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  • Relapse
  • Multiple factors have an impact on the selection of salvage therapy, including the relapsed or refractory status of the disease, the biochemical or clinical pattern of relapse, and patient- and disease-related characteristics. (bloodjournal.org)
  • epilepsy
  • In order to investigate the involvement of lesions of AchNs in refractory epilepsy, we performed immunohistochemical analyses of AchNs in the PPN in autopsy cases who had a past history of WS and/or LGS and in DRPLA cases who showed progressive myoclonic epilepsy. (hindawi.com)
  • Phase
  • In human sexuality , the refractory period is usually the recovery phase after orgasm during which it is physiologically impossible for a man to have additional orgasms. (wikipedia.org)
  • approximately
  • This period is approximately equal to the absolute refractory period (ARP), it occurs because the fast sodium channels remain closed until the cell fully repolarizes. (wikipedia.org)
  • multiple
  • Anecdotal reports on cabergoline suggest it may be able to eliminate the refractory period altogether, allowing men to experience multiple ejaculatory orgasms in rapid succession. (wikipedia.org)
  • period
  • This is termed the effective refractory period (ERP) of the tissue. (wikipedia.org)
  • An increased infusion of the hormone oxytocin during ejaculation is believed to be chiefly responsible for the male refractory period, and the amount by which oxytocin is increased may affect the length of each refractory period. (wikipedia.org)
  • It is additionally proposed that the gonadotropin inhibitory hormone (GnIH), which is considered to inhibit the hypothalamic-pituitary-gonadal axis and sexual functions causes refractoriness of the post-ejaculatory refractory period. (wikipedia.org)
  • One alternative theory explains the male refractory period in terms of a peripheral autonomic feedback mechanism, rather than through central chemicals like oxytocin, serotonin, and prolactin. (wikipedia.org)
  • Once the feedback loop has been created, the refractory period remains until the loop is broken through restoration of the wall tension in the seminal vesicles. (wikipedia.org)
  • However, there are many women who experience clitoral hypersensitivity after orgasm, which can effectively create a refractory period. (wikipedia.org)
  • According to some studies, 18-year-old males have a refractory period of about 15 minutes, while those in their 70s take about 20 hours, with the average for all men being about half an hour. (wikipedia.org)
  • Although rarer, some males exhibit no refractory period or a refractory period lasting less than 10 seconds. (wikipedia.org)
  • During the study, six fully ejaculatory orgasms were experienced in 36 minutes, with no apparent refractory period. (wikipedia.org)
  • Studies
  • 4 Additional studies also showed that the activity of isatuximab was enhanced by lenalidomide and dexamethasone, with an ORR of 56% (52% in the lenalidomide-refractory subgroup) and a median PFS of 8.5 months. (bloodjournal.org)
  • disease
  • As such, this article includes some references relating to follicular lymphoma, with some details about relapsed and refractory forms of the disease. (news-medical.net)
  • Both males and females appear to be equally affected by follicular lymphoma, including the relapsed and refractory forms of the disease. (news-medical.net)
  • useful
  • Structures of bonded silicon carbide are useful in many refractory areas and especially as saggers and kiln furniture in the ceramic industry. (google.com)
  • Another
  • Another object is to provide a process for the binding of nonoxide refractories aifording improved dimensional control of the structures during firing and use. (google.com)
  • less
  • When reviewing the literature, it is accepted that an endometrial thickness of less than 7 mm would be considered as a refractory endometrium (or thin endometrium) and that would entail to altered pregnancy and live birth rates [1, (springer.com)
  • Open
  • Open the refractory mortar bucket and aggressively stir the contents with a wooden stir stick or a trowel. (ehow.com)