SuperfamilyEnzymeDeficiencyNADPKeto reductasePyridine nucleotide disulfideThioredoxinSynthaseInhibitorsEnzymesMemberInhibitionInvolved in the biosynthesisInhibitorCharacterizationCatalyzesConsistsCrystallographyGenesHereditarySubunit familyMotifsHumanMetabolismActivityLiverStructureSpeciesCompoundsGene belongs
Superfamily5
- Short-chain dehydrogenases/reductases (SDR) constitute a superfamily of proteins catalysing reactions of a wide range of substrates in all life forms. (avhandlingar.se)
- Short-chain dehydrogenases/reductases (SDRs) constitute a universal superfamily of functionally heterogeneous proteins and participate in the metabolism of steroids, prostaglandins, retinoids, aliphatic alcohols, and xenobiotics. (avhandlingar.se)
- Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. (cathdb.info)
- This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
- The MDR superfamily with ~350-residue subunits contains the classical liver alcohol dehydrogenase (ADH), quinone reductase, leukotriene B4 dehydrogenase and many more forms. (researchgate.net)
Enzyme7
- In vertebrates, membrane-bound HMG-CoA reductase is the rate-limiting enzyme in the biosynthesis of cholesterol and other isoprenoids. (wikipedia.org)
- In archaea, HMG-CoA reductase is a cytoplasmic enzyme involved in the biosynthesis of the isoprenoids side chains of lipids. (wikipedia.org)
- The effect of disease associated point mutations on 5beta-reductase (AKR1D1) enzyme function. (medlineplus.gov)
- Children with this condition lack an enzyme (5-alpha reductase). (chkd.org)
- Nucleotide reductase is an enzyme specifically expressed in replicating cells or rapidly growing tumor cells, and treatment of cells with TrxR inhibition and compounds such as adriamycin results in inhibition of nucleotide reductase and inhibition of cell growth. (pharmiweb.com)
- This intermediate will allow for the development of a Cinnamoyl-CoA reductase 2 enzyme expression system. (igem.org)
- The relative lack of the methemoglobin reductase enzyme needed to convert methemoglobin to functioning hemoglobin can lead to methemoglobinemia in young infants. (cdc.gov)
Deficiency4
- Pyrroline-5-carboxylate reductase 2 (PYCR2) deficiency causes hereditary spastic paraplaegia in late childhood. (nih.gov)
- 5 alpha-reductase deficiency without hypospadias. (bmj.com)
- The two primary causes of male pseudohermaphroditism are androgen insensitivity syndrome and 5-alpha reductase deficiency. (chkd.org)
- Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. (thermofisher.com)
NADP1
- Class I HMG-CoA reductases catalyse the NADP-dependent synthesis of mevalonate from 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). (wikipedia.org)
Keto reductase4
- 1.-.-.- Oxidoreductases: aldo-keto reductase family 1 member B. Last modified on 13/08/2015. (guidetopharmacology.org)
- Prognostic value of aldo-keto reductase family 1 member B10 (AKR1B10) in digestive system cancers: A meta-analysis. (bvsalud.org)
- Numbers of studies have reported that the expression of aldo-keto reductase family 1 member B10 (AKR1B10) is abnormal in digestive system cancers , and could be used as a prognostic biomarker . (bvsalud.org)
- SPR encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). (thermofisher.com)
Pyridine nucleotide disulfide2
- TrxR is a dimeric flavoproteinase, a member of the pyridine nucleotide disulfide reductase family, widely expressed in cells of all levels of organisms from prokaryotes to humans. (pharmiweb.com)
- The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. (cancerindex.org)
Thioredoxin6
- Thioredoxin reductase (TrxR) is similar in activity to glutathione reductase (GR), catalyzing the reduction of GSSG to GSH, and is one of the key enzymes of the glutathione redox cycle. (pharmiweb.com)
- Mammalian thioredoxin reductase (TrxR) enzymes are a family of selenoproteins with a unique but essential selenocysteine (Sec) residue at their C-terminal redox center. (pharmiweb.com)
- Thioredoxin reductases (3 genes) use NADPH to reduce oxidized thioredoxin and its homologs, which regulate a plethora of redox signaling events. (usda.gov)
- Methionine sulfoxide reductase B1 reduces methionine sulfoxide back to methionine using thioredoxin as a reductant. (usda.gov)
- The most widely distributed selenoprotein family in Nature is represented by the highly conserved thioredoxin-like selenoprotein W and its homologs that have not yet been assigned specific biological functions. (usda.gov)
- Three thioredoxin reductase (TrxR) isozymes are found in mammals. (cancerindex.org)
Synthase2
- FAE ( Fatty Acid Elongation ) like genes take part in the biosynthesis of VLCFAs, growth regulation, and stress responses, and are further comprised of KCS ( Ketoacyl-CoA synthase ) and ELO ( Elongation Defective Elongase ) sub-gene families. (nature.com)
- In turn, PGH2 is converted to biologically active products (ie, prostaglandin E 2 [PGE2]) by individual synthase and reductase reactions. (medscape.com)
Inhibitors2
- 2005) Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. (guidetopharmacology.org)
- In addition, SAMS will evaluate prognostic factors, criteria for intervention and the effects of 5-alpha-reductase inhibitors, the outcome after treatment with curative intent, time to symptoms and metastases from prostate cancer, prostate cancer specific survival, and overall survival. (cancercentrum.se)
Enzymes5
