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  • donor T cells
  • Thus, despite significant early TRM, ex vivo alloanergization can support administration of large numbers of haploidentical donor T cells, resulting in rapid immune reconstitution with very few viral infections. (bloodjournal.org)
  • We previously reported early results of a clinical trial using ex vivo induction of alloanergy in donor T cells within bone marrow (BM) grafts via CTLA4-Ig-mediated CSB. (bloodjournal.org)
  • However, unlike chemotherapy or auto-HCT, the strategy of allo-HCT is fundamentally based upon utilizing the beneficial effect of donor T cells, and we believe therapies to improve T cell reconstitution will be especially beneficial in this area. (jimmunol.org)
  • HSCT
  • Hematopoietic stem cell transplantation (HSCT) has become an accepted and widely used treatment option for defined malignant and nonmalignant diseases. (wiley.com)
  • Although nsTCD has been combined with high CD34 + stem cell doses to achieve engraftment without severe GVHD in haploidentical HSCT, 3 , 4 the overall success of such strategies may be limited by delayed immune reconstitution, increased infectious complications, and higher relapse rates potentially associated with the loss of pathogen- and tumor-specific T cells. (bloodjournal.org)
  • Various experimental strategies to selectively deplete alloreactive T cells within the donor graft to prevent GVHD while preserving pathogen- and tumor-specific immunity have been developed with the aim of improving immune reconstitution after HLA-mismatched HSCT. (bloodjournal.org)
  • cord blood
  • The laboratory's team, headed by Prof. Reuven Or, includes a number of highly respected and accomplished scientists who conduct advanced research with a focus on the immuno-biological mechanism of stem cells derived from cord blood and bone marrow. (isracast.com)
  • Moreover, Prof. Or serves as the Medical Director of the Volunteer Bone Marrow Bank and also as the Medical Director of the Israeli National Public Umbilical Cord Blood Bank. (isracast.com)
  • In December 2008 Prof. Or received the Menachem Begin Prize for his extensive medical and research work and for the establishment of two essential and life saving national projects: The unrelated volunteer bone marrow donor registry and the national public umbilical cord blood bank. (isracast.com)
  • Immunology
  • An Absence of T Cells in Murine Bone Marrow Allografts Leads to an Increased Susceptibility to Rejection by Natural Killer Cells and T Cells", Journal of Immunology 144:3305-11 (1990). (patentgenius.com)
  • GvHD
  • This review focuses on the bone marrow as a target of GvHD, the factors that contribute to myelosuppression, and the possible therapeutic approaches. (wiley.com)