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  • vaccine
  • Recombinant DNA of the hepatitis B virus surface antigen is produced in yeast cells to be included in the vaccine. (news-medical.net)
  • The recombinant vaccine will have a much longer shelf-life which is important for rinderpest campaigns in tropical countries since the Plowright-type RBOK tissue culture preparation applied at present is thermolabile. (fao.org)
  • Recombinant dengue vaccine development- Dengue is a neglected mosquito-borne viral disease that is rapidly spreading globally. (icgeb.org)
  • This vaccine candidate is a tailored recombinant VLP based tetravalent vaccine candidate displaying host cell receptor binding domain, envelope domain III (EDIII), of all four serotypes on the VLPs. (icgeb.org)
  • If you have an allergy to influenza virus vaccine (recombinant) or any part of this medicine. (drugs.com)
  • Currently, the use of MVA as a recombinant HIV vaccine (MVA-B) is being tested in approximately 300 volunteers in several Phase I studies conducted by the International AIDS Vaccine Initiative. (wikipedia.org)
  • Immunization regimens incorporating priming with DNA vaccine and boosting with recombinant MVA-based vaccine have been found to provide some protection in non-human primates following challenge with an immunodeficiency virus. (wikipedia.org)
  • genome
  • Recovery of virus from DNA was verified by (i) the presence of two genetic tags generating restriction sites in DNA derived from the genome, (ii) direct sequencing of the genomic RNA of the recovered virus, and (iii) production of a VSV recombinant in which the glycoprotein was derived from a second serotype. (pnas.org)
  • inbred strains
  • A panel of recombinant inbred strains derived from a cross between two parental strains can be used to establish linkage between any marker that is polymorphic between the parental strains and other polymorphic markers that have been typed in each strain in the panel. (jax.org)
  • A recombinant inbred strain (or recombinant inbred line) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. (wikipedia.org)
  • Families of recombinant inbred strains numbering from 25 to 5000 are often used to map the locations of DNA sequence differences (quantitative trait loci) that contributed to differences in phenotype in model organisms. (wikipedia.org)
  • Recombinant inbred strains or lines were first developed using inbred strains of mice but are now used to study a wide range of organisms - Saccharomyces cerevisiae (yeast), Zea mays (maize), barley, Drosophila melanogaster, C. elegans and rat. (wikipedia.org)
  • The origins and history of recombinant inbred strains are described by Crow. (wikipedia.org)
  • While the potential utility of recombinant inbred strains in mapping analysis of complex polygenic traits was obvious from the outset, the small number of strains only made it feasible to map quantitative traits with very large effects (quasi-Mendelian loci). (wikipedia.org)
  • One of the initial motivations to use recombinant inbred strains is that expensive genotype data can be accumulated and reused - greatly simplifying mapping studies. (wikipedia.org)
  • As genotyping became progressively less expensive and more accurate the main advantage of using recombinant inbred strains and other genetic reference panels shifted to the ability to assemble massive and coherent databases on phenotypes (e.g., the GeneNetwork web service), and to use these coherent open-source data sets for large-scale collaborative research projects in predictive medicine and plant and animal research. (wikipedia.org)
  • Recombinant inbred strains are now widely used in systems genetics and to study gene-environment interactions. (wikipedia.org)
  • It is possible to accumulate extensive genetic and phenotype data for each member of a family of recombinant inbred strains under several different conditions (e.g., baseline environment versus stressful environment). (wikipedia.org)
  • Chromosomes of recombinant inbred strains typically consist of alternating haplotypes of highly variable length that are inherited intact from the parental strains. (wikipedia.org)
  • All else being equal, the larger the family of recombinant inbred strains, the greater the power and resolution with which phenotypes can be mapped to chromosomal locations. (wikipedia.org)
  • Somewhat larger families of recombinant inbred strains were generated concurrently by Benjamin Taylor to map Mendelian and other major effect loci. (wikipedia.org)
