Recombinant hcv core. Medical search. Frequent questions

Antigens are peptides or recombinant or native dependent on the production method.The kilo Daltons subunit weight of HCV core recombinant antigen a.a 2 a.a 192 of HCV polyprotein 22 [HCV core] compared to your protein ladder can be shifted a little due to electrophoresis effects. (anigenetics.com)
Studies have shown that in a majority of cases, when detectable IgM response to both structural and non-structural HCV antigens occurs, the IgM response happens more frequently to the structural (core) antigen. (rapidtest.com)
Antibody to hepatitis B core antigen. (cdc.gov)
2.1%) tested positive for both HBV surface antigen and HBV core antibody. (who.int)
After translation, host signal peptidases cleave the HCV core protein antigen (HCcAg) from the precursor polyprotein and remove the signal peptide located at its C-terminus. (thenativeantigencompany.com)
The core antigen is a promising marker for the diagnosis of infection in humans. (thenativeantigencompany.com)
2014). Comparison of HCV core antigen and anti-HCV with HCV RNA results. (thenativeantigencompany.com)
2013). Is HCV core antigen a reliable marker of viral load? (thenativeantigencompany.com)
An evaluation of HCV core antigen automated immunoassay. (thenativeantigencompany.com)
Analytical performance characteristics and clinical utility of a novel assay for total hepatitis C virus core antigen quantification. (thenativeantigencompany.com)
2015). Significance of the hepatitis C virus core antigen testing as an alternative marker for hepatitis diagnosis in Egyptian patients, Egypt. (thenativeantigencompany.com)
Tests comprising of mosaic recombinant antigen from the CORE, NS3, NS4 and NS5 genomic regions. (arkray.co.in)
In this study, we aimed to compare the HCV core antigen test with the HCV RNA assay for confirming anti-HCV results to determine whether the HCV core antigen test may be used as an alternative confirmatory test to the HCV RNA test and to assess the diagnostic values of the total HCV core antigen test by determining the diagnostic specificity and sensitivity rates compared with the HCV RNA test. (omu.edu.tr)
Sera from a total of 212 treatment-naive patients were analyzed for anti-HCV and HCV core antigen both with the Abbott Architect test and with the molecular HCV RNA assay consisting of a reverse transcription-PCR method as a confirmatory test. (omu.edu.tr)
The diagnostic sensitivity, specificity, and positive and negative predictive values of the HCV core antigen assay compared to the HCV RNA test were 96.3%, 100%, 100%, and 89.7%, respectively. (omu.edu.tr)
The levels of HCV core antigen showed a good correlation with those from the HCV RNA quantification (r = 0.907). (omu.edu.tr)
In conclusion, the Architect HCV antigen assay is highly specific, sensitive, reliable, easy to perform, reproducible, cost-effective, and applicable as a screening, supplemental, and preconfirmatory test for anti-HCV assays used in laboratory procedures for the diagnosis of hepatitis C virus infection. (omu.edu.tr)
Description: This is Hepatitis C virus core recombinant antigen for ELISA,WB. (10genomics.com)
Description: anti-HBcAg core IgM (monoclonal) Produced against recombinant HBcAg core antigen. (10genomics.com)
Polystyrene microwell strips pre-coated with recombinant HIV antigens indicated make up this two-step incubation antigen sandwich enzyme immunoassay kit (HIV1, 2 ELISA). (rapidtest.com)
B core antigen (anti-HBc) were excluded. (who.int)

The recombinant immunoblot assay is used to confirm HCV infection. (medscape.com)
For HCV, 48 (9.6%) of 500 participants were positive by enzyme immunoassay and recombinant immunoblot assay (95% confidence interval [CI], 7.0%-12.2%), and prevalence was lowest in the most geographically isolated participants. (cdc.gov)
Recombinant immunoblot assays are used as supplemental tests and for the final detection and quantification of HCV RNA in confirmatory tests. (omu.edu.tr)
Prior to 2013, specimens with a reactive anti-HCV screening test result were tested with a confirmatory recombinant immunoblot assay (RIBA) (Chiron RIBA HCV 3.0 Strip SIA) to confirm the presence of anti-HCV. (cdc.gov)

