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  • serum
  • Traditional treatments with oral contraceptives are associated with reduction in serum androgens and improvements in menstrual cycles in adolescents with PCOS, however these have not been well-studied in obese adolescents. (clinicaltrials.gov)
  • participants
  • Participants who carried at least one copy of the allele had marked reductions in the volume of various brain structures compared to average volumes in non-carriers and in the general population. (scienceblogs.com)
  • A reduction in temporal lobe volume was observed in participants with a higher body-mass index, but not in carriers of the risk allele who have a body-mass index within the normal range. (scienceblogs.com)
  • Using a similar approach, the Diabetes Prevention Program randomly assigned 3,234 participants with IGT to a placebo with standard lifestyle recommendations, the antihyperglycemic agent metformin with standard lifestyle recommendations, or a lifestyle modification program designed to achieve and maintain a 7% body weight reduction (9). (amazonaws.com)
  • A factorial design with repeated measures was used by which the participants acted as their own control. (annexpublishers.co)
  • Researchers measured the waist circumference and weight of all participants at the beginning of and throughout the study, according to the summary. (aafp.org)
  • overweight and obese
  • Promoted as a motivation tool to encourage long term dietary change, and conducted in accordance with the NICE recommendations for body mass reduction, short term (~14 day) proprietary meal replacement diet plans, such as the Special K Challenge, have been reported to achieve an energy deficit approximating to 600kcal per day and a commensurate 2kg reduction in body mass in healthy overweight and obese individuals [ 7 , 14 ]. (annexpublishers.co)
  • incidence
  • During the long-term follow-up, severely obese patients treated with bariatric surgery exhibited sustained body weight reductions without a long-term effect on the incidence of arterial hypertension . (lww.com)
  • clinical
  • Tesamorelin acetate administration to rats during organogenesis and lactation resulted in hydrocephalus in offspring at a dose approximately two and four times the clinical dose, respectively, based on measured drug exposure (AUC). (drugs.com)
  • It has also become possible to look at the presence of subclinical organ damage through measures and markers much more sensitive than those available years ago, with the opportunity of detecting incipient modifications of organ function and structure previously impossible to discover, thus gaining a more precise assessment of the clinical significance of the existing BP abnormalities. (spotidoc.com)
  • association
  • Two new studies strengthen this association: the first, just published in the Annals of Neurology , shows that abdominal fat is linked to reduced brain volume in otherwise healthy middle-aged adults. (scienceblogs.com)
  • mortality
  • WHO estimates that if appropriate preventive measures are not taken, 20 million deaths by 2015 will be due to CVD and 80% of this mortality burden will occur in DCs [ 6 ]. (hindawi.com)