• BACKGROUND: Mild hypothermia, 32-35°C, reduces infarct size in experimental studies, potentially mediating reperfusion injuries, but human trials have been ambiguous. (lu.se)
  • Analysis of covariance at 24 hours indicated that hypothermia has cardioprotective properties incremental to reducing infarct size, such as higher external power (p=0.061) and lower arterial elastance (p=0.015). (lu.se)
  • This hypothesis-generating study suggests hypothermia to have cardioprotective properties, incremental to reducing infarct size. (lu.se)
  • The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. (uni-wuerzburg.de)
  • Aromatase metabolizes testosterone to 17b- estradiol (E2) and thereby significantly contributes The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. (uni-wuerzburg.de)
  • Anastrozole blocked DES induced preconditioning and increased infarct size compared to DES alone (37.94615.5% vs. 17.163.62%) without affecting area at risk and systemic hemodynamic parameters following ischemia/reperfusion. (uni-wuerzburg.de)
  • 2 Paradoxically, reperfusion itself can enlarge the infarct size, by complex mechanisms collectively termed ischemia/reperfusion injury. (dovepress.com)
  • 3 In 2003, Zhao and et all published experimental data demonstrating a considerable reduction of infarct size by a reperfusion procedure termed ischemic postconditioning (IPost), consisting of brief, repetitive cycles of reperfusion and reocclusion, followed by sustained reperfusion. (dovepress.com)
  • 4 An infarct-reducing effect of IPost was confirmed in several animal models, 3 and subsequently, in small-sized "proof of concept" clinical studies, reduction of infarct size by IPost was reported. (dovepress.com)
  • Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
  • Interestingly, however, the HFD did not reduce infarct size in Epac1−/− deficient mice hearts (Epac1−/− HFD 65.1 ± 5.1% vs. Epac1−/− ND 56.1 ± 3.5%, ns. (uib.no)
  • Although intralipid inhibits the opening of the mitochondrial permeability transition pore as efficiently as cyclosporine-A, intralipid is more effective in reducing the infarct size and improving the cardiac functional recovery. (silverchair.com)
  • Short series of repetitive cycles of brief reperfusion and re-occlusion of the coronary artery applied at the onset of reperfusion, reduce the infarct size and coronary artery endothelial dysfunction. (eurekaselect.com)
  • In animal models of hepatic ischemia-reperfusion injury, use of octreotide resulted in a possible protective effect. (ectrx.org)
  • It has also been reported that triiodothyronine (T3) alleviates oxidative stress, inflammation and apoptosis caused by hepatic ischemia-reperfusion injury, and its mechanism of action is associated with negative regulation of the NLRP3 signaling pathway ( 10 ). (spandidos-publications.com)
  • We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental autoimmune uveoretinitis (EAU) in rats. (nature.com)
  • It has also been shown to be protective against IR injury in rats. (unifesp.br)
  • Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. (biomedcentral.com)
  • The rats were fed by gavage immediately after reperfusion. (biomedcentral.com)
  • The abundance and diversity of the intestinal flora in rats decreased after cerebral ischaemia - reperfusion injury (CIRI). (biomedcentral.com)
  • Methods The ischemia-reperfusion model in anesthetized rats was established using hemorrhage and a 3-hour tourniquet application. (bmj.com)
  • The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats. (medscape.com)
  • We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
  • F Park "Selective cannabinoid 2 receptor stimulation reduces tubular epithelial cell damage following renal ischemia-reperfusion injury," accepted to Journal of Pharmacology and Experimental Therapeutics (11/2017). (winterschool.cc)
  • 2. The transition from acute kidney injury (AKI) through to chronic kidney disease. (ed.ac.uk)
  • Acute kidney injury and early allograft dysfunction are 2 common complications after liver transplant. (ectrx.org)
  • Cell-Free Hemoglobin in Acute Kidney Injury after Lung Transplantation and Experimental Renal Ischemia/Reperfusion. (stanford.edu)
  • Lung transplantation (LuTx) is a clinical condition with a high incidence of acute kidney injury (AKI). (stanford.edu)
  • Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
  • Acute kidney injury following cardiac surgery is a serious complication. (medscape.com)
  • Dexmedetomidine prevents acute kidney injury after adult cardiac surgery: a meta-analysis of randomized controlled trials. (medscape.com)
  • To elucidate the cardioprotective mechanisms of mild hypothermia, we analyzed cardiac performance in a porcine model of ischemia/reperfusion, with serial cardiovascular magnetic resonance (CMR) imaging throughout one week using non-invasive pressure-volume loops. (lu.se)
  • Our goals are to identify cardiovascular risk early in patients with CKD and, through to investigate novel therapies that might reduce this risk and so improve longer-term patient outcomes. (ed.ac.uk)
  • Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H 2 S) have been reported previously. (hindawi.com)
  • We perform pre-clinical and experimental medicine studies as well as investigating cardiovascular risk at a population level. (ed.ac.uk)
  • Using mouse models of ischaemia-reperfusion injury, we are investigating the cardiovascular and renal sequelae of AKI and examining new experimental medicine strategies to reduce the risks of developing these. (ed.ac.uk)
  • We are examining if short- and long-term ET receptor blockade will reduce cardiovascular risk in optimally managed patients with AAV. (ed.ac.uk)
  • The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)
  • The problem arises when, as we age, the proper supply of nutrients to our body decreases, making us vulnerable to cognitive decline, reduced mobility, impaired metabolic control, declining cardiovascular performance, and increased susceptibility to cancer. (phytocurexl.com)
  • Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
  • For example, introducing a 2-methoxyethoxy group onto one of the benzene rings gave DMX-5804, a compound with a significantly greater water solubility and a reduced metabolic clearance. (domainex.co.uk)
  • ZO-1 expression is significantly reduced in many breast cancer lines. (thermofisher.com)
  • Moreover, CFH levels inversely correlated with haptoglobin levels, which were significantly reduced at the end of surgery in LuTx patients with AKI. (stanford.edu)
  • At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. (biomedcentral.com)
  • The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury. (biomedcentral.com)
  • Importantly, VSIG4 is significantly reduced after myocardial ischemia-reperfusion injury in patients undergoing coronary artery bypass grafting [ 11 ]. (thno.org)
  • Results: All groups fed a HFD presented with significantly enhanced body weight, visceral fat content and reduced glucose clearance compared to corresponding ND groups. (uib.no)
  • From the point of view of "self-medication" or "preventive medicine," Cordyceps sinensis was used in the prevention of cerebral ischemia in this paper. (biomedcentral.com)
  • These experimental results suggest that complement Cordyceps sinensis extract is protective after cerebral ischemia in specific way. (biomedcentral.com)
  • The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis. (biomedcentral.com)
  • Recently, from the point of view of "self-medication" or "preventive medicine," several dietary supplements are used in the prevention of life-style related diseases including cerebral ischemia. (biomedcentral.com)
  • Moreover, some devices may selectively cool the brain primarily with less effect on core body temperature and thus more rapidly protect cerebral cells from ischemia/reperfusion injury. (medscape.com)
  • The model used in this study was established by middle cerebral artery occlusion (MCAO) and reperfusion. (biomedcentral.com)
  • According to the World Health Organization, cerebral ischaemia is the second leading cause of death and the third leading cause of disability in the world [ 1 ]. (biomedcentral.com)
  • Cerebral ischaemia is caused by middle cerebral artery occlusion, which leads to some brain tissue damage, accompanied by inflammation and immune response [ 2 ]. (biomedcentral.com)
  • According to the theory of TCM, cerebral ischaemia, which is also called stroke, can be induced by hyperactivity of liver Yang, disordered diet, stagnation of blood, etc. (biomedcentral.com)
  • Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
  • Retinal I/R injury is associated with pathological increases in reactive oxygen species and inflammation, resulting in retinal neuronal cell death. (mdpi.com)
  • We further discuss how injuries alter tissue environments and how this primes mononuclear phagocytes to enforce this particular environment, for example, to support host defense and pathogen clearance, to support the resolution of inflammation, to support epithelial and mesenchymal healing, and to support the resolution of fibrosis to the smallest possible scar. (hindawi.com)
  • Exogenous administration of CFH after reperfusion caused overt AKI with creatinine increase, tubular injury, and enhanced markers of renal inflammation compared with vehicle-treated animals. (stanford.edu)
  • The cascade of events leading to neuronal injury and death in ischemia includes the release of cytokines and free radicals, and induction of inflammation, apoptosis, and excitotoxicity [ 1 ]. (biomedcentral.com)
  • These results provide evidence that reactive oxygen metabolites play an important role in the regulation of IL-8 production and suggest that reduction of IL-8 release may contribute to the beneficial effects of antioxidants in experimental models of inflammation and ischemia/reperfusion injury. (jci.org)
  • 11 However, doctors in Germany have used lipoic acid for more than a decade to reduce pain and inflammation in those suffering from diabetic peripheral neuropathy. (lifeextension.com)
  • It is believed to have antioxidant effects and may help reduce oxidative stress associated with the aging process. (phytocurexl.com)
  • Aortic cross-clamping is a typical example of ischemia/reperfusion injury-related oxidative stress, and therefore we investigated whether this melon extract/gliadin would also reduce DNA damage after aortic cross-clamping and reperfusion. (glisodin.org)
  • Pre-treatment with the oral melon extract/gliadin may be a therapeutic option to reduce oxidative cell injury affiliated with aortic cross-clamping. (glisodin.org)
  • Trans-resveratrol is a polyphenol with great antioxidant action that reduces the oxidative stress. (bvsalud.org)
  • Because multiple other factors can contribute to AKI development in the complex clinical setting of LuTx, we next investigated the role of exogenous CFH administration in a mouse model of mild bilateral renal ischemia reperfusion injury (IRI). (stanford.edu)
  • the immunosuppressive properties of FTY720 have been shown in clinical and experimental situations. (unifesp.br)
  • 16-20 In a recent placebo-controlled clinical trial, researchers found that after only 6 months of lipoic acid supplementation, patients with type II diabetes had reduced fasting blood glucose and lowered levels of oxidized lipids. (lifeextension.com)
  • However, clinical and preclinical results using various cardioprotective strategies to attenuate reperfusion injury have generally not been applicable for every day clinical practice. (eurekaselect.com)
  • Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial. (medscape.com)
  • Intravenous dexmedetomidine pre-medication reduces the required minimum alveolar concentration of sevoflurane for smooth tracheal extubation in anesthetized children: a randomized clinical trial. (medscape.com)
  • METHODS AND RESULTS: Normothermia and Hypothermia groups sessions (n=7+7 pigs, nonrandom allocation) were imaged with CMR at baseline and subjected to 40 minutes of normothermic ischemia by catheter intervention. (lu.se)
  • Thereafter, the Hypothermia group was rapidly cooled (mean 34.5°C) for 5 minutes before reperfusion. (lu.se)
  • CONCLUSION: Using non-invasive pressure-volume loops by CMR, we observed that mild hypothermia at reperfusion alleviates the heart's work after ischemia/reperfusion injuries during the first week and preserves short-term cardiac performance. (lu.se)
  • The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
  • Glucose-insulin-potassium (GIK) has been advocated in the setting of acute coronary syndrome (ACS) to reduce ischemia-related arrhythmias and myocardial injury. (biomedcentral.com)
  • Ischemia-reperfusion (IR) injury is a common early feature that contributes to graft damage by impairing resident cell function. (unifesp.br)
