Refractory cutaneous involvement refractory disease. Medical search. Frequent questions

Localized scleroderma (also known as morphea) is a chronic autoimmune disorder characterized by depressed, fibrotic, and dyschromic cutaneous lesions. (bvsalud.org)
It has a significant impact on the patient's daily life due to the unaesthetic evolution of the cutaneous lesions. (bvsalud.org)
Localized scleroderma is a rare disease, characterized by sclerotic lesions. (hindawi.com)
Computed tomography and magnetic resonance imaging have aided the characterization of central nervous system lesions, and cerebral angiograms have pointed to vasculitis as a part of disease pathogenesis. (hindawi.com)
A 4-day-old preterm male neonate was transferred to the neonatal intensive care unit (NICU) for evaluation of respiratory failure and cutaneous hemorrhagic pustular lesions. (thieme-connect.de)
On one end, the clinical spectrum includes an acute, fulminant, disseminated disease called Letterer-Siwe disease, and, on the other end, solitary or few, indolent and chronic lesions of bone or other organs called eosinophilic granulomas . (medscape.com)
The intermediate clinical form called Hand-Schüller-Christian disease is characterized by multifocal, chronic involvement and classically presents as the triad of diabetes insipidus, proptosis, and lytic bone lesions. (medscape.com)
however, systemic vinblastine (or other chemotherapy) attacks both cutaneous and visceral lesions. (medscape.com)
The authors usually inform patients that this is a multicentric disease that has silent gut lesions that also may regress with the systemic approach. (medscape.com)
The two groups were compared in terms of demographic data, age at disease onset, number and site of bone lesions, laboratory biomarker values, and need of escalation to a second-line therapy. (biomedcentral.com)
The disease course is recurrent or persistent with a variable number of osteolytic lesions developing over time. (biomedcentral.com)
In patients with new skin lesions and no involvement of blood by flow cytometry HTS demonstrated hematogenous spread of small numbers of malignant T cells. (biomasswars.com)
OBJECTIVE: We sought to determine whether viral transcripts were present within the skin of patients with HCV and LP, and if systemic virologic response to interferon alfa and ribavirin correlated with response of the LP.Materials and methods A total of 4 men and 1 woman all presented with cutaneous eruptions of LP, and 1 had oral LP lesions. (thedoctorsdoctor.com)
H&E staining of cutaneous lesions may show necrotizing granuloma formation and neutrophilic infiltrate. (amboss.com)
Oral lesions occur in approximately one-third of patients 31 and are predictors of pulmonary involvement and less favorable treatment outcomes. (hiv.gov)

For the treatment cutaneous T-cell lymphoma (CTCL), including mycosis fungoides. (pdr.net)
In the US, about 8,000 new cases of Hodgkin lymphoma are diagnosed annually, and about 900 people die of the disease. (msdmanuals.com)
This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
Istodax remains on the market for treatment of patients with cutaneous T-cell lymphoma (CTCL) who have received at least one prior systemic therapy. (bms.com)
While the outcome of the confirmatory study in peripheral T-cell lymphoma is disappointing, Bristol Myers Squibb will continue to provide Istodax for patients with cutaneous T-cell lymphoma, where it remains an approved and important treatment option," said Noah Berkowitz, M.D., Ph.D., senior vice president, Hematology Development, Bristol Myers Squibb. (bms.com)
HHV-8 is etiologically associated with all forms of Kaposi sarcoma (KS) including classic, endemic, transplant-related, and AIDS-related, as well as rare neoplastic disorders (primary effusion lymphoma [PEL] and solid organ variants) and the lymphoproliferative disorder known as multicentric Castleman's disease (MCD). (hiv.gov)
Hodgkin lymphoma with cutaneous involvement. (medscape.com)