  • In the 1990s the utility of recombinant inbred strains for mapping was significantly improved thanks to higher density genotypes made possible by the use of microsatellite markers. (wikipedia.org)
  • antibodies
  • Recombinant Dengue Virus 4 Envelope Glycoprotein Virus-Like Particles Derived from Pichia pastoris are Capable of Eliciting Homotypic Domain III-Directed Neutralizing Antibodies. (icgeb.org)
  • enzymes
  • A specific variety of rice, golden rice, is genetically engineered with recombinant DNA to express enzymes that promote B-carotene biosynthesis. (news-medical.net)
  • The Corning® Gentest™ Supersomes™ recombinant drug metabolizing enzymes product line includes more than 40 different human and animal cytochrome P450 isoforms, UDP-glucuronsyl transferases (UGTs), Flavin-Containing Monooxygenases (FMOs), monoamine oxidases (MAOs), soluble N-Acetyltransferases (NATs), and carboxylesterases (CESs). (corning.com)
  • Students will model the process of using restriction enzymes and plasmids to form recombinant DNA . (accessexcellence.org)
  • enzyme
  • Negative control microsomes and cytosols are prepared using procedures identical to those for recombinant enzyme products. (corning.com)
  • Halozyme's business is primarily focused on its proprietary and patented recombinant human hyaluronidase enzyme, rHuPH20. (wikipedia.org)
  • PEGPH20: A PEGylated drug candidate based on Halozyme's proprietary rHuPH20 enzyme (a recombinant human hyaluronidase enzyme). (wikipedia.org)
  • PEG-ADA2: An engineered human recombinant enzyme, adenosine deaminase 2, for decreasing the concentration of immune-suppressive adenosine in the tumor microenvironment, and PEGylated to prolong its circulation in the body. (wikipedia.org)
  • Sequences
  • That is, their appearance, behavior and metabolism are usually unchanged, and the only way to demonstrate the presence of recombinant sequences is to examine the DNA itself, typically using a polymerase chain reaction (PCR) test. (wikipedia.org)
  • human
  • Recombinant human growth hormone is used to support normal growth and development for patients with malfunctions in the pituitary gland. (news-medical.net)
  • Recombinant human. (bmj.com)
  • On 27 July the US Food and Drug Administration held a public hearing on an application for a licence for the use of recombinant human parathyroid hormone in the treatment of postmenopausal osteoporosis. (bmj.com)
  • Recombinant human factor VII, while initially looking promising in intracerebral hemorrhage, failed to show benefit following further study and is no longer recommended. (wikipedia.org)
  • The prefix "rh" for "recombinant human" appears less and less in the literature. (wikipedia.org)
  • Recombinant human parathyroid hormone, marketed under the trade name Natpara, is an artificially manufactured form of the parathyroid hormone used to treat hypoparathyroidism. (wikipedia.org)
  • Halozyme has one FDA approved product (Hylenex recombinant, hyaluronidase human injection). (wikipedia.org)
  • Hylenex is a hyaluronidase (human recombinant) injection indicated for use in subcutaneous fluid administration, dispersion and absorption of injected drugs, and subcutaneous urography. (wikipedia.org)
  • Enhanze: Uses recombinant human hyaluronidase to degrade HA and aids in the absorption and dispersion of co-administered injected drugs. (wikipedia.org)
  • FDA Drug Approval Package: Hylenex Recombinant (Hyaluronidase) Human Injection. (wikipedia.org)
  • pharmaceutical
  • In this respect some of the group members and their respective institutes have recently entered into a collaboration agreement with the Italian pharmaceutical company Dompé based in L'Aquila, central Italy with the intention of developing one of the RICG produced recombinant immunotoxins for investigation in early phase clinical trials for patients with leukaemia and lymphoma. (wikipedia.org)
  • Genetics
  • Recombinant is an attempt to assemble a body of discourses surrounding contemporary molecular genetics and biotechnology at the end of the millennium. (turbulence.org)
  • manufacture
  • The ability to manufacture recombinant blood clotting factor VIII allows larger quantities to be used in practice and reduces the need for blood donation to obtain the factor naturally. (news-medical.net)
  • research
  • Now, with all this risk to life as we know it, why are scientists spending all the time, money, and resources that they are to research recombinant DNA? (everything2.com)
  • scientists
  • The Recombinant Immunotoxin Collaborative Group (RICG) is a group of scientists specialising in immunology, biochemistry and molecular biology from the United Kingdom and Italy. (wikipedia.org)