This HCV IgM ELISA test is an enzyme-linked immunosorbent assay for qualitative identification of IgM antibodies to hepatitis C virus in human serum/plasma. (rapidtest.com)
The principle of the HCV ELISA test involves a two-step incubation procedure in which an indirect ELISA assay for IgM antibodies to HCV is established. (rapidtest.com)
An enzyme-linked immunosorbent assay was developed using the purified recombinant HCV F protein. (org.ir)
2013). Enzyme-linked immunosorbent assay (ELISA)-based HCcAg detection is widely employed in clinical practice as an auxiliary method in the diagnosis of HCV infection (Ross, 2010). (thenativeantigencompany.com)
Antibodies to hepatitis C virus (anti-HCV) screening-test-positive with a signal to cut-off ratio predictive of a true positive as determined for the particular assay as defined by CDC. (cdc.gov)
Data from serum surplus testing with a second anti-HCV screening assay (sometimes referred to as reflex testing), performed to evaluate potential new HCV testing algorithms for NHANES specimens collected after the 2011-2012 cycle, are reported in this file, along with initial anti-HCV screening test and RIBA results. (cdc.gov)
Abbott ARCHITECT anti-HCV assay is a chemiluminescent microparticle immunoassay (CMIA) for the qualitative detection of immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies to hepatitis C virus (anti HCV) in human serum and plasma (potassium EDTA, lithium heparin, and sodium heparin). (cdc.gov)

HCV Core antigens or envelope proteins are used for immunization to obtain diagnostic antibodies. (anigenetics.com)
Before incubation, recombinant, highly immunoreactive antigens corresponding to the core and non-structural regions of HCV, are pre-coated to the polystyrene microwell strips. (rapidtest.com)
This study has implications for investigations requiring high virus concentrations, such as studies of HCV particle composition and development of whole-virus vaccine antigens. (birmingham.ac.uk)
After this stage the second set of recombinant antigens conjugated to the enzyme Horseradish Peroxidase (HRP-Conjugate) is added. (rapidtest.com)
Analysis of the peripheral blood T cell proliferative response to core, E1, E2, NS3, NS4, and NS5 recombinant antigens and synthetic peptides showed that responses to all hepatitis C virus antigens, except E1, were significantly more vigorous and more frequently detectable in patients who normalized transaminase levels than in those who did not. (unipr.it)

HCcAg is antigenic, interacts with numerous cellular proteins, induces specific cellular and humoral responses, and through various pathways likely plays an important role in the pathogenesis of HCV infection. (thenativeantigencompany.com)
Its primary sequence is the most conserved sequence among the HCV proteins, making it the most versatile protein marker for HCV infection (Hadziyannis et al. (thenativeantigencompany.com)
Recombinant viruses with altered NP proteins were generated, and these viruses acquired second-site mutations. (a-inhibitor.com)
HCV antibody was confirmed by Western blot using genotype 2 recombinant core, E2 and NS3 proteins. (ox.ac.uk)
Twelve out of 24 confirmed recovered, 1 out of 5 chronically infected and none of the 6 false-positive controls reacted to recombinant proteins. (ox.ac.uk)
We demonstrated for the first time that HCV replication was inhibited in LSD1-overexpressing cells, while specific HCV proteins differentially fine-tuned endogenous LSD1 expression levels. (bvsalud.org)
Is the Subject Area "Recombinant proteins" applicable to this article? (plos.org)
Serologic studies have also shown that the core proteins of HIV-1 and HIV-2 display frequent cross-reactivity whereas the envelope proteins are more type-specific. (rapidtest.com)
While there are various proposed methods for accomplishing this, Bruce Walker's now high-profile work with long-term nonprogressors suggests that certain cellular immune responses to core HIV proteins are the ones most deserving of coaxing back. (treatmentactiongroup.org)
Qingjiao Liao , Jiansheng Tian , Yang Wu , Xulin Chen , 2013: The Identification of Three Sizes of Core Proteins during the Establishment of Persistent Hepatitis C Virus Infection in vitro , Virologica Sinica, 28, 129-135. (virosin.org)

