• Can be paired for ELISA with Rabbit polyclonal to Apolipoprotein CIII (ab21032) . (abcam.co.jp)
  • Description: A sandwich ELISA kit for detection of Apolipoprotein H from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (wildpalm.net)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Apolipoprotein H (APOH) in samples from serum, plasma or other biological fluids. (wildpalm.net)
  • Description: Quantitativesandwich ELISA kit for measuring Human Apolipoprotein H (APOH) in samples from serum, plasma, tissue homogenates. (wildpalm.net)
  • Mouse Apolipoprotein B48 (apo-B48) ELISA Kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
  • MIA1609 targets Apolipoprotein B in ELISA, IP and RIA applications and shows reactivity with Human samples. (thermofisher.com)
  • Apolipoprotein E (ApoE) is expressed as Molecular Biology of Neurodegenerative Diseases. (web.app)
  • APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. (web.app)
  • Apolipoprotein E spielt im Katabolismus von Chylomikronen, IDL und VLDL-Remnants wie auch von ApoE-reichem HDL eine wichtige Rolle. (web.app)
  • Apolipoprotein E (APOE) plays an important role in cholesterol transport and genetic variants in APOE have been linked to the risk of Alzheimer's disease. (web.app)
  • 2020-08-16 · The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (web.app)
  • APOE / Apolipoprotein E Protein LS-G39871 is a Recombinant Human APOE / Apolipoprotein E produced in Human Cells Lys19-His317 with 6His, C-terminus tag(s). (web.app)
  • Previously published data have shown an allele-specific variation in the in vitro binding of apolipoprotein E (apoE) to tau, which prompted the hypothesis that apoE binding may protect tau from phosphorylation, apoE3 being more efficient than apoE4. (ox.ac.uk)
  • A portion of apolipoprotein E (apoE) internalized by hepatocytes is spared degradation and is recycled. (elsevierpure.com)
  • To investigate the intracellular routing of recycling apoE, primary hepatocyte cultures from LDL receptor-deficient mice and mice deficient in receptor-associated protein [a model of depressed expression of LDL receptor-related protein (LRP)] were incubated with human VLDL containing 125 I-labeled human recombinant apoE3. (elsevierpure.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Apolipoprotein H (APOH) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (wildpalm.net)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Apolipoprotein H (APOH) in serum, plasma and other biological fluids. (wildpalm.net)
  • Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. (wikipedia.org)
  • It circulates as a component of lipoprotein particles and as a lipid-free serum protein (6). (rndsystems.com)
  • Serum amyloid A (SAA) is a household of historic proteins that may be traced from present-day people again half a billion years to sea cucumbers and oysters. (vizintee.com)
  • Shobini Jayaraman et al, Lipid Clearance and Amyloid Formation by Serum Amyloid A: Exploring the Hyperlinks Between Helpful and Pathologic Actions of an Enigmatic Protein, Journal of Lipid Analysis (2023). (vizintee.com)
  • When released into blood circulation, SAA1 is present as an apolipoprotein associated with high-density lipoprotein (HDL). (wikipedia.org)
  • ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. (reliatech.de)
  • The major apolipoproteins of high-density lipoprotein (HDL) are alpha lipoproteins (ie, apolipoprotein A-I [apo A-I], apo A-II, apo A-IV), which are soluble and can move between different classes of lipoproteins. (medscape.com)
  • Apolipoprotein A-I (Apo-A1) is a structural and functional protein that constitutes approximately 70% of the protein in high density lipoprotein (HDL). (medscape.com)
  • The Ratio of High-Density Lipoprotein Cholesterol to Apolipoprotein A-I Predicts Myocardial Injury Following Elective Percutaneous Coronary Intervention. (medscape.com)
  • The product of human SAA1 is a pre-protein of 122 amino acids, with a cleavable signal peptide of 18 amino acids. (wikipedia.org)
  • The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. (justia.com)
  • The pro-peptide-polypeptide fusion protein can be cleaved and the recombinant polypeptide released under the appropriate conditions. (justia.com)
  • Finally, the use of a fusion partner may enable the production of a peptide which would otherwise be too small to accumulate and recover efficiently from a recombinant host cell system. (justia.com)
  • The twin nature of proteins that each transport lipids and type amyloids is current in different ailments, like Alzheimer's amyloid-beta peptide. (vizintee.com)
  • The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. (thermofisher.com)
