LesionsMesial temporal lobe epiHippocampusFrontalAmygdalaSeizuresPosteriorPrefrontal cortexMedically refractoryHippocampalRight temporal lobectomyOccipitalInterictalBilateralUncusInferiorAtrophyCerebellumEpilepsy patientsDysfunctionUnilateralAnteriorSclerosisStructuresSeizureCognitiveBehaviorPatientsSpatialMemoryElectrodesCommonlyHemisphereSurgicalSuperiorAnimalOriginFormHighSideSpecificEvidenceTreatment
Lesions5
- All patients fulfilled the following criteria: unilateral seizure onset of temporal lobe origin shown by continuous interictal and ictal video/EEG monitoring with scalp and sphenoidal electrodes, and unilateral lesions within the temporal lobes demonstrated by high resolution routine MRI. (biomedcentral.com)
- Ten patients had hippocampal sclerosis, three vascular lesions, two tumors, and six miscellaneous or cryptogenic temporal lobe lesions. (biomedcentral.com)
- the memory deficits in patients with temporal lobe epilepsy (tle) are associated with epileptogenic lesions of the temporal lobes, especially hippocampal sclerosis. (brain-knowledge-engine.org)
- It has been shown that lesions of the medial prefrontal cortex lead to an impairment of the ability to follow changing spatial rules 34 . (nature.com)
- The absence of temporal lobe lesions on MRI reduces the likelihood of HSV encephalitis and should prompt consideration of other diagnostic possibilities. (basicmedicalkey.com)
Mesial temporal lobe epi5
- Hippocampal sclerosis occurs in 3 distinct settings: mesial temporal lobe epilepsy, adult neurodegenerative disease and acute brain injury. (wikipedia.org)
- 1508 TDP-43 immunochemistry does not identify TDP-43 proteinopathy if hippocampal sclerosis arises from hypoxia or mesial temporal lobe epilepsy. (wikipedia.org)
- OBJECTIVE: Mesial Temporal Lobe Epilepsy-associated Hippocampal Sclerosis (MTLE-HS) is a syndrome associated with various aetiologies. (bvsalud.org)
- For patients who had mesial temporal lobe epilepsy and disabling seizures for no more than 2 consecutive years following adequate trials of 2 brand-name AEDs, resective surgery plus AED treatment resulted in a lower probability of seizures for at least 2 years posttreatment, as well as improved health-related quality of life, than continued AED treatment alone. (medscape.com)
- our results suggest that complex mdr expression changes not only in the hippocampus but in the gph may play a role in aed pharmacoresistance in intractable epilepsy patients with mesial temporal lobe epilepsy (mtle) by altering the permeability of aeds across the blood-brain barrier (bbb). (brain-knowledge-engine.org)
Hippocampus6
- Hippocampal sclerosis (HS) or mesial temporal sclerosis (MTS) is a neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus. (wikipedia.org)
- Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes. (jamanetwork.com)
- The hippocampus is located in the medial temporal lobe. (brainline.org)
- in temporal lobe epilepsy (tle) with evidence of hippocampal sclerosis (tle-mts) volumetric gray (gm) and white (wm) matter abnormalities are not restricted to the hippocampus but also are found in extrahippocampal structures. (brain-knowledge-engine.org)
- Reorganization of CA3 area of the mouse hippocampus after pilocarpine induced temporal lobe epilepsy with special reference to the CA3-septum pathway. (brain-knowledge-engine.org)
- we used the mouse pilocarpine model of temporal lobe epilepsy (tle), and injected iontophoretically the anterograde tracer phaseolus vulgaris leucoagglutinin (pha-l) into gliotic ca3, medial septum and the nucleus of diagonal band of broca, median raphe, and lateral supramammillary nuclei, or the retrograde tracer cholera toxin b subunit (ctb) into gliotic ca3 area of hippocampus . (brain-knowledge-engine.org)
Frontal8
- Located behind the forehead, the frontal lobes are the largest lobes of the brain. (brainline.org)
- The left frontal lobe plays a large role in speech and language. (brainline.org)
- The temporal lobes are located on the sides of the brain under the parietal lobes and behind the frontal lobes at about the level of the ears. (brainline.org)
- Executive functioning in children with intractable frontal lobe or temporal lobe epilepsy. (gov.gy)
- Multifactorial etiology of interictal behavior in frontal and temporal lobe epilepsy. (gov.gy)
- PET 영상을 SPM 을 사용하여 비교한 결과 치료를 받은 후의 영상에서 좌뇌의 상/중간전두고랑(superior / middle frontal gyrus)과 각이랑/모서리위이랑(angular / supramarginal gyrus)의 포도당대사 증가소견과, 우뇌의 내측 측두엽(medial temporal bobe)의 포도당대사 감소소견을 관찰할 수 있었다. (123dok.co)
- We found significant differences in white matter FA in the frontal lobe, limbic lobe and cerebellum between TRD patients and controls. (biomedcentral.com)
- [ 9 ] Sphenoid wing meningiomas may be associated with hyperostosis of the sphenoid ridge and may be very invasive, spreading to the dura of the frontal, temporal, and orbital regions. (medscape.com)
Amygdala2
- and decreases in the motor and somatosensory cortex, temporal lobe including left amygdala, cingulate cortex, insula and thalamus. (researchgate.net)
