Recordings pyramidal cells. Medical search. Frequent questions

In certain sensory neurons (pseudounipolar neurons), such as those for touch and warmth, the axons are called afferent nerve fibers and the electrical impulse travels along these from the periphery to the cell body and from the cell body to the spinal cord along another branch of the same axon. (wikipedia.org)
Axons make contact with other cells - usually other neurons but sometimes muscle or gland cells - at junctions called synapses. (wikipedia.org)
Changes in [Cl - ] i were measured in area CA1 pyramidal neurons using optical imaging of 6-methoxy- N -ethylquinolinium chloride, a Cl - -sensitive fluorescent indicator. (jneurosci.org)
Cell assemblies and central pattern generators (CPGs) are related types of neuronal networks: both consist of interacting groups of neurons whose collective activities lead to defined functional outputs. (degruyter.com)
It is likely that constituent neurons in a cell assembly can be spread over large territories, intermixed with many other neurons ( Wallace and Kerr, 2010 ). (degruyter.com)
Electrical and inhibitory synaptic properties were obtained from auditory cortex pyramidal neurons using whole-cell recordings after bilateral earplug insertion or following earplug removal. (nih.gov)
Here we provide a protocol for integrating in vivo recording with optogenetic manipulation of genetically-defined subsets of prefrontal cortical and subicular pyramidal neurons. (jove.com)
Because ChR2 and NpHR are genetically targetable, we describe the use of this technology to control the electrical activity of specific populations of neurons ( i.e. , pyramidal neurons) embedded in heterogeneous tissue with high temporal precision. (jove.com)
We describe herein the hardware, custom software user interface, and procedures that allow for simultaneous light delivery and electrical recording from transduced pyramidal neurons in an anesthetized in vivo preparation. (jove.com)
Within the forebrain, CaMKIIα expression is exclusive to glutamatergic pyramidal neurons 9 . (jove.com)
Ariav G, Polsky A, Schiller J (2003) Submillisecond precision of the input-output transformation function mediated by fast sodium dendritic spikes in basal dendrites of CA1 pyramidal neurons. (yale.edu)
Colbert CM, Johnston D (1996) Axonal action-potential initiation and Na+ channel densities in the soma and axon initial segment of subicular pyramidal neurons. (yale.edu)
Colbert CM, Pan E (2002) Ion channel properties underlying axonal action potential initiation in pyramidal neurons. (yale.edu)
Gasparini S, Migliore M, Magee JC (2004) On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons. (yale.edu)
Golding NL, Spruston N (1998) Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. (yale.edu)
Helmchen F, Svoboda K, Denk W, Tank DW (1999) In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons. (yale.edu)
The percentage of neurons in the neuron glia co-culture was increased without affecting the total number of cells, indicating an enhancement of neurogenesis. (frontiersin.org)
Dendritic axon origin enables information gating by perisomatic inhibition in pyramidal neurons. (uni-tuebingen.de)
In the current study, we analysed the biophysical effects of Org 34167 on HCN channels in stably transfected human embryonic kidney 293 (HEK293) cells and mouse layer V neurons using patch-clamp electrophysiology, and we utilised three high-throughput screens for depressive-like behaviour to assess the activity of Org 34167 in mice. (frontiersin.org)
On the first day of exploration of a novel environment, the firing rate and spatial tuning of CA1 pyramidal neurons was similar between wild-type (WT) and Fmr1−/y rats. (ed.ac.uk)
However, while CA1 pyramidal neurons from WT rats showed experience-dependent changes in firing and spatial tuning between the first and second day of exposure to the environment, these changes were decreased or absent in CA1 neurons of Fmr1−/y rats. (ed.ac.uk)
Lastly, activity patterns of CA1 pyramidal neurons were dis-coordinated with respect to hippocampal oscillatory activity in Fmr1−/y rats. (ed.ac.uk)
The combination of dense recording sites and high channel count yielded well-isolated spiking activity from hundreds of neurons per probe implanted in mice and rats. (janelia.org)
