Recombinant monoclonal anti idiotypic antibodies. Medical search. Frequent questions

3) Binding to a complex of therapeutic antibody and its target antigen. (avacta.com)
Binding to an antibody-antigen complex allows the measurement of only the bound therapeutic antibody within a sample. (avacta.com)
scFv is the smallest of the recombinant antibody formats, which is capable of antigen binding. (wikipedia.org)
Bispecific antibodies combine two different antigen binding specificities within one molecule. (wikipedia.org)
Chain recombination by somatic cell fusion was used instead to study the effects on antigen specificity and idiotypy of recombinants in which an homologous light (L) chain substituted for the parental L chain. (aai.org)
Hybridoma-hybridoma fusion provides an alternative to in vitro chain recombination for studying the contribution of chain combinational diversity to antibody diversity, antigen binding, and idiotypy. (aai.org)
One of the first critical steps in an effective antibody response is the recognition of a foreign antigen by a membrane anchored B cell receptor (BCR) on the surface of a naïve B cell. (washington.edu)
Expanded pools of diverse B cell clones compete for antigen and T cell help in a Darwinian process that ultimately selects for B cells with higher affinity receptors which can be secreted as soluble molecules (antibodies). (washington.edu)
Identification of such tumor-associated cell surface antigen polypeptides, i.e. tumor associated antigens (TAA), allows specific targeting of cancer cells for destruction via antibody-based therapies. (justia.com)
hsv specific antibody production was detected in culture supernatants of pbmc from hsv seropositive healthy individuals by stimulating with optimal concentrations of hsv antigen without mitogens. (liverpool.ac.uk)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
c) Effect of antibodies and antigen-specific B cells on antigen uptake. (hindawi.com)
Left panel: antigen bound by antibody is taken up via FcR on APCs such as dendritic cells or macrophages. (hindawi.com)
Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
Choosing the guinea pigs as model, we specialize in the antigen preparation, guinea pig immunization, sera collection, and titer dectection, antibody purification and offer a full set of services. (abvigen.com)
Abvigen is committed to providing one-stop antibody customization services from antigen synthesis to antibody manufacturing for scientific research institutions and pharmaceutical enterprises. (abvigen.com)
Collaborative, experienced, and conducted completely in our own facilities, our custom antibody production services can drive your project from the design and synthesis of your antigen through to production and characterization of your antibody. (abocdn.com)
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
Abvigen enables the high-throughput delivery and the generation high-quality of recombinant proteins and antibodies that are widely used in applications such as antigen preparation, antibody discovery, protein structure elucidation, and research for protein function. (abvigen.com)
The antibody transports the toxin in the body and selectively targets it to tumour cells by binding to a cell-surface antigen. (creativebiolabs.net)

High specificity, sensitivity and reproducibility in assay performance are key for any anti-idiotypic reagent, in addition to consistent batch-to-batch control, because any specific anti-idiotypic reagent may be used for several years over the lifetime of the drug evaluation process. (avacta.com)
In this respect, the development of recombinant anti-idiotypic reagents, such as Affimer binders, is ideal, as it allows guided selection to achieve binders with sufficient specificity and sensitivity to be able to identify a biotherapeutic target against a complex background of serum. (avacta.com)
Being able to drive the specificity of the anti-idiotypic binder to the idiotope of the biotherapeutic, in this way, is difficult with the use of traditional animal methods for the generation of these reagents. (avacta.com)
In contrast to monoclonal antibodies produced by hybridoma technology, which may lose the capacity to produce the desired antibody over time or the antibody may undergo unwanted changes, which affect its functionality, recombinant antibodies produced in phage display maintain high standard of specificity and low immunogenicity. (wikipedia.org)
Based on their binding specificity 3 types of anti-idiotypic antibodies can be distinguished, which partially overlap with the previously mentioned formats: the classical ones, a group including Fab fragment antibodies, antibodies binding to idiotope outside of the drug binding site and antibodies, which only bind to the already assembled complex of drug bound to the target. (wikipedia.org)
However, this recombinant antibody binds digoxin with decreased affinity and altered specificity relative to native 26-10. (aai.org)
As an alternative to using HIV-1 Env as a vaccine immunogen, we are pursuing a novel vaccine strategy where we generate anti-idiotypic antibodies: antibodies raised in a non-human animal model that bind with high affinity and specificity to bNAb precursors. (washington.edu)
The antibody has been tested against a broad range of other biosimilars to ensure specificity. (rndsystems.com)
When choosing a secondary antibody product, consideration must be given to species and immunoglobulin specificity, conjugate type, fragment and chain specificity, level of cross-reactivity, and host-species source and fragment composition. (rockland.com)

