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  • antigen
  • To enhance the immunogenicity of this protein, which has a low molecular weight, the aim of the present work was to express, isolate, and characterize a chimeric protein based on the fusion of the bacterial chaperone HSP70 of Yersinia pseudotuberculosis and EIII (DIII + stem) as a prospective antigen for an adjuvanted delivery system, the tubular immunostimulating complex (TI-complex). (mdpi.com)
  • IMP321 is a 200 kDA soluble dimeric recombinant fusion protein of the extracellular portion of LAG3 with immunoglobulin, designed to activate antigen presenting cells. (wikipedia.org)
  • had successfully produced a soluble fusion protein of LAG3 and immunoglobulin around 1995 and had initially envisaged its use as an immunosuppressant after evidence that its interaction with MHC class II molecules leads to the down-regulation of CD4+ antigen-specific T cell clone proliferation and cytokine secretion, and that it inhibited the alloresponses of naive peripheral blood lymphocytes. (wikipedia.org)
  • The investigators for this work used influenza matrix protein antigen and the tumor antigens Melan-A/MART-1 and survivin when seeking this CD8+ T cell response. (wikipedia.org)
  • The cells are incubated ex vivo in the presence of a recombinant fusion protein PA2024 containing a prostate antigen, prostate acid phosphatase and GM-CSF, an immune-cell activator. (wikipedia.org)
  • hemagglutinin
  • Most importantly, immune responses to NPLs that also contained recombinant hemagglutinin (HA) were strongly enhanced in a CTA1-enzyme dependent manner and we achieved broadly protective immunity against a lethal infection with heterosubtypic influenza virus. (frontiersin.org)
  • Attention has been given to epitopes from the hemagglutinin (HA) stem region in order to raise neutralizing antibodies against conserved structures of the protein ( 2 - 6 ). (frontiersin.org)
  • Pneumoviruses replicate entirely in the cytoplasm, and this process begins with adsorption of the virus to the cellular receptor on the host cell, directed by the viral attachment protein, variously called G, H (hemagglutinin) or HN (hemagglutinin-neuraminidase). (wikipedia.org)
  • human
  • The recombinant protein was produced by transient gene expression (TGE) in suspension-adapted human embryonic kidney cells (HEK-293E) in 4L orbitally shaken bioreactors. (epfl.ch)
  • BDD-rFVIIIFc is produced by recombinant DNA technology from a human embryonic kidney (HEK) cell line, which has been extensively characterized. (rxlist.com)
  • The HEK cell line expresses BDD-rFVIIIFc into a defined, cell culture medium that does not contain any proteins derived from animal or human sources. (rxlist.com)
  • Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria. (wikipedia.org)
  • Aflibercept is a recombinant fusion protein consisting of vascular endothelial growth factor (VEGF)-binding portions from the extracellular domains of human VEGF receptors 1 and 2, that are fused to the Fc portion of the human IgG1 immunoglobulin. (wikipedia.org)
  • antibodies
  • Domain III (DIII) of the tick-borne encephalitis virus (TBEV) protein E contains epitopes, which induce antibodies capable of neutralizing the virus. (mdpi.com)
  • Anti-CD22 immunotoxins, being tested in hairy cell leukemia Antibody-drug conjugates, most, if not all, are immunotoxins but use whole antibodies and non-protein drugs Immunopharmacology and Immunotoxicology (medical journal) Pastan I, Hassan R, FitzGerald DJ, Kreitman RJ (2007). (wikipedia.org)
  • vaccine
  • We have previously developed a fusion protein with 3 copies of the ectodomain of matrix protein 2 (M2e), which is one of the most explored conserved influenza A virus antigens for a broadly protective vaccine known today. (frontiersin.org)
  • Rodrigues, Mauricio M. "Immunogenicity of a Prime-Boost Vaccine Containing the Circumsporozoite Proteins of Plasmodium vivax in Rodents. (wikipedia.org)
  • encodes
  • The HMPV fusion (F) protein encodes an RGD (Arg-Gly-Asp) motif that engages RGD-binding integrins as cellular receptors, then mediates fusion of the cell membrane and viral envelope in a pH-independent fashion, likely within endosomes. (wikipedia.org)
  • vivo
  • This product is an active protein and may elicit a biological response in vivo, handle with caution. (abcam.com)
  • It also makes it relatively non-toxic in vivo as the recognized sequence scarcely occurs in proteins. (wikipedia.org)
  • Kex2
  • The invention relates to a fusion DNA construct comprising a KEX2 region comprising a KEX2 site and a KEX2 site pre-sequence immediately 5' to the KEX2 site, a fusion polypeptide, vectors and cells comprising the fusion DNA construct, methods for producing desired proteins from filamentous fungal cells and methods for enhancing the secretion and/or cleavage of a desired protein from a cell. (patentsencyclopedia.com)
  • 2. The fusion DNA construct of claim 1, wherein the KEX2 region is X 4 X 3 X 2 X 1 KR. (patentsencyclopedia.com)
  • tumor
  • We can used specific TAAs, tumor lysates,created DC-cancer cell fusions, electroporation/transfection of DCs with total cancer cell-mRNA or tumor derived exosomes (TDEs) by the stimulation.There is also possibility of aditonal co-stimulating with cytokine "cocktails" to assure strong maturation. (wikipedia.org)
  • Interactions
  • HMPV is thought to attach to the target cell via the glycoprotein (G) protein interactions with heparan sulfate and other glycosaminoglycans. (wikipedia.org)
  • cells
  • The designer protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells - B-lymphocyte stimulator (BLyS) and A proliferation-inducing ligand (APRIL), with the constant region of immunoglobin. (wikipedia.org)
  • citation needed] These patients were treated with the recombinant immunotoxin, BL22, which targets the CD22 cell surface receptor, which is highly expressed on these leukemic cells. (wikipedia.org)
  • It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. (wikipedia.org)
  • enzyme
  • 11. The fusion DNA construct of claim 1, wherein the desired protein is an enzyme. (patentsencyclopedia.com)
  • The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. (wikipedia.org)
  • activity
  • Fitches EC, Pyati PS, King GF, Gatehouse JA (2012) Fusion to snowdrop lectin dramatically enhances the oral activity of the insecticidal peptide ω-hexatoxin-Hv1a by mediating its delivery to the central nervous system. (springer.com)
  • Binding of activated protein C to protein S leads to a modest increase in its activity. (wikipedia.org)
  • activation
  • It is activated by the catecholamine epinephrine and couples to the G protein Gs to mediate adenylate cyclase activation. (abcam.com)
  • production
  • a useful experimental tool in protein engineering and production. (springer.com)
  • Modeling and Simulation of Production of Metallothionein and Red Fluorescent Fusion Protein by Recombinant Escherichia Coli Using Graphical Programming, Modeling, Programming and Simulations Using LabVIEW™ Software Riccardo De Asmundis, IntechOpen, DOI: 10.5772/14091. (intechopen.com)