Reduced catalase activity. Medical search. Frequent questions

Glutathione stabilizes ROS, and after being converted (oxidizing) to glutathione disulfide, it is reduced back to GSH by glutathione reductase. (medscape.com)
To address this questions, we investigated the antioxidant defense system enzymatic (glucose-6-phosphate dehydrogenase (G6PDH), glutathione reductase (GR), glutathione peroxidase (Gpx), catalase (CAT), and superoxide dismutase (SOD)) and nonenzymatic (reduced glutathione (GSH)) in gastrocnemius muscle of diabetic rats. (hindawi.com)
After sacriﬁce, extricated pup lenses were analyzed for mean activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glutathione reductase. (molvis.org)

Lead blocks the activity of 5-aminolevulinic acid dehydratase and leads to hemoglobin oxidation, which along with the lipid peroxidation can result in red cell hemolysis. (medscape.com)
MATERIALS AND METHODS: DPPH radical scavenging and lipid peroxidation inhibitory activities were observed. (nutrimedical.com)
RESULTS: Ellagic acid showed high DPPH radical scavenging and lipid peroxidation inhibition activities. (nutrimedical.com)
In vivo antioxidant parameters such as lipid peroxidation (MDA), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) were also monitored. (ijp-online.com)
superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) and tissue antioxidant, reduced glutathione (GSH) along with a concomitant increase in the lipid peroxidation product malonaldehyde (MDA). (scialert.net)
Pretreatment with T. terrestris resulted in the increased activities of SOD, CAT, GSHPx and prevention of depletion of tissue glutathione along with inhibition of lipid peroxidation. (scialert.net)
The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)
In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)

Lead also interferes with the activity of other antioxidant enzymes including superoxide dismutase and catalase. (medscape.com)
Hyperglycemia and activation of the nuclear factor-κB (NF-κB) pathway stimulate the production of reactive oxygen species (ROS), which lead to the induction of insulin resistance and subsequently reduce the activity of antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT). (nutraingredients.com)

Catalase and superoxide dismutase activity were reduced in the HFDF animals, whose levels were increased statistically significantly by extract of P farcta leaves. (uwi.edu)

SDS-gel electrophoresis results indicated that chicken erythrocyte catalase consists of four apparently identical subunits, with a molecular weight of around 57.5 kDa. (tubitak.gov.tr)

In summary, mixed planting treatment was more helpful to improve soil enzyme activity, microbial biomass, and enrich soil microbial diversity, which was of great significance to maintain the balance of soil ecosystem. (bioone.org)
Enzyme activity was stable at temperatures between 10 and 30°C. The activity of purified catalase was inhibited by azide, cyanide, \beta -mercaptoethanol, dithiotreitol (DTT) and iodoacetamide. (tubitak.gov.tr)
It has been shown to enhance antioxidant enzyme activity and have positive effects on blood pressure and QOL in diabetic patients, and one previous study showed that the use of rutin along with vitamin C played an important role in increasing the QOL of diabetic patients. (nutraingredients.com)

If hydrogen peroxide is not broken down by catalase, additional reactions convert it into compounds called reactive oxygen species that can damage DNA, proteins, and cell membranes. (medlineplus.gov)
It is well documented that a blockage this complex leads to decreased production of reactive species, due to reduced transport of electrons from NADH plus H + [ 15 , 16 ]. (hindawi.com)
However, if hydrogen peroxide is not completely reduced by these enzymes, it can generate an extremely reactive hydroxy radical when oxidized by iron (Fenton reaction). (dojindo.com)
The ROS and reactive nitrogen compounds have many different activities in biological systems. (dojindo.com)
The concentrations of renal malondialdehyde, reactive oxygen species, 8-hydroxydeoxyguanosine, serum creatinine, blood urea nitrogen, and renal arsenic accumulation were significantly decreased and reduced renal morphologic injury was observed compared with the As 2 O 3 -treated group. (springer.com)

