Recombinant human bone morphogenetic protein 4. Medical search. Frequent questions

As an adjuvant to allograft bone or as a replacement for harvested autograft, bone morphogenetic proteins (BMPs) appear to improve fusion rates after spinal arthrodesis in both animal models and humans, while reducing the donor-site morbidity previously associated with such procedures. (wikipedia.org)
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. (peprotech.com)
Along with other BMPs, including BMP-2, -4 and -7, which are well known as potent osteoinductive growth factors, GDF-5 plays important roles in the development of bones, cartilage and tendons, as evidenced by the tendency for the gene and protein expression levels of GDF-5 to increase over time in these tissues. (ispub.com)
It may be feasible in the near future for BMPs to replace autologous and allogenic bone grafts. (allenpress.com)
BMPs comprise the largest subfamily of TGF-beta and belong to a group of noncollagen proteins. (allenpress.com)
It shares 85% aa sequence identity with human BMP-4 and less than 51% with other BMPs. (novusbio.com)
Bone morphogenetic proteins (BMPs) normally maintain the balance of ECM proteins via opposing TGF-β2 stimulated ECM proteins in various cell types. (tdl.org)
Elevated TGF-β2 directly increases ECM and also induces gremlin expression, which further aids TGF-β2 to stimulate ECM via inhibiting BMPs antagonism of TGF-β2 signaling, leading to unopposed TGF-β2 stimulated ECM proteins. (tdl.org)
Among them, bone morphogenic proteins (BMPs) are thought to be the most potent osteoinductive factors and play a key role in the process of bone formation during DO. (hindawi.com)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily, which includes the families of TGF-βs, BMPs, activins and inhibins. (ijbs.com)
BMPs were originally identified because of their ability to induce endochondral bone formation and are important regulators of key events in the process of bone formation during embryogenesis, postnatal growth, remodelling and regeneration of the skeleton [ 1 , 2 , 3 ]. (ijbs.com)
Comparisons with other BMPs known for their ability to stimulate bone growth have suggested that BMP-13 is not strongly osteo-inductive [ 9 , 10 , 11 , 12 ]. (ijbs.com)
The function of BMPs in bone remodelling and fracture repair is associated with the recruitment of stem cells from surrounding tissues and with effects on the osteogenic lineage commitment of these cells. (ijbs.com)
Further, there are signaling pathways that participate in regulation, such as Wnt channel, mitogen-activated protein kinase (MAPK) channel, bone morphogenetic protein (BMPs) channel, peroxisome proliferator activated-receptors (PPARs) channel, and Notch channel. (frontiersin.org)

They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around alloplastic materials. (allenpress.com)
The application of specific growth factors for osteoinduction without using a bone graft constitutes a real impact on bone regeneration. (allenpress.com)
In this review, we will highlight the role of the BMP in bone, periodontal and dental regeneration. (allenpress.com)
Grafting with autogenous bone, guided bone regeneration (GBR), distraction osteogenesis, and tissue engineering have been developed to perform intraoral bone augmentation in dentistry. (allenpress.com)
A variety of growth factors (GFs)-including bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), and peptides of the parathyroid hormone (PTH)-have been tested for local bone regeneration. (allenpress.com)
13. Verna C, Bosch C, Dalstra M, Wikesjö UM, Trombelli L. Healing patterns in calvarial bone defects following guided bone regeneration in rats: a micro-CT scan analysis. (bvsalud.org)
It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration (1, 2). (novusbio.com)
Although different stem cells, morphogens and scaffolds can be combined to simulate natural odontogenic regeneration, it is crucial to determine which options most closely replicate the characteristics of human dental tissues. (scielo.br)
Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. (scielo.br)
Regeneration of large bone defects is a common clinical problem. (dovepress.com)
Our results suggested that PEI-al nanocomposites efficiently deliver the BMP-2 gene to bone marrow mesenchymal stem cells and that BMP-2 gene-engineered cell sheet is an effective way for promoting bone regeneration. (dovepress.com)
Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
Recently, carbon-modified biomaterials for bone tissue engineering have been extensively investigated to potentially revolutionize biomaterials for bone regeneration. (openorthopaedicsjournal.com)
This review summarizes the chemical and biophysical properties of carbon nanostructures and discusses their functionality in bone tissue regeneration. (openorthopaedicsjournal.com)
In the quest for alternative therapeutic strategies, research is focusing on the concept of tissue engineering to assist the progress of bone tissue regeneration. (openorthopaedicsjournal.com)

