• Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin. (wikipedia.org)
  • Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. (nih.gov)
  • 1,2 The 4 primary disorders of MPNs are chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (oncomine.com)
  • Characterized by excessive, abnormal white blood cell (granulocyte) production and the presence of the Philadelphia chromosome/BCR-ABL mutation, chronic myeloid leukemia (CML) is a slow-growing cancer of the blood-forming tissue (bone marrow). (oncomine.com)
  • See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
  • Enlarged spleen is characteristic of chronic myelomonocytic leukemia . (symptoma.com)
  • Reportable disorder s include: MDS, refractory anemia , refractory anemia with excess blasts in transformation, refractory anemia with ring sideroblast s, refractory anemia with excess blasts, chronic myelomonocytic leukemia and acute myeloid leukemia. (symptoma.com)
  • Consider hemolysis in patients with acute or chronic anemia in whom an obvious cause (e.g., bleeding) is not apparent. (amboss.com)
  • Following diagnosis and treatment as pre-B cell acute lymphoblastic leukaemia (pre-B ALL) the patient developed an acute myeloid leukaemia (AML) which was refractory to all available curative therapies. (cambridgemedicine.org)
  • Relapsed acute lymphoblastic leukemia: Is it crucial to achieve molecular remission prior to transplant? (nih.gov)
  • Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing more than a quarter of all pediatric cancers. (medscape.com)
  • The image below depicts bone marrow aspirate from a child with T-cell acute lymphoblastic leukemia. (medscape.com)
  • Also, see the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
  • Children with acute lymphoblastic leukemia (ALL) often present with signs and symptoms that reflect bone marrow infiltration and/or extramedullary disease. (medscape.com)
  • See Acute Lymphoblastic Leukemia Staging for more complete information. (medscape.com)
  • Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)
  • 5-7 Morphologically, BL involves monomorphic medium-sized B cells with basophilic cytoplasm, numerous mitotic figures, rounded nuclei with finely clumped chromatin, myriad apoptosis, and tingible body macrophages, which result in a classic "starry sky" pattern. (cancernetwork.com)
  • These blasts were large with basophilic cytoplasm and no granulation. (cambridgemedicine.org)
  • BL is characterized by monomorphic medium-sized B cells with basophilic cytoplasm and numerous mitotic figures [ 3 , 4 ]. (longdom.org)
  • The peripheral monocytosis leads us to believe that this patient may have transformed via a juvenile myelomonocytic leukaemia (JMML) which subsequently transformed into a refractory AML. (cambridgemedicine.org)
  • Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study. (nih.gov)
  • 5 Hematopoietic disruptions in the myeloid lineage can lead to 3 major disease categories: acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndrome (MDS). (oncomine.com)
  • Two months later the bone marrow aspirate indicated refractory disease with 30-50% blasts and a reduced number of mature myeloid cells and abnormal monocytoid cells. (cambridgemedicine.org)
  • 90% of reported cases is prolonged and profound neutropenia in patients with acute leukemia ( 6 , 7 , 9 ). (cdc.gov)
  • Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • Epigenetic modifying enzymes such as histone deacetylases (HDACs), p300, and PRMT1 are recruited by AML1/ETO, the pathogenic protein for t(8;21) acute myeloid leukemia (AML), providing a strong molecular rationale for targeting these enzymes to treat this disease. (ashpublications.org)
  • citation needed] Historically, hematological malignancies have been most commonly divided by whether the malignancy is mainly located in the blood (leukemia) or in lymph nodes (lymphomas). (wikipedia.org)
  • Because these tissues are all intimately connected through both the circulatory system and the immune system, a disease affecting one will often affect the others as well, making aplasia, myeloproliferation and lymphoproliferation (and thus the leukemias and the lymphomas) closely related and often overlapping problems. (wikipedia.org)
  • The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. (nih.gov)
  • Up-regulation of VEGF and its receptor in refractory leukemia cells. (nih.gov)
  • T-cell depleted allogeneic hematopoietic cell transplants as a platform for adoptive therapy with leukemia selective or virus-specific T-cells. (nih.gov)
  • The pro-inflammatory cytokines produced by the mast cells and basophils play an important role in the development of acute- and late-phase inflammatory reactions. (biomedcentral.com)
  • 14. Evidence for basophilic differentiation of acute promyelocytic leukaemia cells during arsenic trioxide therapy. (nih.gov)
  • 7. Arsenic trioxide in the management of acute promyelocytic leukaemia. (nih.gov)
  • 15. Successful pregnancy after arsenic trioxide therapy for relapsed acute promyelocytic leukaemia. (nih.gov)
  • Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin. (wikipedia.org)
  • treatment of newly-diagnosed CD33-positive acute myeloid leukemia (AML) in adults and pediatric patients 1 month and older ( 1.1 ). (nih.gov)
  • treatment of relapsed or refractory CD33-positive AML in adults and pediatric patients 2 years and older ( 1.2 ). (nih.gov)
  • MYLOTARG is indicated for the treatment of newly-diagnosed CD33-positive acute myeloid leukemia in adults and pediatric patients 1 month and older. (nih.gov)
  • However, in some cases acute myeloid leukemia (AML) demonstrates APL-like morphological features such as atypical promyelocytes accumulation. (bvsalud.org)
  • citation needed] Historically, hematological malignancies have been most commonly divided by whether the malignancy is mainly located in the blood (leukemia) or in lymph nodes (lymphomas). (wikipedia.org)
  • 1. Arsenic trioxide: its role in acute promyelocytic leukemia and potential in other hematologic malignancies. (nih.gov)
  • 3. Arsenic derivatives in hematologic malignancies: a role beyond acute promyelocytic leukemia? (nih.gov)
  • 9. Treatment of acute promyelocytic leukemia and other hematologic malignancies with arsenic trioxide: review of clinical and basic studies. (nih.gov)
  • 12. Acute promyelocytic leukemia: new issues on pathogenesis and treatment response. (nih.gov)
  • Acute promyelocytic leukemia (APL) pathogenesis is based on RARA gene translocations, which are of high importance in the diagnosis of and proper therapy selection for APL. (bvsalud.org)
  • With anemia due to acute blood loss, a reduction in oxygen-carrying capacity occurs along with a decrease in intravascular volume, with resultant hypoxia and hypovolemia. (medscape.com)
  • For unexplained acute anemia after exclusion of other causes, performing bone marrow biopsy is imperative to diagnose PRCA and rule out involvement of bone marrow by primary tumor. (amjcaserep.com)
  • 4. Clinical usefulness of arsenic trioxide in the treatment of acute promyelocytic leukemia. (nih.gov)
  • 8. [Pharmacological and clinical properties of arsenic trioxide (Trisenox) for relapse or refractory acute promyelocytic leukemia therapy]. (nih.gov)
  • the physician will run further diagnostic procedure s and look for various clinical presentations to identify a more specific leukemia . (cancer.gov)
  • Mutations in FLT3 are most common in acute promyelocytic leukemia and basophilic leukemia, and in AML patients with primary refractory disease. (medscape.com)
  • Animal model studies also indicate that FLT3 mutations cooperate with other molecular alterations in the generation of leukemia, since the expression of a mutated FLT3 in primary hematopoietic cells results in the appearance of a lymphoproliferative syndrome and is not sufficient to cause leukemia. (medscape.com)
  • Acute myeloid leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)
  • There are no life-threatening causes of pancytopenia that require acute treatment within 24 hours. (wikidoc.org)
  • Mixed-phenotype acute leukemia (MPAL), a rare and heterogeneous category of acute leukemia, is characterized by cross-lineage antigen expression. (bvsalud.org)