- PET imaging revealed decreased regional cerebral blood flow (rCBF) in areas including the left amygdala, dorsal anterior cingulate, posterior cingulate, medial temporal lobe (MTL), and bilateral insula (Gamma et al, 2000). (researchgate.net)
Seizures3
- Stauder linked mesial temporal lobe seizures to hippocampal sclerosis. (wikipedia.org)
- In the past 10 years, epilepsy surgery has increasingly been recognized as a viable treatment for patients with medically refractory seizures. (medscape.com)
- Activation of Fos during spontaneous hippocampal seizures in a model of temporal lobe epilepsy. (brain-knowledge-engine.org)
Posterior2
- Operations on tumors of the posteromedial temporal (PMT) region, that is, on those arising from the posterior parahippocampal, fusiform, and lingual gyri, are challenging to perform because of the deep-seated location of these tumors between critical cisternal neurovascular structures and the adjacent temporal and occipital cortexes. (thejns.org)
- The SCTT approach uses a sitting position that offers a direct route to the posterior fusiform and lingual gyri of the temporal lobe. (thejns.org)
Prefrontal cortex1
- Together, these results demonstrate that ovarian hormone status can broadly influence normal cognitive aging in monkeys, affecting capacities mediated by multiple brain regions, including the prefrontal cortex and the medial temporal lobe memory system. (jneurosci.org)
Medically refractory1
Hippocampal4
- A dual pathology is a temporal lobe abnormality that accompanying hippocampal sclerosis. (wikipedia.org)
- layer ii stellate cells of the entorhinal cortex, which are hyperexcitable in animal models of temporal lobe epilepsy , provide the predominant synaptic input to the hippocampal dentate gyrus. (brain-knowledge-engine.org)
- Hippocampal intrinsic bursting-firing neurons and temporal lobe epilepsy]. (brain-knowledge-engine.org)
- Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy. (brain-knowledge-engine.org)
Right temporal lobectomy1
- Moreover, healthy controls and right temporal lobectomy patients made more swap errors following shape than space probes. (eneuro.org)
Occipital1
- Traditional surgical approaches require temporal or occipital transgression, retraction, or venous sacrifice. (thejns.org)
Interictal1
- Temporal lobe interictal spikes disrupt encoding and retrieval of verbal memory: a subregion analysis. (neurotree.org)
Bilateral1
- Both temporal lobes herniate through the tentorial notch because of bilateral mass effects or diffuse brain edema. (msdmanuals.com)
Uncus1
- 1503 In 1825, Bouchet and Cazauvieilh described palpable firmness and atrophy of the uncus and medial temporal lobe of brains from epileptic and non-epileptic individuals. (wikipedia.org)
Inferior2
- Right hemisphere is inferior, and left hemisphere is superior. (medscape.com)
- Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease: x-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies. (jamanetwork.com)
Atrophy1
- Mean rating scores for medial temporal lobe atrophy (MTA), periventricular hyperintensities (PVH), and white matter hyperintensities (WMH) for all subjects with dementia (n=71) according to APOE ϵ4 status. (jamanetwork.com)
Cerebellum1
Epilepsy patients1
- To address this issue, we compared performance in two tasks of 13 epilepsy patients, who had undergone a temporal lobectomy, and 15 healthy controls. (eneuro.org)
Dysfunction2
- Idiopathic generalised epilepsy: a pilot study of memory and neuronal dysfunction in the temporal lobes, assessed by magnetic resonance spectroscopy. (brain-knowledge-engine.org)
- These findings support the deficits in preattentive automatic processing of auditory stimuli, especially in the left hemisphere, and indicate the correlation between positive symptoms, especially auditory hallucination, and left temporal lobe dysfunction in schizophrenia. (neurotransmitter.net)
Unilateral1
- The medial temporal lobe is squeezed by a unilateral mass across and under the tentlike tentorium that supports the temporal lobe. (msdmanuals.com)
Anterior1
- [ 14 ] Furthermore, medial (clinoidal) meningiomas are further differentiated into 3 subcategories based on their relation to the anterior clinoidal process. (medscape.com)
Sclerosis2
- Voxel-based optimized morphometry (VBM) of gray and white matter in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis. (brain-knowledge-engine.org)
- 22 The prototypical example of a surgically-remediable epilepsy syndrome is temporal lobe epilepsy associated with mesial temporal sclerosis (MTS). (neurosurgicalatlas.com)
Structures1
- Using a recently described memory fMRI paradigm for single case studies we aimed to determine possible interactions between CBZ serum levels and fMRI response in mesial temporal lobe structures of patients with chronic symptomatic temporal lobe epilepsy (TLE) [ 9 ]. (biomedcentral.com)
Seizure2
- Nevertheless, many patients with epilepsy never receive treatment that leaves them seizure free. (medscape.com)
- All patients presented with a seizure disorder related to a tumor in a PMT region involving the parahippocampal and fusiform gyri of the left (n = 3) or right (n = 2) temporal lobe. (thejns.org)
