forest School of Medicine, Winston-Salem, NC, USA) recently assessed the possible differentiation of ECs from urine-derived stem cells (USCs), cells originating from the parietal cells in kidney glomeruli that possess robust proliferative abilities, multipotent differentiation capacity, and robust paracrine-acting effects [1-4]. (stemcellsportal.com)
Being of autologous origin, platelet rich plasma (PRP) has gained popularity in tissue repair and regeneration as potential treatment for various acute and chronic disorders in human and veterinary medicine, including tendon and craniomaxillofacial applications. (aofoundation.org)
Both innovations are fully implantable, autologous, personalized with patient cells, and can replace all aspects of kidney function. (krcp-ksn.org)
Our findings suggest that SKPs may be used as a source of autologous cells for the treatment of corneal endothelial disease. (elsevierpure.com)

This may contribute to impaired regeneration processes in ischemic heart disease patients, who are characterized by a reduced systemic NO bioactivity. (nih.gov)
In fact, they unpredictably indicated modest, yet significant, clinical benefits in patients compared to the outstanding results using stem cells in animal models of ischemic heart and peripheral disease. (mpi.nl)

The further specialized a cell is, the more differentiated it is and as a result it is considered to be more committed to a certain cellular lineage. (wikipedia.org)
Lgr5 is a well-established marker of these basal stem cells in the gastrointestinal tract 1 and lineage tracing experiments have demonstrated that Lgr5 + cells give rise to clonal cell populations establishing entire colonic crypts 2 . (nature.com)

Human and rabbit artificial corneal endothelial grafts were developed through the culture of human and rabbit corneal endothelial cells (CECs) on SF films. (arvojournals.org)
To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)

Role of insulin-like growth factors in endothelium differentiation ECs derived from stem cells are the beginning of vasculogenesis. (wikipedia.org)
Vasculogenesis is new production of a vascular network from mesodermal progenitor cells. (wikipedia.org)
It is important to talk more about vasculogenesis because this is what makes ECs different from other types of cells that are found in the body. (wikipedia.org)

The formation of new vessels in the hypoxic area restores blood flow, provides oxygen and nutriments to the surviving cells, and promotes the migration and engraftment of new cells. (elifesciences.org)
Actin filaments are instrumental in driving processes such as migration, cytokinesis and endocytosis and provide cells with mechanical support. (biologists.com)
The cell-free media from MWCNT-polarized macrophages induced the migration of neutrophilic cells (differentiated from HL-60), which was blocked by Acebilustat, a specific leukotriene A4 hydrolase inhibitor, or LY239111, an LTB4 receptor antagonist, but not NS-398, a cyclooxygenase 2 inhibitor, revealing LTB4 as a major mediator of neutrophil chemotaxis from MWCNT-polarized macrophages. (cdc.gov)

Some of the notable growth factors present in PRP are transforming growth factor-beta, platelet-derived growth factor, insulin-like growth factor, vascular endothelial growth factor, fibroblast-like growth factor, epidermal growth factor, etc. (advancellsgroup.com)

The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
By understanding these mechanisms, researchers and clinicians can further explore the potential therapeutic applications of BPC 157 and develop new strategies for enhancing tissue healing and regeneration. (marketingoutsourcing.es)
Ongoing research is focused on understanding mechanisms of endothelial cell specification towards hemogenic, arterial, venous and lymphatic fates. (hirschilabuva.com)
Research in the Hirschi Lab aims to uncover the developmental mechanisms of hemogenic endothelial cell specification and endothelial-to-hematopoietic transition, and apply insights gained to the generation of human HSPCs for clinical therapies. (hirschilabuva.com)

However, under the "wrong" environmental circumstances, polyfunctional T-cells(poly-T) can drive autoimmune-disease pathogenesis. (dcu.ie)