Please note that guidelines for the current diagnostic workup and management of hepatitis C (HCV) infection continue to evolve rapidly. (medscape.com)
if the result is positive, confirm current infection with a sensitive HCV-RNA test. (medscape.com)
Positive HCV-antibody test with negative HCV RNA by polymerase chain reaction (PCR): Inform patients they do not have evidence of current (active) HCV infection. (medscape.com)
All patients with HCV infection are recommended to have an evaluation for advanced fibrosis with the use of liver biopsy, imaging, and/or noninvasive markers to aid in decision making regarding treatment strategies and to determine whether additional measures for the management of cirrhosis should be initiated (eg, screening for hepatocellular carcinoma). (medscape.com)
If HCV infection is diagnosed, therapy can be instituted. (medscape.com)
The purpose of the HCV IgM ELISA Test is for clinical lab diagnosis and treatment of patients who are suspected of having a hepatitis C virus infection. (rapidtest.com)
HCV is now accepted as the major agent for non-A and non-B hepatitis transfusion infection. (rapidtest.com)
Newly acquired symptomatic hepatitis C virus (HCV) infection. (cdc.gov)
In order to assess the presence of antibodies specific for F protein we characterized specific anti-F antibodies in patients with chronic HCV infection. (org.ir)
Serum samples were collected from 72 patients with chronic HCV infection and from 30 healthy controls. (org.ir)
We also compared the seropositivity of patients for hepatitis B (HBV) and C (HCV) infection with a healthy control group to determine whether there is an association. (who.int)
Infection with HCV is widespread and part in the study. (who.int)
24 women and 24 men) and 96 healthy ous extra-hepatic disorders have been rec- volunteer blood donors (43 women and 53 ognized in association with HCV infection, men) participated in the study. (who.int)
Notably, HCcAg is present in blood 10 to 15 days after infection, which appears only 3 to 5 days later than HCV RNA (Buket et al. (thenativeantigencompany.com)
2015). Therefore, HCcAg is a useful marker for the early diagnosis of HCV infection. (thenativeantigencompany.com)
The prevalence of HCV infection was high among older citizens of Linxian, China, in 2000. (cdc.gov)
We conclude that HCV is now a common infection among older adults in Linxian, China. (cdc.gov)
Hepatitis C virus (HCV) infection is becoming a global public health problem ( 1 ). (cdc.gov)
The overall prevalence of HCV infection is 1%-2% in most countries that have been studied ( 2 ), but the distribution of HCV varies considerably among populations. (cdc.gov)
Very high rates of HCV infection are found among persons exposed to HCV through these routes ( 3 ). (cdc.gov)
Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population. (ox.ac.uk)
Eighty-one percentage of subjects with chronic infection (RNA positive) carried genotype 2 HCV. (ox.ac.uk)
HLA-B*57 was significantly more frequent in the group which had recovered from HCV infection compared with chronically infected subjects (P = 0.0053, OR = 8.02). (ox.ac.uk)
We investigated the putative role of LSD1 in the establishment of HCV infection using genetic engineering and pharmacological inhibition to alter endogenous LSD1 levels. (bvsalud.org)
Electroporation of the full-length HCV genome and subgenomic replicons in LSD1 overexpression enhanced translation and partially restored HCV replication, suggesting that HCV might be inhibited by LSD1 during the early steps of infection. (bvsalud.org)
Conversely, the inhibition of LSD1, followed by HCV infection in vitro, increased viral replication. (bvsalud.org)
Our study proposes that HCV-mediated LSD1 oscillations over countless viral life cycles throughout chronic HCV infection may promote epigenetic changes related to HCV-induced hepatocarcinogenesis. (bvsalud.org)
Diagnosis of HCV infection is mainly based on the detection of anti-HCV antibodies as a screening test with serum samples. (omu.edu.tr)
An infection with HCV is the leading cause for liver transplantation in the United States and Europe.The cellular immune response is supposed to play an important role in the course of infection with the HCV. (uni-giessen.de)
UNLABELLED: Neutralizing antibodies (NAbs) targeting glycoprotein E2 are important for the control of hepatitis C virus (HCV) infection. (ox.ac.uk)
Hepatitis C virus (HCV) chronic infection induces liver fibrosis and cirrhosis but is also responsible for a significant portion of hepatocellular carcinoma (HCC) occurrence. (wjgnet.com)
Because only 67.7% (323 of 477) of NHANES specimens with a reactive anti-HCV screening test result during NHANES 2007-2012 were found to be RIBA positive, reporting all specimens with a reactive anti-HCV screening test result as anti-HCV positive would result in an apparent increase in prevalence of ever having HCV infection due merely to the reporting of screening anti-HCV false-positives as antibody positive. (cdc.gov)
Thus, for NHANES to continue to track trends in prevalence of ever having HCV infection via anti-HCV after the 2011-2012 cycle, it is necessary to employ a new HCV testing algorithm, which can produce a prevalence for ever having HCV infection closer to that obtained using RIBA confirmation than would be obtained if all specimens with a reactive anti-HCV screening test result were reported as antibody positive. (cdc.gov)
HIV/HCV co-infection in Taiwan - HIV/HCV co-infection in Taiwan Nai-Ying Ko RN. (powershow.com)
HCV infection. (who.int)
All individuals with HCV infection responded to vaccination. (who.int)
Fisher exact tests were used to compare in haemodialysis patients infected with the antibody levels by age, sex, duration hepatitis C virus (HCV) and some authors of haemodialysis and concurrent HCV could not find the effective conversion rate infection. (who.int)
Terms and Abbreviations Used in This Publication Acute hepatitis C Newly acquired symptomatic hepatitis C virus (HCV) infection. (cdc.gov)
characterized by detection of HCV RNA greater than or equal to 6 months after newly acquired infection. (cdc.gov)

