Recombinant modified vaccinia virus. Medical search. Frequent questions

Modified vaccinia Ankara (MVA) is an attenuated (weakened) strain of the vaccinia virus. (wikipedia.org)
By inserting antigen genes into its genome, modified vaccinia Ankara virus is also used as an experimental viral vector for vaccines against non-poxvirus diseases. (wikipedia.org)
Modified vaccinia Ankara virus is a highly attenuated strain of vaccinia virus that was developed in Munich, Germany between 1953 and 1968. (wikipedia.org)
It was produced by more than 500 serial passages of vaccinia virus (from a wild strain discovered by the Turkish vaccine institute of Ankara) in chicken embryo fibroblasts. (wikipedia.org)
It was later found that through the passaging, modified vaccinia virus Ankara had lost about 10% of the ancestral vaccinia genome and with it the ability to replicate efficiently in most mammalian cells. (wikipedia.org)
Modified vaccinia Ankara strains engineered to express foreign genes are vectors for production of recombinant proteins, the most common being a vaccine delivery system for antigens. (wikipedia.org)
MVA-B is an experimental vaccine to protect against HIV infection, produced by inserting HIV genes into the genome of modified vaccinia virus Ankara. (wikipedia.org)
Safety and immunogenicity of novel recombinant BCG and modified vaccinia virus Ankara vaccines in neonate rhesus macaques. (lonelyjoeparker.com)
Here, two groups of neonate Indian rhesus macaques were immunized with either novel candidate vaccine BCG.HIVA(401) or its parental strain AERAS-401, followed by two doses of recombinant modified vaccinia virus Ankara MVA.HIVA. (lonelyjoeparker.com)
Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara. (ox.ac.uk)
Prime-boost vaccination regimes involving plasmid DNA and recombinant modified vaccinia virus Ankara-encoding liver-stage malaria antigens have been shown to be powerfully immunogenic for T cells and capable of inducing partial protection against experimental malaria challenge in humans, manifested as a delay in time to patent parasitemia. (ox.ac.uk)
Working model is the modified vaccinia virus Ankara (MVA) which is a highly attenuated vaccinia virus strain and currently tested as a vaccine vector against infectious diseases and cancer. (uniklinik-duesseldorf.de)
MVA-HPV is a modified vaccinia virus Ankara vector (MVA). (biosafety.be)
A recombinant modified vaccinia Ankara (MVA) virus expressing mature viral protein 2 (VP2) of the infectious bursal disease virus (IBDV) was constructed to develop MVA-based vaccines for poultry. (koreamed.org)
Recombinant vaccinia virus, recombinant modified vaccinia Ankara (MVA), and recombinant fowlpox were comparable in their immunogenicity. (duke.edu)
Immunogenicity and Protective Efficacy of Prime-Boost Regimens with Recombinant Delta ureC hly(+) Mycobacterium bovis BCG and Modified Vaccinia Virus Ankara Expressing M-tuberculosis Antigen 85A against Murine Tuberculosis. (mpg.de)
Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine. (ox.ac.uk)
In this study, we performed a comprehensive analysis of the changes in virus-specific CD8(+) and CD4(+) T-cell responses occurring after vaccination of 16 HIV-1-infected individuals with a recombinant modified vaccinia virus Ankara-vectored vaccine expressing the consensus HIV-1 clade A Gag p24/p17 sequences and multiple CD8(+) T-cell epitopes during highly active antiretroviral therapy. (ox.ac.uk)
The GMO MVA-HBV is a modified vaccinia virus Ankara vector (MVA) encoding a fusion of sequences derived from two hepatitis B virus (HBV) protein antigens. (biosafety.be)
Rimmelzwaan GF, Sutter G. Candidate influenza vaccines based on recombinant modified vaccinia virus Ankara. (medscape.com)
Development of modified vaccinia Ankara-5T4 as specific immunotherapy for advanced human cancer. (medscape.com)
Verheust C, Goossens M, Pauwels K, Breyer D. Biosafety aspects of modified vaccinia virus Ankara (MVA)-based vectors used for gene therapy or vaccination. (medscape.com)
Modified vaccinia virus Ankara (MVA), an attenuated vaccinia strain, is a safe and effective vaccine vector against various infectious agents and cancers. (mskcc.org)
Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model. (helmholtz-hzi.de)
BACKGROUND: Modified vaccinia virus Ankara (MVA), a highly attenuated strain of vaccinia virus, has been used as vaccine delivery vector in preclinical and clinical studies against infectious diseases and malignancies. (helmholtz-hzi.de)
Modified Vaccinia Virus Ankara Can Induce Optimal CD8(+) T Cell Responses to Directly Primed Antigens Depending on Vaccine Design. (helmholtz-hzi.de)
Expanding the repertoire of Modified Vaccinia Ankara-based vaccine vectors via genetic complementation strategies. (helmholtz-hzi.de)
Potent Anti-hepatitis C Virus (HCV) T Cell Immune Responses Induced in Mice Vaccinated with DNA-Launched RNA Replicons and Modified Vaccinia Virus Ankara-HCV. (helmholtz-hzi.de)
Vaccination with recombinant modified vaccinia virus Ankara prevents the onset of intestinal allergy in mice. (helmholtz-hzi.de)
Our vaccine platform consists of recombinant BCG prime- recombinant modified vaccinia virus Ankara (MVA) boost. (ac.ke)
Modified vaccinia Ankara (MVA) belongs to the family of poxviruses and is a versatile vaccine platform that combines several attributes crucial for cancer therapy. (bvsalud.org)
Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. (bvsalud.org)
Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa. (ox.ac.uk)
The safety and immunogenicity of plasmid pTHr DNA, modified vaccinia virus Ankara (MVA) human immunodeficiency virus type 1 (HIV-1) vaccine candidates were evaluated in four Phase I clinical trials in Kenya and Uganda. (ox.ac.uk)
Our team previously developed a fast cloning system for the modified vaccinia virus Ankara (MVA) vaccine platform. (bvsalud.org)
This polyprotein was expressed by a plasmid DNA vaccine vector (DNA) and by two attenuated poxvirus vectors, modified vaccinia virus Ankara (MVA) and fowlpox virus of the FP9 strain. (ox.ac.uk)
Modified vaccinia virus Ankara (MVA) is a highly attenuated, non-replicative vaccinia virus with a long history of human use. (bvsalud.org)
MVA-BN-Filo is a recombinant DNA vaccine based on modified vaccinia Ankara (MVA). (msdmanuals.com)