  • Glucose-insulin-potassium (GIK) has long been advocated as an adjunctive treatment for patients with cardiac dysfunction during episodes of ischemia and reperfusion. (biomedcentral.com)
  • In other areas of transplantation research, we have an experimental article on preclinical allogeneic nerve transplantation, and a survey-based study on developing a tool-set for maximizing proper patient access to organ transplantation programs. (tts.org)
  • The aim of the current study is to determine the efficacy of DHOPE in reducing the incidence of NAS after DCD liver transplantation. (amsterdamumc.org)
  • Whether reduced IRI of the bile ducts leads to lower incidence of NAS after DCD liver transplantation can only be examined in a randomized controlled trial. (amsterdamumc.org)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • The transplantation of a "foreign" organ, despite meticulous matching for donor-recipient compatibility, leads to a complex adaptive and innate immune system-mediated injury. (medscape.com)
  • Although aimed at protecting the host from infection, in the context of transplantation, this injury leads to allograft rejection. (medscape.com)
  • In a spinal trauma model, PEA reduced the resulting neurological deficit via the reduction of mast cell infiltration and activation. (wikipedia.org)
  • It has been shown to reduce mortality from stroke and to mitigate the harmful effects of stroke on the brain itself. (phytocurexl.com)
  • This study was designed to investigate the ability of VPA to mitigate ischemia-reperfusion injury produced by prolonged tourniquet application to an extremity. (bmj.com)
  • Our previous results showed that IR injury impaired renal function, by causing extensive tubular necrosis and increasing MHC class II and ICAM-1 molecule expression by mesangial cells (MC). (unifesp.br)
  • At a concentration of 1% (vol/vol), DMSO blocked IL-8 release by approximately 90% in the presence of 1 microgram/ml LPS at a 24-h time point, but did not affect cell viability or reduce the production of tumor necrosis factor (TNF), interleukin 6, or interleukin-1 beta (IL-1 beta). (jci.org)
  • Results We found that VPA sustained Protein kinase B (Akt) phosphorylation and Insulin-like growth factor signaling and modulated the systemic release of interleukin (IL)-1β, tumor necrosis factor alpha, and IL-6 after 2 hours of limb reperfusion. (bmj.com)
  • Necrotizing enterocolitis (NEC), which typically occurs in the second to third week of life in premature, formula-fed infants, is characterized by variable damage to the intestinal tract, ranging from mucosal injury to full-thickness necrosis and perforation (see the image below). (medscape.com)
  • Deletion of p66Shc has been shown to reduce I/R injury as well as vascular abnormalities associated with diabetes and ageing. (nih.gov)
  • Casualty demographics compiled under the Joint Theater Trauma System describe a fivefold increase in vascular injury during the Iraq and Afghanistan wars when compared with previous conflicts. (bmj.com)
  • 3 hours after the onset of symptoms reduce mortality or cardiac arrest. (biomedcentral.com)
  • Although the mechanism remains elusive, the interest in exploring the therapeutic potential of MSC-Exo has greatly increased after the first report of MSC-Exo ameliorating myocardial ischemia/reperfusion injury in a mouse model 10 . (nature.com)
  • VPA as a therapeutic for focal ischemia associated with prolonged tourniquet application was investigated in this study. (bmj.com)
  • The VSIG4-Fc fusion protein protects against the development of experimental autoimmune arthritis, uveoretinitis, and hepatitis [ 10 ]. (thno.org)
  • Studies in experimental animals show that ReLifeCure®, given before or after an induced stroke, protects brain cells from the so-called ischemia-reperfusion injury that occurs. (phytocurexl.com)
  • ReLifeCure® also protects the heart muscle from ischemia (inadequate blood flow), which can ultimately lead to a heart attack. (phytocurexl.com)
  • We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. (silverchair.com)
  • Mean arterial pressure remained stable in Normothermic animals (-3%, p=0.77) but dropped two hours post-reperfusion in hypothermic animals (-18%, p=0.007). (lu.se)