A nanoscale modular design strategy was employed to synthesize six engineered, recombinant proteins intended to mimic aspects of the extracellular matrix proteins fibronectin, laminin, and elastin as well as the cell-cell adhesive protein neural cell adhesion molecule. (frontiersin.org)

We previously demonstrated that human ONH expresses BMP-4, BMP receptor and BMP antagonist gremlin. (tdl.org)
Gremlin stimulation of ECM proteins required activation of the TGF-β receptor and R-Smad3. (tdl.org)
Optimized DNA sequence encoding Human extracellular domain of human IL-1 receptor including a C-terminal Fc tagwas expressed in HEK293 cells. (reprokine.com)
Moreover, there is recent evidence that EGFRL/MAP kinase signaling modulates FSH receptor (FSHR) transcription, in part, via inhibitor of differentiation/DNA-binding (ID) proteins. (psu.edu)
Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
RANK binds to transmembrane protein nuclear factor-κB receptor activating factor ligand (RANKL) to activate RANK/RANKL, TRAF6/RANKL/MAPKs, TRAF6/ RANKL/NF-κB, Wnt/RANKL/RANKL, and JAK2/STAT3/RANKL. (frontiersin.org)
Luspatercept and Sotatercept, (hybrid molecules, fusion proteins, composed of the extracellular domain of the human activin IIA receptor and the Fc part of IgG1), are competitors of the activins and morphogenic proteins of the bone and thus block the signal transduction via the SMAD path. (haema-journal.gr)

In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)

BMP-4 plays an important role indifferentiation of overlying ectodermal tissue. (anhsci.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Bone Morphogenetic Protein 1 (BMP1) in serum, plasma, tissue homogenates and other biological fluids. (srbiosystem.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Bone Morphogenetic Protein 1 (BMP1) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (srbiosystem.com)
Description: A sandwich quantitative ELISA assay kit for detection of Rat Bone Morphogenetic Protein 1 (BMP1) in samples from serum, plasma, tissue homogenates or other biological fluids. (srbiosystem.com)
Recombinant human amelogenin, connective tissue growth factor, and bone morphogenetic protein-2 were spatially delivered and time-released in Phases A, B, and C, respectively. (desktopmetal.com)
Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. (scielo.br)
The decrease in the bone mass associated with osteoporosis caused by ovariectomy, aging, and other conditions is accompanied by an increase in bone marrow adipose tissue. (ironmagazine.com)
The development of modalities to promote local/systemic bone formation by inhibiting bone marrow adipose tissue is important in the treatment of fractures or metabolic bone diseases such as osteoporosis. (ironmagazine.com)
Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
2 , 3 Bone tissue engineering (BTE) attempts to solve the referred problems mentioned. (dovepress.com)
Urgent surgical intervention typically follows and involves both soft-tissue and bone management. (medscape.com)
A wide range of synthetic and natural biomaterials is being used to develop tissue-engineered bone. (openorthopaedicsjournal.com)
A selective literature review was performed for carbon nanostructure composites in bone tissue engineering. (openorthopaedicsjournal.com)
Bone is an active metabolism tissue, which constantly undergoes bone remodeling. (frontiersin.org)

The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
In this study, we found that BMP-13 inhibited the osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells (BM MSCs) in vitro. (ijbs.com)
PEI-al nanocomposites carrying BMP-2 gene could efficiently transfect bone marrow mesenchymal stem cells. (dovepress.com)

