Recombinant ga binding protein transcription factor subunits. Medical search. Frequent questions

The canonical pathway involves Janus kinase-signal transducer and activator of transcription-interferon regulatory factor (JAK-STAT-IRF) signaling. (wikipedia.org)
The noncanonical signaling pathway includes mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase thymoma viral proto-onco- gene 1 (PI3K-AKT1) cascades. (wikipedia.org)
Active mTORC1 phosphorylates the eukaryotic initiation factor 4E-binding protein-1 (4E-BP1) and 40S ribosomal protein S6 kinase 1 (S6K1) to promote protein synthesis [ 3 , 4 ]. (springer.com)
Conversely, during starvation mTORC1 is inhibited and autophagy is induced by AMP-activated protein kinase (AMPK), leading to generation of intracellular nutrients and energy during degradation of non-functional or non-essential organelles or protein aggregates [ 4 , 6 ], in turn contributing to cell survival. (springer.com)
The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient shortage. (biomedcentral.com)
GCN2 is an evolutionarily conserved serine/threonine kinase that senses amino acid restriction through binding to uncharged tRNAs [ 18 ]. (biomedcentral.com)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
The intact receptor lacks tyrosine kinase activity, but binding of GH and dimerization results in association with JAK2, a member of the Janus kinase family, which results in self-phosphorylation of the JAK2 and a cascade of phosphorylation of cellular proteins. (medscape.com)

Similar to other Type I interferons, IFN-τ binds to the Interferon-alpha/beta receptor (IFNAR). (wikipedia.org)
Receptor binding site can be found at the C-terminus, biologically active site is located at the N-terminus. (wikipedia.org)
IFN-τ binds to IFNAR cell membrane receptor and induces dimerization of its subunits, IFNAR1 and IFNAR2, which leads to activation of canonical and noncanonical signaling pathways. (wikipedia.org)
Macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) are two cytokines secreted mainly by osteoclast. (biomedcentral.com)
RANKL binds specifically to receptor activator of nuclear factor (NF)-κB (RANK) that mediates osteoclastogenesis by subsequent signal transduction to intracellular molecules through the TRAF6 adaptor protein. (biomedcentral.com)
The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is usually associated with aggressive and infiltrating breast cancer (BC) phenotype, and metastases. (dovepress.com)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
IGF-I deficiency can be the result of GH resistance or insensitivity due to genetic disorders of the GH receptor causing GH receptor deficiency (growth hormone receptor deficiency [GHRD], Laron syndrome) or postreceptor defects, including the principal transduction agent STAT5b, the IGF-I/IGFBP3 stabilizer acid labile subunit (ALS), the IGF-I gene, or the IGF-I receptor. (medscape.com)
The GH molecule binds to its specific cell surface receptor (GHR), which dimerizes with another GHR molecule so that the single GH molecule is enveloped by 2 GHR molecules. (medscape.com)
IGF binding involves 3 basic types of receptors: the structurally homologous insulin receptor and type 1 IGF receptor and the distinctive type 2 IGF-II/mannose-6-phosphate receptor. (medscape.com)
The SFRPs inhibit Wnt receptor binding to down-regulate pathway signaling during development [ 8 ]. (biomedcentral.com)

