Reduction dose fractionation. Medical search. Frequent questions

Radiotherapy for acute metastatic epidural spinal cord compression (MESCC) involves conventional techniques and dose fractionation schemes, as it needs to be initiated quickly. (hindawi.com)
Image-guided three-dimensional conformal radiotherapy (IG-3DCRT) was started with 25 Gy in 5 fractions followed by a boost of 12 Gy in 3 fractions, for which a field-in-field (FIF) technique was used to optimize the dose distribution. (hindawi.com)
This case demonstrates that image-guided FIF radiotherapy with a dose-escalated hypofractionated regimen can potentially improve functional outcome and local control. (hindawi.com)
Furthermore, a field-in-field (FIF) technique has been applied to three-dimensional conformal radiotherapy (3DCRT) for various indications to amend dose distribution [ 5 , 6 ]. (hindawi.com)
Different radiotherapy fractionation schedules are in practice for palliation of painful bone metastases. (thieme-connect.com)
Time, dose, and fractionation in radiotherapy. (appliedradiationoncology.com)
SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellent rates of local control. (biomedcentral.com)
For patients receiving SABR, radiotherapy dose and fractionation depends on the site of metastasis and the proximity to critical normal structures. (biomedcentral.com)
Ablation of metastatic deposits can be achieved surgically, or through stereotactic ablative radiotherapy (SABR), a new radiotherapy technology that delivers very large, hypofractionated doses of radiotherapy with high precision to small tumor targets, with high rates of local control. (biomedcentral.com)
Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
High Dose Rate brachytherapy (HDR) is a therapeutic modality of radiotherapy in which radioactive sources are used in close contact with the region to be treated. (biomedcentral.com)
The next 31 patients received carboplatin at the same dose on days 1 to 5, 15 to 19, 29 to 33, and 43 to 47 of radiotherapy. (cancernetwork.com)
Dose-volume data for myelopathy in humans treated with radiotherapy to the spine was reviewed by Kirkpatrick et al. (biomedcentral.com)
More recently, his group has described seminal mechanistic findings on bystander signal transduction pathways in response to high-dose ablative radiotherapy. (tcgcrest.org)

More recently, phase I/II studies using SBRT for dose escalation after conventional chemoradiation in locally advanced NSCLC have been promising with good apparent safety. (frontiersin.org)
By building on the proven concept of conventional chemoradiation for patients with locally advanced NSCLC with a subsequent radiation dose intensification to residual disease with SBRT concurrent with immunotherapy, we hope address the issues of metastatic and local failures. (frontiersin.org)
Metastatic RCC has been treated with higher doses and more hypofractioned radiation including stereotactic radiosurgery, whereas curative cases have used lower total doses and conventional fractionations. (cancernetwork.com)
All patients had definitive radiochemotherapy with a conventional fractionation, linear accelerator using single doses of 2 Gy to a whole dose of 60 Gy to the primary tumor and cervical nodes, with a boost to 70 Gy for sites of tumor. (cancernetwork.com)
We construct three virtual populations of tumours in the NL, SL and BS regimes and, for each population, we study tumour responses to conventional fractionation schedules for RT, HT, and combined RT and HT. (smb.org)

Despite being adjacent to the heart, the intensity-modulated radiation (IMRT) plan allowed for a mean heart dose of 18.1 Gy and a mean left lung dose of 23 Gy, with much of the lung dose confined to an area already irradiated by the initial breast tangents. (appliedradiationoncology.com)
Clinicians should take advantage of fractionation, IMRT, reduced target volumes, and image guidance to maximize local control while minimizing the risk of late toxicities. (appliedradiationoncology.com)
The aim of this study is to evaluate the dosemetric parameters and acute toxicity of dose-escalated whole pelvis (WP) Intensity Modulated Radiation Therapy (IMRT) and volumetric modulated arc therapy (VMAT) prostate boost following neoadjuvant and concomitant with androgen deprivation therapy in high-risk prostate cancer patients. (scirp.org)
Dose escalation can be achieved with either 3-Dimensional Conformal Radiation Therapy (3-DCRT) or with intensity-modulated Radiation Therapy (IMRT). (scirp.org)
IMRT permits the use of different total doses and different doses/fraction to different volumes within the irradiation field, utilizing the "simultaneous integrated boost" (SIB) technique. (scirp.org)
Consequently, the IMRT-SIB technique allows different doses to the prostatic area and the pelvic lymph nodes. (scirp.org)
However, in the context of dose escalation to the prostate, dosimetric and clinical results from the literature comparing WP IMRT with PO IMRT are still limited. (scirp.org)
advocated reduction of V10 and V20 for thoracic normal tissues using IMRT. (biomedcentral.com)
One important advantage of the IMRT/VMAT techniques is the ability to shape dose distributions, thus avoiding nearby critical structures such as bladder and rectum. (onkder.org)
1 - 3 ] In addition, with the simultaneous integrated boost (SIB) technique, different doses can be applied to multiple targets simultaneously with high conformity in IMRT/VMAT plans. (onkder.org)
Therefore, consecutive-IMRT/VMAT may be more appropriate than SIB-IMRT/VMAT when the fraction doses to the critical organs or target volumes are the major concern. (onkder.org)
The optimization of the boost plan would be adjusted based on dose distributions of the phase1 VMAT/IMRT plan. (onkder.org)