Differentiate human pluripotent stem cells (hPSCs) to cells of the endoderm lineage with our specialized cell culture media. (stemcell.com)
In cultured stem cells, BMP-4 plays a distinct role in mouse and human embryonic stem (ES) cells. (anhsci.com)
In contrast, BMP-4 induces extra-embryonic trophoblast differentiation in human pluripotent stem cells 5 . (anhsci.com)
Stemfactor BMP-4 is a recombinant protein expressed and purified from human 293 cells as a glycosylated homodimer with a molecular mass of 34 kDa. (anhsci.com)
Stemfactor BMP-4 was expressed in and purified from human 293 cells. (anhsci.com)
First, we examined whether human ONH tissues and ONH cells express the canonical BMP signaling pathway. (tdl.org)
This study demonstrated that ONH tissues and ONH cells express BMP-4 and Smad signaling pathway. (tdl.org)
Treatment of ONH cells with BMP-4 increased phosphorylation of R-Smad/1/58/ phosphorylation and interaction with Co-Smad4 indicating activation of the Smad signaling pathway. (tdl.org)
Therefore, cells within the human ONH can respond to locally released BMP via activation of Smad signaling. (tdl.org)
Recombinant TGF-β2 increased ECM deposition in ONH cells. (tdl.org)
Thus, TGF-β2 requires R-Smad2/3 to stimulate ECM proteins in ONH cells. (tdl.org)
Lastly, we investigated the potential effects of BMP-4 and gremlin on TGF-β2 stimulated ECM in ONH cells. (tdl.org)
Addition of gremlin blocked the BMP-4 effect, increasing ECM proteins in ONH cells. (tdl.org)
Interestingly, recombinant gremlin also increased ECM proteins in ONH cells. (tdl.org)
TGF-β2 increased gremlin mRNA and protein in ONH cells. (tdl.org)
Optimized DNA sequence encoding Human BCMA extracellular domain fused to C terminal Human IgG1 Fc tag was expressed in CHO Cells. (reprokine.com)
Optimized DNA sequence encoding Human Kallikrein-11- hK11 (GLU19 - ASN250) preprotein including a C-terminal His tag was expressed in HEK293 cells. (reprokine.com)
DNA sequence encoding the extracellular domain of Human NECTIN2 including a C-terminal cleavage tag was expressed in HEK293 Cells. (reprokine.com)
BACKGROUND: This Phase 1 study evaluates the intra- and peritumoral administration by convection enhanced delivery (CED) of human recombinant Bone Morphogenetic Protein 4 (hrBMP4) - an inhibitory regulator of cancer stem cells (CSCs) - in recurrent glioblastoma. (bvsalud.org)
Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells. (scielo.br)
The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(L-lactic acid) scaffolds in vitro and in vivo. (scielo.br)
editors Culture of human stem cells. (scielo.br)
These stem cells, extracted from bone marrow, can develop into fat cells but also into bone cells in the body. (ironmagazine.com)
The Japanese hypothesised that raspberry ketone might inhibit the development of stem cells into fat cells but promote the development of the stem cells into bone cells. (ironmagazine.com)
In an experiment the Japanese researchers exposed the stem cells to rhBMP-2, a protein that induces stem cells to develop into bone cells. (ironmagazine.com)
The higher the concentration, the more alkaline phosphatase the cells manufacture, an indication that the cells were developing into osteoblasts, bone cells that build up the skeleton. (ironmagazine.com)
This compound also stimulates the development of stem cells into bone cells. (ironmagazine.com)
The more raspberry ketone there was present, the more alkaline phosphatase the cells manufactured - and the greater the bone cell development. (ironmagazine.com)
Confluent C3H10T1/2 stem cells were treated for 6 days with 10-100 ?g/mL of RK in culture medium containing 10?nM all-trans-retinoic acid (ATRA) or 300?ng/mL recombinant human bone morphogenetic protein (rhBMP)-2 protein as an osteoblast-differentiating agent. (ironmagazine.com)
Our results suggest that RK enhances the differentiation of C3H10T1/2 stem cells into osteoblasts, and it may promote bone formation by an action unrelated to adipocyte differentiation. (ironmagazine.com)
Pluripotent stem cells can be derived from the inner cell mass of a blastocyst (an early-stage embryo), termed embryonic stem (ES) cells, or induced from somatic cells by ectopic expression of a set of transcription factors including Oct3/4, Sox2, c-Myc, Klf4, Nanog, named iPS cells. (sciencellonline.com)
As confirmation that ligand density in these engineered systems impacts neuronal cell behavior, we demonstrate that increasing the density of fibronectin-derived RGD ligands on coated surfaces while maintaining uniform protein surface coverage results in enhanced neurite extension of PC-12 cells. (frontiersin.org)

BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. (wikipedia.org)
In addition, development and genetic studies have shown that GDF-5 null mutation or transgenic mice exhibit abnormal growth patterns or overgrowth of limbs, long bones, cartilage, joints and digits (Storm et al. (ispub.com)
BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). (novusbio.com)
BMP-13, also known as growth differentiation factor 6 (GDF6) and cartilage-derived morphogenetic protein-2 (CDMP-2), was first identified and isolated as a component of bovine cartilage [ 5 ]. (ijbs.com)
Could be involved in bone and cartilage formation. (abcam.com)

The use of dual tapered threaded fusion cages and recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge obtained and maintained intervertebral spinal fusion, improved clinical outcomes, and reduced pain after anterior lumbar interbody arthrodesis in patients with degenerative lumbar disc disease. (wikipedia.org)

Recombinant human protein (rhBMP-2) is currently available for orthopaedic usage in the United States. (wikipedia.org)
We report two cases of ectopic bone formation in the head and neck following treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). (stanfordhealthcare.org)
Ectopic bone formation following rhBMP-2 has been previously reported. (stanfordhealthcare.org)
Background: Use of recombinant human bone morphogenetic protein-2 (rhBMP-2) has increased considerably since its introduction in 2002. (wustl.edu)
Objective: The objective of this study was to test the hypothesis that a compression-resistant bone graft augmented with recombinant human morphogenetic protein-2 (rhBMP-2) will promote lateral ridge augmentation without the use of protective mesh in a canine model. (uthscsa.edu)
The release kinetics of rhBMP-2 from CR bone grafts in vitro and in vivo in a femoral condyle defect model in rabbits was also evaluated. (uthscsa.edu)
Conclusions: At the same dose of rhBMP-2, an injectable, compression-resistant bone graft resulted in a comparable volume of new bone formation with the clinical control (ACS). (uthscsa.edu)

Physical adsorption isotherms were experimentally determined for these engineered proteins, allowing for direct calculation of the available ligand density present on coated surfaces. (frontiersin.org)
Therefore, this engineered protein adsorption approach allows for the facile preparation of tunable, quantifiable, and reproducible surfaces for in vitro studies of cell-ligand interactions and for potential application as coatings on neural implants. (frontiersin.org)

RecombinantMouse EGF, generated by the proteolytic removal of the signal peptide and propeptide, is a monomer protein. (reprokine.com)

Effect of recombinant human bone morphogenetic protein-4 with carriers in rat calvarial defects. (bvsalud.org)
10. Marden LJ, Hollinger JO, Chaudhari A, Turek T, Schaub RG, Ron E. Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rats. (bvsalud.org)
Tissueengineered bone biomimetic to regenerate calvarial critical-sized defects in athymic rats. (bvsalud.org)
Large bone defects resulting from trauma, congenital defects, neoplasm, failed arthroplasty, and infection are quite common [ 1 , 2 ], and the incidences of nonunion and delayed union are very high [ 3 ]. (hindawi.com)
It remains a great challenge for orthopedic surgeons to achieve osseous reconstruction for nonunion and bone defects. (hindawi.com)
To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)
Recent advances in developing biocompatible materials for treating bone loss or defects have dramatically changed clinicians' reconstructive armory. (openorthopaedicsjournal.com)
Results: All four bone grafts promoted new bone formation (11-31.6 volume%) in the lateral ridge defects. (uthscsa.edu)

Growth/differentiation factor-5 (GDF-5) belongs to the bone morphogenetic protein (BMP) family, which is expressed in dental pulp tissues. (ispub.com)
Gremlin levels were significantly increased in the human glaucomatous ONH tissues. (tdl.org)
Tooth-supporting periodontium forms a complex with multiple tissues, including cementum, periodontal ligament (PDL), and alveolar bone. (desktopmetal.com)