Two-photon microscopy of calcium-dependent sensors has enabled unprecedented recordings from vast populations of neurons. (janelia.org)
Whole cell voltage clamp recordings of CA1 pyramidal neurons from the rat hippocampal brain slice. (hellobio.com)
Classification of neurons is also essential to manipulate cell types in controlled ways and to understand their variation and vulnerability in brain disorders. (bvsalud.org)
2015). Optimizing computer models of layer 5 motor cortex pyramidal neurons using somatic whole-cell recordings . (neurosimlab.com)
A set of reduced models of layer 5 pyramidal neurons (Bahl et al. (modeldb.science)
Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type. (modeldb.science)
Unifying Long-Term Plasticity Rules for Excitatory Synapses by Modeling Dendrites of Cortical Pyramidal Neurons. (modeldb.science)
The brain is composed of a wide array of interconnected neurons, including both excitatory principal cells and a diverse assortment of regulatory interneurons. (solteszlab.com)
With whole cell electrophysiology, we use finely pointed glass electrodes to precisely record the electrical signal from within individual neurons. (solteszlab.com)
Through paired patch-clamp recordings, we explore how two simultaneously recorded neurons (whether of the same or different cell types) are interconnected and how they influence the electrical properties of each other. (solteszlab.com)
Neurons recorded with whole cell electrophysiology can be filled with intracellular tracers, allowing enabling later morphological reconstruction of the cell. (solteszlab.com)
Amygdala pyramidal neurons a re spiny projection neurons that use glutamate as an excitatory neurotransmitter. (europa.eu)
In contrast, most non-pyramidal neurons in the amygdala are aspiny interneurons that use GABA as an inhibitory neurotransmitter. (europa.eu)
Endocannabinoid-dependent effects of corticosterone on inhibitory synaptic transmission in the rat PL were determined using whole-cell recordings in layer V pyramidal neurons. (marquette.edu)
Somatostatin, a signaling molecule produced by many inhibitory neurons in the brain, broadly dampens communication among a variety of cell types in the prefrontal cortex and promotes exploratory and risk-taking-like behavior in mice, according a Penn State-led research team. (bestallergymedicinehq.org)
Once released, it works by binding to receptor molecules expressed on other neurons, and potentially other cell types in the brain, which sets off a cascade of molecular changes in the cell. (bestallergymedicinehq.org)
Activity of pyramidal neurons in the prefrontal cortex before (left) and after (right) application of somatostatin. (bestallergymedicinehq.org)
Inhibitory neurons (pink) release somatostatin, a neuropeptide, that binds to receptors on the surface of pyramidal neurons (purple) and other cells in the brain. (bestallergymedicinehq.org)
They measured the activity of these pyramidal neurons before and after artificially introducing the neuropeptide. (bestallergymedicinehq.org)
In both cases, the researchers saw the activity of the pyramidal neurons dampened. (bestallergymedicinehq.org)
Operative GABAergic inhibition in hippocampal CA1 pyramidal neurons in experimental epilepsy. (brain-knowledge-engine.org)
CRT aims to replace neurons that have degenerated in PD, with donor cells that have the potential to functionally re-integrate into the host circuitry. (lu.se)
This involves transplantation of developing midbrain cells from aborted fetuses, (the part that form mesDA neurons), into the striatum of a PD patient. (lu.se)
A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)
Pyramidal neurons of CA1 of anesthetized gerbils showed stable spontaneous activities before ischemia (5.21±0.54 Hz). (en-journal.org)
We used single neuron recordings and controlled whisker deflections to examine responses of thalamocortical neurons to sensory stimulation in rat survivors of 9 min of asphyxial cardiac arrest incurred on post-natal day 17. (cdc.gov)
Early research indicated that Zika virus has tropism for glial cells and neurons, a finding consistent with the severity of abnormalities in seen the fetal brain ( 4 ). (cdc.gov)