Objectives This study was aimed to compare and report the outcomes of various fractionation schedules of radiation therapy (RT) in terms of pain relief and quality of life in patients with painful bone metastases. (thieme-connect.com)
Materials and Methods Eighty patients were randomized into four treatment arms with different RT fractionation schedules, namely, 8 Gy in 1 fraction, 20 Gy in 5 fractions, 24 Gy in 6 fractions, and 30 Gy in 10 fractions. (thieme-connect.com)
Conclusion This study demonstrated that pain reduction by various RT fractionation schedules were similar, and no statistically significant difference was noted. (thieme-connect.com)
Mainly two classes of fractionation schedules showed to be promising: the acceleration and the hyper-fractionation. (biomedcentral.com)
An early dose-finding study by the Radiation Therapy Oncology Group (RTOG) 7301 study was conducted from 1973 to 1978 and studied four different doses and schedules: 40 Gy split course, 40 Gy continuously, 50 Gy, and 60 Gy. (frontiersin.org)

They should be clearly defined in deciding and individualizing the dose and regimen. (thieme-connect.com)
If reoxygenation is applied efficiently between dose fractions, the presence of hypoxic cells does not have a significant impact on the outcome of a multifraction regimen [ 16 - 18 ]. (biomedcentral.com)
This allows us to evaluate which treatment (RT, HT or RT+HT) and dosing regimen maximise the reduction in tumour burden. (smb.org)

3,4 However, the greatest challenge with this case was delivering re-irradiation to the left chest in the setting of previous radiation therapy and managing heart and lung dose, particularly with a close deep margin. (appliedradiationoncology.com)
It should be noted that limited data are available with respect to repair to the heart and lungs following breast radiation therapy and subsequent dose constraints in the setting of re-irradiation. (appliedradiationoncology.com)

A dose of 30 Gy in 10 fractions (10 x 3 Gy) in 2 weeks is the standard treatment in many centers. (nih.gov)
Patients were treated with VMAT (RapidArc) and SIB in 33 fractions for a total dose of 69.96 and 54.45Gy, respectively. (biomedcentral.com)
Methods: We assessed clinical data of patients receiving five fractions of 7 Gy each (cumulative physical dose of 35 Gy) to BM or surgical cavities. (mdpi.com)
The pilot trial was a controlled phase II study involving 14 patients randomized to receive standard radiochemotherapy, with radiation administered in 2-Gy fractions to a total dose of 60 Gy plus carboplatin (Paraplatin) 70 mg/m² as a radiosensitizer weeks 1 and 5. (cancernetwork.com)

The organs of the abdomen including the liver and small bowel have a relatively low tolerance for radiation, and thus the curative and adjuvant trials have generally been restricted to moderate radiation doses of 30 to 55 Gy. (cancernetwork.com)

Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)

Local and distant failure remains high in this group of patients, so dose escalation has been studied in both single institution and national clinical trials. (frontiersin.org)
Though initial studies showed a benefit to dose escalation, phase III studies examining dose escalation using standard fractionation or hyperfractionation have failed to show a benefit. (frontiersin.org)
Dose escalation in two phases utilizing Simultaneous integrated boost (SIB) combined with ADT in high risk prostate cancer patient is feasible and associated with acceptable acute GI and GU toxicity. (scirp.org)
Hence, there is increased interest in radiation dose escalation combined with androgen deprivation in high risk prostate cancer patients [6] [7]. (scirp.org)
An ongoing GETUG-AFU-18 phase III trial is evaluating the impact of dose escalation in combination with 3-year androgen deprivation treatment on 5-year biochemical or clinical control in high-risk prostate cancer patients [8]. (scirp.org)
This study investigates the efficacy and toxicity of a de-escalation of the marginal prescribed dose from 16 to 11 Gy. (novaliscircle.org)
Improved accuracy in target volume delineation and radiation therapy delivery has the potential to improve treatment outcomes in NSCLC by facilitating radiation dose escalation and ensuring geographic misses are avoided. (cancer.org.au)