IFN-τ is essential to maintain the levels of progesterone production by the corpus luteum for the maternal recognition of pregnancy, and together with progesterone increases expression of genes for transport of nutrients into the uterine lumen, growth factors for hematopoiesis and angiogenesis and other molecules that are crucial for implantation and placentation. (wikipedia.org)
Furthermore, gene-gene and gene-metabolite network analyses discovered that the light-responsive expression of genes encoding bHLH, MYB, WRKY, NAC, and MADS-box transcription factors, and proteins involved in genetic information processing and epigenetic regulation such as nucleosome assembly and histone acetylation, showed a high positive correlation with grape berry phenolic accumulation in response to different light regimes. (biomedcentral.com)
Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that the candidate reference genes were significantly enriched in cellular metabolic process, protein metabolic process and ribosome in early development and normal adult tissues as well as in cellular localization and endocytosis in the hindgut under sulfide stress. (biomedcentral.com)
Output from the circadian clock is transduced through regulating transcription of downstream genes directly by the oscillator components. (go.jp)
hRSV is an enveloped virus with a negative-stranded, non-segmented RNA genome containing 10 genes distributed along 15.2 kilobases in the order 3′-NS1-NS2-N-P-M-SH-G-F-M2-L-5′ and encoding 11 proteins [8]. (fortunejournals.com)
Accordingly, the two tools, all constituent genes were found, a window of ten genes which were previously reconfigured to comply with such organization, confirmed that bending propensity is mostly defined by the duplication and deletion of signaling protein to produce fibroblast values similar to taking a finite difference approximation of gradients. (thehazeltines.com)
1000 Mb with up to 18,000 protein-coding genes [ 12 ]. (biomedcentral.com)

In most metazoans, GCN2 is one of the four known kinases that phosphorylate eukaryotic initiation factor 2, α subunit (eIF2α) to inhibit translation initiation [ 19 ]. (biomedcentral.com)

Reduced SMO-dependent expression of Gli1 was demonstrated in both Tsc1 −/− and Tsc2 −/− cells, and we found that Tsc1 is required for TGF-β induced phosphorylation of SMAD2/3 and subsequent expression of the HH signaling effector and transcription factor GLI2. (springer.com)
This complex behavioral profile was accompanied by decreases in ERK2 mRNA and protein phosphorylation within the VTA, while stress alone resulted in opposite neurobiological effects. (jneurosci.org)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
Immunologic and confocal microscopic evidence also suggested a transient but significant stimulation of tyrosine phosphorylation of Cav-1 in β-cells briefly (for 15 min) exposed to IL-1β that was markedly attenuated by three structurally distinct inhibitors of protein tyrosine phosphorylation. (diabetesjournals.org)

Such assays can be used to study binding affinity and recruitment specificity of either recombinant or cellular proteins [ 27 , 28 ]. (biomedcentral.com)

IFN-τ binds to the same IFN receptors as IFN-α and induces intracellular signalling through STAT1, STAT2, and Tyk2. (wikipedia.org)
It was observed that IFN-τ decreased intracellular HIV RNA in human macrophages and inhibited reverse transcription of viral RNA into proviral DNA. (wikipedia.org)
Role of intracellular trafficking of thyroperoxidase and involvement generated at the apical surface of thyroid cells in covalent heme binding. (rusmedserv.com)
This review summarizes the unique immunomodulatory aspects of hRSV infection, the viral proteins involved in intracellular immune signaling, and the viral interactions in play with the host's immune system. (fortunejournals.com)
This review summarizes the unique immune-modulatory aspects of hRSV infection that are associated with the roles performed by viral proteins in intracellular immune signaling, their interactions with the host immune system, and their possible implications for disease pathology. (fortunejournals.com)
The most critical of these proteins is the signal transducer and activator of transcription 5b (STAT5b), which couples GH binding to the activation of gene expression that leads to the intracellular effects of GH, including synthesis of IGF-I, insulin-like growth factor binding protein 3 (IGFBP3), and ALS. (medscape.com)

Mammalian mitochondrial respiratory chain (MRC) complexes are able to associate into quaternary structures named supercomplexes (SCs), which normally coexist with non-bound individual complexes. (elifesciences.org)
The functional significance of SCs has not been fully clarified and the debate has been centered on whether or not they confer catalytic advantages compared with the non-bound individual complexes. (elifesciences.org)
Genomic sites of DNA methylation can be bound by methyl-CpG-binding domain proteins (MBDs) and specific zinc finger proteins, which can recruit co-repressor complexes to silence transcription on targeted loci. (biomedcentral.com)
We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema factor (EF), and their toxin complexes, lethal toxin and edema toxin in plasma, during the course of inhalation anthrax in 23 cynomolgus macaques. (cdc.gov)
From Protein Complexes to Subunit Backbone Fragments: a Novel Approach to Native Mass Spectrometry. (chicagobiomedicalconsortium.org)