  • Experimental studies have shown that dual hypothermic oxygenated machine perfusion (DHOPE) is associated with less IRI, improved hepatocellular function, and better preserved mitochondrial and endothelial function compared to conventional static cold storage (SCS). (amsterdamumc.org)
  • Ischemia-reperfusion injury (IRI) is a syndrome affecting the myocardium upon blood flow restoration following a sufficiently long interruption, such as encountered in a coronary thrombosis or heart surgery [1,2]. (justia.com)
  • This study explores if long-term feeding of an obesogenic high fat diet renders the myocardium less susceptible to ischemic-reperfusion induced injury via Epac-dependent signaling. (uib.no)
  • Protection of the ischemic myocardium is known to occur as a result of ischemic preconditioning (PC), in which repetitive brief periods of ischemia protect the heart from a subsequent prolong ischemic insult. (eurekaselect.com)
  • Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
  • If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)
  • Conclusions Our results demonstrate that VPA sustains early prosurvival cell signaling, reduces the inflammatory response, and improves renal function in a hemorrhage with prolonged ischemia and reperfusion model. (bmj.com)
  • Intravenous administration of FTY720 (1 mg/kg) immediately before IR induction did not improve the short-term (24 hours) outcome of renal function or reduced MHC class II and ICAM-1 surface molecule expression. (unifesp.br)
  • Furthermore, Lycium barbarum has been reported to inhibit the NLRP3 inflammasome signaling pathway, thereby reducing alcohol-induced liver cell damage ( 11 ). (spandidos-publications.com)
  • Ischemia-reperfusion injury was evaluated by investigating pathway signaling, immune modulation of cytokine release, remote organ injury, and skeletal muscle function during convalescence. (bmj.com)
  • In conclusion, CFH is a possible factor contributing to postoperative AKI after LuTx and promotes AKI in an experimental model of mild transient renal ischemia. (stanford.edu)
  • However, p66Shc-induced ROS formation is also involved in insulin signalling and might contribute to self-endogenous defenses against mild I/R injury. (nih.gov)
  • An important role of this protein was also demonstrated in different experimental studies on heart damage. (springer.com)
  • The invention pertains to a polypeptide for the protection against heart ischemia-reperfusion injury. (justia.com)
  • The phenomenon may be modelled in an experimental setting, in this case on an isolated rat heart. (justia.com)
  • One object of the present invention is to provide a therapy of heart ischemia-reperfusion injury by applying GLP-1 analogues which can be administered as single component and avoiding administration of the drug with a second compound. (justia.com)
  • Postconditioning using N-Ac-GLP-1(7-34)amide N-terminally blocked and C-terminally truncated results in a limitation of ischemia-reperfusion injury in an isolated rat heart. (justia.com)
  • The mitochondrial permeability transition pore is a recognized drug target for neurodegenerative conditions such as multiple sclerosis and for ischemia-reperfusion injury in the brain and heart. (rcsb.org)
  • Here, we review the information linking the adaptor protein p66Shc with cardiac injury induced by ischaemia and reperfusion (I/R), including the contribution of risk factors, such as metabolic syndrome and ageing. (nih.gov)
  • Protein modeling is also important to carry out, including effective use of experimental structural information. (winterschool.cc)
  • Intralipid was as efficient as cyclosporine-A in inhibiting the mitochondrial permeability transition pore opening (calcium retention capacity = 280 ± 8.2 vs. 260.3 ± 2.9 nmol/mg mitochondria protein in cyclosporine-A, P = 0.454, n = 6) and in reducing cardiac mitochondrial superoxide production. (silverchair.com)
  • In an experimental autoimmune encephalomyelitis disease model of neurodegeneration in multiple sclerosis, JW47 demonstrated significant protection of axons and improved motor assessments with minimal immunosuppression. (rcsb.org)
  • Recent data suggested that initiating TH during CPR, before the reperfusion phase, would provide additional beneficial effects against post-anoxic brain injury. (medscape.com)