  • Recombinant Human C-C chemokine receptor type 8(CCR8) referenced in "The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis", Immunity , 2021. (cusabio.com)
  • Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
  • Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. (thermofisher.com)
  • Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.co.jp)
  • Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. (thermofisher.com)
  • The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. (thermofisher.com)
  • Recombinant Human Novel Coronavirus Spike glycoprotein(S) (D614G), partial (Active) referenced in "Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries", Cell discovery , 2021. (cusabio.com)
  • Blood levels of heat shock protein (HSP27) and natural IgG auto-antibodies to HSP27 (AAbs) are higher in healthy controls compared to cardiovascular disease patients. (biorxiv.org)
  • The researchers used recombinant murine or human SAA. (vizintee.com)
  • Vaccination of mice with recombinant HSP25 (rHSP25, murine ortholog of human rHSP27) increased AAb levels, attenuated atherogenesis and reduced plaque inflammation and cholesterol content. (biorxiv.org)
  • PVDF membrane was probed with 0.25 µg/mL of Sheep Anti-Mouse/Rat Apolipoprotein H/ApoH Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6575) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). (rndsystems.com)
  • Acute administration of recombinant APOA4 protein elevates BAT thermogenesis in chow-fed mice. (ohio.edu)
  • Whether it is for protein electrophoresis or western blot, our pre-stained protein markers help you quickly determine the molecular weight of the target protein or evaluate the transfer efficiency. (acrobiosystems.com)
  • Detection of Rat and Mouse Apolipoprotein H/ApoH by Western Blot. (rndsystems.com)
  • The N-terminal helices 1 and 3 have been identified as amyloidogenic peptides of SAA1.1, that are not presence on protein surface in native SAA1 protein. (wikipedia.org)
  • A wide list of potential new antimicrobial peptides was obtained by applying this method to about 4,000 human extracellular proteins. (unina.it)
  • Once optimized the production system, a broad characterization of two novel recombinant peptides, previously identified in human Apolipoprotein B (ApoB), was performed. (unina.it)
  • Apolipoprotein H (APOH) attaches to numerous kinds of negatively charged substances for instance heparin, phospholipids, and dextran sulfate. (assaygenie.com)
  • Detects mouse and rat Apolipoprotein H/ApoH in Western blots and detects recombinant mouse Apolipoprotein H/ApoH in direct ELISAs. (rndsystems.com)
  • In direct ELISAs, approximately 40% cross-reactivity with recombinant human Apolipoprotein H/ApoH is observed. (rndsystems.com)
  • A specific band was detected for Apolipoprotein H/ApoH at approximately 50-60 kDa (as indicated). (rndsystems.com)
  • Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)
  • ApoH inhibits thrombosis by blocking the activation of Coagulation Factor XI but also shows procoagulant activity by inhibiting the activation of Protein C (10, 11). (rndsystems.com)
  • Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases. (acrobiosystems.com)
  • Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. (thermofisher.com)
  • Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. (assaygenie.com)
  • Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)
  • Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. (thermofisher.com)
  • Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). (thermofisher.com)
  • The proteins, termed apolipoproteins, play an important role in lipoprotein metabolism. (medscape.com)
  • The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano). (reliatech.de)
  • Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. (medscape.com)
  • In addition to its association with HDL, SAA1 interacts with a number of mammalian proteins, mostly cell surface proteins such as receptors. (wikipedia.org)
  • In addition to cytidine deaminase activity, however, the fusion protein demonstrates RNA binding activity with specificity for AU-rich sequences and was found to bind an RNA template spanning the edited site of mammalian apolipoprotein B (apoB) mRNA. (elsevierpure.com)
  • Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3 beta identified by nano-electrospray mass spectrometry. (ox.ac.uk)
  • Apolipoprotein A-I (ApoAI) is internalized into hepatocytes during the centripetal transport of cholesterol. (unav.edu)
  • The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee. (web.app)