A recombinant MVA-based vector for vaccination with different fluorescent reporter genes was developed, which indicate the progress of genetic recombination with the transgene of an antigen (green, colorless, red). (wikipedia.org)
Vaccination with vaccinia virus has been directly responsible for the successful eradication of smallpox (variola). (medscape.com)
Laboratory personnel working with vaccinia and others for whom the benefits outweigh the risks of vaccination may also receive vaccinations. (medscape.com)
In 1796, when Jenner made his seminal report on vaccinia, the potential benefits of vaccination became widely accepted. (medscape.com)
Routine vaccination with ACAM2000 is recommended for laboratory personnel who directly handle 1) cultures or 2) animals contaminated or infected with replication-competent vaccinia virus, recombinant vaccinia viruses derived from replication-competent vaccinia strains (i.e., those that are capable of causing clinical infection and producing infectious virus in humans), or other orthopoxviruses that infect humans (e.g., monkeypox, cowpox, and variola) (recommendation category: A, evidence type 2). (cdc.gov)
Health care personnel (e.g., physicians and nurses) who currently treat or anticipate treating patients with vaccinia virus infections and whose contact with replication-competent vaccinia viruses is limited to contaminated materials (e.g., dressings) and persons administering ACAM2000 smallpox vaccine who adhere to appropriate infection prevention measures can be offered vaccination with ACAM2000 (recommendation category: B, evidence type 2). (cdc.gov)
The induction of antiviral innate immunity by systemic immunization with live virus can be employed to positively impact the response to therapeutic vaccination. (bvsalud.org)
At the other end of the spectrum has been the view that SARS-CoV-2 is so threatening that it absolutely necessitates acceptance of the risks associated with mass vaccination with suboptimal and inadequately studied vaccines, as well as the risks associated with prolonged lockdown measures, until 100% of the world's population (including children) has been fully vaccinated (i.e., "zero tolerance," complete eradication of the virus). (notesfromthesocialclinic.org)
Vaccination and vaccine derive from vaccinia, the virus once used as smallpox vaccine. (cdc.gov)
Thus, vaccination originally meant inoculation with vaccinia virus to make a person immune to smallpox. (cdc.gov)