Moreover, in addition to the expansion in innovator and biosimilar therapeutic antibodies, advances in the field of antibody engineering have led to the development of antibody-derived molecules, such as bispecific antibodies and antibody drug conjugates, which are now approaching the clinic for use as antibody drugs. (avacta.com)
Cysteine engineered anti-MUC16 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-MUC16 antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. (justia.com)
The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer (Lambert, J. (2005) Curr. (justia.com)
Drug moieties used in antibody drug conjugates include bacterial protein toxins such as diphtheria toxin, plant protein toxins such as ricin, small molecules such as auristatins, geldanamycin (Mandler et al (2000) J. of the Nat. (justia.com)
For this purpose, we synthesized carcinogen-protein conjugates and prepared mono- and polyclonal antibodies to benzo[a]pyrene. (actanaturae.ru)
Antibody-toxin conjugates (immunotoxins) can be produced by using conventional chemical coupling techniques or recombinant DNA techniques. (creativebiolabs.net)

If the anti-idiotypic antibody binds in a neutralising fashion to the therapeutic antibody paratope, this allows us to measure only the levels of free antibody in a sample. (avacta.com)
They take advantage of a special hydrazide linkage that binds antibodies through the carbohydrate residues on their Fc regions. (biaseparations.com)
Binds the A2 domain of recombinant human factor VIII in solid-phase ELISA. (greenmoab.com)
An antibody which binds the isolated protein is also described. (patentsencyclopedia.com)

The invention provides antibodies that bind to a plurality of β-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. (justia.com)
Immunoaffinity columns using antibodies as ligands against mammalian proteins could be used for different applications in protein expression control and, if a standard available, for direct protein quantification in complex sample solutions. (biaseparations.com)
Additionally, these columns are ideal for polishing step of recombinant proteins, such as mammalian receptor Fc fusion proteins. (biaseparations.com)
Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com.cn)

In case the IgG immunoglobulin was more suitable for the treatment or some other particular application, experiments have also been conducted, in which the recombinant Fab fragments were converted into recombinant IgG form. (wikipedia.org)
Immunoglobulin chain recombination among antidigoxin antibodies by hybridoma-hybridoma fusion. (aai.org)

To be able to specifically identify the therapeutic antibody, amongst this million-fold excess of IgG, highly sensitive affinity reagents are essential. (avacta.com)
An anti-idiotypic antibody can therefore specifically bind to the idiotope of the target antibody, such as a therapeutic antibody, to act as capture and detection reagents in PK assays. (avacta.com)
Donkey IgG F(ab')2 fragment Peroxidase conjugated secondary antibody reagents are ideal for ELISA, western blotting, Immunohistochemistry, Fluorescence Microscopy, Flow Cytometry as well as other antibody detection methods. (rockland.com)

an enzyme linked immunosorbent assay (elisa) system to study specific anti-herpes simplex virus (hsv) antibody production in vitro by human peripheral blood mononuclear cells (pbmc) has been developed. (liverpool.ac.uk)
Using ELISA, we demonstrated that the recombinant protein specifically interacts with the anti-benzo[a]pyrene monoclonal antibody (mAB B2). (actanaturae.ru)
In a phase 2 safety and immunogenicity study of a chikungunya virus virus-like particle (CHIKV VLP) vaccine in an endemic region, of 400 total participants, 78 were found to be focus reduction neutralizing antibody seropositive at vaccination despite being ELISA seronegative at screening, of which 39 received vaccine. (bvsalud.org)
Enzyme-linked immunosorbent assay (ELISA) is the gold standard when interrogating serum analytes but even so the challenge with interfering human anti-animal IgG antibodies (HAAA) and heterophilic antibodies can cause unnoticeable false positive or negative results (Willman et al. (springeropen.com)