We discuss how the chromatin substrate is prepared for heterochromatic spreading, and how trans-acting factors beyond writer enzymes regulate it. (bvsalud.org)
We examine mechanisms by which trans-acting factors in Suv39, PRC2, SETDB1 and SIR writer systems regulate spreading of the respective heterochromatic marks across chromatin. (bvsalud.org)
Similarly, primary cilia have been implicated in regulation of mTOR signaling, in which Tuberous Sclerosis Complex proteins 1 and 2 (TSC1/2) negatively regulate protein synthesis by inactivating the mTOR complex 1 (mTORC1) at energy limiting states. (springer.com)

The uPA converts cell surface-bound plasminogen to plasmin, a process that is regulated by the binding of plasminogen to specific receptors on the cell surface, however, the identity of the plasminogen receptors that function in this capacity is unclear. (oncotarget.com)

Relatively little is known about regulatory mechanisms in HIF signalling, especially with regards to HIF-2 but other putative mechanisms for the maintenance of HIF expression include stabilisation through binding of the molecular chaperone heat shock protein, HSP90 [ 28 ]. (biomedcentral.com)
In order to study the biology of endogenous Thap1 protein, we have applied a series of molecular and immunochemical approaches. (biomedcentral.com)
The relative molecular mass (M r ) of authentic exogenous Thap1 was previously established by in vitro translation of recombinant c-Myc-tagged human Thap1 protein from a human THAP1 cDNA. (biomedcentral.com)
Other molecular components of hRSV, such as the G or N proteins, have also been explored as potential targets for disease control. (fortunejournals.com)

Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression. (embl.de)
Tristetraprolin (TTP), the prototype of a class of CCCH zinc finger proteins, is a phosphoprotein that is rapidly and transiently induced by growth factors and serum in fibroblasts. (embl.de)

Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1β−induced nitric oxide (NO) release in the isolated β-cell. (diabetesjournals.org)

Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. (origene.com)

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
The principal BP, IGFBP3, binds approximately 90% of circulating IGF-I in a large (150-200 kD) ternary complex consisting of IGFBP3, ALS, and the IGF molecule. (medscape.com)

Recent evidence suggests that a physiological function of TTP is to inhibit tumor necrosis factor alpha secretion from macrophages by binding to and destabilizing its mRNA (Carballo, E., Lai, W.S., Blackshear, P.J., 1998. (embl.de)

The two enrichment strategies allow probing of methyl-CpG protein interactions in early vertebrate oocytes and embryos. (biomedcentral.com)
A number of methods to study DNA-protein interactions have been developed over the years. (biomedcentral.com)
Another protein containing this domain is the human splicing factor U2AF 35kDa subunit, which plays a critical role in both constitutive and enhancer-dependent splicing by mediating essential protein-protein interactions and protein-RNA interactions required for 3' splice site selection. (embl.de)
This paper reviews the core subunits of PRC2 and their interactions, and outlines the mechanisms of aberrant PRC2 expression in cancer and its role in tumor immunity. (bvsalud.org)
Disruption of plant plasma membrane by Nep1-like proteins in pathogen/plant interactions. (ki.si)

The Thap1 DNA binding domain (DBD) interacts with an 11-nucleotide consensus sequence 5´-TxxxGGCA-3´ in a target motif known as THABS (Thap1-binding sequence). (biomedcentral.com)

GL7 encodes a protein homologous to LONGIFOLIA in Arabidopsis thaliana and increase grain length and improvement of grain appearance quality [12]. (researchsquare.com)
The recently reported GL6 encodes a plant-specific PLATZ transcription factor and positively regulates grain length to increase TGW [10]. (researchsquare.com)
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. (origene.com)

