InfarctionSingle photon emiRadionuclideLexiscanIschemiaDipyridamolePatientsAdenosine receptor agonistLate gadolinium enhancementSPECT MPIVolumetric analysisVasodilator stressPharmacologicEchocardiographyQuantitativeArterialAminophyllineDiagnosticCardiac arrestAssessAttenuationNoncontrastVentricularTissueClinicalReversibleCoronary arteryPatternsMultimodalityAdministrationWidelyStudyDecreaseExerciseRiskAgentsAdvances
Infarction12
- Cases of myocardial infarction and death have occurred following the administration of Lexiscan (regadenoson) injection or Adenoscan (adenosine) infusion. (fda.gov)
- Some cases of myocardial infarction and death have occurred in patients with pre-existing unstable angina or cardiovascular instability. (fda.gov)
- Due to limitations in the currently available data, FDA is unable to discern a difference in risk for acute myocardial infarction or death between Lexiscan and Adenoscan. (fda.gov)
- Kassab K, Matar R, Alyousef T, Malhotra S. Acute Myocardial Infarction in a Young Woman: Role of Cardiac Magnetic Resonance Imaging in Establishing the Diagnosis. (yumaregional.org)
- There are an increasing number and type of cardiac tests used to help stratify patients thought to be at risk for symptomatic coronary artery disease (CAD), specifically for short-term complications such as myocardial infarction (MI) or sudden cardiac death. (medscape.com)
- The goal of cardiac testing in the emergency department (ED) setting is to help stratify patients thought to be at risk for symptomatic coronary artery disease , specifically for short-term complications such as myocardial infarction (MI) or sudden cardiac death (SCD). (medscape.com)
- CMR identifies areas of increased interstitial space where gadolinium is retained (eg, areas of myocardial infarction, acute edema/inflammation due to capillary leak, myocardial fibrosis/scar, or amyloid protein infiltration). (medscape.com)
- Risk stratification in patients with unstable angina and non-ST segment elevation myocardial infarction: evidence-based review. (rush.edu)
- Background: This study aimed to evaluate the multiple interactions between therapeutic ultrasound (TUS), microbubbles (MB), and recombinant tissue plasminogen activator (r-tPA) by using three-dimensional (3D) ultrasound to examine the impact of thrombolysis with r-tPA on epicardial recanalization and microcirculation in patients with acute ST-segment-elevation myocardial infarction (STEMI). (bvsalud.org)
- Surgical ventricular reconstruction (SVR) has been used to reverse cardiac remodeling in post-myocardial infarction (MI) patients with large left ventricular (LV) aneurysm, however, residual LV remodeling and dysfunction remain postoperatively. (bvsalud.org)
- Fatal and nonfatal myocardial infarction, ventricular arrhythmias, and cardiac arrest have occurred following Lexiscan injection. (lexiscan.com)
- Because coronary artery plaques that are not significantly stenotic (ie, do not result in ischemia during stress testing) may nonetheless rupture and cause an acute coronary syndrome, a normal stress test result does not guarantee future freedom from myocardial infarction. (msdmanuals.com)
Single photon emi2
- A myocardial perfusion SPECT (single photon emission computed tomography) test is a procedure that demonstrates the function of the myocardium. (medscape.com)
- a Symphony Health Solutions, NonRetailSource, July 2022, based on Astellas market definition of pharmacologic stress agents, as used in single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI). (lexiscan.com)
Radionuclide6
- The agency approved adenosine in 1995 and regadenoson in 2008 for radionuclide myocardial perfusion imaging in patients who cannot undergo exercise stress testing. (medscape.com)
- Target: A2A adenosine receptorRegadenoson produces hyperemia quickly and maintains it for a duration that is useful for radionuclide myocardial perfusion imaging. (chemspider.com)
- Lexiscan is an A2A adenosine receptor agonist used alongside radionuclide myocardial perfusion imaging (MPI) in patients being assessed for cardiovascular disease who are not physically able to carry out standard exercise stress testing on a treadmill or stationary bike. (pharmaphorum.com)
- Lexiscan ® (regadenoson) injection is a pharmacologic stress agent indicated for radionuclide myocardial perfusion imaging (MPI) in patients unable to undergo adequate exercise stress. (lexiscan.com)