Therefore, evidence suggests that metformin reduces endogenous ROS mitochondrial levels [ 17 , 18 ]. (hindawi.com)
Ubiquinol (reduced form coenzyme Q 10 ) serves as an endogenous antioxidant which increases the concentration of CoQ 10 in the diseased gingiva and effectively suppresses advanced periodontal inflammation. (ijp-online.com)
ISP-administration produced a significant decrease in the activities of endogenous antioxidant defence enzymes viz. (scialert.net)
The possible underlying mechanism of the cardioprotective effect of T. terrestris could be due to restoration of endogenous myocardial antioxidant status or free radical scavenging activity along with correction of the altered hemodynamic parameters and preservation of histoarchitectural and ultrastructural alterations. (scialert.net)
The researchers also discovered that the brassinosteroid boosted the activity of endogenous antioxidant enzymes like superoxide dismutase, catalase and GSH, and reduced the peroxidation of fats, particularly in the testes of the rats with diabetes. (ironmagazine.com)

The levels of total proteins, transaminases, malondialdehyde, nitrites, superoxide dismutase, catalase and reduced glutathione were restored after treatment of infected mice with SpAE. (nih.gov)
In addition, the mean concentrations of reduced glutathione (GSH) and of malondialdehyde were analyzed in samples of lenses and hemolysate. (molvis.org)
The statistically significant increases in liver malondialdehyde in HFDF rats were reduced after treatment with P farcta. (uwi.edu)

ABSTRACT There is growing evidence that dietary antioxidants may have favourable effects in reducing cancer risk. (who.int)

A statistically significant correlation was found only between MDA level and G6PDH activity. (pjoes.com)
At low concentrations (10(-7) to 10(-9) M), this compound displayed a small but significant estrogenic activity via ERalpha, whereas it was a complete estrogen antagonist via ERbeta. (nutrimedical.com)
Moreover, superoxide dismutase and catalase activities showed a significant increase in relation to their contact with CBZ. (scielo.br)
In addition, a significant decrease in the activities of myocardial injury markers i.e., creatine phosphokinase-MB (CK-MB isoenzyme) and lactate dehydrogenase (LDH) was also observed in the heart of ISP control group as compared to sham control. (scialert.net)

While SOD catalyzes the dismutation of superoxide anion (O2') to H2O2, catalase and glutathione (peroxidase, reductase) system reduce cellular toxicity degrading peroxides into oxygen and water 9 . (bvsalud.org)

0.05) in the cerebrum, reduced in the brain stem and remained unchanged in the cerebellum. (scialert.net)

At least 13 mutations in the CAT gene have been found to cause acatalasemia, a condition characterized by very low catalase activity. (medlineplus.gov)
The mutations that cause acatalasemia occur in both copies of the CAT gene in each cell, and they reduce the activity of catalase to less than 10 percent of normal. (medlineplus.gov)
Goth L, Rass P, Pay A. Catalase enzyme mutations and their association with diseases. (medlineplus.gov)
Based on the structure, we performed integrative analysis of the cellular trafficking, protein thermostability, ATP hydrolysis, and the transport activity of representative mutations. (elifesciences.org)

At the baseline and end of the intervention, mean arterial pressure (MAP), heart rate (HR), pulse pressure (PP), systolic and diastolic blood pressure (SBP and DBP), serum levels of antioxidant enzymes, such as catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) and quality of life (QOL) parameters, were evaluated. (nutraingredients.com)

The liver glutathione peroxidase (GPx) and reductase (GR) activities as well as GSH and hydrogen peroxide levels were determined using Bioxytech Assay kits. (pjoes.com)

For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
RESULTS: In the EMR-exposed group, while tissue MDA and urine NAG levels increased, SOD, CAT, and GSH-Px activities were reduced. (greenmedinfo.com)
In this study, the increase in MDA levels of renal tissue and in urine NAG and also the decrease in renal SOD, CAT, GSH-Px activities demonstrated the role of oxidative mechanism induced by 900-MHz mobile phone exposure, and melatonin, via its free radical scavenging and antioxidant properties, ameliorated oxidative tissue injury in rat kidney. (greenmedinfo.com)
D+I+M reduced the oxidative stress levels and the activity of catalase and superoxide dismutase in skeletal muscle when compared to D+I rats. (hindawi.com)
In contrast, the levels of SOD, and catalase activities significantly decreased after treatment. (edu.sa)
Prosopis farcta extract reduced the elevated levels of total cholesterol, triglycerides, LDL and body weight. (uwi.edu)
The new study follows earlier work from the same research group , which indicated that green tea may reduce levels of a protein called amyloid alpha linked to heart disease. (nutraingredients-usa.com)
However, no changed were observed in in blood carotenoid and tocopherol levels, nor in the activities of glutathione peroxidase and catalase. (nutraingredients-usa.com)
We show that mutant mitochondria display defective fatty acid-driven oxidative phosphorylation due to reduced levels of carnitine palmitoyl transferases. (bvsalud.org)

