Reduced cardiomyocyte proliferation. Medical search. Frequent questions

MiR-125 family members are involved in cell differentiation, proliferation and apoptosis as a result of targeting messenger RNAs related to these cellular processes. (wikipedia.org)
Here we show that changes in the composition of the extracellular matrix during this week can affect cardiomyocyte growth and differentiation in mice. (nature.com)
Remarkably, neural differentiation of P19 cells leads to dramatically reduced SRSF5 shuttling. (uni-frankfurt.de)
The impairment of proliferation, differentiation, and mineralization in osteoblast is the main pathophysiological mechanism of osteoporosis, which has been proven by previous studies ( 4 , 5 ). (frontiersin.org)
Potential systems of MSC-mediated safety from ischemic damage will be the differentiation of MSCs into cardiomyocytes, the excitement of cardiac stem cell proliferation, and/or cells that enhance vascularization [3]. (mycareerpeer.com)
EMSCs also have the high capacity proliferation, multidirectional differentiation that is indicative for the potentiality for tissue regeneration. (samploon.com)
Large body of data of experiment concludes that EMSCs have the ability to differentiation in multiple lineages such as osteoblast, cartilage, adipose, smooth muscle cell(1/18), hepatocytes, cardiomyocyte, neural cells. (samploon.com)
Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, and immune regulation. (techscience.com)
Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
In the heart, histone acetylation is a mediator of the transcriptional programs that underlie cardiomyocyte proliferation, differentiation, and cardiac remodeling in pathological hypertrophy. (fosterlab.org)
The kinase has a critical function in the activation from the RAS/RAF/MEK/ERK pathway, which participates in the legislation of cell proliferation, differentiation and success [25]. (rawveronica.com)
A well-established method of cardiomyocyte differentiation from PSCs provides an ideal source of cardiomyocytes and makes regenerative therapy for myocardial muscle damage a promising strategy. (biomedcentral.com)

For instance, high levels of miR-125b can protect cardiomyocytes from apoptosis and inflammation. (wikipedia.org)
While at the same time, overexpression of miR-125 can support cardiac fibrosis by enhancing proliferation of fibroblasts and reducing their apoptosis. (wikipedia.org)
AD is associated with abnormal proliferation, apoptosis and phenotype of VSMCs[ 4 ]. (ijpsonline.com)
It was demonstrated that NAE can inhibit the proliferation of irradiated transformed cells that are associated with the activation of apoptosis. (org.ua)
Researchers speculate that PEG-MGF may protect cardiac and skeletal muscle by preventing apoptosis and boosting the proliferation of cardiac stem cells. (com.pk)
Activin receptor-like kinase 7 silencing alleviates cardiomyocyte apoptosis, cardiac fibrosis, and dysfunction in diabetic rats. (nih.gov)
In cardiac conditional Ezh2-knockout mice, cardiomyocyte proliferation was repressed, and the apoptosis process was induced [ 10 ]. (hindawi.com)
These include higher overhead hemodynamic dysfunction associated with ventricular ischemia, remodeling with neurohumoral excessive stimulation, myocyte cycling abnormal calcium, an inadequate or excessive proliferation of the extracellular matrix, accelerated apoptosis and genetic mutations. (cardiologyresearchjournal.com)
Individual ether-a-go-go related-gene K+ stations (hERG) take part in the regulation of tumor cell proliferation and apoptosis. (rawveronica.com)
Because of the need for hERG stations in tumor cell proliferation and apoptosis and due to the fact B-RAF is normally up-regulated in tumor cells, we hypothesized that B-RAF may take part in the legislation of these stations. (rawveronica.com)
In cardiomyocytes, the actions of NO are more complex as it can induce different, and sometimes opposing effects on cardiac functioning such as triggering apoptosis and improving left ventricular function. (medscape.com)

Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration. (nih.gov)
Figure 4: Agrin promotes cardiomyocyte proliferation through Dag1, ERK and Yap signalling. (nature.com)