  • Several other promising scientific studies now show that lipoic acid has a beneficial effect on a number of the factors involved in metabolic syndrome: it reduces triglyceride levels, lowers cholesterol, improves fasting plasma glucose, and causes weight loss in rodent models of obesity. (lifeextension.com)
  • PEA in this model also reduced the activation of microglia and astrocytes. (wikipedia.org)
  • Here we use a mouse model of ischaemia-reperfusion injury to investigate new experimental medicine strategies to reduce the risk of developing CKD after AKI. (ed.ac.uk)
  • We conclude that desflurane efficiently regulates aromatase expression and activity which might lead to increased local estrogen synthesis and thus preserve cellular integrity and reduce cardiac damage in an acute myocardial infarction model. (uni-wuerzburg.de)
  • These results suggest a protective role of FTY720 in an IR injury model. (unifesp.br)
  • More studies are required to identify the mechanisms involved in the protective activity of FTY720 in the IR injury model. (unifesp.br)
  • [ 21 ] Finally, in a model of prolonged CA, trans-nasal evaporative cooling (TNEC) initiated during CPR improved the success of resuscitation compared with IATH induced by cold fluids and reduced the duration of CPR. (medscape.com)
  • To reduce the frequency of this outcome, continuing improvements in the efficacy of antirejection drugs are a top priority to enhance the long-term survival of transplant recipients. (uthscsa.edu)
  • This study was undertaken to determine the influences of various doses of peppermint oil on the hepatic en-zymes, alanine transaminase, apartate tranaminase, alkaline phosphotase and gamma glutamyl transferase and the level of malondialdehyde in the serum of mice with and without immobility stress. (openbiochemistryjournal.com)
  • Six experimental groups were included: (1) control wt ND (wt ND), (2) control wt HFD (wt HFD), (3) Epac1−/− mice on ND (Epac1−/− ND), (4) Epac1−/− mice on HFD (Epac1−/− HFD), (5) Epac2−/− mice on ND (Epac2−/− ND), and (6) Epac2−/− mice on HFD (Epac2−/− HFD). (uib.no)
  • Isolated ex vivo mice hearts were perfused in a constant pressure Langendorff mode, and exposed to 30min of global ischemia (GI) and 60min of reperfusion. (uib.no)
  • The aim of the present study was to investigate the effect and mechanism of triiodothyronine (T3) on alcoholic liver disease (ALD)‑induced injuries in mice. (spandidos-publications.com)
  • Thus, we hypothesize that Cordyceps sinensis possess protective effect of against ischemia-induced brain infarction by modulating 17β-estradiol production. (biomedcentral.com)
  • Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
  • In vivo rat hearts or isolated Langendorff-perfused mouse hearts were subjected to ischemia followed by reperfusion with intralipid (0.5%, 1% and 2% ex-vivo, and 20% in vivo), cyclosporine-A (0.2 μM, 0.8 μM, and 1.5 μM ex- vivo and 10 mg/kg in vivo), or vehicle. (silverchair.com)
  • X-ray analysis was used to validate the design concept, and biological evaluation revealed selective cellular inhibition of CypD and the permeability transition pore with reduced cellular toxicity compared with cyclosporine. (rcsb.org)
  • Over the last three decades, a large body of experimental research has accumulated aiming to elucidate the pathophysiology of IRI, with a major focus on cardiomyocyte death and approaches to its limitation. (justia.com)
  • This study showed that octreotide infusion in the first 3 days after liver transplant could improve renal and allograft function and reduce infection and length of hospital stay. (ectrx.org)
  • Alcoholic liver disease (ALD), characterized by liver metabolic disorder, is an acute, chronic liver injury caused by long-term heavy drinking ( 1 ). (spandidos-publications.com)
  • The National Institute for Occupational Safety and Health, USA, stated that reference blood lead levels for adults should be ≥5 μ g/dL [ 11 ] and lead-induced hypertension has been shown in experimental animals with low blood lead levels (9-37 μ g/dL) [ 9 , 12 - 14 ]. (hindawi.com)
  • 8,9 Amputation is sometimes the only way to end the rampant infections and ulcers that accompany reduced blood flow to the lower limbs caused by neuropathy. (lifeextension.com)
  • Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)