The maximal activity of catalase was observed between pH 6.0 and 8.0. (tubitak.gov.tr)

The aim of this study was to determine the effect of acute intoxication with chlorfenvinphos on the liver reduced glutathione (GSH) level and the activities of two enzymes involved in glutathione metabolism, as well as the activity of catalase (CAT), glucose-6-phosphate dehydrogenase (G6PDH) and the level of liver hydrogen peroxide. (pjoes.com)
SOD is a potential therapeutic agent in diseases related to oxidative stress and as a material for moderating the aging process, because of its high antioxidant efficiency (much higher than that of glutathione or other reducing agents) and early action in the initial stages of ROS metabolism. (dojindo.com)
Apart from these remarkable actions of vinpocetine it also acts though PDE1 inhibition Phosphodiesterases (PDEs) are the enzymes which reduce the level of cyclic nucleotides by their metabolism (Oliva Jr et al. (researchsquare.com)

The beneficial effect of ASTA is associated with a reduction intracellular O2 (-) production by restoring the antioxidant network activity of superoxide dismutase (SOD) and catalase (CAT), which influence HO-1 expression and activity by inhibiting nuclear translocation of Nrf2. (nih.gov)

Catalase is active in cells and tissues throughout the body, where it breaks down hydrogen peroxide (H 2 O 2 ) molecules into oxygen (O 2 ) and water (H 2 O). Hydrogen peroxide is produced through chemical reactions within cells. (medlineplus.gov)
Cells make the enzyme catalase to remove hydrogen peroxide. (practicalbiology.org)
To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor subtypes ERalpha and ERbeta in HeLa cells. (nutrimedical.com)
Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured in ellagic acid-treated V79-4 cells. (nutrimedical.com)
SOD, CAT and GPX activities were significantly increased in ellagic acid-treated V79-4 cells. (nutrimedical.com)
CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
Treated cells with MTT assay reduced cell viability at 1000 lg/ml and higher after 48hrs. (edu.sa)
Since glutathione also has superoxidescavenging activity, it contributes to a reductive atmosphere in cells and tissues to avoid oxidative damage. (dojindo.com)
In CGD, white blood cells (WBCs) do not produce hydrogen peroxide , superoxide, and other activated oxygen compounds because nicotinamide adenine dinucleotide phosphate oxidase activity is deficient. (msdmanuals.com)

Hebert-Schuster M, Fabre EE, Nivet-Antoine V. Catalase polymorphisms and metabolic diseases. (medlineplus.gov)

Reduced glutathione acts as the electron donor to the enzyme GPx that efficiently scavenges hydrogen peroxide, thus preventing cellular oxidative damage. (nutraingredients-usa.com)
In order to prevent oxidative damage, the antioxidant system presents a group of cellular enzymes (SOD, catalase and glutathione system) responsible for the control of free radicals. (bvsalud.org)

8-Nitroguanosine is involved in controlling cell functions and is related to oxidizing and reducing reactions. (dojindo.com)

Petroleum ether, chloroform, and alcohol extracts of Mimusops elengi bark were evaluated for antiurolithiatic and antioxidant activity in male albino Wistar rats. (ijp-online.com)
28-Homobrassinolide boosted the activity of 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxy steroid dehydrogenase in the rats' testes. (ironmagazine.com)

Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice. (cdc.gov)
In addition, inhibition of xanthine oxidase activity decreased caspase-3 activity, but it had no effect on other markers of mitochondrial-associated apoptosis. (cdc.gov)

The results of the present study suggest that the ingestion of large amounts of MSG with diet causes an increase in the weight of cerebrum with simultaneous increase in LP and reduction in CAT activity. (scialert.net)
Despite these efforts and in spite of successes to reduce initiation and increase cessation, a substantial portion of Americans still become regular smokers. (nationalacademies.org)

