ChronicMyeloid leukaemiaLymphoblastic leukemiaPromyelocytic leukemiaCytoplasmMyelomonocytic leukaemiaRecurrentMyelodysplasticBlastsNeutropeniaPatientsMolecularMalignancyDiseaseDiseasesCellsDifferentiationPromyelocytic leukaemiaLymphocyticPediatricAtypicalMalignanciesPathogenesisAnemiaMyeloproliferativeClinicalMutationsBoneTreatmentSecondaryRare
Chronic8
- Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin. (wikipedia.org)
- Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. (nih.gov)
- 1,2 The 4 primary disorders of MPNs are chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (oncomine.com)
- Characterized by excessive, abnormal white blood cell (granulocyte) production and the presence of the Philadelphia chromosome/BCR-ABL mutation, chronic myeloid leukemia (CML) is a slow-growing cancer of the blood-forming tissue (bone marrow). (oncomine.com)
- See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
- Enlarged spleen is characteristic of chronic myelomonocytic leukemia . (symptoma.com)
- Reportable disorder s include: MDS, refractory anemia , refractory anemia with excess blasts in transformation, refractory anemia with ring sideroblast s, refractory anemia with excess blasts, chronic myelomonocytic leukemia and acute myeloid leukemia. (symptoma.com)
- Consider hemolysis in patients with acute or chronic anemia in whom an obvious cause (e.g., bleeding) is not apparent. (amboss.com)
Myeloid leukaemia1
- Following diagnosis and treatment as pre-B cell acute lymphoblastic leukaemia (pre-B ALL) the patient developed an acute myeloid leukaemia (AML) which was refractory to all available curative therapies. (cambridgemedicine.org)
Lymphoblastic leukemia6
- Relapsed acute lymphoblastic leukemia: Is it crucial to achieve molecular remission prior to transplant? (nih.gov)
- Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing more than a quarter of all pediatric cancers. (medscape.com)
- The image below depicts bone marrow aspirate from a child with T-cell acute lymphoblastic leukemia. (medscape.com)
- Also, see the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
- Children with acute lymphoblastic leukemia (ALL) often present with signs and symptoms that reflect bone marrow infiltration and/or extramedullary disease. (medscape.com)
- See Acute Lymphoblastic Leukemia Staging for more complete information. (medscape.com)
Promyelocytic leukemia1
- Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)
Cytoplasm3
- 5-7 Morphologically, BL involves monomorphic medium-sized B cells with basophilic cytoplasm, numerous mitotic figures, rounded nuclei with finely clumped chromatin, myriad apoptosis, and tingible body macrophages, which result in a classic "starry sky" pattern. (cancernetwork.com)
- These blasts were large with basophilic cytoplasm and no granulation. (cambridgemedicine.org)
- BL is characterized by monomorphic medium-sized B cells with basophilic cytoplasm and numerous mitotic figures [ 3 , 4 ]. (longdom.org)
Myelomonocytic leukaemia1
- The peripheral monocytosis leads us to believe that this patient may have transformed via a juvenile myelomonocytic leukaemia (JMML) which subsequently transformed into a refractory AML. (cambridgemedicine.org)
Recurrent1
- Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study. (nih.gov)
Myelodysplastic1
- 5 Hematopoietic disruptions in the myeloid lineage can lead to 3 major disease categories: acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndrome (MDS). (oncomine.com)
Blasts1
- Two months later the bone marrow aspirate indicated refractory disease with 30-50% blasts and a reduced number of mature myeloid cells and abnormal monocytoid cells. (cambridgemedicine.org)
Neutropenia1
Patients2
- Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
- Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
Molecular1
- Epigenetic modifying enzymes such as histone deacetylases (HDACs), p300, and PRMT1 are recruited by AML1/ETO, the pathogenic protein for t(8;21) acute myeloid leukemia (AML), providing a strong molecular rationale for targeting these enzymes to treat this disease. (ashpublications.org)
Malignancy1
- citation needed] Historically, hematological malignancies have been most commonly divided by whether the malignancy is mainly located in the blood (leukemia) or in lymph nodes (lymphomas). (wikipedia.org)