The IGFBPs are a family of 6 structurally related proteins with a high affinity for binding IGF. (medscape.com)

The heterodimeric TSC complex negatively regulates mTORC1 activity via the GTPase activity of TSC2, towards the small G-protein RHEB (Ras homologue enriched in brain) [ 5 ]. (springer.com)
Transcription factor bHLH121 regulates root cortical aerenchyma formation in maize. (harvard.edu)

Overexpression of ZmWUS1-B is due to multimerized binding sites for type-B RESPONSE REGULATORs (RRs), key transcription factors in cytokinin signaling. (nature.com)

Endogenous MeCP2 and MBD3 were precipitated from Xenopus oocyte extracts and conditions for methylation-specific binding were optimized. (biomedcentral.com)
To investigate possible functions of CCCH proteins in early development of Xenopus, we isolated four Xenopus cDNAs encoding members of this class. (embl.de)
Based on 49% overall amino acid identity and 84% amino acid identity within the double zinc finger domain, one of the Xenopus proteins (XC3H-1) appears to be the homologue of TTP. (embl.de)

Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor. (rusmedserv.com)

Activation of CLV3 in the OC is prevented by the action of WUS in conjunction with the GRAS-transcription regulators HAIRY MERISTEMs (HAMs) 4 , 5 . (nature.com)

In addition, after transcription, a wide array of RNA-binding proteins interacts with cis -acting elements located mainly in the 3' untranslated region, determining the fate of mRNAs in eukaryotic cells. (frontiersin.org)

Methylated DNA affinity capture by methyl-CpG binding proteins produces fractions highly enriched for methylated DNA, suitable for coupling to next generation sequencing technologies. (biomedcentral.com)

Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)

Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. (rndsystems.com)

By contrast, SFE did not affect phospholipase C gamma 2 or subsequent cAMP response element binding activation. (biomedcentral.com)

Human thyroid peroxidase: complete protein sequence, chromosome mapping, and identification two alternately spliced mRNAs. (rusmedserv.com)
Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl.de)
Towards in silico CLIP-seq : predicting protein-RNA interaction via sequence-to-signal learning. (ki.si)

MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

In addition, proteomic profile confirmed that a set of proteins, related to tumor aggressiveness, were positively affected by targeted nanoparticles. (dovepress.com)

Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
The regulation of WUS transcription is crucial for meristem homeostasis, whereby high WUS expression leads to enlarged meristems and low expression leads to the formation of small meristems 3 , 14 . (nature.com)

Based on the distinct phylogeny of the polymerase (L) protein and the presence of a conserved M2 gene, both of which are involved in transcriptional regulation and virus morphology, hRSV was renamed human Orthopneumovirus to fit with its taxonomical classification as a member of the Orthopneumovirus genus ( Pneumoviridae family) [7]. (fortunejournals.com)
Distinct and overlapping factors are involved in lifespan extension by bacterial DR (bDR) and liquid DR (lDR) - two protocols of bacterial dilution in liquid cultures. (biomedcentral.com)

Canonical regulation of HIF abundance is governed after transcription and translation in part due to the action of oxygen sensitive enzymes, the hif-α prolyl hydroxylases. (biomedcentral.com)

Although their photoreceptors contain a protein, retinochrome, that recycles retinal and replicates one of the functions of the vertebrate RPE, cephalopod photoreceptors are likely not maintained as well as in vertebrates, and that as a result, the useful lifetime of photoreceptors in invertebrates is much shorter than in vertebrates. (wikipedia.org)

This recruitment and the associated cilia elongation is not inhibited by blockade of HIFα transcription activity or rescue of basal HIF-2α expression. (biomedcentral.com)
In particular, recent studies have implicated the cAMP response element-binding protein (CREB) as a critical factor guiding LA neuron recruitment into a fear memory network. (nature.com)