- Візуалізація перфузії міокарда Radionuclide imaging uses a special detector (gamma camera) to create an image following injection of radioactive material. (msdmanuals.com)
- Dr. Seo leads a group of physicists and engineers working in the field of radionuclide and x-ray imaging instrumentation and physics, and directs the UCSF PRL. (ucsf.edu)
Lexiscan5
- [11-20-2013] The U.S. Food and Drug Administration (FDA) is warning health care professionals of the rare but serious risk of heart attack and death with use of the cardiac nuclear stress test agents Lexiscan (regadenoson) and Adenoscan (adenosine). (fda.gov)
- Heart attack and death have occurred in patients who received Lexiscan (regadenoson) or Adenoscan (adenosine) for a cardiac nuclear stress test. (fda.gov)
- Clinicians should avoid using the imaging agents regadenoson ( Lexiscan , Astellas Pharma US) and adenosine ( Adenoscan , Astellas Pharma US) for cardiac nuclear stress tests of patients with signs or symptoms of unstable angina or cardiovascular instability because the drugs may increase their risk for a fatal heart attack, the US Food and Drug Administration (FDA) announced today. (medscape.com)
- The most widely available pharmacologic agents for stress testing are dipyridamole (Persantine), adenosine , regadenoson (Lexiscan), and dobutamine . (medscape.com)
- A US district court in Delaware has granted an interim injunction that will prevent Hospira from launching its generic version of Lexiscan (regadenoson injection) until 5 October, but said no to the Japanese drugmaker's request for a preliminary injunction, which would prevent a launch while the patent dispute is being appealed. (pharmaphorum.com)
Ischemia3
- Some events occurred in patients with signs or symptoms of acute myocardial ischemia, such as unstable angina or cardiovascular instability. (fda.gov)
- The diagnostic and prognostic value of near- normal perfusion or borderline ischemia on stress myocardial perfusion imaging. (yumaregional.org)
- Background In patients with suspected coronary artery disease (CAD), myocardial perfusion is assessed under rest and pharmacological stress to identify ischemia. (unav.edu)
Dipyridamole1
- Wall motion (WM), Doppler-derived measurement of the coronary flow reserve (CFR) in the left anterior descending coronary artery (LAD), and myocardial perfusion imaging (MPI) can be sequentially assessed during dipyridamole stress echocardiography. (thoracickey.com)
Patients30
- Kassab K, Doukky R. Cardiac Imaging for the Assessment of Patients Being Evaluated for Liver Transplantation. (yumaregional.org)
- However, the US Food and Drug Administration (FDA) warns against the use of adenosine and regadenoson in patients with signs or symptoms of unstable angina or cardiovascular instability. (medscape.com)
- Patients presenting for regadenoson stress myocardial perfusion imaging were asked their amounts of daily caffeine intake. (snmjournals.org)
- to test its ability to accurately determine the presence, location, extend and severity of perfusion abnormalities in agreement with conventional diagnostic techniques (ICA and MPI) in patients with normal and abnormal coronary arteries and/or perfusion patterns 3. (drugpatentwatch.com)
- to test this approach in patients undergoing vasodilator stress tests with MDCT imaging in combination with the new vasodilator stress agent Regadenoson. (drugpatentwatch.com)
- In patients, single-delay PCASL (1200 msec) and first-pass perfusion images were acquired under rest and adenosine conditions. (unav.edu)
- Three observers classified patients into 'switch-off' and 'failed switch-off' groups by visually comparing rest-stress perfusion data acquired with PCASL and first-pass, independently. (unav.edu)
- Attenuation of the side effect profile of regadenoson: a randomized double-blinded placebo-controlled study with aminophylline in patients undergoing myocardial perfusion imaging. (rush.edu)
- Attenuation of the side effect profile of regadenoson: a randomized double-blind placebo-controlled study with aminophylline in patients undergoing myocardial perfusion imaging and have severe chronic kidney disease--the ASSUAGE-CKD trial. (rush.edu)
- The safety and tolerability of regadenoson in patients with end-stage renal disease: the first prospective evaluation. (rush.edu)
- The prognostic value of transient ischemic dilatation with otherwise normal SPECT myocardial perfusion imaging: a cautionary note in patients with diabetes and coronary artery disease. (rush.edu)