However, a recent study by Mackensen et al has raised the possibility that CAR T cell therapy may also have a role outside of the treatment in cancer, through positive findings that have been published in the treatment of refractory systemic lupus erythematosus (SLE). (consultantlive.com)
Systemic lupus erythematosus (SLE), a prevalent autoimmune disease predominantly affecting women of childbearing age, presents ongoing challenges despite notable advances in diagnosis and treatment. (degruyter.com)
This guideline is jointly sponsored by the National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), the Chinese Systemic Lupus Erythematosus Treatment and Research Group (CSTAR), and the Chinese Research Committee of Pregnancy and Reproduction in Autoimmune Rheumatic Diseases (CHOPARD). (degruyter.com)
Intriguingly, many of these polymorphisms are shared with other rheumatic diseases, such as systemic lupus erythematosus. (hindawi.com)
A 25-year-old Mexican American woman with a five-year history of systemic lupus erythematosus (SLE) presents with refractory, acute cutaneous lupus erythematosus (ACLE) and subacute cutaneous lupus erythematosus (SCLE) affecting the scalp, face and hands. (the-rheumatologist.org)

For the treatment of cutaneous manifestations of CTCL in patients who are refractory to at least 1 prior systemic therapy. (pdr.net)
Early diagnosis of CTCL is difficult and takes on average six years after presentation in part because the clinical appearance and histopathology of CTCL can resemble that of benign inflammatory skin diseases. (biomasswars.com)
CTCL from benign inflammatory diseases. (biomasswars.com)
There was a maximal T cell density in skin in benign inflammatory diseases that was exceeded in CTCL suggesting a niche of finite size may exist for benign T cells in skin. (biomasswars.com)
In summary HTS accurately diagnosed CTCL in all stages discriminated CTCL from benign inflammatory skin diseases and provided insights into the cell of origin and location of malignant CTCL cells in skin. (biomasswars.com)
Introduction Cutaneous T-cell lymphomas (CTCL) are a heterogeneous collection of non-Hodgkin's lymphomas derived from pores and skin tropic T cells. (biomasswars.com)
L-CTCL is normally refractory to median and therapy survival is certainly 3 years with loss of life occurring mostly from infection. (biomasswars.com)
A more reliable method of discriminating between CTCL and benign inflammatory skin disease would both facilitate timely diagnosis of the disease and help to discriminate CTCL recurrences from unrelated benign inflammatory Gadd45a reactions in the skin. (biomasswars.com)

OBJECTIVES Methotrexate (MTX) has been used in several autoimmune diseases. (bmj.com)
Rheumatic and autoimmune diseases are disorders which can affect any part of the body including the joints, muscles, connective tissues, and soft tissues around the joints and bones. (clevelandclinic.org)

Another interest lies in the identification of improved treatment strategies that incorporate radiation in the management of aggressive and refractory lymphomas. (mdanderson.org)
Zhang QY, Foucar K. Bone marrow involvement by Hodgkin and non-Hodgkin lymphomas. (medscape.com)

Centers for Disease Control and Prevention. (cdc.gov)
In 1981, Kaposi sarcoma seen in AIDS (KS-AIDS) in America was identified in 3 reports of Kaposi sarcoma as an original defining element of what later became known as AIDS (plus an important editorial and a Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report bulletin). (medscape.com)

Clinical manifestations include cutaneous leishmaniasis (CL), visceral leishmaniasis (VL), or mucocutaneous leishmaniasis, depending mainly on the specific causative leishmania species ( 1 ). (cdc.gov)
Hermansky-Pudlak syndrome (HPS) is a rare group of autosomal recessive diseases whose manifestations include oculocutaneous albinism , bleeding, and lysosomal ceroid storage. (medscape.com)

Apart from its use in rheumatoid arthritis, MTX has been assessed in small studies in patients with vasculitis, uveitis, and inflammatory bowel disease. (bmj.com)
Methotrexate (MTX) has been successfully used in several rheumatological diseases, such as rheumatoid arthritis, psoriatic arthritis, Reiter's syndrome, and more recently vasculitis. (bmj.com)
Naive B-Lymphopenia Possible Biomarker of Disease Activity in Vasculitis. (medscape.com)
We are a regional, national, and international referral center for families seeking initial evaluation or second opinion services for pediatric rheumatologic conditions, including juvenile arthritis, vasculitis and childhood autoinflammatory diseases. (clevelandclinic.org)