Recent studies have shown the involvement of oxidative stress and mitochondrial activity in AGA. (nature.com)

interventions consider a broader set of outcomes than would be considered in an approach that aims solely to reduce prevalence. (nationalacademies.org)
A tobacco harm reduction approach also considers strategies that would reduce tobacco-related health risks while assuming continued use of tobacco or nicotine-containing products (i.e., those that reduce risks without reducing prevalence of tobacco use or exposure to nicotine). (nationalacademies.org)
The authors acknowledge, however, that the study does not prove that the reduced prevalence of H pylori has directly impacted obesity rates. (medscape.com)

The total antioxidant capacity was assayed by ferric reducing ability of plasma (FRAP), phosphomolybdenum antioxidant power (PAP), reduction assays. (degruyter.com)

CAT activity was determined by Aebi method, G6PDH activity was measured using Sigma Assay kit. (pjoes.com)

Therefore, DNA Damage Quantification Kit is useful for the detection of carcinogen toxicity and for the detection of DNA repair activities. (dojindo.com)

The results showed that the urease activity and microbial biomass nitrogen content of mixed planting were higher than other treatments. (bioone.org)
Our results show that compared to control conditions, suppression of xanthine oxidase activity by allopurinol reduced xanthine oxidase activity. (cdc.gov)
The results of the present investigation suggest the antioxidant and free radical scavenging activities of leaf extract of M. piperita are the likely mechanism of radiation protection. (unboundmedicine.com)
These results confirm that AlE of M. elengi possess potent antiurolithiatic activity. (ijp-online.com)
These results indicate the lipid-lowering and antioxidative activity of extract of P farcta leaves. (uwi.edu)
The results also indicate that acetylcholinesterase activity (AChE) was inhibited in all CBZ concentrations during the 48 h exposure period. (scielo.br)
RESULTS: In bronchoalveolar lavage fluid, WPS increased neutrophil and lymphocyte numbers, lactate dehydrogenase, myeloperoxidase and matrix metallopeptidase 9 activities, as well as several proinflammatory cytokines. (who.int)

2020 . Reducing mortality from 2019-nCoV: host-directed therapies should be an option . (ajtmh.org)
The adverse health consequences of combustible tobacco use have been documented extensively ( HHS, 2014 ), and a major goal of tobacco control efforts is to reduce their health burden ( Healthy People 2020, 2017 ). (nationalacademies.org)

Resveratrol is a well-known polyphenolic compound that is reported to reduce As 2 O 3 -induced cardiotoxicity. (springer.com)
In the resveratrol + As 2 O 3 -treated group, activities of glutathione peroxidase, catalase, and superoxide dismutase, the ratio of reduced glutathione to oxidized glutathione, the total arsenic concentrations, and the percentage of methylated arsenic in urine were significantly increased. (springer.com)
Trans-resveratrol is a polyphenol with great antioxidant action that reduces the oxidative stress. (bvsalud.org)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)
A suplementação com trans-resveratrol atenuou o estresse oxidativo cardíaco e aumentou a atividade enzimática de defesa catalase. (bvsalud.org)

How these janus-faced activities are regulated in response to cellular nutrient status is poorly understood. (bvsalud.org)

BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)

On the sixth day, the cats were killed to determine the histological renal damage, renal function, the accumulation of arsenic, and antioxidant activities in the kidney. (springer.com)

Ninety percent of glutathione in the cell exists in reduced form and 10% in oxidative form, and it typically acts as an antioxidant defense mechanism. (medscape.com)
The application of ascorbic acid reduced cell membrane damage and increased catalase activity in water-stressed trees of both cultivars. (frontiersin.org)
Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
Hydrogen-rich saline also increased B-cell lymphoma 2 (Bcl-2) expression and the activity of the antioxidant enzyme superoxide dismutase (SOD). (arvojournals.org)

Catalase plays a major role in the protection of tissues from the toxic effects of H_{2}O_{2} and partially reduced oxygen species. (tubitak.gov.tr)
Studies have also shown that ellagic acid may protect against chromosome damage and reduce the effects of chemically induced hepatic structural degeneration. (nutrimedical.com)

Oxidative stress is a putative factor responsible for reducing function and increasing apoptotic signaling in skeletal muscle with aging. (cdc.gov)

Hereditary catalase deficiencies and increased risk of diabetes. (medlineplus.gov)

Exposure to acrolein vapor resulted in reduced respiratory epithelial GSH concentrations. (cdc.gov)

