PeroxidationProteinsReactiveOxidative damageHydrogen peroxide and lipidH2O2HomeostasisRegulating redox balanceAntioxidantsHydroperoxidesRegulationAnti-oxidantMitochondrialGlutathione reductaseMetabolismOxidationSignalingProteinEnzymesPeroxidasesGpx1HydroxylBiologicalLiverGenesIonsNitricElectron donorSubstratesSubstancesRegulatoryBiologyEnzymeHarmfulLevelsMechanismAcidActivityPreventPotential
Peroxidation12
- The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
- 2006 ). The major role of antioxidants is to reduce the free radicals and prevent the lipid peroxidation that protects cells from ROS (Nanari et al. (springeropen.com)
- AFB 1 induces lipid peroxidation in rat liver, and this may be an underlying mechanism of carcinogenesis [ 7 ]. (hindawi.com)
- This ultimately results in membrane damage, fragmentation, or random cross-linking of molecules like DNA, enzymes, and structural proteins and even lead to cell death induced by DNA fragmentation, lipid peroxidation and finally to cancer formation [ 15 ]. (hindawi.com)
- Here, we investigated the effect of pretreatment with exogenous melatonin on the net photosynthetic rate, the maximum photochemical efficiency of PSII, chlorophyll content, lipid peroxidation, reactive oxygen species (ROS) accumulation, antioxidant potential, and redox homeostasis in leaves of tea plants following cold stress. (mdpi.com)
- The tibialis anterior muscle (TA) was removed and assayed for biomarkers of oxidative stress that included: the ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), which is a measure of redox status, malondialdehyde (MDA) which is a biomarker for lipid peroxidation, 8hydroxy-2'-deoxyguanosine (8-OHdG), which is a marker of oxidative damage to DNA, catalase concentration, and cytosolic hydrogen peroxide (H2O2) levels. (cdc.gov)
- Biomarkers of oxidative damage (DNA single-strand breaks, lipid peroxidation and free radical metabolism) and inflammation were determined using conventional biochemistry techniques. (biomedcentral.com)
- The aim of this study was to clarify whether phytic acid possesses the ability to inhibit autooxidation and Fe(II)/ascorbate-induced peroxidation of linoleic acid, to scavenge of hydrogen peroxide, and chelate ferrous ions. (edu.pl)
- The eff ect of IP6 (1-500 μM) on autooxidation and Fe(II)/ascorbate-induced lipid peroxidation in micelles of linoleic acid after 24 h incubation was investigated using a reverse-phase high-performance liquid chromatography (RP-HPLC) with UV detection. (edu.pl)
- The inhibitory effect of IP6 on Fe(II)/ascorbate-induced lipid peroxidation was lower due to its direct interaction with Fe(II) ions. (edu.pl)
- Comporti M. Lipid peroxidation and biogenic aldehydes: from the identifi cation of 4-hydroxynonenal to further achievements in biopathology. (edu.pl)
- The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)
Proteins6
- Recent evidence suggests selenoprotein W and the six other small thioredoxin-like mammalian selenoproteins may serve to transduce hydrogen peroxide signals into regulatory disulfide bonds in specific target proteins. (usda.gov)
- 1992). These oxygen free radicals can modify DNA, proteins and membrane lipids, leading to cellular degeneration (Olanow, 1992). (scialert.net)
- Free radicals can cause damage in structural and metabolic components like lipids, proteins, enzymes, carbohydrates and DNA in cells and tissues. (hindawi.com)
- Through these mechanisms, GSH helps to prevent oxidative damage to proteins, lipids, and DNA in neurons, which can lead to cell death. (cellg8.com)
- Since ROS and RNS have been a highly reactive molecule it will cause some alteration to vital biological proteins, carbohydrates, DNA, lipids and other molecules, further prelude to physiological dysfunction of cells and pathologic condition like diabetes, heart diseases and cancer. (ijpsr.com)
- 49 Reactive oxygen species can induce oxidative damage to DNA, 50 proteins, 51 and lipids. (herbnerdnz.com)
Reactive9
- The most abundant selenoproteins in mammals are the glutathione peroxidases (5-6 genes) that reduce hydrogen peroxide and lipid hydroperoxides at the expense of glutathione and serve to limit the strength and duration of reactive oxygen signals. (usda.gov)
- Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
- In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
- It has the ability to prevent damage from reactive oxygen species (ROS), free radicals, peroxides, lipid peroxides and heavy metals to cells. (upgradedformulas.com)