This represents a group of patients with significantly active disease that was refractory to multiple therapies. (consultantlive.com)
The current review enlightens the pathogenesis of the disease, clinical indications, diagnostic evaluation, and various therapies for the treatment. (ijpsr.com)
Intense pruritus refractory to usual therapies may occur early. (msdmanuals.com)

None of the patients had systemic disease. (cdc.gov)
The severity of these symptoms varies greatly among patients: Some having scleroderma of only a limited area of the skin (such as the fingers) and little involvement of the underlying tissue, while others have progressive skin involvement. (wikipedia.org)
Patients with greater cutaneous involvement are more likely to have involvement of the internal tissues and organs. (wikipedia.org)
Patients may develop muscle weakness, or myopathy, either from the disease or its treatments. (wikipedia.org)
Patients with renal and central nervous involvement were excluded from the study. (bmj.com)
For the many patients with mild disease who are well managed with symptomatic treatment and antimalarial drugs, there is certainly no need for intensification of treatment. (bmj.com)
However there remains a group of patients with moderate non-life threatening disease, which nevertheless has a high morbidity. (bmj.com)
In their recent Nature Medicine publication, the authors demonstrated the use of anti-CD19 CAR T cell therapy in the treatment of 5 patients with severe and refractory SLE. (consultantlive.com)
Patients had active disease with a SLE Disease Activity Index 2000 (SLEDAI-2K) of 8-16 at the time of treatment. (consultantlive.com)
All had cutaneous disease, in addition to proliferative lupus nephritis (Class III or IV) with 2 having overlapping membranous nephritis (Class V). Four of the 5 patients also had joint involvement. (consultantlive.com)
It is quite astonishing that patients with severe disease that was refractory to multiple other agents showed a drastic improvement and ultimately were able to discontinue all therapy including glucocorticoids! (consultantlive.com)
The symptoms of the disease have a negative influence on patients' quality of life (QOL) which is an important consequence of treatment concerning chronic diseases 4 . (ijpsr.com)
DL patients are relatively refractory to therapy. (uab.edu)
About 90% of people with SSc have GI tract involvement, and understanding the connection between GI symptoms, their severity and abnormal GI transit may permit targeted therapeutic approaches for these patients. (the-rheumatologist.org)
Patients often exhibit extraosseous co-morbidities such as psoriasis, inflammatory bowel disease, and arthritis. (biomedcentral.com)
All but 3 patients presented with multifocal disease. (biomedcentral.com)
Bone lesion distribution differed between the two groups with significantly more frequent involvement of clavicle ( p = 0.011) and pelvis ( p = 0.038) in patients with complex CRMO. (biomedcentral.com)
Most patients also develop a slowly progressive defect in cell-mediated immunity (T-cell function) that, in advanced disease, contributes to common bacterial and unusual fungal, viral, and protozoal infections. (msdmanuals.com)
Since the initial identification of vaccine-derived rubella virus (RuV) in the cutaneous granulomas of pediatric patients with inborn errors of immunity (IEI) in 2014, more than 80 cases of RuV granulomas have been reported implicating both vaccine-derived and wild type RuV. (cdc.gov)
However, extracutaneous involvement occurs in 5-10% of patients, mostly to the draining regional lymph nodes. (medscape.com)
The initial diagnostic evaluation of patients with any lymphoproliferative malignancy should include a careful history and physical examination, with close attention paid to the presence of systemic B symptoms, lymph node involvement, organomegaly, and evidence of cutaneous involvement. (medscape.com)
Our research with KEYTRUDA has contributed to recent advances in the treatment of gastric cancer, and we are continuing to advance studies to help more patients with this disease. (merck.com)
KEYTRUDA was also granted accelerated approval in September 2019, and received full approval in July 2021, in combination with LENVIMA ® (lenvatinib) for the treatment of patients with advanced endometrial carcinoma that is not MSI-H or dMMR, who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. (businesswire.com)
however, 70% to 80% of patients with HCV go on to develop chronic liver disease during a prolonged period of up to 40 years, and up to 50% of them may remain relatively asymptomatic during that time. (thedoctorsdoctor.com)
A number of associated cutaneous findings have been reported in up to 15% of these patients including lichen planus-like eruptions (LP). (thedoctorsdoctor.com)
Cutaneous biopsies were performed on all patients. (thedoctorsdoctor.com)
Updated results will also be presented from a phase 1 study of the investigational agent SEA-BCMA in patients with relapsed/refractory multiple myeloma. (businesswire.com)
Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease. (medscape.com)