Disease1
- Because these tissues are all intimately connected through both the circulatory system and the immune system, a disease affecting one will often affect the others as well, making aplasia, myeloproliferation and lymphoproliferation (and thus the leukemias and the lymphomas) closely related and often overlapping problems. (wikipedia.org)
Diseases1
Cells3
- Up-regulation of VEGF and its receptor in refractory leukemia cells. (nih.gov)
- T-cell depleted allogeneic hematopoietic cell transplants as a platform for adoptive therapy with leukemia selective or virus-specific T-cells. (nih.gov)
- The pro-inflammatory cytokines produced by the mast cells and basophils play an important role in the development of acute- and late-phase inflammatory reactions. (biomedcentral.com)
Differentiation1
- 14. Evidence for basophilic differentiation of acute promyelocytic leukaemia cells during arsenic trioxide therapy. (nih.gov)
Promyelocytic leukaemia2
Lymphocytic1
- Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin. (wikipedia.org)
Pediatric3
- treatment of newly-diagnosed CD33-positive acute myeloid leukemia (AML) in adults and pediatric patients 1 month and older ( 1.1 ). (nih.gov)
- treatment of relapsed or refractory CD33-positive AML in adults and pediatric patients 2 years and older ( 1.2 ). (nih.gov)
- MYLOTARG is indicated for the treatment of newly-diagnosed CD33-positive acute myeloid leukemia in adults and pediatric patients 1 month and older. (nih.gov)
Atypical1
- However, in some cases acute myeloid leukemia (AML) demonstrates APL-like morphological features such as atypical promyelocytes accumulation. (bvsalud.org)
Malignancies4
- citation needed] Historically, hematological malignancies have been most commonly divided by whether the malignancy is mainly located in the blood (leukemia) or in lymph nodes (lymphomas). (wikipedia.org)
- 1. Arsenic trioxide: its role in acute promyelocytic leukemia and potential in other hematologic malignancies. (nih.gov)
- 3. Arsenic derivatives in hematologic malignancies: a role beyond acute promyelocytic leukemia? (nih.gov)
- 9. Treatment of acute promyelocytic leukemia and other hematologic malignancies with arsenic trioxide: review of clinical and basic studies. (nih.gov)
Pathogenesis2
- 12. Acute promyelocytic leukemia: new issues on pathogenesis and treatment response. (nih.gov)
- Acute promyelocytic leukemia (APL) pathogenesis is based on RARA gene translocations, which are of high importance in the diagnosis of and proper therapy selection for APL. (bvsalud.org)
Anemia2
- With anemia due to acute blood loss, a reduction in oxygen-carrying capacity occurs along with a decrease in intravascular volume, with resultant hypoxia and hypovolemia. (medscape.com)
- For unexplained acute anemia after exclusion of other causes, performing bone marrow biopsy is imperative to diagnose PRCA and rule out involvement of bone marrow by primary tumor. (amjcaserep.com)
Myeloproliferative1
- Associated with myeloproliferative disorders like leukemia and polycythemia vera. (labpedia.net)
Clinical3
- 4. Clinical usefulness of arsenic trioxide in the treatment of acute promyelocytic leukemia. (nih.gov)
- 8. [Pharmacological and clinical properties of arsenic trioxide (Trisenox) for relapse or refractory acute promyelocytic leukemia therapy]. (nih.gov)
- the physician will run further diagnostic procedure s and look for various clinical presentations to identify a more specific leukemia . (cancer.gov)
Mutations2
- Mutations in FLT3 are most common in acute promyelocytic leukemia and basophilic leukemia, and in AML patients with primary refractory disease. (medscape.com)
- Animal model studies also indicate that FLT3 mutations cooperate with other molecular alterations in the generation of leukemia, since the expression of a mutated FLT3 in primary hematopoietic cells results in the appearance of a lymphoproliferative syndrome and is not sufficient to cause leukemia. (medscape.com)
Bone1
- Acute myeloid leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)
Treatment1
- There are no life-threatening causes of pancytopenia that require acute treatment within 24 hours. (wikidoc.org)
Rare1
- Mixed-phenotype acute leukemia (MPAL), a rare and heterogeneous category of acute leukemia, is characterized by cross-lineage antigen expression. (bvsalud.org)