• This thesis focuses on determining the function of Orf in phage and bacterial recombination pathways by analysing its impact on recombinases encoded by λ and E. coli. (bl.uk)
  • Experiments revealed that Orf interacts with bacterial and phage recombination proteins in the initial exchange step of recombination, modulating the activities of both Exo and RecA. (bl.uk)
  • Significantly, this would direct recombination down the bacterial RecA pathway of break restoration rather than the phage Red pathway with potentially important consequences for the outcome of the exchange reaction. (bl.uk)
  • Bacterial speciation usually takes place with lasting homologous recombination, which not only acts as a cohering force between diverging lineages but brings advantageous alleles favored by natural selection, and results in ecologically distinct species, e.g., frequent host shift in Xanthomonas pathogenic to various plants. (biomedcentral.com)
  • It is thought that perhaps recombination occurred in chimpanzees dually infected with SIV that infects red-capped mangabeys and SIV that infects greater spot-nosed monkeys to generate a novel chimeric virus, SIVcpz. (asm.org)
  • 1 Evolutionists commonly try to buttress their claim of a universal tree of life by pointing to the genetic similarity between chimpanzees and humans. (icr.org)
  • Recombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. (blogspot.com)
  • The first method is to count the number of fixed genetic changes between humans and another species, such as chimpanzees [ 4 ]. (prolekare.cz)
  • This work shows that genetic recombination facilitates adaptation and it estimates the evolutionary cost of its absence or depletion in a genome for the first time. (eurekalert.org)
  • Human-Chimp Genetic Similarity: Is the Evolutionary Dogma Valid? (icr.org)
  • We investigated the molecular epidemiological processes at work and the contribution of genetic recombination to the evolutionary history of EV-A in Madagascar, focusing on the recently described EV-A71 genogroup F in particular. (pasteur.fr)
  • The three EV-A71 isolates had different evolutionary histories in terms of recombination, with one isolate displaying a mosaic genome resulting from recent genetic exchanges with Madagascan coxsackieviruses A7 and possibly -A5 and -A10 or common ancestors. (pasteur.fr)
  • They also provide an intriguing array of evolutionary solutions to the genetic conflict that arises from their uniparental inheritance. (plos.org)
  • Thus, shorter evolutionary time frames are needed to understand the evolution of recombination. (blogspot.com)
  • These data are being made available at a time of intense interest in studying the genetic basis for evolutionary changes in the malaria-causing P. falciparum parasite, such as the emergence and spread of antimalarial drug resistance. (malariagen.net)
  • One implication of these findings is that at any one moment there will be linked genetic variants, exposed simultaneously to selection in the genome, and therefore selection will be sub-optimal due to the linkage cost. (eurekalert.org)
  • If linkage cost exists, wherever recombination is low there will be a greater density of selective variants that do not segregate freely, lowering the efficiency of the selection and therefore the adaptation rate. (eurekalert.org)
  • The results showed a very positive correlation between recombination and adaptation, corroborating the existence of the linkage cost in the genome. (eurekalert.org)
  • There's a bit of a mystery being solved now about how certain molecular, biological, and genome phenomena have evolved in response to selfish genetic elements," says Daven Presgraves, a dean's professor of biology at the University of Rochester. (rochester.edu)
  • In the current issue of Nature , researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the EMBL-European Bioinformatics Institute (EMBL-EBI) in Hinxton, UK, present the most precise map of genetic recombination yet. (phys.org)
  • The level of recombination was determined by tracking molecular markers for both BC3F6 and F2 generations. (academicjournals.org)
  • The first glossary, on basic molecular genetic terms, 1 provided the basis to understand the concepts presented here. (bmj.com)
  • Drawing on Smith's work, American molecular biologist Daniel Nathans helped advance the technique of DNA recombination in 1970-71 and demonstrated that type II enzymes could be useful in genetic studies. (britannica.com)
  • Recombination is important-it's not hard to convince anyone of that-but when we look across different species, we see that the rates of crossing over are different," Brand says. (rochester.edu)
  • The team focused on two closely related species of fruit flies-Drosophila melanogaster and its sister species, Drosophila mauritiana-because large differences have evolved in their rates of recombination: D. mauritiana does about 1.5 times more crossing over than D. melanogaster. (phys.org)
  • We examined a data set comprising 18 distinct strains from 13 named species for evidence of recombination. (uct.ac.za)