Eighty-two percent of chronic HCV patients had evidence of anti-F antibodies. (org.ir)
Flow through Immuno-dot Test for Qualitative Detection Of Antibodies to HCV in Serum or Plasma. (arkray.co.in)
This study aimed to assess the seroprevalence and correlates of HBV, HCV, HDV, and HTLV 1&2 antibodies among MSM in Ouagadougou, Burkina Faso. (biomedcentral.com)
IMPORTANCE: Approximately 180 million people worldwide are infected with hepatitis C virus (HCV), and neutralizing antibodies play an important role in controlling the replication of this major human pathogen. (ox.ac.uk)
Types Of HCV Test - HCV or Hepatitis C Virus test is another type of blood testing that seeks for the RNA or genetic material of the kind of virus that caused hepatitis or the antibodies the patient's body makes against the virus. (powershow.com)

Serum specimens obtained were tested for the presence of HBV, HCV, HDV and HTLV-1&2 infections. (biomedcentral.com)
characterized by sustained disappearance of serum HCV RNA and normalization of liver enzymes. (cdc.gov)

Results for "confirmed anti-HCV" (LBDHCV) were reported as positive if the RIBA was positive, as indeterminate if the RIBA was indeterminate, and as negative if the RIBA was negative or if the anti-HCV screening test result was negative. (cdc.gov)
RIBA positive and indeterminate specimens were further tested for HVC RNA, and, if RNA positive, for HCV genotype. (cdc.gov)
As of late 2012, Chiron is no longer producing RIBA kits and thus no confirmatory test for anti-HCV was available for the 2013-2014 NHANES cycle. (cdc.gov)
The eligible samples are those from the 2007-2012 NHANES which had a reactive screening anti-HCV test result and were tested with RIBA. (cdc.gov)