In South America it is important to distinguish Leishmania species that cause only cutaneous disease from the mucocutaneous species. (uab.edu)
More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)

Twenty-three children (62%) had at least one extraosseous manifestation (13 sacroiliitis, 8 inflammatory bowel disease, 6 skin disease [acne, pustulosis, or psoriasis], 7 arthritis). (biomedcentral.com)
Clinically, CRMO shares significant overlap with TNFα-related autoimmune conditions such as spondyloarthritis, psoriasis, and inflammatory bowel disease (IBD). (biomedcentral.com)
Arthritis associated with inflammatory bowel disease . (clevelandclinic.org)
Gastrointestinal : inflammatory bowel disease (Crohn's disease and ulcerative colitis). (clevelandclinic.org)
Pulmonary fibrosis , inflammatory bowel disease , and kidney disease are all symptoms linked to ceroid accumulation in the cells of these organs. (medscape.com)

establish a convolutional neural network-based model to predict acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation. (nature.com)

Prognosis is determined by the form of the disease and the extent of visceral involvement. (wikipedia.org)

The primary cutaneous form of ALCL (PC-ALCL), seen in the image below, is defined by skin-only involvement without systemic dissemination at presentation. (medscape.com)
PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)

The findings of this study of anti-CD19 directed CAR T cell therapy offers new hope for the most severe and refractory cases. (consultantlive.com)
Especially in infants in whom these cutaneous findings are accompanied by severe illness, providers must rapidly navigate the broad range of possibilities. (thieme-connect.de)
[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
The clinical presentation, cutaneous findings, and likely presence of RVC-positive granulocytes in bone marrow provide potential support to the evolving hypothesis of persistent RuV within neutrophils contributing to chronic granulomatous inflammation in a milieu of immune dysregulation. (cdc.gov)

The molecular pathogenesis is not fully understood, but there is a consensus that CRMO is an autoinflammatory disease, characterized by unprovoked spontaneous flares of tissue-specific bone inflammation. (biomedcentral.com)
Studies advancing our understanding of RuV granulomas may provide insights into the role of viral infectious agents in granulomatous disease pathogenesis and guide the development of improved therapeutic options. (cdc.gov)

Striking clinical features include frequent cutaneous and extranodal involvement, young age at presentation, and male predominance. (medscape.com)

In scleroderma en coup de sabre (LScs) the atrophic lesion in frontoparietal area is the disease hallmark. (hindawi.com)
Linear scleroderma en coup de sabre (LCsc) is a rare subset of LS. (hindawi.com)

If this is left untreated, acid from the stomach can back up into the esophagus, causing esophagitis and gastroesophageal reflux disease. (wikipedia.org)
Nexium ( esomeprazole magnesium ) is a proton pump inhibitor (PPI) that blocks acid production in the stomach and is used to treat stomach and duodenal ulcers, gastroesophageal reflux disease ( GERD ), and Zollinger-Ellison syndrome . (rxlist.com)
Healing of Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD) ( 1.1 ). (nih.gov)

One or more 5-10 mm large, erythematous , nontender cutaneous papules or vesicles develop approx. (amboss.com)

Cutaneous lesion caused by Leishmania infantum on the right lower eyelid of a patient seen at Chaim Sheba Medical Center, Israel, 2021. (cdc.gov)
In 1877, English doctor Jonathan Hutchinson described this disease as a mimic of sarcoma (sarcoid-sarcoma-like) as a painless skin lesion 1 . (ijpsr.com)