Bacillus Calmette-Guérin (BCG) is given to most infants at birth, and its recombinant form could be used to prime HIV-1-specific responses for a later boost by heterologous vectors delivering the same HIV-1-derived immunogen. (lonelyjoeparker.com)
Our group focuses on the immunobiology of poxviruses and their development and characterization as viral vectors and recombinant vaccines. (uniklinik-duesseldorf.de)
We explored this issue in the simian human immunodeficiency virus/rhesus monkey model in the course of assessing the relative immunogenicity of vaccine regimens that included a cytokine-augmented plasmid DNA prime and a boost with DNA or recombinant pox vectors. (duke.edu)
In contrast to the dominant T helper (Th) 1 biased responses elicited against Ags produced by recombinant MVA vectors, the use of nrMVA as adjuvant for the co-administered soluble Ags resulted in a long lasting mixed Th1/Th2 responses. (helmholtz-hzi.de)
Improving recombinant MVA immune responses: potentiation of the immune responses to HIV-1 with MVA and DNA vectors expressing Env and the cytokines IL-12 and IFN-gamma. (helmholtz-hzi.de)
Ad26.ZEBOV/MVA-BN-Filo is a combination of two vaccine vectors that are genetically modified so that they cannot replicate in human cells. (msdmanuals.com)

Our results indicate that the use of a mutated minigene construct directing the expression of a modified melanoma tumor Ag leads to improved Ag recognition and, more importantly, to enhanced immunogenicity. (ox.ac.uk)
4: Liu J, Lin J, Cai L, Sun J, Ding X, Wang C, Wu Y, Gao X, Su W, Jiang C. Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice. (jlu.edu.cn)

The HIV-1-specific responses induced in infants were lower compared to historic data generated by the two HIVA vaccines in adult animals but similar to other recombinant poxviruses tested in this model. (lonelyjoeparker.com)
Poxviruses are large cytoplasmic DNA viruses that cause significant human and veterinary diseases. (mskcc.org)
A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses. (ox.ac.uk)

ChAdOx1-HPV is a recombinant replication-incompetent chimpanzee-derived adenovirus (ChAdY25) viral vector. (biosafety.be)

This also includes to broaden our knowledge and understanding of virus-host interactions on the molecular level for instance with components of the antigen processing and presentation machinery. (uniklinik-duesseldorf.de)
We found that CTL responses against MVA-produced antigens were dominated by cross-priming in vivo , despite the ability of the virus to efficiently infect professional antigen-presenting cells (APC) such as dendritic cells (DC). (uniklinik-duesseldorf.de)
the description of a novel recombinant bacille Calmette-Guérin (BCG) vaccine candidate that works by over-expressing not an antigen, but a membrane-perforating enzyme (Grode 2005). (tuberculosistextbook.com)
In contrast, only transgenic mice failed to generate a cytolytic T-cell response to soluble H-2Kk antigen expressed by recombinant vaccinia virus and presented by the H-2Db molecule. (uni-muenchen.de)
Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA3C) is one of the essential latent antigens for primary B-cell transformation. (interleukinreceptor.com)
Pseudorabies virus glycoprotein E (PRV gE) has been recognized as a suitable diagnostic antigen for pseudorabies. (creativebiomart.net)
On September 24, rabies was confirmed by the presence of laboratory evaluation to determine the cause of his encepha- rabies virus antigen in the skin biopsy, and the detection of lopathy, including a urine drug screen, tricyclic antidepressant rabies virus in saliva and skin by reverse transcription poly- levels, an arbovirus panel, and testing for antibodies to Rocky merase chain reaction. (cdc.gov)
e) Specific immune globulin: Special preparations obtained from blood plasma from donor pools preselected for a high antibody content against a specific antigen (e.g., hepatitis B immune globulin, varicella-zoster immune globulin, rabies immune globulin, tetanus immune globulin, vaccinia immune globulin, and cytomegalovirus immune globulin). (cdc.gov)