Our Guaranteed Recombinant Protein Expression Service Package consists of codon optimization service, followed by gene synthesis and subcloning, all the way through protein expression and purification. (biozoomer.com)
Recombinant HCV Fusion protein produced in E. coli containing HCV core (120 a.a. (creativebiomart.net)
HCV Fusion protein is purified by proprietary chromatographic techniques. (creativebiomart.net)
Right here we try to ascertain a manufacturing platform of recombinant 38 kDa protein in mammalian cells and to guage the potential worth of 38 kDa protein in TB serodiagnosis. (tbdb.org)
The hepatitis C virus (HCV) F protein is a recently described, frameshift product of HCV core encoding sequence. (org.ir)
The F protein was cloned from the HCV genome. (org.ir)
The recombinant protein was expressed in Escherichia coli and purified by immunoaffinity chromatography. (org.ir)
Based on these findings, HCV F protein elicits a specific antibody response, so frameshift could occur in the core-coding sequence in HCV genotype 1a in Iranian patients. (org.ir)
This core protein fragment represents part of the infectious virions inner core particle, which encloses the viral genome. (thenativeantigencompany.com)
The virus capsid is formed by polymerization of the HCV core protein, a structural protein encoded by the 5' end of the HCV open reading frame (amino acids 1-191). (thenativeantigencompany.com)
Recombinant viruses propagated in Vero cells acquired mutations that mainly affected components of the viral polymerase, while recombinant viruses propagated in MDBK cells acquired mutations that mainly affected the viral M protein. (a-inhibitor.com)
LSD1 was shown to participate in an intriguing antiviral mechanism, where it activates endolysosomal interferon-induced transmembrane protein 3 (IFITM3) via demethylation, leading endocytosed HCV virions to degradation. (bvsalud.org)
Dabei bestehen die HCVpp aus lentiviralen Core-Partiken, die an ihrer Oberfläche unmodifizierte HCV E1- und E2-Hüllglykoproteine tragen, um so als Pseudotypen das native Hepatitis C-Virus zu imitieren.Die Verwendung von HCVpp im Lymphozytenstimulationstest führte zu vergleichbaren Ergebnissen wie die Protein-Stimulation, wobei die HCVpp zu einer stärkeren Stimulation der CD4-Lymphozyten führten. (uni-giessen.de)
a synthetic codon optimized DNA sequence, encoding a 183-aa recombinant protein, fused to His-tag at the N-terminus. (bioclon.com)
a synthetic codon optimized DNA sequence, encoding HCV core protein (a.a. 1 - 191), fused to His-tag at the N-terminus. (bioclon.com)
a synthetic codon optimized DNA sequence, encoding gag p17 (a.a.77-132) + gag p24 (a.a.133-363) + gag p15 (a.a.364-436) recombinant protein, fused to His-tag at the N-terminus. (bioclon.com)
In this report antiviral effects of IFN- α 2b on translation were examined in a hepatic cell line using chimeric clones of internal ribosome entry site (IRES) sequences from six different HCV genotypes and the green fluorescence protein (GFP) gene. (microbiologyresearch.org)

Classification of hepatitis C virus is established through six major genotypes and series of subtypes of HCV. (rapidtest.com)
The preponderance and distribution of HCV genotypes varies globally. (creativebiomart.net)
The preponderance and distribution of HCV genotypes varies globally and this is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. (thenativeantigencompany.com)
While it is possible to produce HCV particles resembling isolates of all HCV genotypes in human hepatoma cells (HCVcc), production efficacy varies. (birmingham.ac.uk)
Recombination between genotypes 1 and 4 was confirmed in both samples, and the parental lineages of each recombinant belong to HCV subtypes that are cocirculating at a high prevalence in Cameroon. (ox.ac.uk)
Certain genotypes of hepatitis C virus (HCV) respond less often than others to treatment with interferon (IFN). (microbiologyresearch.org)
It was determined that IFN- α 2b specifically inhibited the translation of GFP mediated by IRES sequences from six major HCV genotypes in a concentration-dependent manner. (microbiologyresearch.org)