Cognitive1
- Investigating higherorder cognitive functions in temporal lobe epilepsy: cognitive estimation. (gov.gy)
Behavior1
- Left MMN ECD power and the asymmetry coefficient (AC) were negatively correlated with the positive scores from Positive and Negative Syndrome Scale (PANSS) (r = -0.673, p = 0.008), especially with the hallucinatory behavior subscale (r = -0.677, p = 0.008). (neurotransmitter.net)
Patients8
- We aimed to investigate the influence of CBZ on memory induced activation of the mesial temporal lobes in patients with symptomatic temporal lobe epilepsy (TLE). (biomedcentral.com)
- Twenty-one individual patients with refractory symptomatic TLE with different CBZ serum levels and 20 healthy controls were studied using BOLD fMRI. (biomedcentral.com)
- In TLE patients, carbamazepine reduces the fMRI-detectable changes within the mesial temporal lobes as induced by effortful memory retrieval. (biomedcentral.com)
- In 13 patients a right-sided and in eight patients a left-sided TLE was diagnosed. (biomedcentral.com)
- Left temporal lobectomy patients, showed the opposite pattern of errors instead. (eneuro.org)
- This study examined color recall in temporal lobectomy patients and healthy controls, to determine whether patients show differential impairments binding color and shape versus color and location of memorized objects. (eneuro.org)
- Left temporal lobectomy patients were less accurate recalling color, especially when the target object was identified by the location, rather than the shape it had in the initial display. (eneuro.org)
- Approximately 80% of patients with proven HSV encephalitis have MRI abnormalities involving the temporal lobes. (basicmedicalkey.com)
Spatial2
- Mesial temporal lobe (MTL) activation was induced by a task that is based on the retrieval of individually familiar visuo-spatial knowledge. (biomedcentral.com)
- We conclude that left MTL damage impairs spatial binding in vWM, and that this impairment does not reflect a perceptual or attentional deficit. (eneuro.org)
Memory3
- Although less clinically tested and proven than temporal lobectomy, Garrett opted for laser ablation, which is minimally invasive and does not present the same risk of language and memory complications. (rchsd.org)
- Disorders of the medial temporal lobe (MTL) adversely affect visual working memory (vWM) performance, including feature binding. (eneuro.org)
- The role of the medial temporal lobe (MTL) in episodic memory is well established ( Squire, 2009 ). (eneuro.org)
Electrodes1
- a clever way to create a sham condition using tVNS is by attaching the stimulation electrodes to the center of the left ear lobe, which is known to be free of cutaneous vagal innervation ( Peuker and Filler, 2002 ), see Figure 1 . (frontiersin.org)
Commonly2
- Temporal lobe epilepsy (TLE) is a common and commonly devastating form of human epilepsy for which only symptomatic therapy is available. (jneurosci.org)
- Temporal lobe epilepsy (TLE) is a common and commonly devastating form of human epilepsy because of its suboptimal responsiveness to antiseizure medications and frequent psychiatric comorbidities ( French, 2007 ). (jneurosci.org)
Hemisphere2
- In this position, left hemisphere will be held out of field by falx cerebri, and right hemisphere will fall away from field, minimizing need for traction. (medscape.com)
- Within these key sections, there is a left and right hemisphere, gray matter, white matter, connecting fibers, and those 100 billion neurons. (swedish.org)
Surgical1
- In June 2018, his surgical team, who Kathy calls "amazing," completed ablation on his right medial temporal lobe. (rchsd.org)
Superior1
- For both groups, the MMN source was determined to be located in the superior temporal gyrus (STG). (neurotransmitter.net)
Animal1
- The value of radiosurgery as a "lesion generator" was based on small and large animal studies that defined the critical dose, the volume, and the temporal evolution of the radiosurgical lesion. (surgicalneurologyint.com)
Origin1
- Sphenoid wing meningiomas are categorized as lateral, middle, or medial (clinoidal), depending on the origin of the tumor along the sphenoid ridge. (medscape.com)
Form1
- SIGNIFICANCE STATEMENT Temporal lobe epilepsy (TLE) is a common and devastating form of human epilepsy that lacks preventive therapies. (jneurosci.org)
High1
- We investigated the roles of storage and parsing in the visual domain for the productive Dutch plural suffix -en.Two experiments are reported that show that storage occurs for high-frequency noun plurals. (mpi.nl)
Side1
- Note the area of increased signal in the right temporal lobe ( left side of image ) confined predominantly to the gray matter. (basicmedicalkey.com)
Specific1
- Partir c'est mourir un peu: Universal and culture specific features of leave taking. (mpi.nl)
Evidence1
- Her chest radiograph showed atelectasis at the left base with no evidence of sub-diaphragmatic free air. (daysurgeryuk.net)
Treatment1
- Treatment options and paradigms in childhood temporal lobe epilepsy. (brain-knowledge-engine.org)