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S100 Calcium Binding Protein GCalcium-Binding ProteinsCalbindinsS100 ProteinsCalbindin 1Calbindin 2Calgranulin BParvalbuminsCalgranulin ACalciumS100 Calcium Binding Protein beta SubunitMolecular Sequence DataEF Hand MotifsAmino Acid SequenceCalmodulinRecoverinCalsequestrinRecombinant ProteinsSalamandraFluorescamineCalcium SignalingBase SequenceCollodionBinding SitesProtein BindingEntamoeba histolyticaCalcium RadioisotopesCloning, MolecularSequence Homology, Amino AcidCalcium ChannelsProtein ConformationEgtazic AcidCell LineSarcoplasmic ReticulumRabbitsProtein Structure, TertiaryCalcium, DietaryRNA, MessengerSpectrometry, FluorescenceModels, MolecularMusclesPoly(A)-Binding ProteinsMolecular WeightCattleTroponin CCalcium IsotopesRecombinant Fusion ProteinsCarrier ProteinsKineticsCalcitriolImmunohistochemistryChickensGene Expression RegulationNerve Tissue ProteinsCalcium ChlorideCalcium CarbonateSequence Homology, Nucleic AcidNeuronsRats, Sprague-DawleyRibosomal ProteinsTerbiumTroponinZincMagnesiumCells, CulturedEscherichia coliMutationCalcium PhosphatesNerve Growth FactorsTacrolimus Binding ProteinsDNA, RecombinantElectrophoresis, Polyacrylamide GelHydrogen-Ion ConcentrationCircular DichroismPoly(A)-Binding Protein IDNA-Binding ProteinsCalcium Channels, L-TypeInsulin-Like Growth Factor Binding ProteinsDNA, ComplementaryHippocalcinStaphylococcus aureusRestriction MappingSequence AlignmentMutagenesis, Site-DirectedTransfectionRNA-Binding ProteinsProtein Structure, SecondaryChelating AgentsStaphylococcal InfectionsBlotting, WesternPeptide FragmentsGene ExpressionCalcium OxalateYtterbiumTime FactorsCations, DivalentLanthanumMicrofilament ProteinsCalcium GluconateDose-Response Relationship, Drug
AntibodyS100BAntibodiesMotifsParathyroid hormoneS100A4VitroS100PDifferentiationWestern BlotLysatesSerumColiCellsMolecular WeightHomoGlial fibrillDifferentially expressedMRNACytoplasmQuantitativeAntigenHomologousReagentsTissueInflammationAffinityProductsBufferZincTranscription factorsS100A7Annexin A1GenesPhysiologicalAssayInteractIonsMouseNative ProteinHOMEOSTASISFamily
Antibody13
  • This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling. (abcam.com)
  • Description: A competitive ELISA for quantitative measurement of Human Anti centriole and centrosome antibody IgG in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (microarraystation.com)
  • Human IgG antibody Laboratories manufactures the s100b elisa reagents distributed by Genprice. (microarraystation.com)
  • Description: A polyclonal antibody for detection of Met from Human, Mouse, Rat. (biocatnet.com)
  • Immunohistochemistry: Formalin-fixed and paraffin-embedded Human placenta tissue stained with ARG66241 anti-S100P antibody [SQab1730] at 1:200. (arigobio.com)
  • ProSci's human tissue slides can be used with any antibody shown to be effective in formalin-fixed tissue using a standard immunostaining protocol. (agtcbioproducts.com)
  • This assay employs an antibody specific for Human S100 P coated on a 96-well PCR plate. (raybiotech.com)
  • Standards and samples are pipetted into the wells and S100 P present in a sample is bound to the wells by the immobilized antibody. (raybiotech.com)
  • This antibody reacts with alpha and beta subunits of human S-100 protein (21-24 kD). (abcam.cn)
  • Immunohistochemical analysis of paraffin-embedded human oesophagus cancer tissue slide using 13061-1-AP (S100A7/Psoriasin antibody at dilution of 1:50 (under 10x lens). (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human oesophagus cancer tissue slide using 13061-1-AP (S100A7/Psoriasin antibody at dilution of 1:50 (under 40x lens). (ptglab.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Wilms Tumor Protein (WT1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Wilms Tumor Protein (WT1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
S100B1
  • The S100B Elisa reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (microarraystation.com)
Antibodies1
  • Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.cn)
Motifs6
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (wikipedia.org)
  • Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. (lookformedical.com)
  • In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. (lookformedical.com)
  • Calcium-binding motifs composed of two helices (E and F) joined by a loop. (lookformedical.com)
  • These motifs are found in many proteins that are regulated by calcium. (lookformedical.com)