- Age and gender as predictors of benefit from aminophylline administration in patients undergoing regadenoson stress myocardial perfusion imaging: a substudy of the ASSUAGE trial. (rush.edu)
- Regadenoson use in patients with chronic obstructive pulmonary disease: the state of current knowledge. (rush.edu)
- The impact of regimented aminophylline use on extracardiac radioisotope activity in patients undergoing regadenoson stress SPECT myocardial perfusion imaging: a substudy of the ASSUAGE trial. (rush.edu)
- Are cardiologists truly better at appropriately selecting patients for stress myocardial perfusion imaging? (rush.edu)
- Cardiac imaging for the assessment of patients being evaluated for kidney or liver transplantation. (rush.edu)
- Effective risk stratification of patients on the basis of myocardial perfusion SPECT is dependent on appropriate patient selection. (rush.edu)
- Severe chronic kidney disease as a predictor of benefit from aminophylline administration in patients undergoing regadenoson stress myocardial perfusion imaging: A substudy of the ASSUAGE and ASSUAGE-CKD trials. (rush.edu)
- Prognostic implications of stress modality on mortality risk and cause of death in patients undergoing office-based SPECT myocardial perfusion imaging. (rush.edu)
- Prognostic value of heart rate response during regadenoson stress myocardial perfusion imaging in patients with end stage renal disease. (rush.edu)
- Myocardial perfusion imaging (MPI) is an important imaging modality in the management of patients with cardiovascular disease. (snmjournals.org)
- Myocardial perfusion imaging (MPI) is a valuable tool in the management of patients with cardiovascular disease. (snmjournals.org)
- In this regard, non-invasive stress imaging tests were shown to be excellent tools for properly selecting patients who would further benefit from an invasive procedure, thus providing both precise diagnostic classification and risk stratification [ 1 ] [ 2 ] . (encyclopedia.pub)
- The heart rate response to regadenoson in patients with atrial fibrillation. (harvard.edu)
- Association with symptoms and prognosis, Doppler Echocardiography comparison with alternative invasive and non-invasive imaging modalities, and possible Assessment of Coronary Microvascular Function in Patients interventions in angina patients with low CFVR were discussed, and key research With Angina and No Obstructive questions were proposed. (readkong.com)
- Schroder and Prescott CFVR in Non-obstructive Angina INTRODUCTION and prognosis, comparison with alternative invasive and non- invasive imaging modalities, and possible interventions in angina Coronary artery disease remains one of the leading causes of patients with low CFVR were discussed. (readkong.com)
- Ultimately, only a coronary blood flow is increased due to a simultaneous increase fraction of angina patients is treated with revascularization (5- in coronary perfusion pressure and a decrease in coronary 7). (readkong.com)
- Cardiologists cannot solely rely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischaemia. (rcpe.ac.uk)
- Of the 422 patients who consented to participate, 22 (5.2%) met exclusion criteria (10 with inadequate baseline echocardiographic image quality, 3 with sulfonamide allergy, and 9 with severe chronic obstructive pulmonary disease). (thoracickey.com)
- To assess myocardial perfusion (stress, rest) and late gadolinium enhancement in adult patients with known or suspected coronary artery disease (CAD). (nih.gov)
Adenosine receptor agonist1
- Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing. (chemspider.com)
Late gadolinium enhancement1
- The principal utility of CMR and its advantage over echocardiography for cardiomyopathy is its use of late gadolinium enhancement (LGE) , which visualizes myocardial tissue and detects scar, fibrosis, or infiltration. (medscape.com)
SPECT MPI2
- A total of 164 inpatients received single-photon emission computerized tomography-myocardial perfusion imaging (SPECT/MPI) and coronary angiography (CAG) between March 2018 and October 2019 at the Third Affiliated Hospital of Soochow University were enrolled in the retrospective cross-sectional study. (amegroups.org)
- Hemodynamically significant CAD was defined by coronary stenosis severity ≥50% with reversible perfusion defects in the corresponding areas of SPECT/MPI. (amegroups.org)
Volumetric analysis2
- Owing to its high-spatial resolution and 3D tomography, CMR provides superior myocardial border definition and volumetric analysis, accurate determination of regional wall thickness and myocardial mass, and sensitive detection of WMA. (medscape.com)