In order to better understand differences in the outcome of infectious bursal disease virus (IBDV) infection, we inoculated a very virulent (vv) strain into White Leghorn chickens of inbred line W that was previously reported to experience over 24% flock mortality, and three inbred lines (15I, C.B4 and 0) that were previously reported to display no mortality. (imperial.ac.uk)

Smallpox vaccines containing vaccinia virus were used to successfully eradicate smallpox as a disease of humans ( 3 ). (cdc.gov)

Here, we report that substitution of plasmid DNA as the priming vector with a specific attenuated recombinant fowlpox virus, FP9, vaccine in such prime-boost regimes can elicit complete sterile protection that can last for 20 months. (ox.ac.uk)

The traditional smallpox vaccine, which was used in the smallpox eradication campaign 1958-1977, consists of a live vaccinia virus which can replicate in humans but usually does not cause disease. (wikipedia.org)
Eradication was made possible by the ability of vaccinia virus to induce cross-protective immunity against other viruses within the orthopoxvirus genus capable of producing human infection (e.g., variola, monkeypox, and cowpox) ( 3 ). (cdc.gov)
Vaccinia virus is a prototypical poxvirus successfully used for smallpox eradication. (mskcc.org)

In animal models, MVA-based vector vaccines have been found to be immunogenic and protective against various infectious agents including immunodeficiency viruses, influenza, parainfluenza, measles virus, flaviviruses, tuberculosis, Plasmodium parasites as well as certain cancers. (wikipedia.org)
The adoption of up-to-date methodology for convenient vector generation, vector quality control, and vector vaccine immune monitoring has increased the pace bringing recombinant MVA vaccines into clinical trials. (uniklinik-duesseldorf.de)
Next to the optimization of the vector backbone and expression of target genes, we aim to optimize protocols for generation, isolation and molecular characterization of MVA vector viruses e.g. by using recombinant BAC-technology. (uniklinik-duesseldorf.de)
An open-label, phase I, dose-escalation and safety study of two intramuscular injections at dose of 2.9 log or 4 log CCID50 of the recombinant HIV I clade B measles vaccine vector in healthy adults. (biosafety.be)
Of the 120 strains of variola virus in the collection held at VECTOR in the Russian Federation, 55 isolates had been tested for viability and 32 could be propagated. (who.int)

Ad26.ZEBOV is a recombinant DNA vaccine based on adenovirus type 26 (Ad26). (msdmanuals.com)

The nOPV2 candidate strains include different combinations of 5 distinct modified regions of the Sabin-2 genome, including changes to the RNA sequence in the 5' untranslated region of polio genome (5' UTR), the capsid protein coding region (P1), the non-structural protein 2C, and the polymerase 3D. (biosafety.be)
Natural T-Cell immunity provides stronger and more comprehensive protection against all SARS-CoV-2 strains than vaccines, because naturally primed immunity recognises multiple virus epitopes and costimulatory signals, not merely a single (spike) protein. (zeromandatoryvaxx.com)

In this study, a genetically stable, marker-free recombinant MVA expressing α-crystallin of M. tuberculosis (rMVA. (nature.com)
Here, we report rational engineering of an immune-activating recombinant MVA (rMVA, MVA∆E5R-Flt3L-OX40L) with deletion of the vaccinia E5R gene (encoding an inhibitor of the DNA sensor cyclic GMP-AMP synthase, cGAS) and expression of two membrane-anchored transgenes, Flt3L and OX40L. (bvsalud.org)

