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  • mice
  • The study, published today in the OnlineFirst version of the Journal of Parenteral and Enteral Nutrition ( JPEN ), the research journal of the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), used a mice model to compare the effects of GLN on hind limb ischemia reperfusion (IR) injury. (nutritioncare.org)
  • The study subjected three groups of mice to 90 minutes of ischemia followed by a variable period of reperfusion. (nutritioncare.org)
  • Because H₂ is reported to eliminate peroxynitrite, it was expected to reduce the adverse effects of NO. In mice, left anterior descending coronary artery ligation for 60 min followed by reperfusion was performed with inhaled NO [80 parts per million (ppm)], H₂ (2%), or NO + H₂, starting 5 min before reperfusion for 35 min. (nih.gov)
  • At the end of 8-week exercise training, mice underwent 30-min left anterior descending coronary artery occlusion followed by 60-min or 24-h reperfusion. (iupui.edu)
  • Here, we investigated this possibility in mice by studying the role of conventional DCs (cDCs) in liver ischemia/reperfusion (I/R) injury, a model of sterile inflammation. (jci.org)
  • Anticancer agent 2-methoxyestradiol improves survival in septic mice by reducing the production of cytokines and nitric oxide," Shock , vol. 36, no. 5, pp. 510-516, 2011. (hindawi.com)
  • We used male wild-type (WT) and heterozygous HKII knockout mice (HKII(+/-)) and performed in vivo unilateral skeletal muscle I/R, executed by 90 min hindlimb occlusion using orthodontic rubber bands followed by 1 h, 1 day, or 14 days reperfusion. (nih.gov)
  • At 1 day reperfusion, the model resulted in 36% initial cell necrosis in WT gastrocnemius medialis (GM) muscle that was doubled (76% cell necrosis) in the HKII(+/-) mice. (nih.gov)
  • In conclusion, reduced muscle HKII protein content results in impaired muscle functionality during recovery from I/R. The impaired recovery seems to be mainly a result of a greater susceptibility of HKII(+/-) mice to the initial I/R-induced necrosis (not apoptosis), and not a HKII-related deficiency in muscle regeneration. (nih.gov)
  • In mice, SMM-295 was immediately administered upon reperfusion of the kidneys following the ischemia episode. (aspetjournals.org)
  • Importantly, Irb-NP was effective to reduce IR injury even in AT1-deficient mice. (medpdffinder.com)
  • Inhibitor
  • molecular weight 526.60), a specific chymase inhibitor (CM), on a clinically relevant swine model of AMI-R. A 60-min ischemia followed by a 120-min reperfusion was chosen to assess an early effect of chymase inhibition (it is the shorter time point where necrosis can be determined with accuracy and reproducibility) and to allow comparison with previous experiments performed by our group. (aspetjournals.org)
  • cardiomyocytes
  • Madecassoside (MA), one of the principle terpenoids in Centella asiatica , has shown protect effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in our previous studies. (go.jp)
  • Intervention
  • This exercise-induced cardioprotective mechanism may provide a potential therapeutic intervention targeting VSMC sarc-K(ATP) channels and reperfusion recovery. (iupui.edu)
  • cardiac
  • Cardiac conditioning: a review of evolving strategies to reduce ischaemia-reperfusion injury. (ox.ac.uk)
  • 3. The method of claim 2, wherein the condition or procedure is selected from the group consisting of retinal ischemia-induced eye injury, age-related macular degeneration, sleep apnea, diabetes, transient ischemic attack, cardiovascular surgery, cardiac arrest, and a combination thereof. (sumobrain.com)
  • Metabolic parameters, echocardiography, heart rate variability and then cardiac I/R protocol involving 30-min coronary artery ligation, followed by 120-min reperfusion, were performed. (bioscientifica.com)
  • model
  • Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1 α and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model," Journal of Neurochemistry , vol. 102, no. 6, pp. 1831-1841, 2007. (hindawi.com)
  • The aim of the present study was to show the effects of ozone in ischemia reperfusion model in intestine. (hindawi.com)
  • findings
  • These findings indicate that probucol can protect testicular spermatogenesis by reducing overgeneration of reactive oxygen species by inhibiting E-selectin protein expression and neutrophil accumulation in the testis. (hindawi.com)
  • damage
  • Brain-specific knock-out of hypoxia-inducible factor-1 α reduces rather than increases hypoxic-ischemic damage," Journal of Neuroscience , vol. 25, no. 16, pp. 4099-4107, 2005. (hindawi.com)
  • These results show the beneficial effects of the antioxidative and anti-inflammatory drugs and those that prevent calcium canals before or after reperfusion in impeding the I/R damage and its comploications. (ivsajournals.com)
  • Intestinal ischemia-reperfusion injury is associated with mucosal damage and has a high rate of mortality. (hindawi.com)
  • decreases
  • Peri-operative administration of taurolidine decreases inflammatory response to cardiopulmonary bypass (CPB) and attenuates ischaemia-reperfusion (I-R) injury. (isrctn.com)
  • The probucol-treated group showed significant decreases in E-selectin protein expression, myeloperoxidase activity, and malondialdehyde level and significant increase in testicular spermatogenesis in the ipsilateral testes, compared with the ischemia-reperfusion group. (hindawi.com)
  • receptor
  • In HEK-293 cells, SMM-295 was capable of reducing cAMP production with a 66-fold selectivity for the CB2 versus the cannabinoid receptor 1 (CB1), and dose-dependently increased MAPK and Akt phosphorylation. (aspetjournals.org)
  • Here we hypothesized that nanoparticle-mediated delivery of irbesartan, an angiotensin receptor blocker that possesses a partial agonistic effect on peroxisome reperfusion ameliorates IR injury - . (medpdffinder.com)
  • group
  • E-selectin protein expression, myeloperoxidase activity, and malondialdehyde level were significantly increased, and testicular spermatogenesis was significantly decreased in the ipsilateral testes in the ischemia-reperfusion group, compared with the control group. (hindawi.com)
  • 1. A method of protecting against ischemia-reperfusion injury in a subject in need thereof, said method comprising administering a neuroprotective compound to the subject, wherein the subject is selected from the group consisting of a non-glaucomatous subject and a glaucomatous subject not using a neuroprotective compound. (sumobrain.com)