  • Maintaining normal levels of cholesterol is essential for the Apolipoprotein E has been found in amyloid plaques in the cerebral cortex of patients with Alzheimer's disease as well as in other types of amyloid. (web.app)
  • Apolipoprotein A-I, the most important protein in "good ldl cholesterol," also can type pathologic amyloids leading to atherosclerosis and systemic amyloidosis, stated Gursky. (vizintee.com)
  • Recombinant Human Apolipoprotein B-100 is produced by our E.coli expression system and the target gene encoding Glu28-Ser127 is expressed with a 6His tag at the N-terminus. (assaygenie.com)
  • Purified human Apolipoprotein CIII. (abcam.co.jp)
  • Here, we generated a recombinant protein formed by linking ApoAI to the amino terminus of human PBGD (rhApoAI-PBGD) in an attempt to transfer PBGD into liver cells. (unav.edu)
  • Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial (Active) referenced in "Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile", Science Advances , 2021. (cusabio.com)
  • A major difference between human and mouse SAA genes is the expression of the mouse Saa3 gene for a functional protein, generally considered an inducible SAA in inflammatory tissues. (wikipedia.org)
  • Recombinant human ApoA-I is a 28.2 kDa protein of 244 amino acid residues. (reliatech.de)
  • Many human proteins with functions not necessarily related to host defense behave as sources of HDPs. (unina.it)
  • In order to identify by a rational approach further human proteins carrying cryptic HDPs, we recently developed an in-silico screening method to localize antimicrobial regions hidden inside the primary structure of precursor proteins. (unina.it)
  • One of these HDPs has been identified in human 11-hydroxysteroid dehydrogenase-1 β-like, the other represents the first HDP from an archaeal protein, the transcription factor Stf76 encoded by the hybrid plasmid-virus pSSVx from Sulfolobus islandicus. (unina.it)
  • CDKN2AIPNL Human Recombinant produced in E. coli is. (neuromics.com)
  • APOA1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 264 amino acids (25-267 a.a.) and having a molecular mass of 30.3kDa. (lifetein.com)
  • No. 4,743,679 which discloses a process for the production of human epidermal growth factor comprising cleavage of a fusion protein by Staphylococcus aureus V8 protease. (justia.com)
  • Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
  • Due to the large number of proteins, no protein array platform has yet been designed that covers the entire human placental proteome. (hindawi.com)
  • Definition of human apolipoprotein A-I epitopes recognized by autoantibodies present in patients with cardiovascular diseases. (medscape.com)
  • Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. (thermofisher.com)
  • 2D-PAGE for proteome studies gives a map of proteins which reflect changes in protein expression levels, as well different isoforms and posttranslational modifications. (hindawi.com)
  • However, the physiological role of continuous infusion of recombinant APOA4 protein in regulating sympathetic activity, thermogenesis, and lipid and glucose metabolism in low-fat-diet (LFD)-fed mice remained elusive. (ohio.edu)
  • The hypothesis of this study was that continuous infusion of mouse APOA4 protein would increase sympathetic activity and thermogenesis in BAT and subcutaneous inguinal white adipose tissue (IWAT), attenuate plasma lipid levels, and improve glucose tolerance. (ohio.edu)
  • Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. (web.app)
  • 1-3 Although individuals carrying the ε4 allele have higher and those carrying the Apolipoprotein (apo) E is a 299‐residue protein which functions as a key regulator of plasma lipid levels. (web.app)
  • Conversion of this insoluble material involves often slow and complex refolding methods, making protein purification difficult. (justia.com)
  • SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. (wikipedia.org)
  • They are found in a varying number of copies in some plasma proteins including prothrombin and urokinase-type plasminogen activator, which are serine proteases belonging to MEROPS peptidase family S1A. (embl.de)
  • Plasminogen, HGF/SF and HGF1/MSP represent paradigmatic examples of the modern, multi-domain proteins typically associated with vertebrate organisms and illustrate a novel evolutionary pathway that led to the emergence of molecules with growth regulatory activity from proteolytic enzymes. (embl.de)
  • Description: Clusterin Canine Recombinant produced in HEK293 cells is a glycosylated, Polypeptide chain containing 436 amino acids and having a molecular mass of 50.72 kDa. (tlr-4.com)
  • Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. (acrobiosystems.com)