The main characterized symptom of this disease is non-caseating granulomas, specifically in the lungs and lymph nodes progressing to lungs impairment to pass oxygen, and finally total failure of lungs as well as heart. (ijpsr.com)
Stage 3: Granulomas developed in the lungs (Parenchymal Lung Disease). (ijpsr.com)
Sarcoidosis is a systemic granulomatous disease that involves the development of non-caseating granulomas of multiple organs in the body. (ijpsr.com)

Response of Behçet's refractory oral and/or genital ulcers to apremilast in combination vs monotherapy. (unican.es)

Hodgkin disease (C81. (who.int)

Stage 2: Granuloma of both lymph nodes and lungs (Lymphadenopathy and Parenchymal Lung Disease). (ijpsr.com)
B symptoms are significant to prognosis and staging because they may signify involvement of internal lymph nodes (mediastinal or retroperitoneal), viscera (liver), or bone marrow. (msdmanuals.com)

RESULTS Disease activity was evaluated after six months of MTX treatment. (bmj.com)
Without doubt treatment with corticosteroids is very effective for SLE, but in longstanding disease complications such as infections and osteoporosis are worrying. (bmj.com)
Our results support the need for continuous monitoring of all children with morphea following the completion of treatment, including topical treatment, due to high rates of disease relapse. (bvsalud.org)
Systemic treatment in Behcet's disease According to clinical phenotypes. (unican.es)
Treatment with Tofacitinib in refractory psoriatic arthritis. (unican.es)
Treatment usually is based on the extent of disease and the patient's immune status. (medscape.com)
Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. (medscape.com)
Ulcer was refractory to treatment in spite of antibiotics and antiseptic therapy. (e-ijd.org)
The Center for Pediatric Rheumatology provides comprehensive diagnosis, treatment, and follow-up care for children and adolescents who are living with juvenile arthritis and a wide range of autoimmune and rheumatologic diseases. (clevelandclinic.org)
Epilepsy: refractory epilepsy requiring immune modulation treatment. (clevelandclinic.org)
ganciclovir, foscarnet, and cidofovir use for treatment of CMV disease). (hiv.gov)

Here, we present a case of RuV-associated cutaneous granuloma with RuV localized to neutrophils. (cdc.gov)

Blueberry muffin baby" is a term describing the cutaneous manifestations of various congenital infections and neoplastic diseases. (thieme-connect.de)
A congenital, self-healing form called Hashimoto-Pritzker disease has also been described. (medscape.com)

However, in about 32% of cases, it may arise in adulthood, showing a more aggressive course with also an increased risk of systemic involvement. (bvsalud.org)
This should include detailed history taking including age of onset, seasonality, presence or absence of signs suggestive of systemic involvement, and whether other areas of the integument are involved. (vin.com)
Mercury absorption can manifest in varied forms due to its vast systemic involvement. (statpearls.com)

Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries. (wikipedia.org)

The follow-up period is currently only at a maximum of 17 months, however long-term steroid-free response offers hope for a decrease in damage secondary to prolonged exposure to glucocorticoids (including osteoporosis and increased risk of cardiovascular disease). (consultantlive.com)

Cutaneous leishmaniasis (CL) is endemic to Israel. (cdc.gov)
This clinical syndrome should be distinguished from DCL or diffuse cutaneous leishmaniasis, which has been well described throughout central/south America and the Caribbean, but is usually due to L. amazonensis or L. mexicana . (uab.edu)

Morphea is a rare fibrosing disorder with a highly variable disease course, which can complicate management. (bvsalud.org)
Linear morphea en coupe de sabre (LM) usually arises in childhood. (bvsalud.org)

Emerging Infectious Diseases , 29 (11), 2189-2197. (cdc.gov)
Emerging Infectious Diseases , 29 (11), 2198-2202. (cdc.gov)

Sarcoidosis develops slow and steadily, but the symptoms of the disease last for years. (ijpsr.com)
Discontinue at the first signs or symptoms of severe cutaneous adverse reactions or other signs of hypersensitivity and consider further evaluation. (nih.gov)

The reservoir is dogs, and the epidemiology of the disease among dogs indicates wide distribution in Israel ( 5 ). (cdc.gov)