An axon (from Greek ἄξων áxōn, axis), or nerve fiber (or nerve fibre: see spelling differences), is a long, slender projection of a nerve cell, or neuron, in vertebrates, that typically conducts electrical impulses known as action potentials away from the nerve cell body. (wikipedia.org)
The swollen end of a telodendron is known as the axon terminal which joins the dendrite or cell body of another neuron forming a synaptic connection. (wikipedia.org)
2 . Poirazi P, Brannon T, Mel BW (2003) Pyramidal neuron as two-layer neural network. (yale.edu)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. (yale.edu)
There is a lot of K+ inside a neuron, so it wants to flow out of the cell and drive the potential down. (gnxp.com)
A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells. (modeldb.science)
Thus, we can examine both the functional electrical properties intrinsic to that particular cell and monitor the synaptic inputs that neuron receives. (solteszlab.com)
I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)

Intracellular recording from a cortical pyramidal cell during the "UP" state of the slow oscillation reveals the arrival of barrages of PSPs. (yale.edu)
Buzsáki G, Kandel A (1998) Somadendritic backpropagation of action potentials in cortical pyramidal cells of the awake rat. (yale.edu)
Intelligent behavior and cognitive functions in mammals depend on cortical microcircuits made up of a variety of excitatory and inhibitory cells that form a forest-like complex across six layers. (elifesciences.org)
2015). Normalized cortical depth (NCD) as a primary coordinate system for cell connectivity in cortex: experiment and model . (neurosimlab.com)

Finally, an analysis of the spatial density of NMDA conductance required for NMDA spike production implies that, at least up to the age (postnatal day 35) that these events have been observed, most of the excitatory synaptic conductance arriving at pyramidal cells is NMDA mediated. (jneurosci.org)
Fariñas I, DeFelipe J (1991) Patterns of synaptic input on corticocortical and corticothalamic cells in the cat visual cortex. (yale.edu)
1 . Poirazi P, Brannon T, Mel BW (2003) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. (yale.edu)
The cellular-synaptic generation of theta activity in the hippocampus was investigated by intracellular recordings from the somata and dendrites of CA1 pyramidal cells in urethane-anesthetized rats. (nyu.edu)
Recorded parvalbumin-expressing basket interneurons innervated somata and proximal pyramidal cell dendrites, whereas nitric oxide synthase- and neuropeptide Y-expressing ivy cells provided synaptic and extrasynaptic dendritic modulation. (ox.ac.uk)

Axons are distinguished from dendrites by several features, including shape (dendrites often taper while axons usually maintain a constant radius), length (dendrites are restricted to a small region around the cell body while axons can be much longer), and function (dendrites receive signals whereas axons transmit them). (wikipedia.org)
4 . Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. (yale.edu)
In contrast, cyclic depolarizations in dendrites corresponded to the positive phase of the pyramidal layer field theta (i.e. the hyperpolarizing phase of somatic theta). (nyu.edu)
While recordings are often made from the neuronal cell body, the Soltesz lab has experience recording specifically from smaller structures, including hippocampal dendrites or even axonal terminals. (solteszlab.com)

Our recordings yielded 288 and 246 putative pyramidal cells from 7 WT and 7 Fmr1−/y rats, respectively. (ed.ac.uk)
Chronic multi-array electrodes in primary auditory cortex were used to record single cell firing from putative pyramidal and FSI in awake animals during processing of auditory sensory information. (lu.se)

Electrical coupling is also known to be important in the development of hippocampal and neocortical principal cell networks. (degruyter.com)
Shu Y, Duque A, Yu Y, Haider B, McCormick DA (2007) Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. (yale.edu)
Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. (modeldb.science)

Additionally we outline the steps and hardware for simultaneous light delivery and recording in anesthetized head-fixed rats. (jove.com)
In conclusion, we found that hippocampal place cells from Fmr1−/y rats show similar spatial firing properties as those from WT rats but do not show the same experience-dependent increase in spatial specificity or the experience-dependent changes in network coordination. (ed.ac.uk)
Female Sprague-Dawley rats implanted with bone cancer cells develop mechanical and thermal hyperalgesia but antagonizing GM-CSF in these animals significantly reduced such hypersensitivity. (iasp-pain.org)
We employed a new technique for recording and labeling interneurons and pyramidal cells in drug-free, freely moving rats. (ox.ac.uk)

Using simultaneous dendritic and somatic recordings, and combining results for two different response measures (peak vs. mean EPSP), two different stimulus formats (single shock vs. 50 Hz trains), and two different spatial integration conditions (within vs. between-branch summation), we found the cell's subthreshold responses to paired inputs are best described as a sum of nonlinear subunit responses, where the subunits correspond to different dendritic branches. (yale.edu)
These data indicate that distal dendritic depolarization of the pyramidal cell by the entorhinal input during theta overlaps in time with somatic hyperpolarization. (nyu.edu)

In whole cell patch clamp recordings, from hippocampal pyramidal cells, ephenidine (10 μM) blocked NMDA receptor-mediated EPSCs in a highly voltage-dependent manner. (erowid.org)
Using patch clamp recording from CA1 pyramidal cells in hippocampal slices, we have identified robust changes to intrinsic neuronal excitability and action potential waveforms in 2 different Abeta overproducing mouse lines. (neurodegenerationresearch.eu)
patch-clamp recordings of ca1 interneurons and pyramidal cells were performed in hippocampal slices from kainate- or pilocarpine-treated rat models of temporal lobe epilepsy . (brain-knowledge-engine.org)