- and hydrogen peroxide (http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2448)] and secondary ROS comprising reactive metabolites formed by subsequent reactions of these primary ROS [e.g. with http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2509 to form peroxynitrite (ONOO? (ees2010prague.org)
- 48 Cr, Ni, Co and Ti are redox metals and can generate reactive oxygen species, such as the superoxide radical (O2. (herbnerdnz.com)
- Addition of apoShp inhibited approximately 90% of the lipid oxidation that occurred in minced trout muscle during 9 days of 2 °C storage on the basis of lipid peroxide, hexanal, and thiobarituric acid reactive substances (TBARS) values. (montana.edu)
- Oxidative stress is a plethora of reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, hydroxyl radical, and inducible nitric oxide species that exert a constellation of aberrant changes in the oxidation-reduction status of the cell. (molvis.org)
- Differences between reactive oxygen species and antioxidant defense system unbalance the redox status. (bvsalud.org)
Oxidative damage5
- This is an important observation because healthy skin has reductive characteristics, and the ORP of the skin increases by oxidative damage (from sun exposure) and also by aging (as measured by lipid-peroxide levels). (liveright.world)
- Thus, GSH-based therapies have been suggested as a potential therapeutic target for restoring redox balance and mitigating oxidative damage in the brain. (cellg8.com)
- Alterations in GSH metabolism and function have been implicated in various neurological conditions, suggesting a potential therapeutic target for restoring redox balance and mitigating oxidative damage in the brain. (cellg8.com)
- These results indicate that the AMPK signaling activation, combined with oxidative damage markers, could act as sentinel biomarkers, reflecting the threshold of redox balance that is linked to effective glucose control in diabetes. (elifesciences.org)
- The present study aimed to investigate the potential hepatoprotective effects of diosmetin on hydrogen peroxide (H2O2)‑induced oxidative damage in L02 cells and attempted to evaluate the role of the nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response element pathway in this process. (spandidos-publications.com)
Hydrogen peroxide and lipid1
- It also functions as a cofactor for glutathione peroxidase (GPx), an enzyme that catalyzes the reduction of hydrogen peroxide and lipid peroxides to their corresponding alcohols. (cellg8.com)
H2O23
- Annotated HPLC-ESI-MS lipid data in positive ionization mode from an experiment in which cultures of the marine diatom Phaeodactylum tricornutum were treated with various concentrations of hydrogen peroxide (H2O2) to induce oxidative stress. (bioconductor.org)
- and the hydroxyl radical (.OH) via a Fenton-driven reaction with hydrogen peroxide (H2O2). (herbnerdnz.com)
- Mechanistically, Gpx1 interacts with FAK kinase and prevents the kinase inactivation by H2O2, not lipid hydroperoxide. (ewha.ac.kr)
Homeostasis4
- GSH metabolism and function are closely intertwined with those of other redox-active molecules, such as glutathione reductase (GR), glutathione S-transferase (GST), and thioredoxin reductase (TR), which collectively help to maintain redox homeostasis in the brain. (cellg8.com)
- Exogenous Melatonin Alleviates Cold Stress by Promoting Antioxidant Defense and Redox Homeostasis in Camellia sinensis L. (mdpi.com)
- 2015, "Early perturbation in mitochondria redox homeostasis in response to environmental stress predicts cell fate in diatoms," ISME Journal 9:385-395. (bioconductor.org)
- The versatile regulation of intracellular redox components is the primary factor in lens homeostasis. (molvis.org)
Regulating redox balance2
- Glutathione (GSH) is a tripeptide molecule composed of cysteine, glutamate, and glycine that plays a critical role in regulating redox balance in the brain. (cellg8.com)
- It also plays a vital role in regulating redox balance and modulating cellular signaling pathways. (cellg8.com)
Antioxidants3
- Superoxide dismutase and glutathione peroxidase are enzymatic antioxidants whereas, lipid-soluble vitamins (E and A), pro-vitamin A (beta-carotene) and water-soluble vitamin C are non-enzymatic antioxidants. (springeropen.com)
- AFB 1 -administered HCC-bearing rats (Group II) showed increased levels of lipid peroxides (LPOs), thiobarbituric acid substances (TBARs), and protein carbonyls (PCOs) and decreased levels of enzymic and nonenzymic antioxidants when compared to control animals (Group I). Administration of TD orally (300 mg/kg body weight/day) for 45 days to HCC-bearing animals (Group III) significantly reduced the tissue damage accompanied by restoration of the levels of antioxidants. (hindawi.com)
