The heterotetramer with CBR4 has NADH-dependent 3-keto acyl-acyl carrier protein reductase activity, so it plays a role in the biosynthesis of mitochondrial fatty acids. (bocsci.com)
to form isonicotinic acyl-NADH complex. (genaxxon.com)
Synthesis4
β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital metabolic pathway in bacteria and a promising target for new antibiotic development. (rcsb.org)
However, like many bacteria and plants, its metabolism does depend upon the type II fatty-acid synthesis (FAS) pathway for lipogenesis, whereas the predominant form of fatty-acid biosynthesis in humans is via the type I pathway. (rcsb.org)
Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. (systemsbiology.net)
Our analysis found that the differences between various metabolic states primarily involved the assignment of two specific reactions in fatty acid synthesis and glycerogenesis. (biomedcentral.com)
Acids14
3-ketoacyl-acyl carrier protein (ACP) reductase is a vital enzyme in the biosynthesis of fatty acids in bacteria and plants. (bdjn.org)
Oleic acid, also known as oleate or 18:1 N-9, belongs to the class of organic compounds known as long-chain fatty acids. (ymdb.ca)
These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms. (ymdb.ca)
belongs to the class of organic compounds known as long-chain fatty acids. (ymdb.ca)
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. (nih.gov)
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. (systemsbiology.net)
Mtb has a complex cell wall made up of mycolic acids (long-chain fatty acids with 60 to 90 carbon atoms), glycolipids, peptidoglycan, and proteins. (ajgreenchem.com)
Bacterial decomposition of apocrine secretions yields ammonia and short-chain fatty acids, with their characteristic strong odors. (medscape.com)
The most abundant of these acids is (E)-3-methyl-2-hexanoic acid (E-3M2H), which is brought to the skin surface bound by 2 apocrine secretion odor-binding proteins, ASOB1 and ASOB2. (medscape.com)
Once acted on by LPL, which is attached to the luminal side of the capillary endothelium adjacent to muscle and adipose tissue, chylomicrons release TGs as monoglycerides and free fatty acids. (medscape.com)
Adipose tissue uses free fatty acids and monoglycerides to resynthesize TGs that are stored for future energy needs. (medscape.com)
FabG2
Here we report the findings of structural, enzymatic, and binding studies of the FabG protein found in the causative agent of cholera, Vibrio cholerae (vcFabG). (rcsb.org)
In this scenario, hydride is predicted to be added to the re face to generate the S configuration resulting in the same stereochemical outcome as other 3-oxoacyl-ACP reductase (FabG) from bacterial type II fatty acid synthases.These findings are critical advancement for interrogating the biosynthesis of the unusual chemical components of the family of antibiotics of capuramycin. (uky.edu)
Enoyl1
This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. (genaxxon.com)
Synthase1
Cpr37, which belongs to the adenylation domain protein in the nonribosomal peptide synthase (NRPS), subsequently activates PABA and loads it to holo-Cpr36 Two proteins Cpr34 and Cpr35 work in concert to catalyze decarboxylative condensation between a thioester linked PABA and malonyl- S -acyl carrier protein (ACP) during aromatic polyketide biosynthesis catalyzed by type II polyketide synthases. (uky.edu)
NADPH1
Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. (systemsbiology.net)
Molecules1
A metabolic disorder is any disease or disorder that negatively affects the biochemical reactions through which individual animal cells process nutrient molecules (such as the components of carbohydrates , proteins , and fats ) to yield energy or perform the functions necessary to sustain life (such as building complex molecules and creating cellular structure). (newworldencyclopedia.org)
Biosynthesis2
Here, transcriptome analysis and fatty acid profiling from developing V. galamensis seeds were integrated to uncover the critical metabolic pathways responsible for high EFA accumulation and identify the targets that could be used in assembly of EFA biosynthesis pathway in existing oilseed crops. (researchsquare.com)
Here we present the functional assignment and biochemical characterization of seven proteins, Cpr33-38 and Cpr12, that initiate the biosynthesis of the polyamide. (uky.edu)
Pathway1
Here, the structure of the third enzyme in the FAS pathway, 3-ketoacyl-(acyl-carrier-protein) reductase, is reported at a resolution of 2.25 Å. (rcsb.org)
Enzyme1
In the case of a metabolic reaction network, gene or even protein expression data may not best capture the interactions between the network's components, as mRNA levels or enzyme concentrations do not necessarily correlate with reaction rate or metabolite turnover. (biomedcentral.com)
Gene4
Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)
Cpr12, encoded by a gene that was originally proposed to be outside the gene cluster and sharing similarity to proteins annotated as ADC lyase, was revealed to catalyze the elimination of pyruvate to form PABA. (uky.edu)
Recently, Tang and coworkers used gene expression data to construct time-course protein interaction networks, and found that functional modules detected in the time-course networks more closely matched known regulatory complexes than those detected in the static networks[ 11 ]. (biomedcentral.com)
Most metabolic disorders are inherited from one or both parents who carry a defective gene that regulates a particular protein in a class of the body's cells. (newworldencyclopedia.org)
Mitochondrial2
Mcl1 antiapoptotic protein is produced by Mtb -infected alveolar macrophages and is important for interrupting apoptosis in infected macrophages by regulating the mitochondrial membrane and blocking the release of cytochrome C and DNA-degrading enzymes [ 7 ⎼ 9 ]. (ajgreenchem.com)
How do Fatty Acyl-CoA's pass the mitochondrial intermembrane space? (flashcardmachine.com)
Genes3
Owing to its small genome (about 800 protein-coding genes), it relies on the host for many basic biosynthetic processes, hindering the identification of potential antipathogenic drug targets. (rcsb.org)
Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)
By comparison, we found that various genes associated with acyl editing, fatty acid β-oxidation, triacylglycerol assembly and oil-body formation had greater expression levels at middle developmental stage (38 DAP), which are consistent with the fast accumulation of EFA in V. galamensis developing seed, implying their fundamental roles in EFA production. (researchsquare.com)
Methyl1
To assess the quality of biodiesel produced, fatty acid methyl esters (FAME) composition was studied. (hindawi.com)
Catalyzes1
Following condensation, Cpr33 acts as 3-oxoacyl-ACP reductase that catalyzes reduction to the β-hydroxythioester intermediate. (uky.edu)
Found1
Interestingly, mutations in hub proteins connecting different modules were found to be more frequently associated with cancer phenotypes than mutations in hub proteins that are highly connected with other proteins in the same modules, suggesting that alterations in global modularity may occur in cancer. (biomedcentral.com)
Structural1
Apoprotein B-48 is a chylomicron structural protein. (medscape.com)
Form1
Cpr36 is demonstrated to function as a free-standingpeptidyl carrier protein (PCP), which is activated to form holo-protein from the apo-form. (uky.edu)
Transport2
It is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. (med-chemist.com)
What happens if you lack the proteins to transport Acyl-Coa into the matrix? (flashcardmachine.com)
Specific1
The most common of these are E-3M2H and (RS)-3-hydroxy-3-methlyhexanoic acid (HMHA), which are released through the action of a specific zinc-dependent N -alpha-acyl-glutamine aminoacylase (N-AGA) from Corynebacterium species. (medscape.com)