Furthermore, localization of CCK to specialized interneurons throughout the hippocampus and cortex relegated CCK to being examined primarily as a static cell type marker rather than a dynamic functional neuromodulator. (stanford.edu)

In experiments of extracellular recording of field excitatory postsynaptic potentials (fEPSPs) from area CA1 of rat hippocampal slices, ephenidine, 1 and 10 μM, respectively, produced a 25 and a near maximal inhibition of the NMDA receptor mediated fEPSP after 4 h superfusion. (erowid.org)

A descending volley in response to non-invasive transcranial magnetic stimulation has been recorded from the pyramidal tract in a conscious monkey and identified by means of a collision test. (nih.gov)
Multichannel electrical recording is the most widely used approach to measure the neural responses to optogenetic stimulation. (elifesciences.org)
The two types of signaling molecules use different pathways to communicate between cells and are released through different stimulation scenarios. (bestallergymedicinehq.org)

Depolarization and hyperpolarization of the cell to different membrane potentials reveals that these PSPs are both excitatory and inhibitory (A). Blocking GABAA-receptor mediated inhibition with the local application of bicuculline demonstrates that the inhibitory PSPs control the amplitude of the "UP" state of the slow oscillation (B). (yale.edu)

As a result, most pyramidal cells are either silent or discharge with single spikes on the negative portion of local field theta (i.e., when the somatic region is least polarized). (nyu.edu)

Optogenetic tools of microbial origin consist of light-sensitive membrane proteins that are able to activate ( e.g. , channelrhodopsin-2, ChR2) or silence ( e.g. , halorhodopsin, NpHR) neural activity ingenetically-defined cell types over behaviorally-relevant timescales. (jove.com)
Her gir vi en protokoll for å integrere in vivo-opptak med optogenetic manipulasjon av genetisk definerte undergrupper av prefrontal hjernebark og subicular pyramidale nevroner. (jove.com)

hippocampal dentate granule cells in temporal lobe epilepsy (tle) patients with mesial sclerosis (mtle) are reported to be hyperexcitable compared to those in patients with a mass lesion outside the hippocampus (matle) (williamson, clin neurosci 1994;2: 47-52). (brain-knowledge-engine.org)

Although long term potentiation (LTP) is a well-established plasticity mechanism of glutamatergic synapses in hippocampal CA1 pyramidal cells, the fine-scale input pattern requirements to induce potentiation so far remained unclear. (mitt.hu)

In vivo EEG recordings reveal network hyperexcitability in these areas, which in some laboratories resembles epileptic activity. (neurodegenerationresearch.eu)
As well as performing our own in vivo recordings, we have been investigating cellular level neurophysiological factors that could be the cause of these disturbed patterns of neuronal activity. (neurodegenerationresearch.eu)

These EEG signals are the result of summated field potentials generated by excitatory and inhibitory postsynaptic potentials in vertically oriented pyramidal cells of the cortex. (psychiatrictimes.com)
The effects of the antipsychotic drugs haloperidol and clozapine on N-methyl- d- aspartate (NMDA) and non-NMDA receptor-mediated neurotransmission were examined and compared in pyramidal cells of the medial prefrontal cortex in rat brain slices by using the techniques of intracellular recording and single-electrode voltage-clamp. (aspetjournals.org)
The behavioral assay was combined with simultaneous recordings from dozens of electrophysiologically identified units in the medial prefrontal cortex (mPFC) and ventral striatum (VS). We found significant relationships between cocaine cue-evoked pupil dilation and the proportion of inhibited principal cells in the mPFC and VS. Additionally, LFP coherence analysis revealed a significant correlation between pupillary response and synchrony in the 25-45 Hz frequency band. (eneuro.org)
Here, we construct a reliable cell census in the frontal lobe of human cerebral cortex at micrometer resolution in a magnetic resonance imaging (MRI)-referenced system using innovative imaging and analysis methodologies. (bvsalud.org)
Their new paper, published online in the journal Cell Reports , describes the signaling mechanism of somatostatin in the prefrontal cortex, a brain region thought to be essential for executive functions like planning, memory, decision making and social behavior. (bestallergymedicinehq.org)