Therapeutic antibodies are the fastest growing drug class, with continuous increases in the number of innovator molecules approaching the market. (avacta.com)
within serum there is approximately 12mg/ml of our natural IgG antibodies, and most therapeutic antibodies are present only at ng/ml levels. (avacta.com)
Anti-idiotypic antibodies and anti-idiotypic antibody mimetics are the specific tools that allow us to monitor therapeutic antibody levels and distribution within PK assays. (avacta.com)
Anti-idiotypic antibodies can bind to a therapeutic antibody for specific recognition in three different modes. (avacta.com)
1) Binding to the binding site of the therapeutic antibody to inhibit the target binding of the therapeutic antibody. (avacta.com)
2) Binding to a region close to the binding site of the therapeutic antibody without inhibiting target binding. (avacta.com)
Bioanalytical scientists are able to gain different information, such as bound drug or total drug levels, regarding the activity of a therapeutic antibody from each of the different methods of anti-idiotypic antibody binding. (avacta.com)
Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed. (justia.com)
The invention relates generally to antibodies engineered with reactive cysteine residues and more specifically to antibodies with therapeutic or diagnostic applications. (justia.com)
Furthermore, antibodies against the idiotype of the original image (anti-idiotypic antibody) and therapeutic antibody that blocks the activity of the reagent capture antibody cause falsely low measurements and lastly anti-anti-idiotypic antibodies, which mimic the reagent capture antibody could also cause falsely low measurement. (springeropen.com)
We currently have 3 therapeutic antibodies already on the market and more than 30 in preclinical and clinical stages. (proteogenix.science)

The isolation of monoclonal bNAbs from HIV-1+ individuals has provided valuable information on how bNAbs develop during infection, and on the epitope specificities on the HIV-1 Envelope protein (Env) that an effective vaccine should aim to elicit. (washington.edu)
HEK293 human cell line transfected with (A) human MS4A1/CD20 or (B) irrelevant protein, and eGFP were stained with Human anti-Human MS4A1/CD20 (Rituximab) Monoclonal Antibody ( MAB9575 ), then Alexa Fluor® 647-conjugated Anti-Rituximab (Anti-Idiotype) (Catalog # FAB9630R). (rndsystems.com)
Some cytotoxic drugs tend to be inactive or less active when conjugated to large antibodies or protein receptor ligands. (justia.com)
As a result, we prepared a recombinant protein composed of the benzo[a]pyrene immunomimetic peptide and pIII-encoding sequences. (actanaturae.ru)
antibodies-online.com is a true Single Source when working on the protein level and we continue to build an exclusive and unique line of products at the cutting edge of science. (abocdn.com)
Having the right, high-quality antibody or protein for the right application can make the difference between success or failure in your experiment. (abocdn.com)
Rockland is a privately held company, operating a 60,000 square feet manufacturing facility with antibody and protein production capabilities near Philadelphia, Pennsylvania, USA. (abocdn.com)
An immunotoxin is a macromolecular drug which consists of a monoclonal antibody linked to a protein toxin.The toxin is usually a cytotoxic protein derived from a bacterial or plant protein, such as Diphtheria toxin (DT), Cholera toxin (CT), Trichosanthin (TCS), Dianthin etc. (creativebiolabs.net)

These highly specific and high-affinity recombinant antibodies are suitable for bioanalysis and drug monitoring of daratumumab and its biosimilars. (the-scientist.com)
The new range of anti-daratumumab antibodies comprises three fully human IgG1 inhibitory antibodies with varying levels of affinity. (the-scientist.com)
Conditions necessary for in vitro chain recombination of high affinity (10(9) to 10(12) M-1) antidigoxin monoclonal antibodies resulted in decreased affinity for both intact "native" and chain recombinant molecules. (aai.org)
The affinity purified recombinant species consisting of 26-10 H chain and 40-20 kappa-chain expresses complete 26-10 idiotypic determinants. (aai.org)
The cysteine engineered antibodies may be conjugated with chemotherapeutic drugs, toxins, affinity ligands such as biotin, and detection labels such as fluorophores. (justia.com)

The antibodies are ideal for use as surrogate positive controls in anti-drug antibody assays, and for the development of pharmacokinetic bridging ELISAs to measure free drug. (the-scientist.com)
Bio-Rad offers a portfolio of recombinant, monoclonal, nonanimal-derived anti-idiotypic antibodies and drug-target complex binders for the development of highly selective and sensitive assays. (the-scientist.com)
earchers can rely on our antibodies to deliver reproducible results over the lifecycle of their bioanalytical assays" she said. (the-scientist.com)
Sheep IgG (H&L) Antibody Texas Red™ Conjugated antibody has been tested by western blot and are designed for immunofluorescence microscopy, fluorescence based plate assays (FLISA) and fluorescent western blotting. (rockland.com)