- to develop software for quantitative volumetric analysis of myocardial perfusion from MDCT images 2. (drugpatentwatch.com)
Vasodilator stress1
- Kassab K, Al-Ogaili A, Malhotra S. Abnormal vasodilator stress electrocardiogram with normal myocardial perfusion: Clinical decision-making and review of literature. (yumaregional.org)
Pharmacologic4
- Regadenoson is an adenosine A 2A receptor agonist widely used as a pharmacologic stress agent for myocardial perfusion imaging. (snmjournals.org)
- Approximately 3.4 million regadenoson pharmacologic stress tests were performed annually as of 2011. (snmjournals.org)
- Regadenoson was approved in 2008 by the U.S. Food and Drug Administration as a pharmacologic stress agent for myocardial perfusion imaging, with approximately 3.4 million regadenoson pharmacologic stress tests performed annually as of 2011 ( 1 ). (snmjournals.org)
- We chose to add PET myocardial perfusion imaging to our noninvasive stress test service line based on the ASNC Position Statement recommending PET MPI as the preferred pharmacologic stress test. (asnc.org)
Echocardiography3
- In this overview based on the latest research, we discuss the integral role of comprehensive imaging studies, particularly transthoracic echocardiography (TTE) and cardiac magnetic resonance imaging (CMR), in differentiating potential causes of HF and diagnosing various cardiomyopathies. (medscape.com)
- Myocardial strain imaging uses speckle-tracking echocardiography to measure tissue deformation through the cardiac cycle. (medscape.com)
- During the past decade, stress echocardiography (SE) has moved beyond the standalone analysis of wall motion (WM), thanks to the clinical feasibility of both Doppler-derived measurement of coronary flow reserve (CFR) in the left anterior descending coronary artery (LAD) and contrast myocardial perfusion imaging (MPI). (thoracickey.com)
Quantitative2
- Data Conclusion This study could demonstrate the feasibility of PCASL to identify splenic switch-off during adenosine perfusion MRI, both by qualitative and quantitative assessments. (unav.edu)
- His primary research focus is to use quantitative SPECT/CT, PET/CT, and PET/MR molecular imaging tools for a broad range of research areas from small animal imaging using dedicated animal imaging systems and basic instrumentation development for physics analysis of clinical research data. (ucsf.edu)
Arterial1
- Activation of cardiac A 2A and A 2B adenosine receptors vasodilates the coronary arterial bed, increases myocardial blood flow, and causes sympathoexcitation ( 6 , 7 ). (snmjournals.org)
Aminophylline1
- Data collected from the regadenoson stress test included symptoms, administration of aminophylline, heart rate, blood pressure, and arrhythmias. (snmjournals.org)
Diagnostic2
- showed that consumption of caffeine equivalent to 2-4 cups of coffee 90 min before regadenoson-stress SPECT myocardial perfusion imaging has the potential to adversely affect diagnostic accuracy ( 10 ). (snmjournals.org)
- Whereas MPI is a valuable diagnostic tool, it is also a complex physiologic imaging process, which exposes it to several potential pitfalls and artifacts that can limit the utility of the study. (snmjournals.org)
Cardiac arrest1
- The most common adverse events associated in fatal cases of regadenoson use included cardiac arrest, MI, loss of consciousness, and respiratory arrest. (medscape.com)
Assess2
- Further, T2* mapping, another parametric imaging approach, can detect and quantify myocardial iron deposition, primarily to assess iron overload cardiomyopathy. (medscape.com)
- With its unique ability to evaluate perfusion at the cellular level and to assess perfusion at peak exercise stress, MPI plays an important role in diagnosing cardiovascular disease, establishing prognosis, assessing the effectiveness of therapy, and evaluating viability. (snmjournals.org)
Attenuation2
- Splenic switch-off, defined as the stress to rest splenic perfusion attenuation in response to adenosine, has been proposed as an indicator of stress adequacy. (unav.edu)
- Soft tissue attenuation patterns in stress myocardial perfusion SPECT images: a comparison between supine and upright acquisition systems. (rush.edu)
Noncontrast1
Ventricular2
- Contrast-enhanced T1 mapping is mostly used for calculating extracellular volume fraction (ECV) - that is, the ratio of pre- and postcontrast myocardial T1 to that of the ventricular blood compartment T1. (medscape.com)