The spinal cord constitutes an excellent model system for studying development and regeneration of a functional nervous system, from specification of its precursors to circuit formation. (biologists.com)
The latest advances in the field of spinal cord development and its regeneration following damage were discussed at a recent EMBO workshop 'Spinal cord development and regeneration' in Sitges, Spain (October, 2014), highlighting the use of direct visualization of cellular processes, genome-wide molecular techniques and the development of methods for directed stem cell differentiation and regeneration. (biologists.com)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)

Some stem cell therapies require the maximum number of stem cells possible in order to increase their chances of success. (cells4life.com)
This step is important not only to enhance the efficacy of MSC expansion but also to facilitate clinical translation of cell therapies according to current regulations [ 11 ]. (biomedcentral.com)
From Gizmodo Shady Stem Cell Therapies Can Cause Tumors, Infections, and Death, Doctors Report and here's the original article " Complications from "Stem Cell Tourism in Neurology . (ipscell.com)

Intravenous infusion of wild-type progenitor cells, but not bone marrow transplantation, rescued the defective neovascularization of Nos3(-/-) mice in a model of hind-limb ischemia, suggesting that progenitor mobilization from the bone marrow is impaired in Nos3(-/-) mice. (nih.gov)
Mechanistically, matrix metalloproteinase-9 (MMP-9), which is required for stem cell mobilization, was reduced in the bone marrow of Nos3(-/-) mice. (nih.gov)
Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)

For cartilage replacement we established two novel ways to use decellularized cartilage matrix for cell therapy. (icgeb.org)
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration. (ipscell.com)

Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart. (nii.ac.jp)
Promotes differentiation and mineralization of MC3T3-E1 osteoblastic cells (Kanazawa et al. (stemcell.com)
Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification. (hirschilabuva.com)

In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)

Journal Article] DNA damage enhanced by the attenuation of SLD5 delays cell cycle restoration in normal cells but not in cancer cells. (nii.ac.jp)
Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis. (cancerindex.org)
Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
Cancer cells often present neoantigens on their cell surface that can be detected as "non-self" by the immune system, resulting in an attack by the immune system. (msdmanuals.com)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology. (stemcellsportal.com)
Human Urine-Derived Stem Cell Differentiation to Endothelial Cells with Barrier Function and Nitric Oxide Production. (stemcellsportal.com)
A major limitation of the current technology is that both implantable BAK and kidney regeneration technology are still in preclinical stages, and thus their potential effects cannot be comprehensively generalized to human patients. (krcp-ksn.org)
Furthermore, we successfully induced corneal endothelial-like cells from human SKPs, and showed that transplanted corneas also maintained corneal transparency and thickness. (elsevierpure.com)

It isn't only attributable to the Adult Mesenchymal Stem Cell. (sheinkopmd.com)

Anatomy67

Organisms22

Diseases8

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture4

Information Science2

Health Care1

Angiogenesis14

Proliferation15

Progenitor cell4

Pluripotent stem3

Hematopoietic Stem5

VEGF4

Vivo10

Induces4

MSCs15

Differentiate into endothelial cells2

Epithelial cells4

Mature endothelial cells1

Pathways6

Stromal11

Role of endothelial1

EPCs3

Fibroblasts2

Microenvironment1

Embryonic7

Progenitors3

Vitro3

Vascular regeneration2

Dysfunction1

Bone Regeneration5

Blood vessels7

Regenerative10

Niche1

Tumor5

Adipose1

Regulation3

Neural3

Translational Medicine4

Types of stem cells3

Extracellular9

Markers5

Capacity to differentiate1

Corneal thickness1

IMMUNODEFICIENT MICE1

Differentiation of stem cells4

20202

Tissues8

Autologous5

Ischemic2

Lineage2

Grafts2

Vasculogenesis3

Migration3

Insulin-like g1

Mechanisms4

Pathogenesis1

Development and regeneration3

Therapies3

Mice3

Cartilage2

Promotes3

Transplantation1

Cancer cells5

Human5

Adult1