In vivo , a single administration of agrin promotes cardiac regeneration in adult mice after myocardial infarction, although the degree of cardiomyocyte proliferation observed in this model suggests that there are additional therapeutic mechanisms. (nature.com)
Figure 2: Agrin delays neonatal cardiomyocyte maturation and is required for P1 cardiac regeneration following surgical resection. (nature.com)
Here, we utilize in vivo biophysical and genetic fate mapping zebrafish studies to reveal that altered hemodynamic forces due to cardiac injury activate a sequential endocardial-myocardial signaling cascade to direct cardiomyocyte reprogramming and heart regeneration. (elifesciences.org)
Consequently, Klf2a then activates endocardial Notch signaling which results in the non-cell autonomous initiation of myocardial Erbb2 and BMP signaling to promote cardiomyocyte reprogramming and heart regeneration. (elifesciences.org)
Overall, these findings not only reveal how the heart senses and adaptively responds to environmental changes due to cardiac injury, but also provide insight into how flow-mediated mechanisms may regulate cardiomyocyte reprogramming and heart regeneration. (elifesciences.org)
This endocardial Notch signaling can in turn non-cell autonomously initiate myocardial Erbb2 and BMP signaling to promote cardiomyocyte reprogramming and heart regeneration, whereas its inhibition through either using tissue-specific genetic-based strategies or altering blood flow impairs this reparative event. (elifesciences.org)
CDMG treatment of amputated zebrafish hearts reduces nuclear β-catenin in injured heart tissue, increases cardiomyocyte (CM) proliferation, and expedites wound healing, thus accelerating cardiac muscle regeneration. (vanderbilt.edu)
Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration, highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. (vanderbilt.edu)
The regeneration of the zebrafish heart tissue is accomplished through immediate clotting of the injury site, activation of the three cardiac tissue types (epicardium, myocardium, and endocardium), neovascularization, redifferentiation, cardiomyocyte proliferation, ultimately fully replacing the scar tissue. (wheatoncollege.edu)
Make noticeable progress in pluripotent stem cell-derived cardiomyocyte maturity toward a more clinically relevant model for cardiac regeneration. (unl.pt)

Hypoxia regulates neonatal cardiomyocyte proliferation in a chamber-specific manner. (jci.org)

Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)
Angiogenesis starts from local destruction of the wall of preexisting blood vessel, activation of endothelial cell proliferation, and migration. (samploon.com)
Given its ability to transport important intra- and intercellular mediators such as cyclic nucleotides and eicosanoids, the physiological repertoire of MRP4 is thought to cover platelet aggregation, cell migration and proliferation, angiogenesis, and cardiomyocyte contraction. (solvobiotech.com)

Figure 5: Agrin promotes proliferation and attenuates maturation of human iPSC-CMs. (nature.com)
The effect of excess maternal testosterone exposure on fetal cardiomyocyte growth and maturation is unknown. (elsevierpure.com)
Pregnant ewes received biweekly injections of vehicle (control) or 100 mg testosterone propionate between 30 and 59 days of gestation (early T) or between 60 and 90 days of gestation (late T). Fetuses were delivered at ~135 days of gestation, and their hearts were enzymatically dissociated to measure cardiomyocyte growth (dimensional measurements), maturation (pro-portion binucleate), and proliferation (nuclear Ki-67 protein). (elsevierpure.com)
NEW & NOTEWORTHY Using measurements of cardiac myocyte growth and maturation in an ovine model of polycystic ovary syndrome, this study demonstrates that early gestation excess maternal testosterone exposure reduces near-term cardiomyocyte proliferation and maturation in intrauterine growth-restricted female and male fetuses. (elsevierpure.com)
Jonker, SS , Louey, S & Roselli, CE 2018, ' Cardiac myocyte proliferation and maturation near term is inhibited by early gestation maternal testosterone exposure ', American Journal of Physiology - Heart and Circulatory Physiology , vol. 315, no. 5, pp. (elsevierpure.com)
Define the signals that promote cardiomyocyte maturation by DAND5 modulation. (unl.pt)

In vitro , recombinant agrin promotes the division of cardiomyocytes that are derived from mouse and human induced pluripotent stem cells through a mechanism that involves the disassembly of the dystrophin-glycoprotein complex, and Yap- and ERK-mediated signalling. (nature.com)
Furthermore, we conduct a cross-species prediction of cardiomyocyte subtypes from in vitro-derived human induced pluripotent stem cells and unexpectedly uncover a predominance of left ventricular (LV) identity that we confirmed by an LV-specific TBX5 lineage tracing system. (stanford.edu)