In a nationwide study conducted in 1992, HCV prevalence was reported to be 3.2% in China overall and 3.1% in rural China ( 4 ). (cdc.gov)
Other smaller studies have reported HCV prevalence rates of 0% to 3% in rural populations from various Chinese provinces ( 5 - 7 ). (cdc.gov)
We used specimens collected in this study to estimate the prevalence of hepatitis B virus (HBV), HCV, and HIV-1 among older adults in Linxian in 2000. (cdc.gov)
Prevalence was 20.4% (95% CI: 16.4-25.1) for HBV, 11.0% (95% CI: 8.0-14.8) for HCV, and 0.0% for HDV. (biomedcentral.com)
This study shows that HBV, HCV and HTLV 1&2 prevalence among MSM in Burkina is high and suggests that comprehensive STI prevention and sexual health education services for this group are needed. (biomedcentral.com)

To investigate the role of cellular immune responses and host genetics in this phenomenon, samples from 104 Ghanaian blood donors reactive with anti-HCV assays were collected between 2000 and 2005. (ox.ac.uk)
Single-cycle virus production assays in CD81-deficient Huh7-derived cells demonstrated that these changes did not affect replication but increased HCV assembly and specific infectivity as early as 24 h posttransfection. (birmingham.ac.uk)
Quantitative assays for HCV RNA Tests to detect HCV RNA concentration (viral load) by amplification of viral genetic sequences or by signal amplification. (cdc.gov)

Clinicians are advised to refer frequently to HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C , the most recent recommendations of the American Association for the Study of Liver Diseases (AASLD) and Infectious Diseases Society of America (ISDA). (medscape.com)
HCV is most frequently transmitted by percutaneous exposure to infectious blood or blood-derived body fluids, such as through transfusion of contaminated blood or blood products, nonsterile medical injections, or injection drug use. (cdc.gov)
High-titer HCVcc like the one described in this study may be pivotal in future vaccine-related studies where large quantities of infectious HCV particles are necessary. (birmingham.ac.uk)
We show here that one of the most conserved antigenic sites within the major glycoprotein E2 (amino acids 412 to 423), which is disordered in the recently reported crystal structure of an E2 core fragment, can adopt different conformations in the context of the infectious virus particle. (ox.ac.uk)

For more than 50% of patients, HCV develops into chronic hepatitis and has become the principal cause of cirrhosis of the liver and hepatocellular carcinomas. (rapidtest.com)
In order to gauge the extent of progressive liver impairment and in aiding antiviral treatment, it is vitally important and useful for the chronic hepatitis C patients to know the detectable amounts of HCV IgM that are present. (rapidtest.com)

Before initiation of antiviral therapy: Obtain quantitative HCV-RNA testing to document baseline viral load. (medscape.com)
still no vaccine against HCV, the current antiviral therapy has strong side effects, and the treatment is successful in only 50 to 60 percent of patients. (uni-giessen.de)

HCV-positive Positive for anti-HCV as verified by supplemental testing or positive for HCV RNA. (cdc.gov)
Supplemental anti-HCV test Additional test (i.e. (cdc.gov)

Here, we investigated two putative genotype 4/1 recombinants from southern Cameroon using a number of approaches, including standard Sanger sequencing, genotype-specific PCR amplification, and non-HCV-specific Illumina RNA sequencing (RNA-seq). (ox.ac.uk)
and c100-3, representing the putative nonstructural (NS3 and NS4) regions of HCV. (cdc.gov)

Our study offers important functional data on how cell culture-adaptive mutations identified in genotype 5a JFH1-based HCVcc permit high-titer culture by affecting HCV genesis through increasing virus assembly and HCV fitness by enhancing the virus specific infectivity and cell-to-cell transmission ability, without influencing the biophysical particle properties. (birmingham.ac.uk)

Thus, for several important studies, including vaccine development, in vitro systems enabling high-titer production of diverse HCV strains would be advantageous. (birmingham.ac.uk)
The local ethics committee approved the Second-generation recombinant vaccine study and informed consent was obtained (expressing the "s" gene) is safer and more from all patients. (who.int)
A tissue-culture system using recombinant DNA technology was recently developed and has advanced the scientific knowledge base considerably, including early forays into vaccine development. (medscape.com)