- Antioxidants & redox signaling. (sci-rep.com)
Hydroperoxides1
- ce {Peroxidase}}]{ROH}+R'OH}}} For many of these enzymes the optimal substrate is hydrogen peroxide, but others are more active with organic hydroperoxides such as lipid peroxides. (wikipedia.org)
Regulation2
- Humans have 25 selenoproteins that have a primary function of facilitating redox regulation and antioxidant activity. (upgradedformulas.com)
- Xiao and intestinal alterations indicative of mucosal dysbiosis (Grasberger IFN\ and IFN\ (Fink (Fink model of lung epithelial injury in mice (Gorissen redox\dependent regulation of cell signalling pathways, by reversible oxidation of functional cysteine residues. (ees2010prague.org)
Anti-oxidant2
- Aerobic organisms generate - or garner from their surroundings - a variety of water- and lipid soluble anti-oxidant compounds. (biomedcentral.com)
- The in vivo anti-oxidant study was determined by evaluating enzymatic anti-oxidants such as Superoxide dismutase (SOD), Lipid peroxidase (LPO) and Catalase (CAT) in hepatic tissue of STZ induced diabetic rats.The MDA levels were depleted and SOD and CAT enzymes were restored in diabetic rats treated with EEHL at the dose of 300 mg/kg body weight. (ijpsr.com)
Mitochondrial1
- 13 ] While MB is known for causing mitochondrial dysfunction and changes in redox cycling,[ 5 ] its use in candidiasis treatment as well as its antifungal and antioxidant properties have also been recognized. (journalmeddbu.com)
Glutathione reductase1
- Whenever these free radicals are produced, their effects are monitored by defence system of the body which includes antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR) and lipid peroxidase (LPO). (ijpsr.com)
Metabolism4
- A potentially lethal flux of hydrogen peroxide (H 2 O 2 ) is continuously generated during aerobic metabolism. (biomedcentral.com)
- Evidences are increasing to suggest the abnormalities induced by hyperglycemia on the lipids and lipoprotein metabolism which in turn results in the triglyceride rich lipoproteins thereby raises the risks for coronary heart disorders [ 9 ]. (jabonline.in)
- Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia with hampered metabolism of vital biological components like carbohydrate, protein and lipids. (ijpsr.com)
- Designing studies for lipid-metabolism-related biomarker discovery is challenging because of the high prevalence of various statin and fibrate usage for lipid-lowering therapies. (cdc.gov)
Oxidation8
- 2006 ). Broilers kept under acute heat stress manifested more than a twofold increase in malondialdehyde content of breast meat, which is a secondary product of lipid oxidation (Mujahid et al. (springeropen.com)
- This relationship between redox potentials of the skin and aging has been investigated in more detail and shows that reductive waters lower the oxidation of the skin. (liveright.world)
- To counter high ROS levels, cells have antioxidant mechanisms that reduce the excess ROS in the cell and keep the 'redox' (from reduction and oxidation) balance of the cell. (elifesciences.org)
- In addition to lipid and protein damage, ROS (namely secondary, injurious derivatives) have the capability of causing DNA single-stand breaks (SSB) and base oxidation [ 10 ]. (biomedcentral.com)
- ApoShp prevented Hb-mediated lipid oxidation in washed cod muscle during 2 °C storage. (montana.edu)
- The prevention of Hb-mediated lipid oxidation by apoShp was likely due to bis-methionyl coordination of hemin that dissociated from metHb. (montana.edu)
- ApoShp was also added to minced muscle from rainbow trout (Oncorhynchus mykiss) to examine the degree to which Hb contributes to lipid oxidation in trout muscle. (montana.edu)
- These results strongly suggest that Hb is the primary promoter of lipid oxidation in trout muscle. (montana.edu)
Signaling3
- MAPK signaling in H9c2 cardiomyoblasts exposed to cholesterol secoaldehyde - Role of hydrogen peroxide. (subr.edu)
- Thioredoxin reductases (3 genes) use NADPH to reduce oxidized thioredoxin and its homologs, which regulate a plethora of redox signaling events. (usda.gov)
- Redox signaling is a dynamic and concerted orchestra of interconnected cellular pathways. (elifesciences.org)
Protein1
- The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. (hindawi.com)
Enzymes2
- Peroxidases or peroxide reductases (EC number 1.11.1.x) are a large group of enzymes which play a role in various biological processes. (wikipedia.org)
- Vitamin C is required as a redox agent, reducing metal ions in many enzymes and removing free radicals. (medscape.com)
Peroxidases2