We quantified CXCL10 in human CKD plasma and tested the response of human iPSC-derived cardiomyocytes and primary cardiac fibroblasts to serum from CKD donors. (biomedcentral.com)
In humans, we found increased plasma CXCL10 concentrations in advanced CKD, and identified the production of CXCL10 in cardiomyocytes and cardiac fibroblasts. (biomedcentral.com)

Determine the role of CCBE1 in myocardial growth and in CM proliferation in the compact layer, suggesting that Ccbe1 is required for proper myocardial compaction. (unl.pt)
The myocardial nicheplays a critical role in directing the function and fate of cardiomyocytes;therefore, engineering a biomimetic scaffold holds excellent promise.We produced an electroconductive cardiac patch of bacterial nanocellulose(BC) with polypyrrole nanoparticles (Ppy NPs) to mimic the naturalmyocardial microenvironment. (ibecbarcelona.eu)
Human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have shed great light on cardiac regenerative medicine and specifically myocardial repair in heart failure patients. (biomedcentral.com)
Myocardial infarction (MI), the most common heart disease, is characterized by a significant reduction in the number of functional cardiomyocytes and leads to the development of progressive heart failure. (biomedcentral.com)

By targeting transcripts of genes such as transcription factors, matrix-metalloproteinases, Bcl-2 family gene members, small GTPases, miR-125 dysregulation may lead to abnormal metabolism, proliferation, cell invasion and metastasis. (wikipedia.org)
Experimental evidence suggests that these factors may be causally related to CVD, but the direction of causality is difficult to determine, as a major confounder is their reduced renal clearance or metabolism with reduced kidney function. (biomedcentral.com)

8 nm).Ppy NPs effectively augment the conductivity, surface roughness, andthickness of BC composites despite reducing scaffolds' transparency.BC-Ppy composites were flexible (up to 10 mM Ppy), maintained theirintricate 3D extracellular matrix-like mesh structure in all Ppy concentrationstested, and displayed electrical conductivities in the range of nativecardiac tissue. (ibecbarcelona.eu)

They have the capacity for unlimited proliferation in vitro while maintaining the potential to differentiate into derivatives of the three germ layers. (biomedcentral.com)

Lower vertebrate and neonatal mammalian hearts exhibit the remarkable capacity to regenerate through the reprogramming of pre-existing cardiomyocytes. (elifesciences.org)
Unlike fish and amphibians, the mammalian cardiomyocytes do not normally regenerate themselves shortly after birth ( 2 ). (amegroups.org)

Indeed, MSCs ex vivo pre-conditioning by hypoxia, inflammatory stimulus, or other factors/conditions may stimulate their survival, proliferation, migration, exosome secretion, and pro-angiogenic and anti-inflammatory characteristics in vivo. (biomedcentral.com)

Here, we describe the development of a TBX5/MYL2 lineage tracing reporter system that allows for the identification of FHF- progenitors and their descendants including left ventricular cardiomyocytes. (stanford.edu)
We compared this data with existing murine and 3D cardiac organoid scRNA-seq data and confirmed the dominance of left ventricular cardiomyocytes (>90%) in our hiPSC-derived progeny. (stanford.edu)
Alveoli, pulmonary vessels, α -smooth muscle actin content in pulmonary arterioles, size of cardiomyocytes, right to left ventricular wall diameter ratio, and endothelin-1 plasma concentrations were assessed. (biomedcentral.com)
The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)

Cardiovascular function is considerably reduced due to pathologic insult after a heart attack. (com.pk)
This study underscores the potential of macitentan to reduce cardiovascular morbidity in preterm infants with chronic lung disease. (biomedcentral.com)
Our preliminary data indicate that reduced levels of DAND5 lead to increased cardiovascular progenitors' numbers and, in addition, extend their progenitor state for a longer period. (unl.pt)

In cultured cardiomyocytes, Lcn2 activated molecular hypertrophic pathways and increased cell size, but reduced proliferation and cell numbers. (edu.au)

The results demonstrated that trolox can resist aging, promote proliferation, and enhance PGE-2 secretion of MSCs without affecting their surface marker expression. (techscience.com)