Here we developed novel replicating poxvirus NYVACbased HIV/AIDS vaccine candidates expressing clade C HIV-1 antigens, with one of them lacking the vaccinia virus B19 protein, an inhibitor of the type I interferon response. (uni-regensburg.de)
others have antigens that are complex or incompletely defined (e.g., killed Bordetella pertussis or live attenuated viruses). (cdc.gov)
Overview of Immunization Immunity can be achieved Actively by using antigens (eg, vaccines, toxoids) Passively by using antibodies (eg, immune globulins, antitoxins) A toxoid is a bacterial toxin that has been modified. (msdmanuals.com)

In 2001, the Advisory Committee on Immunization Practices approved revised recommendations that laboratory and health care personnel occupationally exposed to vaccinia virus, recombinant vaccinia viruses, and other orthopoxviruses that can infect humans be vaccinated with Dryvax smallpox vaccine. (cdc.gov)
Intended for intramuscular administration, IG is primarily indicated for routine maintenance of immunity of certain immunodeficient persons and for passive immunization against measles and hepatitis A. IG does not transmit hepatitis B virus, human immunodeficiency virus (HIV), or other infectious diseases. (cdc.gov)

The variola virus causes smallpox and may have begun infecting humans approximately 10,000 years ago. (medscape.com)

Severe acute respiratory syndrome (SARS) is a serious, potentially life-threatening viral infection caused by a previously unrecognized virus from the Coronaviridae family, the SARS-associated coronavirus (SARS-CoV). (medscape.com)
Multiple lines of research indicate that immunocompetent people display "robust" and lasting cellular (T cell) immunity to SARS-CoV viruses [1], including SARS-CoV-2 and its variants [2]. (zeromandatoryvaxx.com)
We obtained recombinant MVA expressing the unmodified full-length SARS-CoV-2 spike (S) protein containing the D614G amino-acid substitution (MVA-Sdg) and a version expressing a modified S protein containing amino-acid substitutions designed to stabilize the protein a in a pre-fusion conformation (MVA-Spf). (bvsalud.org)
At one end of the spectrum has been the view that COVID has not represented an unusual health threat and the SARS-CoV-2 virus does not even exist. (notesfromthesocialclinic.org)
How deadly was the original SARS-CoV-2 virus? (notesfromthesocialclinic.org)
At the beginning of the COVID pandemic, it was feared that the SARS-CoV-2 virus might represent the most threatening respiratory virus since the deadly 1918 Spanish influenza virus, which was an H1N1 influenza virus of avian origin. (notesfromthesocialclinic.org)

Inoculation with vaccina virus produces a localized skin infection. (medscape.com)
Sub-Objective 2.iii: identifying the immune mechanism mediating effective homologous and heterologous protection against virus infection. (usda.gov)
The immune system could play a crucial role in virus infection. (medsci.org)
The successful development and implementation to intervene prevention and treatment of virus infection over the past hundred years have had great advances on human and animal health. (medsci.org)
However, to this day, in the fight against virus infection, there is no real winner. (medsci.org)
Vulvar vaccinia infection after sexual contact with a military smallpox vaccinee--Alaska, 2006. (medscape.com)
Disruption of TNF-a/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection. (medscape.com)
Egan C, Kelly CD, Rush-Wilson K, Davis SW, Samsonoff WA, Pfeiffer H. Laboratory-confirmed transmission of vaccinia virus infection through sexual contact with a military vaccinee. (medscape.com)
Genetic sequencing tests confirmed losartan and hydrochlorothizide were prescribed to be taken infection with a rabies virus variant associated with tricolored orally for hypertension, but the patient was unable to swallow bats. (cdc.gov)
Human monkeypox is a viral zoonotic infection caused by monkeypox virus, an enveloped double-stranded DNA virus of the genus Orthopoxvirus and family Poxviridae that also contain smallpox, cowpox, Orf, and vaccinia viruses. (bvsalud.org)