TAZG197V mice recapitulate disease-specific pathology including cardiac dysfunction and reduced oxidative phosphorylation. (bvsalud.org)

Xanthine oxidase activity was 65% greater in the gastrocnemius muscle of aged mice compared to young mice. (cdc.gov)

Nevertheless, few in vivo studies on antidiabetic activities of these phenolics were conducted. (mdpi.com)

Main methods: Anticancer activity of the I. obliquus extract was examined in mouse models of Lewis lung carcinoma growth and spontaneous metastasis after 3 weeks of continuous extract intake at the dose of 6 mg/kg/day, which corresponded to that ingested daily with Chaga infusion in Japan. (researchgate.net)
Previous studies have shown that Sida pilosa aqueous extract (SpAE) has schistosomicidal, antioxidant, anti-inflammatory and anti-fibrotic activities in Schistosoma mansoni infection. (nih.gov)
The leaf extract of M. piperita showed strong radical scavenging activity in both the 1, 1 diphenyl-2-picryl hydrazyl radical (DPPH*) and 2, 2 azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS*+) assays. (unboundmedicine.com)
Our previous reports showed that crude extract prepared with 50% ethanol (ethanol crude extract, ECE) from Mongolian oak cups possessed excellent in vitro antioxidant capacities as well as inhibitory activities against α-glucosidase, α-amylase and protein glycation caused by its enrichment in phenolics, including mainly ellagic acid, kaempferol and their derivatives. (mdpi.com)
In addition, plasma iron was significantly reduced when compared with the baseline in the green tea extract group. (nutraingredients-usa.com)

Conclusion : Une exploration chirurgicale doit être réalisée en cas d'hématocèle ou de rupture de l'albuginée testiculaire à l'échographie. (bvsalud.org)

This is supported by reduced proliferation of human dermal papilla and predominantly epithelial keratinocytes after incubation with AICAR, the agonist for AMPK signaling which activates PPARGC1a and serves as co-activator of PPARγ. (nature.com)

In 2007 intrinsic peroxidase-like activity of ferromagnetic nanoparticles was reported by Yan Xiyun and coworkers as suggesting a wide range of applications in, for example, medicine and environmental chemistry, and the authors designed an immunoassay based on this property. (wikipedia.org)

Hypochlorite ion, an ROS derived from hydrogen peroxide by myeloperoxidase in neutrophils, has germicidal activity. (dojindo.com)

The effect of SpAE (4, 8, 16 and 32 mg/mL) on the ileum contractile activity was evaluated either in the absence or in the presence of pharmacological blockers. (nih.gov)
Loss of prM-cholesterol association has a bipartite effect reducing ZIKV entry and leading to assembly defects. (bvsalud.org)

The number of granulomas was reduced by 52.82% in the liver and 52.79% in the intestine, whereas the volume of hepatic granulomas decreased by 48.76% after SpAE treatment. (nih.gov)

There was dense lenticular opaciﬁcation in all of Group II, minimal opaciﬁcation in 33.3% of Group III, no opaciﬁcation in 66.7% of Group III, and no opaciﬁcation in Group I. Signiﬁcantly lower mean activities of lenticular antioxidant enzymes were noted in Group II, compared to Group I and III. (molvis.org)

Anatomy8

Organisms7

Diseases1

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes30

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care2

Glutathione reductase3

Lipid peroxidation8

Enzymes including superoxide2

Superoxide dismutase activity1

Identical subunits1

Enzyme activity3

Reactive5

Endogenous5

Malondialdehyde3

Antioxidants1

Significant4

H2O21

Remained unchanged1

Mutations4

Serum1

Reductase1

Levels9

Maximal1

Metabolism3

Intracellular1

Cells9

Metabolic1

Oxidative damage2

Reactions1

Rats2

Inhibition2

Increase2

Mitochondrial1

Prevalence3

Reduction1

Assay1

Toxicity1

Results7

20202

Resveratrol5

Cellular1

Polyphenolic compound1

Antioxidant activities1

Cell4

Effects2

Apoptotic1

Diabetes1

Concentrations1

Cardiac1

Gastrocnemius muscle1

Vivo studies1

Extract5

Conclusion1

Epithelial1

Nanoparticles1

Myeloperoxidase1

Effect2

Treatment1

Group1