The ability to activate or silence a specific cell type within a neural circuit in a temporally precise fashion is critical for understanding how neural circuits process different types of information underlying emotion and cognition. (jove.com)
Furthermore, we found that Pls3 cell-autonomously regulates cell migration by regulating actin cytoskeleton organization, and its levels are inversely proportional to neural migration speed. (nature.com)
In particular, we found that Cul3 controls the abundance of Plastin 3 (Pls3), a novel player of neural cell migration, whose amount is inversely proportional to neural cell migration speed. (nature.com)
Finally, we found that CRISPR-mediated activation of Cul3 transcription fully rescues neural cell migration defects. (nature.com)
Fully integrated silicon probes for high-density recording of neural activity. (janelia.org)
This combination of high-performance electrode technology and scalable chip fabrication methods opens a path towards recording of brain-wide neural activity during behaviour. (janelia.org)
This study used large-scale neural recordings with silicon microprobe technology to simultaneously examine prefrontal and striatal activity in cocaine-conditioned mice. (eneuro.org)
Furthermore, the results demonstrate the effectiveness of using large-scale recordings spanning multiple brain areas to examine the neural correlates of interindividual variability among drug-experienced animals. (eneuro.org)
The establishment of neural circuits depends on the ability of axonal growth cones to sense their surrounding environment en route to their target. (biologists.com)
The optical transparency and small brain sizes of larval zebrafish have enabled unprecedented access to single-cell neural dynamics across the whole brain. (solteszlab.com)

This will be a multidisciplinary study in which intracellular recordings followed by intracellular filling will be combined with immunocytochemical characterisation and cellular reconstruction. (europa.eu)
After the single, double or triple intracellular recordings, sections will be fixed and re-sectioned. (europa.eu)

2) Determining if similar changes to those observed in pyramidal cells occur in GABAergic interneurones. (neurodegenerationresearch.eu)

We also utilize several variants on the whole cell electrophysiology approach to interrogate other features of neuronal networks. (solteszlab.com)
Furthermore, we have the capacity to combine whole cell electrophysiology with simultaneous high-speed imaging of optical probes (e.g. calcium and voltage indicators), enabling us to incorporate the high single cell precision of electrophysiology with broader population level readouts of activity within a brain slice. (solteszlab.com)
Representative traces from whole-cell current clamp recordings (black lines) show that the activity of pyramidal cells is reduced following both bath applied somatostatin, and light-evoked somatostatin release. (bestallergymedicinehq.org)
Using 2-photon glutamate uncaging combined with whole-cell current clamp recordings, we have recently shown (Weber et al. (mitt.hu)

Here a compartment model of a layer 5 pyramidal cell was used to examine the mechanisms underlying NMDA spikes and to test properties not directly accessible experimentally. (jneurosci.org)

The short latency of the earliest wave was inconsistent with a trans-synaptically mediated activation of pyramidal tract neurones. (nih.gov)
These results are consistent with direct activation of pyramidal tract neurones at a site close to the cell body. (nih.gov)
Fricker D, Verheugen JA, Miles R (1999) Cell-attached measurements of the firing threshold of rat hippocampal neurones. (yale.edu)

Ischemia was done for 5 min in two groups, such that in Group 1 it was done 1 week after implantation of recording micro-wire electrodes and in Group 2 immediately before electrode implantation. (en-journal.org)

Even now, however, cell assemblies are difficult or impossible to isolate physically, in contrast to at least some CPGs. (degruyter.com)

Structural properties of interneuron to principal cell and principal cell to interneuron inputs will also be investigated by electron microscopic analysis. (europa.eu)

This circuitry is organized tonotopically into laminae, each containing cells with an optimal sensitivity to a specific sound frequency. (stanford.edu)
Understanding the neuronal mechanisms mediating emotional information processing in the amygdala will require identification of its main cell types and knowledge of their participation in the intrinsic circuitry of this region. (europa.eu)
The precise identification of the main cell types in the amygdala and knowledge of their participation in the intrinsic circuitry of this region is an essential pre-requisite to understand the neuronal mechanisms mediating the diverse roles of the amygdala subsystems. (europa.eu)

these are called en passant ("in passing") synapses and can be in the hundreds or even the thousands along one axon. (wikipedia.org)
We here argue that electrical coupling - in addition to chemical synapses - may therefore contribute to the formation of at least some cell assemblies in adult animals. (degruyter.com)

Diamantaki M, Frey M, Berens P, Preston-Ferrer P*, Burgalossi A* Sparse activity of identified dentate granule cells during spatial exploration. (uni-tuebingen.de)
Morphology of dentate granule cells in the human epileptogenic hippocampus. (brain-knowledge-engine.org)