Vascular endothelial cell (EC)-derived factors play an important role in endothelial-cardiomyocyte crosstalk and could save cardiomyocytes (CMs) from injury. (mdpi.com)
The purpose of this experiment was to use hyaluronic acid, silver nanoparticles, and a bacteriophage cocktail to create a hydrogel that promotes wound healing by increasing cell proliferation while simultaneously disrupting biofilm formation and breaking down Staphylococcus aureus and Pseudomonas aeruginosa, which are two strains of bacteria that attribute to nosocomial infections and are increasing in antibiotic resistance. (emerginginvestigators.org)
The purpose of our study was to determine if direct administration of CXCL1/KC to cardiomyocytes causes negative changes to cell density or proliferation. (emerginginvestigators.org)
Our question was whether these molecules directly impact cell density through an interaction with the cell proliferation process. (emerginginvestigators.org)
Nevertheless, the reduced retention price of MSCs after transplantation and their low propensity to differentiate right into a cardiac phenotype [4] make it improbable that cell alternative is the major mechanism of great benefit. (mycareerpeer.com)
We are now using the iPS cell technology after generating iPS cell lines for some of these patients and performing studies of patient specific disease modeling on the study of cardiomyocyte formation and most importantly, proliferation. (unl.pt)
and negative regulation of cell population proliferation. (nih.gov)
Treatment every day and night of B-RAF and hERG-expressing oocytes with B-RAF inhibitor PLX-4720 (10 M) considerably reduced hERG-mediated current and hERG cell surface area expression. (rawveronica.com)
Likewise, in rhabdomyosarcoma RD cells, treatment every day and night with B-RAF inhibitor PLX-4720 considerably reduced hERG cell membrane proteins great quantity and hERG-mediated current. (rawveronica.com)
The survival of grafted cardiomyocytes was confirmed by observing the fluorescent cell tracer Vybrant™ CM-DiI or expression of the enhanced green fluorescent protein (eGFP) in transplanted cells, or survival was demonstrated by polymerase chain reaction (PCR)-based detection of human mitochondrial DNA. (biomedcentral.com)
Cell labeling, tracking, and molecular biology techniques indicated that the grafted cardiomyocytes survived in the rat heart 1 month after iPSC-CM transplantation. (biomedcentral.com)

Perinatal hypoxia treatment in mice suppressed Wnt11 expression and induced myocyte proliferation more robustly in the right ventricle, modulating Rb1 protein activity. (jci.org)

Biochemicalanalyses revealed that H9c2 cells showed different cardiomyocyte phenotypesand distinct levels of maturity depending on the amount of Ppy inthe substrate used. (ibecbarcelona.eu)

It has been shown that NSE suspension and compNSE administered when cancer develops can reduce the level of urea in the blood plasma of mice. (org.ua)
Scientists hypothesized that the presentation of PEG-MGF resulted in significantly reduced cardiomyocyte damage in mice. (com.pk)
Studies have shown that caloric restriction in mice is cardioprotective and leads to diminished acetylation of mitochondrial proteins, which in turn, correlates with reduced ROS production from the electron transport chain. (fosterlab.org)

Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue, which are in part attributable to the β-catenin reduction. (vanderbilt.edu)
The scar tissue is inelastic and does not allow for efficient heart contractions thus reducing overall cardiac function. (wheatoncollege.edu)

It has been shown that early diagnosis and treatment reduce joint destruction, and improve survival [1]. (exposed-skin-care.net)

MiR-125 family is related to cardiomyocytes and the development of heart in embryonic period of mammals. (wikipedia.org)
The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. (nature.com)
Conclusions-Direct effects of LCN2 on cardiomyocyte size and number and the consistent associations in experimental and human analyses reveal a central role for LCN2 in the ontogeny of cardiac hypertrophy and heart failure. (edu.au)
Mortality is increased in patients with heart failure (HF) who have a reduced glomerular filtration rate (GFR). (cardiologyresearchjournal.com)
Heart regenerative therapy, such as transplantation of myocytes [ 4 ] and cardiomyocytes to replace lost cells, has become a new strategy for the treatment of heart failure caused by MI [ 5 ]. (biomedcentral.com)

The effect of antioxidant trolox on biological characteristics of MSCS, including aging, proliferation, and gene expression, was examined. (techscience.com)