One of the main risk factors for the infection and development of human toxocariasis, is to cohabit with puppies and kittens. (scielo.org.co)
Human thyroid peroxidase (TPO) isoforms, and TPO-2: analysis of protein expression in Graves' tissue. (rusmedserv.com)
Proteins containing CCCH Znf domains include Znf proteins from eukaryotes involved in cell cycle or growth phase-related regulation, e.g. human TIS11B (butyrate response factor 1), a probable regulatory protein involved in regulating the response to growth factors, and the mouse TTP growth factor-inducible nuclear protein, which has the same function. (embl.de)
Microtubule binding of the human augmin complex is directly controlled by importins and Ran-GTP. (harvard.edu)
Thus, even a small insulin-like effect of IGF-I could be more important than that of insulin itself, were it not for the IGFBPs that control the availability and activity of IGF-I. In fact, intravenous infusion of recombinant human IGF-I (rhIGF-I) can induce hypoglycemia, especially in the IGFBP3 deficient state. (medscape.com)

Inadequate understanding of the antigenic intricacies of its viral proteins and the immune responses they generate in the host is the greatest obstacle to the progress of hRSV prevention and treatment. (fortunejournals.com)

During an outbreak in a congregate setting, we collected paired mid-turbinate nasal swabs for antigen testing and reverse-transcription polymerase chain reaction (RT-PCR) every other day from all consenting infected and exposed persons. (cdc.gov)
They are usually generated from either exons or introns of both protein-coding and non-coding transcripts that are processed by RNA polymerase II (Pol II) [ 12 - 14 ]. (ijbs.com)

The mouse TTP protein is induced by growth factors. (embl.de)
Primary cilia are sensory organelles that coordinate multiple cellular signaling pathways, including Hedgehog (HH), Wingless/Int (WNT) and Transforming Growth Factor-β (TGF-β) signaling. (springer.com)
In the presence of nutrients, mTORC1 is activated and promotes cell growth, including protein synthesis and energy storage. (springer.com)
Furthermore, TSC1 was demonstrated to be required for the proper activation of the transforming growth factor-β (TGF-β)-SMAD2/3 pathway in HeLa cells [ 11 ]. (springer.com)
Insulin-like growth factor I (IGF-I) is the effector of growth induced by growth hormone (GH). (medscape.com)

Here we show that the maize dominant Barren inflorescence3 ( Bif3 ) mutant harbors a tandem duplicated copy of the ZmWUS1 gene, ZmWUS1-B , whose novel promoter enhances transcription in a ring-like pattern. (nature.com)
The genetic model of DR - the eat-2 mutant - has a decreased pumping rate, thus ingesting less bacteria, and requires the FoxA transcription factor PHA-4 [ 8 ] and the dimethoxy ubiquinone hydroxylase CLK-1 [ 9 ] to extend its lifespan. (biomedcentral.com)

The phosphorylated form of 40S ribosome protein S6 is thus a marker for mTORC1 activity. (springer.com)

Importantly, the amino acid diversity of EMAs is distributed throughout the length of the proteins. (biomedcentral.com)

The vaccine-induced immune response is influenced by: (i.) vaccine factors i.e., type and composition of the antigen(s), (ii. (smw.ch)
Currently, the prefusion F protein is considered the most effective antigen for inducing protective immunity. (fortunejournals.com)

Taxonomic distribution of proteins containing ZnF_C3H1 domain. (embl.de)
The complete taxonomic breakdown of all proteins with ZnF_C3H1 domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing ZnF_C3H1 domain in the selected taxonomic class. (embl.de)
Cytotoxicity and DNA cleavage with core-shell nanocomposites functionalized by a KH domain DNA binding peptide. (chicagobiomedicalconsortium.org)
WUS is a homeodomain transcription factor (TF) produced in the organizing center (OC) domain of apical meristems and is transported via plasmodesmata into the apical domain (called central zone, CZ) to promote proliferation of stem cells 3 . (nature.com)
The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. (origene.com)