  • S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. (novoprolabs.com)
Parathyroid hormone3
  • Its production is stimulated by low blood calcium levels and parathyroid hormone. (lookformedical.com)
  • Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption. (lookformedical.com)
  • The current review will explore a hypothesis of the involvement of the calcium-regulating hormones such as parathyroid hormone and parathyroid hormone-related protein in counteracting the detrimental impact of the excess of DAMPs and therefore improving the functional cardiac characteristics especially in the acute phase of the disease. (highwire.org)
S100A49
  • Protein S100-A4 (S100A4) is a protein that in humans is encoded by the S100A4 gene. (wikipedia.org)
  • S100A4 has been shown to interact with S100 calcium binding protein A1. (wikipedia.org)
  • S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis by stimulating angiogenesis. (wikipedia.org)
  • In vivo overexpression of S100A4 led to a significant increase in tumor growth and vascularization in a human melanoma xenograft M21 model. (wikipedia.org)
  • It is concluded that extracellular S100A4 inhibition is an attractive approach for the treatment of human cancer. (wikipedia.org)
  • S100A4 is highly associated with components of the cytoskeleton and when this gene is upregulated, it changes the cell's morphology, making it more susceptible to invasion from proteins, such as cathepsin B and cyclin B1, that contribute to metastasis. (wikipedia.org)
  • S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. (novoprolabs.com)
  • A DNA sequence encoding the human S100A4 (NP_002952.1) (Met 1-Lys 101) was expressed with the fused Fc region of human IgG1 at the N-terminus. (novoprolabs.com)
  • The recombinant human Fc/S100A4 is a disulfide-linked homodimeric protein. (novoprolabs.com)
Vitro4
  • In vitro, S100β/Sca1 cells isolated from atheroprone regions of the mouse aorta expressed hedgehog signalling components, acquired the di-methylation of histone 3 lysine 4 (H3K4me2) stable SMC epigenetic mark at the Myh11 locus and underwent myogenic differentiation in response to recombinant sonic hedgehog (SHh). (dcu.ie)
  • Recombinant SHh promoted myogenic differentiation of human induced pluripotent stem cell-derived S100β neuroectoderm progenitors in vitro. (dcu.ie)
  • The pathological potential of human astroglia in Alzheimer's disease (AD) was analysed in vitro using induced pluripotent stem cell (iPSC) technology. (nature.com)
  • This work not only presents a novel model to study the mechanisms of human astrocytes in vitro , but also provides an ideal platform for further interrogation of early astroglial cell autonomous events in AD and the possibility of identification of novel therapeutic targets for the treatment of AD. (nature.com)
S100P2
  • Synthetic peptide around the C-terminus of Human S100P. (arigobio.com)
  • Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. (cusabio.com)
Differentiation3
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (wikipedia.org)
  • 95% homogeneous populations of human astrocytes within 30 days of differentiation from cortical neural progenitor cells (NPCs). (nature.com)
  • This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
Western Blot1
  • This result was supported by western blot analysis, which demonstrated that LOXL2 protein expression is present in cultured human podocytes and HK?2 human proximal tubular cells. (omicsdi.org)
Lysates1
  • Description: A sandwich quantitative ELISA assay kit for detection of Human High Mobility Group AT Hook Protein 1 (HMGA1) in samples from tissue homogenates, cell lysates or other biological fluids. (lipidx.org)
Serum11
  • Immunoplates for Exosome capture and quantification from human biofluids (plasma, serum, urine, saliva) and from human or mouse cell media. (transcriptionfactor.org)
  • A vascular endothelial growth factor ELISA kit was used to measure vascular endothelial growth factor protein levels in the mice serum. (novecsin.com)
  • RayBio® Human Immunoquantitative (PCR-Based) S100 P ELISA Kit for cell culture supernatants, plasma, and serum samples. (raybiotech.com)
  • The RayBio ® Human S100 P IQELISA™ Kit is a modified ELISA assay with high sensitivity qPCR readout for the quantitative measurement of Human S100 P in serum, plasma, and cell culture supernatants. (raybiotech.com)
  • Description: A sandwich ELISA kit for detection of Zinc Finger, AN1-Type Domain Protein 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)