PeproTech's E.coli-derived Human BMP-4 is a fully active homodimeric protein consisting of two 107 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor, as well as an N-terminal Methionine. (peprotech.com)
The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 24.2 kDa. (peprotech.com)
Optimized DNA sequence encoding Human Bone Morphogenetic protein-4 mature chain was expressed in Escherichia Coli. (reprokine.com)
The aim of the present study was to evaluate the effects of anodized implants coated with Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2) on osseointegration using stability tests and histometric analysis. (ewha.ac.kr)

Human BMP‑2 is synthesized as a 396 amino acid (aa) preproprotein that contains a 23 aa signal sequence, a 259 aa prosegment, and a 114 aa mature region (3). (novusbio.com)
Mature human BMP-2 shares 100% aa sequence identity with mouse and rat BMP-2. (novusbio.com)
Creating sequence-expression-activity maps accelerates the optimization of many protein systems and allows previous measurements to quantitatively inform future designs. (omictools.com)

Furthermore, mechanical stretch may induce the differentiation of BMSCs into mature osteoblasts and enhance the deposition of the bone matrix [ 18 - 20 ]. (hindawi.com)
Indeed, BMP-13 expression was absent from osteoblasts or newly formed osteocytes, rather BMP-13 was strongly detected in chondrocytes in a human osteophyte (bone spur) study [ 13 ]. (ijbs.com)
Bone formation is involved with a large number of osteoblasts (OB) under the periosteum. (frontiersin.org)

but the overall therapeutic process lasts for a relatively long period, and a variety of complications may arise, such as pin loss, infection around the transmucosal pin, bone fracture, and restriction in joint motion [ 8 ]. (hindawi.com)
For example, the tibia has a long medial aspect that is subcutaneous, and therefore, it is "easier" for trauma to the lower leg to expose the bone and fracture site. (medscape.com)
In the most benign form, an open fracture may involve a very small wound caused by a sharp bone spike, creating a small, minimally contaminated hole in the overlying skin. (medscape.com)

The expression levels of dentin sialo-phosphoprotein (DSPP), dentin matrix protein-1 (DMP1), enamelysin/matrix metalloproteinase 20 (MMP20) and phosphate-regulating gene with homologies to endopeptidases on X chromosome (PHEX) were analysed using RT-PCR. (scielo.br)
To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)

Bone morphogenetic protein 2 is shown to stimulate the production of bone. (wikipedia.org)
17 , 19 - 24 BMP-2, −4, and −7 have been shown to stimulate de novo, in vitro, and in vivo bone formation in various animal models. (allenpress.com)

7 , 16 - 18 Only a small number (BMP-2, BMP-4, BMP-6, BMP-7, and BMP-14) seem to have osteoinductive functions. (allenpress.com)
1 The obstacles of current bone substitutes include the limited amounts of donor bone, the bone resorption of autografts, the risk of disease transmission and graft rejection of allografts, and the shortage of osteoinductive property for synthetic grafts. (dovepress.com)

Infuse consists of a collagen sponge that's soaked in a bone-growth protein called recombinant human bone morphogenetic protein-2 and implanted in the spine within a metal device called the LT-Cage. (massdevice.com)

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. (wikipedia.org)
Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family, which is a subgroup of the transforming growth factor- (TGF-) superfamily. (ispub.com)
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. (novusbio.com)

In the present studies with undifferentiated granulosa, recombinant human (rh) bone morphogenetic protein 2 (BMP2) induced the phosphorylation of SMAD1/5/8, and blocked transforming growth factor β and FSH-induced FSHR expression and progesterone production. (psu.edu)

In the United States, these proteins are commercially available INFUSE Bone Graft since its approval by the Food and Drug Administration in July 2002 for its use in anterior lumbar interbody fusion. (allenpress.com)
Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages. (wakehealth.edu)

Further, it regulates osteoblastic extracellular matrix such as osteopontin (OPN), osteocalcin (OCN), bone sialoprotein (BSP) in late differentiation. (frontiersin.org)

Osteoporosis (OP) is a metabolic disorder, which is characterized by the decrease of bone mass, and the increase of bone brittleness ( 1 ). (frontiersin.org)

So zeigte sich, dass rekombinantes SHH Protein spezifisch an das Neuroepithel von Wildtyp-Embryonen nicht aber an das von LRP2-defizienten Embryonen bindet. (fu-berlin.de)