  • Correction of enzymatic deficits in hepatocytes by systemic administration of a recombinant protein is a desired therapeutic goal for hepatic enzymopenic disorders such as acute intermittent porphyria ( AIP), an inherited porphobilinogen deaminase (PBGD) deficiency. (unav.edu)
  • A unique insertion in the primary structure of bovine amyloid AA protein. (joplink.net)
  • 1997) No association between apolipoprotein E epsilon4 allele and the age of onset in type I familial amyloid polyneuropathy. (web.app)
  • A brand new examine by researchers from the Boston College Chobanian & Avedisian Faculty of Medication explores the hyperlink between the twin nature of this small plasma protein: the way it works to clear poisonous particles from wounds and irritation websites, but in addition its position in forming fibrous deposits of the pathologic amyloid in very important organs such because the kidney and liver within the life-threatening illness AA amyloidosis. (vizintee.com)
  • The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. (thermofisher.com)
  • In this study, we explore the structure-function relationships among therapeutic proteins. (crimsonpublishers.com)
  • We collected sequence data of the therapeutic proteins from Drug Bank and KEGG databases, then grouped different mechanistic and therapeutic classes. (crimsonpublishers.com)
  • Eight classes could be made for the various functionalities, and a corresponding correlation between each class and the relevant structure of the therapeutic protein category using RMSD scores was built. (crimsonpublishers.com)
  • Secondly, those proteins which are present in soluble form in the cytoplasm often are subject to degradation by host specific enzymes, thus reducing the amounts of active protein that can be recovered. (justia.com)
  • For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. (lifetein.com)
  • Estetrol is only 46% to 50% bound by plasma proteins, while drospirenone is 96% bound. (uspharmacist.com)
  • The following product was used in this experiment: LDLR Recombinant Rabbit Monoclonal Antibody (4) from Thermo Fisher Scientific, catalog # MA5-29724, RRID AB_2785547. (thermofisher.com)
  • The following product was used in this experiment: Apolipoprotein B Monoclonal Antibody (F2C9) from Thermo Fisher Scientific, catalog # MIA1609, RRID AB_11152638. (thermofisher.com)
  • The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. (thermofisher.com)
  • Analysis of two highly expressed genes from Chlorella virus PBCV-1: Protein characterization and the DNA sequences of the major capsid protein gene and the early/late 33-kDa protein gene. (uml.edu)
  • Frequent occurrence of hypoalphalipoproteinemia due to mutant apolipoprotein A-I gene in the population: a population-based survey. (medscape.com)
  • However, the addi-tion of either recombinant IL-2 or an anti-CD137 mAb markedly improves both outcomes in these mice. (unav.edu)
  • and Lo, Chunmin C., "Apolipoprotein A4 Elevates Sympathetic Activity and Thermogenesis in Male Mice" (2023). (ohio.edu)
  • Many of these genes encode proteins (e.g., enzymes involved in protein glycosylation) rarely associated with viruses. (uml.edu)
  • Enzymes known to the prior art as "proteolytic enzymes" have been found to be particularly well suited for the cleavage of fusion proteins. (justia.com)
  • Long-chain fatty acids induce apolipoprotein A4 (APOA4) production in the small intestine and activate brown adipose tissue (BAT) thermogenesis. (ohio.edu)
  • In conclusion, continuous infusion of mouse APOA4 protein stimulated sympathetic activity in BAT and the liver, elevated BAT thermogenesis and hepatic fatty acid oxidation, and consequently attenuated levels of plasma and hepatic TG and plasma insulin without altering caloric intake, body weight gain and fat mass. (ohio.edu)
  • Transfection of mRNAs encoding the chimeric constructs achieved functional expression of the proteins able to act on their targets. (unav.edu)
  • In order to characterize its function, we have expressed Brugia pahangi CDD in bacteria as a chimera with maltose-binding protein (MBP). (elsevierpure.com)
  • Fusion partners known to the prior art include maltose binding protein (Di Guan et al. (justia.com)
  • Proteins are composed of functional units and carry out their functions primarily through their constituent domains which are the independent folding groups. (crimsonpublishers.com)
  • It is evident that not all domains with a globular structure are the sole composing units that are functional for a protein. (crimsonpublishers.com)
  • The data based on the sequence and three-dimensional surface information are used to categorize proteins in various functional conservation sub-types [5]. (crimsonpublishers.com)