  • Description: A competitive ELISA for quantitative measurement of Human AN1 type zinc finger protein 6(ZFAND6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (operatiebrp.nl)
  • Description: A competitive ELISA for quantitative measurement of Rat AN1 type zinc finger protein 6(ZFAND6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (operatiebrp.nl)
  • Description: A sandwich ELISA for quantitative measurement of Canine Calcium Binding Protein D9K in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (bioinfolab.org)
  • Description: A sandwich ELISA kit for detection of High Mobility Group AT Hook Protein 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
  • Description: Quantitative sandwich ELISA for measuring Human Wilms tumor protein (WT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (kits-elisa.com)
  • Description: Quantitativesandwich ELISA kit for measuring Human Protein jagged-1 (JAG1) in samples from serum, plasma, tissue homogenates. (kits-elisa.com)
Coli5
  • Recombinant Human S100A6 protein(P06703)(1-90aa), fused to N-terminal His-SUMO tag, was expressed in E. coli. (creativebiomart.net)
  • Recombinant Human ANXA1 protein(Met1~Asn346), fused with His tag, was expressed in E. coli. (creativebiomart.net)
  • Recombinant human natriuretic peptide B antigen is produced by E. coli expression system and the target gene encoding His27-His134 is expressed with a 6His tag at the N-terminus. (medixbiochemica.com)
  • Recombinant human S100 calcium binding protein B antigen is produced by E. coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the N-terminus. (medixbiochemica.com)
  • QP6635 protein expressed in E. coli. (enquirebio.com)
Cells11
  • Human and Animal Cells plus corresponding Media and Tools. (pelobiotech.com)
  • Using transgenic eGFP mice and genetic lineage tracing of S100β vSCs in vivo, we identified S100β/ Sca1 cells derived from a S100β non-SMC parent population within lesions that co-localise with smooth muscle α-actin (SMA) cells following iatrogenic flow restriction, an effect attenuated following hedgehog inhibition with the smoothened inhibitor, cyclopamine. (dcu.ie)
  • Both S100β and PTCH1 cells were present in human vessels while S100β cells were enriched in arteriosclerotic lesions. (dcu.ie)
  • This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. (microarraystation.com)
  • In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. (arigobio.com)
  • The present study evaluated LOXL2 expression in human and mouse kidney tissues, as well as in cultured renal cells. (omicsdi.org)
  • LOXL2 protein expression was detected in glomerular capillary loops and tubular epithelial cells in human and mouse kidneys. (omicsdi.org)
  • ITGA7 binds to tissue inhibitor of metalloproteinase 3 (TIMP3) in prostate cancer cells. (cusabio.com)
  • The absence of either alpha7beta1 integrin or alpha6beta1 integrin impairs the ability of Schwann cells to spread and to bind laminin. (cusabio.com)
  • Whereas DNMT1 is the key maintenance methyltransferase, DNMT3A and DNMT3B represent the main de novo methyltransferases, as they can bind unmethylated DNA and establish novel DNA methylation marks not only during early development but also in differentiated cells in a signal-dependent manner 9 . (nature.com)
  • Damaged or stressed cells, cardiomyocytes, in particular, emit damage-associated molecular patterns (DAMPs) including HMGB1, S100 A8/A9, HSP70, and other molecules, unfolding paracrine mechanisms that induce an innate immune response. (highwire.org)
Molecular Weight2
Homo1
  • A DNA sequence encoding the Homo sapiens (Human) S100A1, was expressed in the hosts and tags indicated. (enquirebio.com)
Glial fibrill2
  • LCN2 protein induced upregulation of glial fibrillary acidic protein (GFAP), cell migration, and morphological changes similar to characteristic phenotypic changes termed reactive astrocytosis. (jneurosci.org)
  • In this process, astrocytes proliferate to fill gaps and undergo a typical morphological change: a large cytoplasmic mass, long and branched processes, and increased expression of intermediate filaments such as glial fibrillary acidic protein (GFAP). (jneurosci.org)
Differentially expressed2
  • A calbindin protein that is differentially expressed in distinct populations of NEURONS throughout the vertebrate and invertebrate NERVOUS SYSTEM, and modulates intrinsic neuronal excitability and influences LONG-TERM POTENTIATION. (lookformedical.com)
  • By generating specific Abs, we demonstrate that hS100A7 and hS100A15 proteins are differentially expressed by specific cell types in the skin. (aai.org)