Moreover, whereas the magnitude of the peak vaccine-elicited T lymphocyte responses in the recombinant pox virus-boosted monkeys was substantially greater than that seen in the monkeys immunized with plasmid DNA alone, the magnitudes of recombinant pox boosted CTL responses decayed rapidly and were comparable to those of the DNA-alone-vaccinated monkeys by the time of viral challenge. (duke.edu)

While it can enter host cells, express its genes and replicate its genome, it fails to assemble virus particles that are released from the cell. (wikipedia.org)
Sub-Objective 2.i: Identify novel virus-host genetic determinants of virulence by systematic screening of almost all previously uncharacterized virus genes. (usda.gov)
DNA viruses such as herpesvirus and poxvirus have multiple genes, some of them host-derived, which interfere with effective innate or acquired immune responses. (imperial.ac.uk)

RNA viruses may escape acquired humoral and cellular immune responses by mutations in protective antigenic epitopes (e.g., avian influenza viruses), while accessory nonstructural proteins or multifunctional structural proteins interfere with the interferon system (e.g. (imperial.ac.uk)

Brachyury was genetically modified to prevent nuclear localization of the protein thereby inhibiting its transcriptional activity. (bvsalud.org)

Study on the Shedding of Recombinant Virus in Mice: Found in the Upload File section in Members Services area. (cabs-acsb.ca)
For this purpose, transgenic (H-2b x H-2d)F1 mice were constructed that carry integrated copies of a modified H-2Kk gene resulting in the secretion from various cell types including thymocytes of soluble H-2Kk molecules. (uni-muenchen.de)

Since then, we have been focusing on identifying viral inhibitors of the cGAS/STING pathway through biochemical studies, as well as the generation and characterization of recombinant vaccinia viruses or MVA lacking viral inhibitors. (mskcc.org)
Overall, the Committee judged that significant progress had been made during the past year, particularly in further characterization of the isolates held in the two collections, the development of diagnostic tests for smallpox, and in understanding the genomic diversity of variola virus. (who.int)

Wu M, Zhou E, Sheng R, Fu X, Li J, Jiang C, Su W. Defective Interfering Particles of Influenza Virus and Their Characteristics, Impacts, and Use in Vaccines and Antiviral Strategies: A Systematic Review. (jlu.edu.cn)

Although the exact origins of vaccinia virus are uncertain, vaccinia may represent a hybrid of the variola and cowpox viruses. (medscape.com)
This effort was successful for several reasons, including the lack of any natural reservoir for variola virus and the ease of identifying infected individuals. (medscape.com)
Non-variola virus orthopoxviruses retained in the CDC collection should not be included in the inventory and should be either held separately, in the biosafety level 4 facility, or destroyed. (who.int)

rVSV-ZEBOV is a live-attenuated recombinant viral vaccine. (msdmanuals.com)

Oncolytic vaccinia viruses are promising cancer immunotherapeutics. (mskcc.org)

The public health consequences from some viruses can include impaired immunity, encephalitis, and long-term neurological diseases such as demyelinating disorders and relapsing events such as those seen in multiple sclerosis (MS). (danielsolis.cz)
Yang P, Chen Z, Zhang J, Li W, Zhu C, Qiu P, Quan Y, Cui X, Yuan L, Jiang C. Evaluation of Varicella-zoster virus-specific cell-mediated immunity by interferon-γ Enzyme-Linked Immunosorbent Assay in adults ≥50 years of age administered a herpes zoster vaccine. (jlu.edu.cn)
a) Vaccine: A suspension of live (usually attenuated) or inactivated microorganisms (e.g., bacteria, viruses, or rickettsiae) or fractions thereof administered to induce immunity and prevent infectious disease or its sequelae. (cdc.gov)

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin. (mpg.de)

These revised recommendations update the previous ACIP recommendations for nonemergency use of vaccinia virus smallpox vaccine for laboratory and health care personnel at risk for occupational exposure to orthopoxviruses ( 1 ). (cdc.gov)