His major interest is in the best way to apply radiation fractionation schemes from a mechanistic standpoint. (tcgcrest.org)

With respect to dose and fractionation, we chose an approach to combine acceleration and hyperfractionation with a fractional dose of 1.5 Gy delivered twice daily to a total dose of 66 Gy. (appliedradiationoncology.com)

This patient was treated with image-guided 3DCRT (IG-3DCRT) alone using a FIF technique and a unique hypofractionated dose fractionation scheme, which resulted in good tumor control and sufficient cord decompression, which in turn allowed a delayed but gradual improvement in her severe neurological dysfunction. (hindawi.com)
Because tumor control is related to dose, multi-fraction approaches have been proposed for larger lesions to reduce recurrence without increasing toxicity. (iiarjournals.org)

Patients with stage III-IV HNC treated with VMAT-SIB have been analysed, and doses were correlated to limiting structures and toxicity. (biomedcentral.com)
Accelerating the treatment by one week without dose reduction, as well as using hyper-fractionation, an increase in loco-regional control of intermediate to advanced carcinomas was observed without increasing the late toxicity. (biomedcentral.com)
High Dose Rate (HDR) brachytherapy aims at delivering high dose rates of radiation in restricted volumes of the body, thereby increasing disease control and lower treatment toxicity for adjacent normal tissues. (biomedcentral.com)
The aim of this treatment is to administer high doses of radiation in restricted volumes of the organism, to have greater control of the disease and less toxicity of the treatment to the adjacent normal tissues [ 1 ]. (biomedcentral.com)
established the threshold point dose for Grade 3-5 esophageal toxicity at 58 Gy [ 9 ]. (biomedcentral.com)
Definitive SRS has historically been performed in a single fraction, with dose limited by tumor size in order to minimize toxicity ( 2 ). (iiarjournals.org)

Organs at risk (OAR) are possible to be spared to dose level below tolerance values while keeping high and homogenous doses delivered to the target volume. (biomedcentral.com)
Conclusion: The HALFMOON approach is technically feasible and resulted in high-dose conformity of the target with a significant reduction of radiation dose delivered to implant and other organs. (unimi.it)
Drawing the dose volume histograms (DVHs) was done for planning target volumes (PTVs), including Prostate PTV & nodal PTV, and organs at risk including rectum, bladder, femoral heads, and bowel bag for the plans. (scirp.org)
The DVH analysis showed good coverage of PTVs and organs at risk doses were acceptable. (scirp.org)
Prolonged exposure to high concentrations of ZDTPs, calcium alkyl phenates, and magnesium, sodium, and calcium sulphonates had significant effects on the reproductive organs of male rabbits (testicular atrophy and reduction or absence of spermatozoa) which appeared to be species specific. (cdc.gov)

As such, we decided to optimize fractionation, treatment volumes and delivery techniques. (appliedradiationoncology.com)

The ultrasound dose fractionation and repetition technique with dual-frequency sonication can have a useful therapeutic effect in sonodynamic therapy with the possibility of use in future clinical applications. (biomedcentral.com)
5 Similarly, to reduce dose to the heart and lungs, the clinical target volume (CTV) was reduced, 6 the initial imaging was fused to the treatment planning scan to allow for creation of a pre-surgical gross tumor volume (GTV). (appliedradiationoncology.com)
Purpose: To report the dosimetric feasibility of the radiation technique HALFMOON (Helical ALtered Fractionation for iMplant partial OmissiON) for post-mastectomy radiation therapy (PMRT) in intermediate-high-risk breast cancer patients with implant-based immediate breast reconstruction, where the clinical target volume (CTV) does not include the whole implant (implant-sparing approach). (unimi.it)
Individualize and titrate dexmedetomidine injection dosing to desired clinical effect. (nih.gov)
His biological study spans a wide range of topics, including Absolute risk reduction, Clinical trial, Medical physics and Carcinoma. (research.com)
Tailor the dose and frequency to the Ig trough levels and to clinical symptoms. (medscape.com)
The biological features of prostate cancer as a tumor with a low alpha beta ratio have led clinicians to consider the use of higher doses per fraction, thus gaining an advantage both in terms of clinical outcomes and of logistic opportunities. (encyclopedia.pub)
The purpose of present study was to compare the dosimetric difference and elucidate the dosimetric quality of the radiotherapeutic plans between synchronous and composite planning approaches in consecutive- VMAT for prostate CA. In addition, it was aimed to evaluate the differences in target and critical organ doses of the two approaches in terms of clinical results. (onkder.org)
His translational, pre-clinical research on low-dose radiation as a chemo-potentiator resulted in the development of novel clinical protocols for head and neck, lung, ovarian, and pancreatic cancers. (tcgcrest.org)