The most commonly used are the scFv, Fab fragments and bispecific antibodies. (wikipedia.org)
The bispecific antibodies are used to crosslink the target molecules with two different cells and mediate direct cytotoxicity. (wikipedia.org)

As many of the major blockbuster antibody therapeutics are beginning to come off patent an increase has been observed in the number of biosimilar antibodies under development. (avacta.com)

If you cannot find an antibody from our extensive antibody catalog to suit your research needs, then our custom antibody service team can help. (abocdn.com)

Anti-idiotypic antibodies bind to a paratope of another specific antibody. (wikipedia.org)
One triple-specific antibody, SKT05, bound proximal to the fusion peptide and neutralized all three Env-pseudotyped encephalitic alphaviruses by using different symmetry elements for recognition across VLPs. (bvsalud.org)

As a member of the anti-idiotypic antibodies, Fab fragment recombinant antibodies bind directly to the paratope of the target antibody. (wikipedia.org)

An idiotope is a specific set of unique antigenic determinants, typically found in the variable portion an antibody, that define that particular antibody. (avacta.com)
The anti-Rituximab antibody is an anti-Idiotype antibody raised against and selected for the antigenic determinants of the variable region of Rituximab. (rndsystems.com)

The majority of biotherapeutics consist of human or humanised antibodies which are highly homologous to the natural antibodies present in the serum. (avacta.com)
2013 ). Circulating HAAAs can result from both iatrogenic and noniatrogenic causes (Kricka 1999 ), while heterophilic arise in healthy individuals as natural antibodies (Levinson and Miller 2002 ). (springeropen.com)

Baseline seropositive vaccine recipients had stronger post-vaccination luciferase neutralizing antibody responses versus seronegative recipients (peak geometric mean titer of 3594 and 1728, respectively) persisting for 72 weeks, with geometric mean fold increases of 3.1 and 13.2, respectively. (bvsalud.org)
Interestingly, the antibody titer in vaccinated dogs was significantly associated with the overall survival. (bmj.com)

Consequently, it is important that the anti-idiotypic antibodies or antibody mimetics used for analysis contain examples of non-neutralising antibodies, to ensures the accurate detection of the target-bound biotherapeutics in addition to free biotherapeutic molecules within any clinical samples. (avacta.com)

As a consequence of bNAb precursors fail to bind most recombinant HIV-1 Envs (such as those that would be used in HIV-1 vaccines). (washington.edu)

The antidigoxin antibody 26-10 utilizes a VL sequence highly homologous to that of antibody 40-20, an antidigoxin antibody which uses a different VH gene than does 26-10 and lacks significant reactivity with an anti-26-10 idiotypic serum. (aai.org)

The in vitro selection process for specific Affimer binders includes the ability to deselect against homologous targets and serum constituents, which focuses selection upon the idiotypic region of the biotherapeutic and prevents matrix issues arising during use. (avacta.com)
Fab fragment antibodies can be used for detection of not bound drugs or free drugs in the serum. (wikipedia.org)
Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Donkey Serum, Sheep IgG and Sheep Serum. (rockland.com)

Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)

After washing and blocking with PBST+5% BSA, detection was performed using HRP conjugated Human Anti-Vedolizumab Antibody, clone AbD30139_hIgG1 (HCA295) at a concentration of 2 μg/ml in HISPEC Assay Diluent ( BUF049A ) followed by QuantaBlu Fluorogenic Peroxidase Substrate. (bio-rad-antibodies.com)
After washing and blocking with PBST+5% BSA, detection was performed using HRP conjugated Human Anti-Vedolizumab Antibody, clone AbD30139_hIgG1 (HCA295) titrated to the given concentrations in HISPEC Assay Diluent ( BUF049A ) and QuantaBlu Fluorogenic Peroxidase Substrate. (bio-rad-antibodies.com)
Detection of Anti-MS4A1/CD20 (Rituximab) on Human MS4A1/CD20 transfectants by flow cytometry. (rndsystems.com)
Another is that HAAAs may diminish the signal by blocking the analyte binding to capture and/or detection antibody producing incorrectly low-test values. (springeropen.com)

For the full-length antibody and glycoprotein biological drug, the folding of expression product polypeptide chain, the disulfide bond, the presence or absence of glycosylation and the type of glycosylation often affect the properties of the synthesis, secretion, biological activity, in vivo stability, and immunogenicity of the expressed product. (abvigen.com)