- Exclusion criteria were (1) a poor acoustic window precluding satisfactory imaging despite contrast administration, (2) severe valvular heart disease, (3) sustained ventricular arrhythmias or hemodynamic instability, (4) active chest pain within the past 24 hours, (5) known allergy to sulfonamides, (6) pregnancy or lactation, (7) severe chronic obstructive pulmonary disease, and (8) previous coronary artery bypass surgery. (thoracickey.com)
Tissue3
- T1 and T2 mapping better characterize myocardial tissue by identifying areas of edema (T2), inflammation, and more diffuse fibrosis (T1), which may aid in diagnosing myocarditis without LGE, amyloidosis , hemochromatosis , and Fabry disease . (medscape.com)
- Because ECV defines the proportion of a volume of tissue that consists of extracellular matrix or space between myocytes, it is a marker of myocardial tissue remodeling. (medscape.com)
- Nuclear cardiology studies employ non-invasive techniques for assessing myocardial blood flow, the heart's pumping function, and also to identify the size and location of the damaged heart tissue. (azheartdoctor.com)
Clinical1
- Alpha-9 Theranostics is a clinical-stage company developing a portfolio of radiolabeled imaging and therapeutic molecules for solid and hematologic malignancies. (frazierls.com)
Reversible1
- Regadenoson-induced coronary vasospasm resulting in severe reversible " by Z. Platsman, A. Auerbach et al. (hofstra.edu)
Coronary artery2
- Kassab K, Iskander M, Malhotra S, Pyslar N. Delineating anatomy and function with multimodality imaging: a case report of giant right coronary artery aneurysms. (yumaregional.org)
- Data were retrospectively reviewed for 61 pts undergoing rest/regadenoson-stress Rb-82 gated PET for evaluation of potential coronary artery disease (CAD) who also had x-ray contrast coronary arteriography. (snmjournals.org)
Patterns1
- Myocardial strain imaging, a reproducible measure of LV systolic function, can identify subclinical LV dysfunction and patterns that suggest specific cardiomyopathies (eg, ischemic cardiomyopathy, amyloidosis, hypertrophic cardiomyopathy, chemotherapy-induced cardiotoxicity). (medscape.com)
Multimodality2
- Kassab K, Kaul S, Gomez J, Delafontaine JL, Sawaqed R, Saini A. Ruptured Sinus of Valsalva Aneurysm: Use of Multimodality Imaging in Delineating Structure and Function. (yumaregional.org)
- Thanks to technologic advances in cardiac imaging, multimodality studies provide insight into the pathophysiology of both ischemic and nonischemic cardiomyopathy. (medscape.com)
Administration2
- An FDA review of the FAERS database found 26 MI cases and 29 deaths that occurred after the administration of regadenoson since its approval. (medscape.com)
- Advanced heart block and unresponsiveness after regadenoson administration during myocardial SPECT study. (harvard.edu)
Widely1
- Myocardial perfusion imaging (MPI) is the most widely used nuclear cardiology technique that deals with the assessment of blood flow to the heart (the myocardium). (azheartdoctor.com)
Study1
- This study assessed the effects of daily caffeine intake on symptoms and hemodynamic changes during stress testing with regadenoson. (snmjournals.org)
Decrease1
- A decrease in the blood flow is detected by the images of MPI. (azheartdoctor.com)
Exercise1
- If a treadmill is used, images are obtained prior to exercise and then within 60-90 seconds of completing exercise. (medscape.com)
Risk2
- The labels for both regadenoson and adenosine had previously warned of the risk for MI. (medscape.com)
- Epicardial angiographic recanalization rate, microcirculation in the at-risk myocardium, ST-segment elevation on electrocardiogram, and changes in the at-risk myocardium and the myocardial infarct area were compared between the groups. (bvsalud.org)
Agents1
- The selective nature of the drug makes it preferable to other stress agents such as adenosine, which are less selective and therefore cause more side-effects.Regadenoson has a 2 to 3 minute biological half-life. (chemspider.com)
Advances1
- Even though most modern scanners exhibit excellent image quality with high isotropic spatial (best 0.35 mm) and temporal (best 65 ms) resolutions, these parameters are still half of what is needed and compared to the resolution provide by invasive coronary angiography (ICA), (0.2 mm and 30 ms, respectively) Developments in hardware technology were mirrored by advances in image processing software. (encyclopedia.pub)