The patient must have measurable disease according to RECIST v1.1 and must have one site amenable to biopsy that, in the opinion of the investigator and/or interventional radiologist, is likely to yield acceptable tumor sample for a core biopsy per the below pathology criteria. (bcan.org)
Ovarian cancer muscle microarrays composed of two cores from each tumor sample were prepared by the Tumor Bank Facility at Fox Chase Cancer Center, as described previously. (deubiquitinase.com)

Men who have sex with men (MSM) are considered to be at significant risk for sexually transmitted infections (STI) and bloodborne viruses including viral hepatitis types B, C, and D (HBV, HCV, and HDV) and human T-cell leukemia virus types 1 and 2 (HTLV 1&2). (biomedcentral.com)
Our results suggest that HCV utilizes conformational flexibility as an immune evasion strategy, contributing to the limited immunogenicity of this epitope in patients, similar to the conformational flexibility described for other enveloped and nonenveloped viruses. (ox.ac.uk)
Hepatitis C virus (HCV) is one of 6 viruses (along with hepatitis A, B, D, E, and G viruses) that cause viral hepatitis. (medscape.com)

The incidence of HCV-related hepatocellular carcinoma (HCC) is increasing and is forecast to peak in 2019.3 The effect of these projections is already becoming evident. (egfrsignals.com)

HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication PLoS Pathog. (usc.edu)

HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae.HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. (creativebiomart.net)
HCV has a high rate of replication, producing approximately one trillion particles/day in an infected individual, as well as an exceptionally high mutation rate, which may help it evade the host's immune response. (thenativeantigencompany.com)

In conclusion, it is hypothesized that the dominance of genotype 2 HCV strains may be an important factor explaining the high rate of recovery from HCV infections in Ghana via an efficient contribution of HLA-B*57 which is relatively frequent in the population. (ox.ac.uk)

For core-needle biopsy specimens, at least three cores should be submitted for evaluation if feasible. (bcan.org)

Recently, the association between Behçet nization after history taking and clinical ex- disease and hepatitis C virus (HCV) [ 4-6 ] amination. (who.int)
50% of HCV infections, the sequential analysis of the T cell response from the early clinical stages of disease may contribute to define the features of the T cell response associated with recovery or chronic viral persistence. (unipr.it)

HCV RNA Hepatitis C virus ribonucleic acid. (cdc.gov)

In Switzerland, for example, HCV annual incidence among MSM increased from 0.23 (95% Confidence Interval [CI]: 0.08-0.54) cases per 100 person-years in 1998 to 4.09 (95% CI: 2.57-6.18) cases per 100 person-years in 2011, compared to a change from 13.5 cases per 100 person-years to less than 1 case per 100 person-years among people who inject drugs [ 20 ]. (biomedcentral.com)

Qualitative RT-PCR for HCV RNA Test to detect HCV RNA by amplification of viral genetic sequences. (cdc.gov)

The World Health Organization (WHO) recommends nucleic acid testing for qualitative or quantitative HCV RNA detection as well as for test of cure at 12 or 24 weeks following antiviral treatment completion. (medscape.com)

Hepatitis C virus (HCV) alters gene expression epigenetically to rearrange the cellular microenvironment in a beneficial way for its life cycle. (bvsalud.org)
刘超红 , 焦成松 , 陈新文 , 2006: Cloning of HCV ns2 Gene and its Expression in Prokaryotic and Mammalian cells, Virologica Sinica, 21, 217-220. (virosin.org)

HCV is defined as an envelope, single stranded positive sense RNA (9.5kb) affiliated with the Flaviviridae family. (rapidtest.com)
Only a small number of intergenotypic recombinants have been identified so far, and each has core and envelope genes classified as belonging to genotype 2. (ox.ac.uk)

Lysine-specific demethylase 1 (LSD1) is an epigenetic controller of critical cellular functions that are essential for HCV propagation. (bvsalud.org)
The enhanced understanding of the cellular immune response can support the development of vaccines as well as be helpful for the prevention and treatment of illness.In this study, a test system for the analysis of HCV-specific T lymphocytes could be established. (uni-giessen.de)

Serologic screening for HCV involves an enzyme immunoassay (EIA). (medscape.com)

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