The anti-daratumumab antibodies are approved for in vitro research purposes and for commercial applications providing in vitro testing services to support preclinical and clinical drug development. (the-scientist.com)
The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
5-(2-fluoroethyl)-2'-deoxyuridine (fedu), its 2'-fluoroarabinofuranosyl analog (fefau) and the 2'-fluoroarabinofuranosyl analog (cefau) of the potent anti-herpesvirus compound 5-(2-chloroethyl)-2'-deoxyuridine (cedu) were evaluated for activity against herpes simplex virus type 1 (hsv-1) and hsv-2 in vitro and in vivo. (liverpool.ac.uk)
fedu, fefau and cefau proved to be potent and selective anti-herpesvirus agents in vitro. (liverpool.ac.uk)
limiting dilution analysis of specific in vitro anti-herpes simplex virus antibody production by human lymphocytes. (liverpool.ac.uk)

This highly specialized anti-idiotypic antibody can be used in a variety of pharmacokinetic (PK) assay formats. (rndsystems.com)

Both the Heavy and Light chains of the antibody molecule are present. (rockland.com)

Benefit from the most productive transient expression system to produce all your humanized monoclonal antibody variants! (proteogenix.science)

Secondary Antibodies are available in a variety of formats and conjugate types. (rockland.com)

Fab antibodies have also been used to avoid the adverse effects caused by unspecific binding of the Fc portion of the antibody, which is missing in the Fab fragment. (wikipedia.org)
In the beginning phases of the recombinant antibody production it was important to achieve the assembly of a functional Fv fragment in Escherichia coli. (wikipedia.org)
This product possesses the F(ab')2 fragment, recognized by the two F(ab) fragments yielded from the digestion of the antibody below the disulfide bond hinge region. (rockland.com)

A Human Monoclonal Antibody Against Domain I Of beta 2-Glycoprotein I prevents Clotting and Fetal Loss Induced By Polyclonal Anti-Phospholipid Antibodies In Animal Models. (units.it)
It is well known that in these patients thrombosis may be the result of a hypercoagulable state related to anti-β2-glycoprotein I (β2-GPI) antibodies. (shengsci.com)

The invention relates to antibodies that specifically recognize β-chemokines. (justia.com)

Finally, binding to a region close to the paratope, yet not the paratope itself, allows the measurement of total antibody levels, both free and bound, within a sample. (avacta.com)

In addition to Rituximab, the anti-Idiotype antibody also detects derivatives of Rituximab (Ibritumumab and Tositumumab). (rndsystems.com)

Antibody charge variants have gained considerable attention in the biotechnology industry due to their potential influence on stability and biological activity and cation-exchange chromatography (CEX) is one of the typical approaches for mAb charge variant analyses. (biaseparations.com)

Recombinant antibodies have many advantages in both medical and research applications, which make them a popular subject of exploration and new production against specific targets. (wikipedia.org)
The functionality may be enhanced by site-specific chemical modifications, adding a peptide-tag or by fusion with a gene to achieve production of bifunctional recombinant antibodies. (wikipedia.org)
The production of recombinant antibodies follows principally similar workflow. (wikipedia.org)
For recombinant antibody production the stable cell lines such as CHO and HEK293 are used. (wikipedia.org)
Yet immunization of humans with recombinant Env leads to the production of antibodies with very narrow breadth of neutralization which fail to block infection of diverse circulating viral isolates. (washington.edu)
Close collaboration with Rockland Immunochemicals, Inc. more than 60 years of expertise in antibody production. (abocdn.com)

The primary objective of this trial was to evaluate the safety and tolerability of H1ssF, and the secondary objective was to evaluate antibody responses after vaccination. (bvsalud.org)

Transmembrane or otherwise tumor-associated polypeptides specifically expressed on the surface of cancer cells as compared to normal, non-cancerous cell(s) have been identified as cellular targets for cancer diagnosis and therapy with antibodies. (justia.com)
The data strongly indicate that CS-GAGs and their biosynthetic pathways are promising targets for the development of anti-metastatic therapies. (biomedcentral.com)

The Fc portion of antibodies in immune complexes can be bound by C1q of the classical complement pathway, which eventually leads to the release of C5a and C3a. (hindawi.com)