At a synapse, the membrane of the axon closely adjoins the membrane of the target cell, and special molecular structures serve to transmit electrical or electrochemical signals across the gap. (wikipedia.org)
In comparison, the cerebellar granule cell axon is characterized by a single T-shaped branch node from which two parallel fibers extend. (wikipedia.org)
In the peripheral nervous system Schwann cells form the myelin sheath of a myelinated axon. (wikipedia.org)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)

Future experiments will focus on this connection as well as the contribution of other neuronal cell types in the hippocampal circuit pathophysiology associated with the loss of FMRP. (ed.ac.uk)

The probability of pyramidal cell discharge, as measured in single cells and from a population of extracellularly recorded units, was highest at or slightly after the negative peak of the field theta recorded from the pyramidal layer. (nyu.edu)

A major advantage of optogenetics is the ability to genetically-target specific cell populations in heterogeneous brain regions and the technique has been successfully applied to a number of model organisms (invertebrates to nonhuman primates) 4-6 . (jove.com)

Accordingly, in the present work, the foregoing questions have been addressed in the setting of a compartment simulation of a layer 5 intrinsically bursting pyramidal cell. (jneurosci.org)
A compartment model ( Rall, 1964 ) of layer 5 thick-trunked pyramidal cell was derived from the Neurolucida file of a cell reconstructed at P28 (kindly supplied by Dr. M. Larkum, University of Bern, Bern, Switzerland). (jneurosci.org)
Myelin is a layer of a fatty insulating substance, which is formed by two types of glial cells: Schwann cells and oligodendrocytes. (wikipedia.org)
We apply our method to simulated data from layer 5 pyramidal cells (L5PCs) and construct a model with reduced neuronal morphology. (modeldb.science)
Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data. (modeldb.science)

Directly addressing these technological challenges, the development and application of genetically-encodable light-sensitive tools has enabled neuroscientists to control the electrical activity of select cell types during well-defined behavioral events. (jove.com)
has been established as a powerful method to examine the causal relationship between the specific cell type and the network activity, cognitive functions or animal behavior ( Deisseroth, 2015 ). (elifesciences.org)

In the diagnosis of epilepsy and localization of seizure onset, both the intericital and ictal recordings are extremely informative. (medscape.com)

Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus. (uni-tuebingen.de)

One of the first electrochemical models proposed that the cell membrane exerts linear physicochemical changes ( 12 , 13 ) to assess the EMF parameters for which biological effects might be expected. (frontiersin.org)
2. A slow (0.5-4 Hz) membrane potential oscillation was observed in thalamocortical cells recorded in motor, sensory, associational and intralaminar thalamic nuclei. (researchgate.net)
Aye votes move the voltage potential across the neuronal membrane in a positive direction by allowing positive ions to flow into the cell. (gnxp.com)
You see, the membrane potential isn't exactly a count of the number of positive and negative charges inside and outside the cell. (gnxp.com)
Rather, the ions have to be lined up right next to the membrane producing a capacitive current for the period of time it takes to push positive charges off the outside of the cell and line other ions up on the inside. (gnxp.com)

Basket and ivy cells showed distinct spike-timing dynamics, firing at different rates and times during theta and ripple oscillations. (ox.ac.uk)
Built biologically constrained single-cell whole brain effective connectivity models optimized from experimentally acquired calcium dynamics as a platform for hypothesis testing. (solteszlab.com)

Basket, but not ivy, cells changed their firing rates during movement, sleep and quiet wakefulness, suggesting that basket cells coordinate cell assemblies in a behavioral state-contingent manner, whereas persistently firing ivy cells might control network excitability and homeostasis. (ox.ac.uk)

Anatomy46

Organisms16

Diseases8

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Psychiatry and Psychology10

Phenomena and Processes38

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science8

Health Care2

Neurons50

Neuron8

Cortical4

Synaptic5

Dendrites4

Putative pyramidal2

Neocortical3

Rats4

Dendritic2

Patch clamp3

Interneurons1

Hippocampal slices1

Stimulation3

Inhibition1

Somatic1

Optogenetic2

Neurosci1

Glutamatergic1

Vivo2

Cortex5

Neural10

Intracellular recordings2

GABAergic1

Whole cell4

Spikes1

Neurones3

Electrode1

Contrast1

Interneuron1

Circuitry3

Synapses2

Dentate granule cells2

Axon4

Neuronal cell1

Probability1

Populations1

Layer5

Activity2

Epilepsy1

Spatial1

Membrane5

Dynamics2

Excitability1