- Peroxidases can contain a heme cofactor in their active sites, or alternately redox-active cysteine or selenocysteine residues. (wikipedia.org)
- Glutathione peroxidases use glutathione as an electron donor and are active with both hydrogen peroxide and organic hydroperoxide substrates. (wikipedia.org)
Gpx12
- Mechanistically, Gpx1 interacts with FAK kinase and prevents the kinase inactivation by H 2 O 2 , not lipid hydroperoxide. (ewha.ac.kr)
- Overall, our study identifies that Gpx1 is a redox safeguard of FAK kinase and its inhibition may provide an effective way to control the metastasis of deadly malignant TNBC. (ewha.ac.kr)
Hydroxyl1
- with transition metals or metalloenzymes to form hydroxyl radical (OHB) or hypohalous acids, or with other biomolecules to form, for example, lipid peroxides]. (ees2010prague.org)
Biological1
- The obtained results suggest that it can play an important role in modulating lipid hydroperoxide level in biological systems. (edu.pl)
Liver1
- Here, by comparing exercise and antioxidant intervention on type 2 diabetic rats, we found moderate exercise upregulated compensatory antioxidant capability and reached a higher level of redox balance in the liver. (elifesciences.org)
Genes3
- Total RNA was isolated on P16, and the relative abundance of mRNA of the crystallin structural genes, redox components, and apoptotic cascade were ascertained with real-time PCR with reference to the internal control β-actin . (molvis.org)
- Real-time PCR analysis showed the crystallin genes ( αA- , βB1- , γD- ) and redox cycle components ( Cat , SOD-1 , Gpx ) were downregulated, the apoptotic components were upregulated, and antiapoptotic Bcl-2 was downregulated in Group II. (molvis.org)
- C-PC treatment possibly prevented cataractogenesis triggered by sodium selenite, by regulating the lens crystallin, redox genes, and apoptotic cascade mRNA expression and thus maintains lens transparency. (molvis.org)
Ions1
- The antioxidant properties of the IP6 at various concentrations (1-500 μM) have been evaluated by using the assays based on hydrogen peroxide scavenging and ferrous metal ions chelating activity determination. (edu.pl)
Nitric1
- GSH interacts with a variety of other cellular components, such as ion channels and nitric oxide synthase, through redox-sensitive mechanisms. (cellg8.com)
Electron donor1
- 1 , 2 ] Among its beneficial properties, MB is a redox cycle stabilizer and an electron donor. (journalmeddbu.com)
Substrates1
- TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. (cancerindex.org)
Substances1
- Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
Regulatory2
- Utilizing the in-vitro studies as well as rats models, this manuscript illustrates the different regulatory mechanisms of exercise and antioxidant intervention on redox balance/redox state(s) that are linked to improved glucose control and thereby effective management of diabetes. (elifesciences.org)
- Its reduced form, leucomethylene blue, is colorless and has a regulatory effect on the redox cycle. (journalmeddbu.com)
Biology1
- Redox Biology , 29 , Article 101391. (ewha.ac.kr)
Enzyme1
- RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
Harmful2
- Among them, glutathione peroxidase (GPx) stands out as it helps mitigate the harmful effects of ROS and inactivates hydrogen and lipid peroxides. (upgradedformulas.com)
- Detoxification of harmful lipid peroxides (Lipid-OOH) to their corresponding hydroxides (lipid-OH) by glutathione peroxidase 4 (GPX4) and glutathione-S-transferases (GST). (medlink.com)
Levels1
- Overall, our results illustrate that both exercise and antioxidant intervention improve blood glucose control in diabetes by promoting redox balance, despite different levels of redox state(s). (elifesciences.org)
Mechanism1
- The exact redox mechanism of these two different approaches remains largely unclear. (elifesciences.org)
Acid1
- There was no effect on plasma lipids or uric acid, but there was a lower glucose and insulin peak concentration after consumption of the FVPD compared with the sugar-matched control. (cambridge.org)
Activity1
- In vitro kinetic assays on crude hktE - pgdx - H. influenzae Rd extracts revealed the presence of NAD(P)H:peroxide oxidoreductase activity, which, however, appears to be physiologically insignificant because of its low affinity for H 2 O 2 ( K m = 1.1 mM). (biomedcentral.com)
Prevent1
- This hexacoordination of hemin appears to prevent peroxide-mediated redox reactions, and there is no component in the matrix capable of dissociating hemin from Shp. (montana.edu)
Potential1
- The redox potential (-446 mV) is independent of pH. (inchem.org)