These are the Fab recombinant antibodies, scFv and diabodies. (wikipedia.org)
Along scFv and Fab fragments, diabodies or bispecific recombinant antibodies are the third major format. (wikipedia.org)

Jul 16, 2018 - Cladribine, EMA/OD/087/17 Recombinant monoclonal antibody to sialic acid-binding Ig-like lectin 8. (pdfkul.com)

A microtiter plate was coated overnight with Human Anti-Vedolizumab Antibody, clone AbD30136 ( HCA292 ) at a concentration of 1 µg/ml. (bio-rad-antibodies.com)
A microtiter plate was coated overnight with Human Anti-Pembrolizumab Antibody, clone AbD30689 ( HCA296 ) at a concentration of 1 µg/ml. (bio-rad-antibodies.com)

Therefore, it can be used for measuring presence of antibodies and drug loads in patients' sera. (wikipedia.org)

This is in contrast to an antibody allotype, in which the variation is found within the constant region. (avacta.com)
The neonatal FcRn is also able for the bidirectional transport, but in contrast to rodents, immuncomplexes and not antibodies were shown to be transferred from Fidarestat (SNK-860) your luminal part of. (biotechpatents.org)

Optimizations of mammalian cell cultures have led to increase the yield of antibodies from HEK293 or CHO cell lines to over 12g/liter. (wikipedia.org)

To identify protective antibodies, we immunized macaques with a mixture of western, eastern, and Venezuelan equine encephalitis virus-like particles (VLPs), a regimen that protects against aerosol challenge with all three viruses. (bvsalud.org)
We found that H1ssF elicited cross-reactive neutralizing antibodies against the conserved HA stem of group 1 influenza viruses, despite previous H1 subtype head-specific immunity. (bvsalud.org)
Typically, guinea pigs have no signs of disease and can generate antibody to clear the viruses upon infection with influenza. (abvigen.com)

Several mechanisms of antibody interference are assumed (Klee 2000 ). (springeropen.com)

Stimulation of antibody synthesis induced by surgical trauma in rats. (shengsci.com)
The effect of a standard laparatomy on antibody synthesis was studied in Wistar R/A rats recieving an intravenous injection of 10(9) sheep red blood cells (SRBC) during the surgical procedure. (shengsci.com)

evaluation of a monoclonal antibody typing system for herpes simplex virus. (liverpool.ac.uk)

However, interfering human anti-animal IgG antibodies and heterophilic antibodies might give rise to false positive or negative results that often go unnoticed. (springeropen.com)

Can Affimer binders meet the need for new anti-idiotypic antibodies? (avacta.com)

Another researched possibility is the development of anti-idiotypic antibodies. (wikipedia.org)
Setting the corresponding isotype control antibody to detect non-specific binding can reduce the generation of false positive results and evaluate the possible influencing factors accurately in the drug development process. (acrobiosystems.com)

Results Vaccinated dogs developed anti-Do-CSPG4 and Hu-CSPG4 immune response. (bmj.com)

The invention also provides cells producing the antibodies, and methods of making and using the same. (justia.com)
Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated. (hindawi.com)
B cells have antibody-dependent and antibody-independent pathogenic functions. (hindawi.com)
Explore our series of recombinant neural factors to support the culture and differentiation of nerve cells. (acrobiosystems.com)
Pre-stimulation ex vivo of allogeneic T cells by exposure to MOPC315.BM MM cells in the presence of IL-2, anti-CD3 and anti-CD28 resulted in expansion of the myeloma-reactive T cell TCRVβ 2, 3 and 8.3 subfamilies. (biomedcentral.com)

Anatomy19

Organisms25

Diseases9

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes48

Disciplines and Occupations3

Information Science3

Health Care4

Antigen20

Specificity9

Conjugates6

Binds4

Proteins4

Immunoglobulin2

Reagents3

ELISA4

Therapeutic11

Protein8

Affinity5

Assays4

Bispecific antibodies2

Biosimilar antibodies1

Find an Antibody1

Specific antibody2

Target antibody1

Determinants2

Natural antibodies2

Titer2

Molecules1

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Highly homologous1

Serum3

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Detection4

Secretion1

Vitro5

Pharmacokinetic1

Molecule1

Transient1

Conjugate1

Fragment3

Glycoprotein2

Invention relates1

Paratope1

Idiotype1

Variants1

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Secondary1

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ScFv2

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Sera1

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