The recombinant IFN-τ had the same antiviral, antiluteolytic and immunosuppressive properties as native IFN-τ. (wikipedia.org)
external factors such as immunosuppressive drugs or diseases. (smw.ch)

The binding to methylated DNA may be regulated by post-translational MBD modifications. (biomedcentral.com)
Hypoxia maintains HIFα protein expression through inhibition of prolyl hydroxylases and IL-1 is suggested to effect subunit expression at the level of transcription and in a similarly post-translational fashion [ 26 ]. (biomedcentral.com)

Lastly, IL-21 also promotes activation of the STAT3 promoter and other transcriptional factors. (intechopen.com)

The HIFs are transcription factors with a very broad biological significance to many cell and tissue types [ 27 ]. (biomedcentral.com)
Dynamic transcription factor activity profiling in 2D and 3D cell cultures. (chicagobiomedicalconsortium.org)
RRM1 , a ubiquitously expressed subunit of ribonucleoside-diphosphate reductase, and CCAR1 (cell cycle and apoptosis regulator 1) have been identified as direct targets for regulation by Thap1 in endothelial or Jurkat cells. (biomedcentral.com)

The neural localization of the 50 kDa species and its nuclear compartmentalization suggests that these may be key Thap1 species controlling neuronal gene transcription. (biomedcentral.com)
Proteins found in any species of insect. (lookformedical.com)

SFE inhibited the RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1). (biomedcentral.com)

At the heart of this process are enzymes that deposit chemical information on chromatin, which attracts the factors that execute chromatin compaction and transcriptional or co/post-transcriptional gene silencing. (bvsalud.org)

A clear genotype/phenotype relationship has not been established, nor is it definitively known that alterations in transcription of Thap1 downstream targets are responsible for DYT6, as Thap1 may have other, yet to be identified functions. (biomedcentral.com)

Both anabolic phenotype and inflammatory pathology are proposed to be dependent on hypoxia-inducible factor 2 alpha (HIF-2α). (biomedcentral.com)
However, important knowledge gaps remain about the role played by various hRSV proteins in immunobiology and pathology. (fortunejournals.com)

Oncogenic RAS expression increased S100A10 gene expression which resulted in an increase in S100A10 protein levels. (oncotarget.com)
miRNAs are able to post-transcriptionally control gene expression by binding to target mRNAs [ 15 ]. (ijbs.com)

host factors i.e., genetic differences in immune-signalling or senescence, and (iii. (smw.ch)

Secreted frizzled-related proteins (SFRPs), such as SFRP1 , function as inhibitors of Wnt signaling. (biomedcentral.com)

Anatomy3

Chemicals and Drugs4

Psychiatry and Psychology2

Phenomena and Processes7

Information Science3

Kinase8

Receptor12

Genes8

Eukaryotic initia1

Phosphorylation4

Cellular proteins1

Intracellular6

Complexes5

Regulate3

Receptors1

Molecular4

Zinc finger p2

Lipid2

Yeast1

Molecule2

Inhibit1

Interactions5

Motif1

Encodes3

Structurally1

Regulates2

Overexpression1

Xenopus3

Granulocyte colony1

Regulators1

Interacts1

Fractions1

Dysfunction1

Cytokines1

Gamma1

Sequence3

Plasma membrane1

Tumor1

Homeostasis2

Distinct2

Canonical1

Vertebrate1

Recruitment2

Human5

Viral1

Polymerase2

Growth5

Mutant2

Ribosome1

Amino1

Antigen2

Domain6

Immunosuppressive2

Post-translational2

Promoter1

Cell3

Species2

Nuclear1

Chromatin1

Downstream1

Pathology2

Gene expression2

Immune1

Inhibitors1