In this study we have used a well-defined human melanoma tumor Ag system to test the possibility of translating the immunological potency of synthetic tumor antigenic peptide analogues into recombinant vaccinia viruses carrying constructs with the appropriate nucleotide substitutions. (ox.ac.uk)

Induction of potent antitumor CTL responses by recombinant vaccinia encoding a melan-A peptide analogue. (ox.ac.uk)

One strategy consists of using recombinant viruses encoding amino acid sequences corresponding to natural CTL-defined peptide from tumor Ags as immunogens. (ox.ac.uk)

rVSV-ZEBOV is indicated for the prevention of Ebola virus disease caused by Zaire ebolavirus species in people 18 years of age and older. (msdmanuals.com)
Ad26.ZEBOV/MVA-BN-Filo is indicated for the prevention of Ebola virus disease caused by the Zaire ebolavirus species in people aged 1 year of age and older. (msdmanuals.com)

2. Develop intervention strategies to control African Swine Fever (ASF) including identify functional genomics of virus-host determinants of virulence and transmission, determining host mechanisms of ASF immune protection, determining host mechanisms of ASF disease tolerance in wild suids. (usda.gov)
To develop strategies to control African Swine Fever Virus (ASFV) studies will be conducted to provide information about the mechanisms of viral replication, virus host interaction and virulence in the natural host. (usda.gov)
Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type 1 (HIV-1) replication and are tailored to the developing world are urgently needed. (ox.ac.uk)
Thus, recombinant vaccinia viruses containing mutated minigene sequences may lead to new strategies for the induction of strong tumor-specific CTL responses in cancer patients. (ox.ac.uk)

Phase 2 Trials - GEO-CM04S1 - GEO-CM04S1 is being studied in a Phase 2 clinical trial (NCT04977024) as a primary vaccine for immunocompromised cancer patients who have difficulty producing antibodies and largely depend on T cells to protect against the virus responsible for COVID-19. (geovax.com)
Anti-Ebola virus glycoprotein (EBOV GP) binding and neutralising antibodies were measured at baseline and at predefined time points throughout the study. (plos.org)

METHODOLOGY/PRINCIPAL FINDINGS: We showed that dendritic cells infected in vitro with non-recombinant (nr) MVA expressed maturation and activation markers and were able to efficiently present exogenously pulsed Ag to T cells. (helmholtz-hzi.de)

Scholars@Duke publication: Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses. (duke.edu)
Recombinant BCG Delta ureC hly plus Induces Superior Protection Over Parental BCG by Stimulating a Balanced Combination of Type 1 and Type 17 Cytokine Responses. (mpg.de)
CONCLUSIONS/SIGNIFICANCE: These findings open new ways to potentiate and modulate the immune responses to vaccine Ags depending on whether they are co-administered with MVA or encoded by recombinant viruses. (helmholtz-hzi.de)
Immunoevasion is a common ploy by which viruses neutralize or evade immune responses. (imperial.ac.uk)

Surveillance guidelines for smallpox vaccine (vaccinia) adverse reactions. (medscape.com)

Recombinant Glycoprotein E (gE) of Pseudorabies Virus produced in E. coli. (creativebiomart.net)

Anatomy19

Organisms77

Diseases17

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes62

Information Science4

Health Care3

Ankara38

Vaccination10

Vectors6

Immunogenicity2

Poxviruses3

Replication-incompetent chimpanzee-derived adenovirus1

Antigen8

Strain1

Vaccines containi1

Fowlpox virus1

Eradication3

Vector5

Adenovirus1

Strains2

RMVA2

Antigens3

Immunization2

Humans1

SARS-CoV6

Infection10

Plasmid1

Genes3

Proteins1

Genetically1

Mice2

Characterization2

Influenza1

Variola3

Live attenuated1

Oncolytic1

Immunity3

Bacille1

Orthopoxviruses1

Antigenic1

Potent1

Amino acid1

ZEBOV2

Strategies4

Antibodies2

Vitro1

Responses4

Adverse reactions1

Coli1