Transforming growth factor-beta2 (TGF-β2) is increased in glaucomatous ONH and is thought to be responsible for increased synthesis and deposition of ECM proteins of the ONH. (tdl.org)
Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)

CHARMM-GUI PDB manipulator for advanced modeling and simulations of proteins containing nonstandard residues. (gewhatman.cn)

In conclusion, BMP-13 inhibited osteogenic differentiation of MSCs, implying that functional mutations or deficiency of BMP-13 may allow excess bone formation. (ijbs.com)

Various approaches have been tested to promote bone formation in order to shorten the DO period. (hindawi.com)

Recombinant human/mouse/rat BMP-2 (355-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. (novusbio.com)

Reconstitute at 100-200 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin. (novusbio.com)

The extensive remodeling of the extracellular matrix (ECM) in the glaucomatous ONH including increased synthesis and deposition of ECM (increased collagens, basement proteins, and elastin) is associated with loss of axons. (tdl.org)
Therefore, we hypothesize that elevated TGF-β2 in the glaucomatous ONH induces gremlin expression that blocks BMP-4 inhibition of TGF-β2 signaling, leading to increased ECM synthesis and deposition. (tdl.org)
OB release bone matrix rich in collagen type I and participate in the hydroxyapatite crystal formation in collagen fiber deposition process, namely bone mineralization process, eventually forming new bone. (frontiersin.org)

We make use of a highly flexible multi-step cloning strategy in order to allow for the rapid synthesis of new recombinant proteins that can introduce many different biofunctionalities. (frontiersin.org)

Because the tibia is a subcutaneous bone, tibial fractures are frequently open fractures (see the image below). (medscape.com)
[ 4 ] Those with reconstructed IIIB fractures had problems with pain and carrying out normal activities more often than amputees and had problems with mobility as frequently as amputees. (medscape.com)
Objective -To determine clinical findings in and outcome of horses with fractures of the second or fourth metacarpal or metatarsal bone that underwent segmental ostectomy, leaving the proximal and distal portions of the bone undisturbed. (avma.org)
and 3 had fractures involving the proximal third of the second (2) or fourth (1) metacarpal bone. (avma.org)
Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. (medscape.com)

Materials & Methods: Compression-resistant (CR) bone grafts were evaluated in a canine model of lateral ridge augmentation. (uthscsa.edu)
These findings highlight the potential of compression-resistant bone grafts without the use of protective mesh for lateral ridge augmentation. (uthscsa.edu)

The results indicated that the BMP-2-producing cell sheet group was more efficient than other groups in promoting bone formation in the defect area. (dovepress.com)

This product is an active protein and may elicit a biological response in vivo, handle with caution. (abcam.com)

In human embryonic development, BMP-4 is a critical signaling molecule required for the early differentiation of the embryo and establishment of a dorsal-ventral axis 2,3 . (anhsci.com)
Predominantly expressed in long bones during embryonic development. (abcam.com)

3 To overcome some of these difficulties, research has been driven toward the use of bioactive molecules to induce local bone formation. (allenpress.com)

Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)

However, GBR has different clinical limitations, including increased treatment time, 1 limited predictability for vertical bone augmentation, 1 risk of infection subsequent to membrane exposure, 2 and technique sensitivity. (allenpress.com)

Anatomy11

Diseases4

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes16

Technology, Industry, Agriculture2

Information Science3

BMPs14

Regeneration15

Extracellular Matrix P1

Receptor7

Mouse recombinant1

Tissue14

Mesenchymal4

Cells32

Cartilage5

Absorbable collagen sponge1

RhBMP7

Ligand2

Monomer1

Defects9

Tissues3

Coli4

Sequence3

Osteoblasts3

Fracture3

Gene2

Stimulate2

Osteoinductive2

Collagen sponge1

Superfamily3

BMP21

Lumbar2

Osteopontin1

Metabolic1

Rekombinantes1

Growth Factor2

Residues1

Osteogenic Differentiation1

Approaches1

Alkaline phosphatase1

Bovine1

Deposition3

Synthesis1

Fractures5

Grafts2

Promoting bone formation1

Vivo1

Embryonic2

Molecules1

Molecular weight1

Infection1