  • Comparative studies have shown wide variation in recombination rate among species, but the characterization of recombination features between cattle breeds has not yet been performed. (beds.ac.uk)
  • Collectively, our results generated breed- and sex-specific recombination maps for multiple cattle breeds, provided a comprehensive characterization and comparison of recombination patterns between breeds, and expanded our understanding of the breed-level variations in recombination features within an important livestock species. (beds.ac.uk)
  • Sex-specific recombination maps have been generated in several mammalian species with the sex difference in recombination confirmed. (beds.ac.uk)
  • Moreover, because of shared ancestral polymorphism, the time to the most recent common ancestor is always older-and sometimes far older-than the time of species divergence, meaning that split-time calibrations cannot always be directly applied to genetic divergences. (prolekare.cz)
  • This open access resource provides a foundation for further research into how genetic variation and sexual recombination affects parasite biology, at a much higher resolution than previously possible. (malariagen.net)
  • The first cross proved that parasites undergo sexual recombination whilst inside the mosquito . (malariagen.net)
  • This sexual recombination is central to how parasites evolve and adapt to new pressures such as antimalarial drugs, and the new P. falciparum crosses data resource provides a unique opportunity to study parasite recombination in detail. (malariagen.net)
  • We observed several different recombination patterns, including those that had crossovers only in gfp . (asm.org)
  • We conducted a comparative population genetic analysis of virulent C. homini s subtype IbA10G2 in children living in a periurban community in Lima, Peru, by multilocus sequence typing (MLST) of 32 genetic markers. (cdc.gov)
  • A 3347-locus genetic recombination map of sequence-tagged sites reveals features of genome organization, transmission and evolution of cotton (Gossypium). (semanticscholar.org)
  • The concatenated sequence was screened for evidence of recombination using a variety of statistical methods, with each proposed event evaluated by comparing maximum-likelihood phylogenies of the recombinant section with the non-recombinant portion of the dataset. (uct.ac.za)
  • This week, the MalariaGEN P. falciparum genetic crosses project released a new data resource , comprising whole-genome sequence and genetic variation data from the parents and offspring of three parasite crosses. (malariagen.net)
  • Although modern DNA sequencing technology has transformed the study of genetic variation in malaria parasites, analysing the raw sequence data is a complex process with many sources of error. (malariagen.net)
  • Because the crosses give us this guidance on which data to trust, we've been able to gain new insights about different types of genetic variation, including insertions and deletions, complex sequence changes, and copy number variation," says Miles. (malariagen.net)
  • Scientists have long recognized that the exchange of genetic material by crossing over-known as recombination-is vital to natural selection. (rochester.edu)
  • They found an unexpectedly high degree of sharing and exchange of genetic material between the tiny, green, photosynthetic cyanobacteria Synechococcus , which are abundant in these scalding, inhospitable environments. (carnegiescience.edu)
  • Some of these genetic variants are heritable, passed down from generation to generation, while others arise sporadically during an organism's life and cause diseases such as cancer. (jove.com)
  • The fundamental principles of recombination are likely to be shared between yeast and humans. (phys.org)
  • by Wendy Gibson, Lori Peacock, Vanessa Ferris, Katrin Fischer, Jennifer Livingstone, James Thomas, Mick Bailey Genetic recombination between pathogens derived from humans and livestock has the potential to create novel pathogen strains, highlighted by the influenza pandemic H1N1/09, which was derived from a re-assortment of swine, avian and human influenza A viruses. (medworm.com)
  • Here we investigated whether genetic recombination between subspecies of the protozoan parasite, Trypanosoma brucei, from humans and animals can generate new strains of human pathogen, T. b. rhodesiense (Tbr) responsible for sleeping sickness (Human African Trypanosomiasis, HAT) in East Africa. (medworm.com)
  • Genetic recombination is the production of offspring with combinations of traits that differ from those found in either parent. (wikipedia.org)
  • But few work has been done to study the genetic architecture of nutritional traits of the oyster. (springer.com)
  • Using this high-qualified genetic map, we then conducted QTL analysis for growth and nutritional traits, the latter of which includes glycogen, amino acid (AA), and fatty acid (FA). (springer.com)
  • Strong genetic correlations were evident among the recombinants, such that 22 measured traits could be well represented by only seven underlying factors, which accounted for 80% of the total variation. (wiley.com)