SRSF5 depletion reduces and overexpression increases their cytoplasmic mRNA levels, suggesting that enhanced mRNA export by SRSF5 is required for the expression of pluripotency factors. (uni-frankfurt.de)
E ) Expression of proliferation marker Ki67 for LV or RV myocardium of WT neonatal mouse hearts in normoxic or hypoxic conditions (qRT-PCR). (jci.org)
ALK7 expression in prolactinoma is associated with reduced prolactin and increased proliferation. (nih.gov)

Damaged or stressed cells, cardiomyocytes, in particular, emit damage-associated molecular patterns (DAMPs) including HMGB1, S100 A8/A9, HSP70, and other molecules, unfolding paracrine mechanisms that induce an innate immune response. (highwire.org)

Wnt11 inactivation was sufficient to induce myocyte proliferation in perinatal mouse hearts and reduced Rb1 protein and phosphorylation in neonatal cardiomyocytes. (jci.org)

This molecule has been shown to reduce inflammation in certain instances. (emerginginvestigators.org)

Combining cytoprotector and antitumor drug on one drug delivery platform solves the fundamental problem of cancer chemotherapy: it reduces the effective dose of chemotherapy agent while cytoprotector NAE molecules protect normal cells from the side effects of the drug. (org.ua)

We used integrated systems genomic and functional biology analyses of the perinatal chamber specific transcriptome and we identified Wnt11 as a prominent regulator of chamber-specific proliferation. (jci.org)

Finally, downregulated Wnt11 in hypoxemic TOF infantile hearts was associated with Rb1 suppression and induction of proliferation markers. (jci.org)
These fetuses have small, immature hearts with reduced proliferation, which may reduce cardiac myocyte endowment and predispose to adverse cardiac growth in postnatal life. (elsevierpure.com)

Introduction Human being ether-a-go-go related-gene K+ stations, hERG (encoded from the KCNH2 gene) are indicated highly in the center and 1423058-85-8 manufacture donate to the repolarization of cardiomyocytes [1]C[4]. (rawveronica.com)

The decreased antioxidant activity of these enzymes and the reduced/oxidized glutathione (GSH/GSSG) ratio [ 6 ] lead to permanent high ROS levels at PND 45 [ 5 ]. (hindawi.com)
MRP4 has long been known to require reduced glutathione for the transport of bile acids [20], but the MRP4-mediated extrusion of other substrates such as halobenzoquinones may also depend on GSH, possibly via conjugate formation [21]. (solvobiotech.com)

We find that Cardiomogen acts as a Wnt inhibitor by targeting β-catenin and reducing Tcf/Lef-mediated transcription in cultured cells. (vanderbilt.edu)

We found that reduced kidney function resulted in the expansion of cardiac macrophages, in particular through local proliferation of resident populations. (biomedcentral.com)

Extracts inhibited oxidative stress and reduced activity of key enzymes involved in the pathogenesis of both diseases in neuroblastoma cells. (emerginginvestigators.org)

We verified an increase in the proliferation index of CMs by modulating DAND5 levels. (unl.pt)

The effect of testosterone is restricted to exposure during a specific period early in pregnancy, and the effects appear mediated through reduced insulin-like growth factor 1 signaling. (elsevierpure.com)

Studies suggest that the proliferation of osteoblasts, cells responsible for bone mineralization, may possibly be stimulated by PEG-MGF. (com.pk)
Osteoporosis is characterized by fragile bones, reduced bone mass, and bone microstructure deterioration ( 1 ). (frontiersin.org)

Anatomy34

Organisms14

Diseases21

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes62

Disciplines and Occupations1

Information Science3

Differentiation13

Apoptosis11

Promotes Cardiomyocyte Proliferation2

Regeneration10

Neonatal cardiomyocyte1

Angiogenesis3

Maturation6

Induced pluri2

Fibroblasts2

Myocardial4

Metabolism2

Extracellular matrix1

Vitro1

Regenerate2

Migration1

Ventricular4

Cardiovascular3

Pathways1

Secretion1

Cell11

Right ventricle1

Maturity1

Mice3

Scar tissue2

Survival1

Heart5

MSCs1

Expression3

Molecular1

Protein1

Inflammation1

Molecules1

Functional1

Hearts2

Human1

Glutathione2

Inhibitor1

Function1

Enzymes1

Levels1

Growth1

Bone2