An option available with the new technologies is the Simultaneous Integrated Boost (SIB) approach that, even with different associated biological mechanisms due to the different treatment timing, could be considered as an alternative to the hyper-fractionation with the concomitant boost which showed some improvements. (biomedcentral.com)
Reduction in dosage of dexmedetomidine hydrochloride or the concomitant medication may be required. (nih.gov)
This study was followed by a controlled, phase II dose-intensification study to evaluate the role of intensified carboplatin dosage with amifostine protection and concomitant radiochemotherapy in locally advanced pharyngeal cancer. (cancernetwork.com)

The scan should encompass the entire lung volume to ensure accurate calculation of dose volume histograms (DVHs). (cancer.org.au)

For high risk prostate cancer, the treatment volumes and even dose levels are still a controversial issue. (scirp.org)
Even if the defined dose is applied in total, hot or cold dose volumes can directly affect the radiobiological gain and the result of the treatment. (onkder.org)
However, in the SIB technique, the fraction doses in the target and boost volumes may be lower or higher than the normal fractionation, and the critical organ fraction doses may be higher. (onkder.org)
Seminal vesicle (PTV56) and Prostate (PTV78) volumes must be irradiated radiobiologically with a dose of 1.8-2.0 Gy per fraction. (onkder.org)

Chromatographic fractionation of the bioactive components revealed the isolation of unsaturated fatty acids and flavonoids in the three plants, while saponins were only present in fenugreek and liquorice. (medicaljournal-ias.org)

The petroleum ether and the aqueous methanolic extract of fenugreek and liquorice as well as the whole powdered fruit of coriander in a dose of 200 mg/kg exhibited a significant reduction in the volume of inflammation with variable degreeses. (medicaljournal-ias.org)
Polozellus multiplex water fraction caused a significant reduction in the proliferating cell nuclear antigen (PCNA) labelling index in the glandular stomach epithelium as compared with the value of MNNG alone. (theinterstellarplan.com)

The choice of the fractionation scheme in HNC patients is a delicate problem, as many factors are involved. (biomedcentral.com)
Also pragmatic factors, as the workload, the costs, the logistic convenience of a centre to treat patients more than once a day, or during weekend, has to be taken into account when choosing the fractionation scheme for HNC patients. (biomedcentral.com)

We also investigate the impact of the fraction dose and dosing frequency on tumour responses. (smb.org)

Despite the fact that steroids were not administered, the patient reported significant pain reduction and showed improved motor function 3 and 4 weeks after the IG-3DCRT, respectively. (hindawi.com)

All such new advances need today to be included in the biological knowledge about the altered fractionation in order to understand which could be the proper fractionation schedule, total dose and dose/fraction that maximize the tumour cells killing while minimizing the acute and late toxicities. (biomedcentral.com)
We also model the time-dependent effects of HT, distinguishing between mild HT, which re-oxygenates the tumour via vasodilation and a reduction in the oxygen consumption rates of tumour cells, and, high HT, which causes tumour and endothelial cell damage and an associated angiogenic response. (smb.org)

We found that fractional doses of vaccines could be an economically viable vaccination strategy compared to alternatives of either full-dose vaccination or no vaccination. (cdc.gov)

Better results were obtained in CP at V5, V10 and V20 doses of the body, rectal and bladder doses. (onkder.org)

Exploring manganese fractionation using a sequential extraction method to evaluate welders' gas metal arc welding exposures during heavy equipment manufacturing. (cdc.gov)

Polyozellus multiplex (PM), a Korean edible mushroom, has biological activities such as chemoprevention of stomach cancer, inhibition of lipid peroxidation, and reduction of prolyl endopeptidase activity. (theinterstellarplan.com)

Repeated small doses of radiation are less damaging to a sensitive cell than a single fraction containing an equivalent total dose (see the image below). (medscape.com)
However, when the overall duration of the treatment is greatly reduced, the acute reactions become not acceptable, and the total dose or the dose/fraction has to be decreased. (biomedcentral.com)
When the phase1+phase2 total dose distribution was evaluated, better results were obtained with CP. (onkder.org)
It has been proven that 1.8-2.0 Gy fraction doses and 76?80 Gy total doses reduce the biochemical failure rates. (onkder.org)
Then, the plans of the two phases are directly summed to obtain the total dose distribution. (onkder.org)