MRNA2
  • In addition, the mRNA and protein expression levels of LOXL2 were higher in a mouse model of tubulointerstitial fibrosis compared with in control mice. (omicsdi.org)
  • To our knowledge, this is the first study in the literature to examine the mRNA expression of CDK2AP1 in human breast cancer over a long-term follow-up period. (cancerindex.org)
Cytoplasm1
Quantitative1
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Jagged 1 Protein (JAG1) in samples from tissue homogenates or other biological fluids. (kits-elisa.com)
Antigen1
  • Recombinant human lactoferrin, also known as lactotransferrin/LTF, antigen is produced by mammalian expression system and the target gene encoding Gly20-Lys710 is expressed with a 6His tag at the C-terminus. (medixbiochemica.com)
Homologous3
  • Although highly homologous, both proteins are chemoattractants with distinct chemotactic activity for leukocyte subsets. (aai.org)
  • SAR-CoV-2 spike proteins, and all other SARS-CoV-2 proteins, immunogenic epitopes in each SARS-CoV-2 protein were compared to human proteins in search of high local homologous matching. (danielsolis.cz)
  • If all of the parts of the epitopes that are homologous to human proteins are excluded from consideration due to risk of pathogenic priming, the remaining immunogenic parts of the epitopes may be still immunogenic and remain as potentially viable candidates for vaccine development. (danielsolis.cz)
Reagents1
  • Binding Elisa Laboratories manufactures the calculate % binding elisa reagents distributed by Genprice. (bioinfolab.org)
Tissue3
  • In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. (novoprolabs.com)
  • Formalin-fixed, paraffin-embedded tissue is useful for a variety of applications including the targeting of proteins, RNA, and DNA by means of Immunohistochemistry (IHC) , in-situ hybridization (ISH) and fluorescence in-situ hybridization (FISH) , respectively. (agtcbioproducts.com)
  • ProSci's single tissue slides contain 4 um sections of formalin-fixed, paraffin-embedded human tissue (1-2 cm x 1-2 cm) affixed to slides. (agtcbioproducts.com)
Inflammation1
  • The functional role of these closely related proteins for inflammation remains undefined. (aai.org)
Affinity1
  • Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. (enquirebio.com)
Products1
  • We offer high quality native and recombinant antigens, enzymes, and other proteins to be used in a wide range of life science research and diagnostics applications, such as calibrator and control products, serological immunoassays, and biological activity assays. (medixbiochemica.com)
Buffer1
  • Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. (lookformedical.com)
Zinc1
Transcription factors1
S100A71
  • Human S100A7 (psoriasin) is overexpressed in inflammatory diseases. (aai.org)
Annexin A11
  • Annexin A1 protein has an apparent relative molecular mass of 40kDa with phospholipase A2 inhibitory activity. (creativebiomart.net)
Genes2
  • S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. (wikipedia.org)
  • Mapping of the genes encoding human protein matches to pathways point to targets that could explain the observed presentation of symptoms in COVID-19 disease. (danielsolis.cz)
Physiological1
  • May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. (enquirebio.com)
Assay1
  • Binding Protein A11 (S100A11) has been identified as an interactor of ANXA1, thus a binding ELISA assay was conducted to detect the interaction of recombinant human ANXA1 and recombinant human S100A11. (creativebiomart.net)
Interact1
  • This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
Ions1
Mouse1
  • Hedgehog signaling has been linked to the development of embryonal RMS (ERMS) through mouse genetics and rare human syndromes. (bvsalud.org)
Native Protein1
  • Full length native protein (purified) corresponding to Cow S100. (abcam.cn)
HOMEOSTASIS2
  • A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. (lookformedical.com)
  • Designed as an adaptive, regenerative reaction, innate immunity may nevertheless become overactivated and thus contribute to the development of HF by altering the pacemaker rhythm, contraction, and electromechanical coupling, presumably by impairing the calcium homeostasis. (highwire.org)
Family2
  • Gentaur AntibodiesOverview: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. (caslab.com)
  • Lipocalin 2 (lcn2) is a member of the lipocalin family that binds to small hydrophobic molecules. (jneurosci.org)