- In molecular biology, the HMG-CoA reductase family is a family of enzymes which participate in the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. (wikipedia.org)
- There are two distinct classes of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase enzymes: class I consists of eukaryotic and most archaeal enzymes EC 1.1.1.34, while class II consists of prokaryotic enzymes EC 1.1.1.88. (wikipedia.org)
- Class I HMG-CoA reductases consist of an N-terminal membrane domain (lacking in archaeal enzymes), and a C-terminal catalytic region. (wikipedia.org)
- Class II HMG-CoA reductases catalyse the reverse reaction of class I enzymes, namely the NAD-dependent synthesis of HMG-CoA from mevalonate and CoA. (wikipedia.org)
- This group of enzymes constitutes a protein family with at least 60 members with highly diverse functions in pro- and eukaryotes. (avhandlingar.se)
Member2
- A member of the monomeric reductase gene family. (drugbank.com)
- Screening may also be indicated when a family member is diagnosed with a genetic disorder. (msdmanuals.com)
Inhibition3
- In vitro inhibition of recombinant human aldose reductase expressed in E coli . (guidetopharmacology.org)
- 2015) The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition. (guidetopharmacology.org)
- Selective competitive inhibition of HMG-CoA reductase decreases cholesterol synthesis and increases cholesterol metabolism. (medscape.com)
Involved in the biosynthesis1
- Fatty acyl reductases (FARs) are involved in the biosynthesis of fatty alcohols that serve a range of biological roles. (mpg.de)
Inhibitor4
- 2. Oka M, Matsumoto Y, Sugiyama S, Tsuruta N, Matsushima M. (2000) A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography. (guidetopharmacology.org)
- 3. Singh SB, Malamas MS, Hohman TC, Nilakantan R, Carper DA, Kitchen D. (2000) Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants. (guidetopharmacology.org)
- Synthetically prepared HMG-CoA reductase inhibitor with some similarities to lovastatin, simvastatin, and pravastatin. (medscape.com)
- 3.Subjects with hypersensitivity reactions to drugs like Atorvastatin, HMG-CoA reductase inhibitor. (who.int)
Characterization1
- Using bumble bee (Bombini) FAR expression analysis and functional characterization, hymenopteran FAR gene tree reconstruction, and inspection of transposable elements (TEs) in the genomic environment of FARs, we uncovered a massive expansion of the FAR gene family in Hymenoptera, presumably facilitated by TEs. (mpg.de)
Catalyzes1
- Competitively inhibits HMG-CoA reductase, which catalyzes the rate-limiting step in cholesterol synthesis. (medscape.com)
Consists2
- specifically, we show that the previously delineated glyoxylate/hydroxypyruvate reductase (GHPR) subfamily consists of two evolutionary separated GHRA and GHRB subfamilies. (rcsb.org)
- In pea (Pisum sativum), the short-chain alcohol dehydrogenase-like protein (SAD) gene family consists of at least three members (SAD-A, -B, and -C). The SAD genes are transiently expressed in plants after short exposures to ultraviolet-B radiation, which in turn leads to formation of SAD protein in leaf and stem tissue upon prolonged irradiation. (avhandlingar.se)
Crystallography1
- X-ray crystallography and site-directed mutagenesis were used to better understand the structure/function relationships in the family of short-chain dehydrogenases/reductases (SDR). (avhandlingar.se)
Genes1
- Screening may be appropriate for people with a family history of a dominantly inherited disorder that manifests later in life, such as Huntington disease or cancers associated with abnormalities of the BRCA1 and BRCA2 genes. (msdmanuals.com)
Hereditary1
- 9.Subjects who with a history of muscle disorders or hereditary muscle disorders or family history. (who.int)
Subunit family1
- Belongs to the shaker potassium channel beta subunit family. (ucsc.edu)
Motifs1
- Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms. (researchgate.net)
Human3
- Disease variants of human Δ(1)-pyrroline-5-carboxylate reductase 2 (PYCR2). (nih.gov)
- 5beta-Reduced steroids and human Delta(4)-3-ketosteroid 5beta-reductase (AKR1D1). (medlineplus.gov)
- Rate of steroid double-bond reduction catalysed by the human steroid 5beta-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis. (medlineplus.gov)
Metabolism1
- Inhibits HMG-CoA reductase, which, in turn, inhibits cholesterol synthesis and increases cholesterol metabolism. (medscape.com)
Activity1
- NADH-dependent methemoglobin reductase activity in infants is 60% that of adults. (cdc.gov)
Liver1
- Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy. (medlineplus.gov)
Structure1
- 4. Steuber H, Zentgraf M, Gerlach C, Sotriffer CA, Heine A, Klebe G. (2006) Expect the unexpected or caveat for drug designers: multiple structure determinations using aldose reductase crystals treated under varying soaking and co-crystallisation conditions. (guidetopharmacology.org)
Species1
- Brassicaceae is a vast family of plants including 372 genera and 4,006 species contributing to condiments, biofuel, food, oil, and fulfilling fodder demands for the ecosystem 1 . (nature.com)
Compounds1
- Two decades later, the prostaglandins were deduced to be a family of related compounds that contain 20-carbon polyunsaturated fatty acids with a cyclopentane ring, as depicted below. (medscape.com)
Gene belongs1
- This gene belongs to the pyrroline-5-carboxylate reductase family. (nih.gov)