For iodine-131 metaiodobenzylguanidine ( 131 I-mIBG) therapy, the important considerations during dose fractionation include disease burden, tumor biology, functional symptoms, and associated comorbidities, all of which are important determinants for the intent and course of treatment. (thieme-connect.com)
It is used for the treatment of spontaneous breast adenocarcinoma of Balb/c mice with a variety of dose repetition and fractionation regimes. (biomedcentral.com)
Altered fractionation started to be explored in the 80-ies trying to improve head and neck cancer (HNC) treatment outcome [ 1 ]. (biomedcentral.com)
Finally, in cases where combination treatments are advisable, higher doses of HT applied with lower doses of RT maximise treatment efficacy. (smb.org)

Cisplatin-based chemoradiation plus high dose rate intracavitary brachytherapy can prevent locoregional relapse and effect cure in 40-75% of patients [ 4 , 5 ]. (biomedcentral.com)
For most patients, a dose of 400-600 mg/kg every 3-4 weeks suffices to reduce the frequency of infection. (medscape.com)
Regarding the dose received by the cochlea, a significant difference in patients with preserved hearing was seen with a minimum cochlear radiation dose less than 5 Gy. (novaliscircle.org)
Most of the guidelines recommend offering annual screening with low-dose computed tomography (LDCT) scanning to patients aged 50 to 80 years who have at least a 20 pack-year smoking history and either continue to smoke or have quit within the past 15 years. (medscape.com)

Anthony Tolisano reported that tumor margin dose less than 12 Gy and cochlear dose less than 4 Gy have also been demonstrated to maximize hearing preservation rate. (novaliscircle.org)

Over the decades Dr. Morrison has been involved in trials of fractionation, radiation protectors, induction and concurrent chemotherapy, and proton beam therapy. (mdanderson.org)

Cumulative carboplatin dose was 700 mg/m². (cancernetwork.com)

Dose-sparing strategies could save a large number of lives, even with the emergence of new variants with higher transmissibility. (cdc.gov)
RCC may be more responsive to radiation at higher doses or in a hypofractionated form (including stereotactic radiosurgery). (cancernetwork.com)
When only the boost plans were compared, the results were 11.8% lower at the D1 dose and 12.01% higher at the D99 dose with the SP. (onkder.org)

We developed a multi-scale model incorporating population-level transmission and individual-level vaccination to estimate the costs of hospitalization and vaccination and the economic benefits of reducing COVID-19 deaths due to dose-fractionation strategies in India. (cdc.gov)

The author classified changes in tumor size after SRS into five categories: enlargement requiring surgical intervention, which means local failure, stable or reduced tumor, initial enlargement with secondary reduction, initial enlargement that remains stable, and enlargement of 1 to 3 millimeter on last MRI with uncertain progression, suggesting a new assessment in one to two years. (novaliscircle.org)

The EAF also exerted a dose-depended inhibition of GPα (IC50 = 0.75 mg/ml). (afpm.org.my)

Consider reduction in loading infusion rate. (nih.gov)
Measure the serum IgG level before each infusion and adjust the dose of IVIG accordingly. (medscape.com)

These were the first data to show a reduction of mucositis from amifostine given prior to chemotherapy. (cancernetwork.com)

Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)
Dose distributions obtained by two techniques were compared. (onkder.org)

However, if there is a heterogeneous dose distribution in phase1 planning, there may be very low or very high fraction doses within the target volume only in phase2 planning. (onkder.org)
Identification of abscopal factors in high dose hypofractionated radiation therapy. (tcgcrest.org)

His DAHANCA study combines topics in areas such as Dose fractionation, Head and neck, Logistic regression and Quality assurance. (research.com)

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes1

Health Care1

Radiotherapy14

Conventional5

IMRT12

Schedules5

Regimen3

Irradiation2

Fractions4

Radiation Doses1

Primary tumor1

Escalation7

Schemes1

Hyperfractionation1

Tumor control2

Toxicity6

Organs5

Optimize1

Clinical9

Concomitant3

Volume histograms1

Volumes4

Revealed the isolation1

Significant reduction2

Scheme2

Fraction dose1

Pain reduction1

Tumour2

Fractional1

Rectal1

Evaluate1

Biological1

Total5

Treatment4

Patients4

Maximize1

Concurrent1

Cumulative1

Higher3

Deaths1

Secondary1

Inhibition1

Infusion2

Chemotherapy1

Techniques2

High2

Study1