Disease incidence peaks in the fifth decade of life in adults, whereas 90% of children are diagnosed between 2 and 14 years of age [ 1 , 3 - 5 ]. (hindawi.com)
Adults and adolescents often display involvement of clavicle and sternum and have various cutaneous manifestations [ 9 , 10 ]. (biomedcentral.com)
Rubella is a highly contagious viral infection that usually causes a mild disease in children and adults. (cdc.gov)

Localized nodular disease may respond well to surgical excision, radiotherapy, and intralesional and outpatient low-dose vinblastine chemotherapy. (medscape.com)

Skin and subcutaneous are the mainly affected tissues, but case reports of muscle, cartilage, and bone involvement are frequent. (hindawi.com)

Thus, LP appears to be related to the pattern of immune dysregulation induced by HCV, probably in a host with an underlying susceptibility for autoimmune disease. (thedoctorsdoctor.com)
The involvement of the immune system in the form of delayed hypersensitivity has been proposed in the causation of acrodynia. (statpearls.com)

certain localized infections - see body system-related chapters infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium [except obstetrical tetanus] (O98. (who.int)

As scleroderma progresses, esophageal involvement from abnormalities in decreased motility may worsen due to progressive fibrosis (scarring). (wikipedia.org)
Scleroderma is a rare disease of unknown etiology, characterized by thickening and hardening of skin resulting from increased collagen production. (hindawi.com)
The term includes a variety of diseases, from localized scleroderma (LS) to systemic sclerosis. (hindawi.com)

Nevertheless clonal malignant T cells constitute just a little minority of total T cells in MF skin damage especially in early disease ( 4 ). (biomasswars.com)

There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse. (wikipedia.org)

Vascular involvement in Behçet's disease: a retrospective analysis of 2319 cases. (medscape.com)

A 62-year-old chronically bedridden, morbidly obese woman (weighing 286 lbs.) with congestive heart failure, hypothyroidism, diabetic nephropathy, and chronic obstructive pulmonary disease was hospitalized in the Intensive Care Unit and subsequently succumbed to refractory cardiac failure. (cdlib.org)

Systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease (AOSD), gout, and pseudogout: rheumatologist. (aetna.com)
The mean age at disease onset was 10 years. (biomedcentral.com)
The groups did not differ in number of foci or in age at disease onset. (biomedcentral.com)
Neonatal-onset multisystem inflammatory disease (NOMID) or Chronic Inflammatory Neonatal Arthritis (CINCA). (clevelandclinic.org)

Once considered an exclusive cutaneous disorder, the neurologic involvement present in LScs has been described in several case reports. (hindawi.com)

The diagnosis is made on the combination of history, clinical signs and ruling out other pruritic skin diseases but diet trials and intradermal/serological testing would be indicated to identify putative causative allergens for avoidance and/or allergen immunotherapy. (vin.com)

We publish original research that can elucidate mechanisms of disease or improve clinical practice in rheumatology, immunology and related sciences. (degruyter.com)

Incidence of Henoch-Schönlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins. (medscape.com)

Anatomy1

Diseases16

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology1

Phenomena and Processes6

Information Science1

Health Care8

Lesions15

Lymphoma7

Lupus erythematosus5

CTCL8

Autoimmune diseases2

Lymphomas2

Centers for Diseas2

Manifestations include2

Vasculitis4

Therapies3

Patients28

Mucocutaneous2

Inflammatory bowel d5

Acute1

Visceral1

ALCL2

Findings4

Pathogenesis2

Extranodal1

Coup de Sabre2

Gastroesophageal reflux3

Papules1

Lesion2

Granulomas3

Ulcers1

Hodgkin1

Lymph nodes2

Treatment11

Granuloma1

Congenital2

Systemic involvement3

Rheumatic1

Glucocorticoids1

Leishmaniasis2

Morphea2

Infectious Diseases2

Symptoms2

Epidemiology1

Adults3

Chemotherapy1

Frequent1

Immune2

Infections1

Scleroderma3

Malignant1

Diffuse1

Vascular1

Chronic obstruc1

Onset4

Disorder1

Skin diseases1

Clinical practice1

Purpura1