Recognizes and binds. Medical search. Frequent questions

Scan the nascent protein in order to recognize and bind sequons. (wikipedia.org)
Here we report a class of mRNA granules in human neuronal processes that are enriched in the nuclear cap-binding protein complex (CBC) and exon junction complex (EJC) core components, Y14 and eIF4AIII. (frontiersin.org)
The existence of mRNAs retaining both nuclear cap binding protein and EJC in the distal sites of neuronal processes suggests that some localized mRNAs have not yet undergone the "very first translation," which contribute to the spatio-temporal regulation of gene expression. (frontiersin.org)
The key comes down to the unique targets expressed by the cancer cells that the bispecific protein drug recognizes. (eurekalert.org)
They carry a special receptor called the T-cell receptor on their surface that recognizes antigens - small protein fragments of bacteria, viruses and infected or cancerous body cells - which are presented by specialized immune complexes. (news-medical.net)
A molecular model of a PPR protein recognizing a specific RNA molecule. (scitechdaily.com)
The identity of specific amino acid residues in the protein (colored sticks) determines the sequence of the RNA molecule it can bind. (scitechdaily.com)
The researchers used their simulations to illuminate details of how the intracellular SARS peptide, QFKDNVILL , binds to an MHC receptor protein known as HLA-A∗24:02 , primarily at dominant anchors on both ends of the peptide (at positions 2 and 9) and presents them for inspection to the immune system's T cells. (rice.edu)
If the peptide and protein don't bind, the T cell is not prompted to attack. (rice.edu)
An illustration shows the electrostatic charges (blue is positive, red negative) in a major histocompatibility protein bound to a peptide drawn from a SARS-CoV virus. (rice.edu)

With the help of cryo-electron microscopy, biochemists and structural biologists from Goethe University Frankfurt, in collaboration the University of Oxford and the Max Planck Institute of Biophysics, were able to visualize the whole T-cell receptor complex with bound antigen at atomic resolution for the first time. (news-medical.net)
After binding of a suitable antigen to the receptor, a signaling pathway is triggered inside the T cell that 'arms' the cell for the respective task. (news-medical.net)
Researchers led by Lukas Sušac, Christoph Thomas, and Robert Tampé from the Institute of Biochemistry at Goethe University Frankfurt, in collaboration with Simon Davis from the University of Oxford and Gerhard Hummer from the Max Planck Institute of Biophysics, have now succeeded for the first time in visualizing the structure of a membrane-bound T-cell receptor complex with bound antigen. (news-medical.net)
A comparison of the antigen-bound structure captured using cryo-electron microscopy with that of a receptor without antigen provides the first clues to the activation mechanism. (news-medical.net)
For the structural analysis, the researchers chose a T-cell receptor used in immunotherapy to treat melanoma and which had been optimized for this purpose in several steps in such a way that it binds its antigen as tightly as possible. (news-medical.net)
The subsequent images collected at the cryo-electron microscope delivered groundbreaking insights into how the T-cell receptor works, as Tampé summarises: 'On the basis of our structural analysis, we were able to show how the T-cell receptor assembles and recognizes antigens and hypothesize how signal transduction is triggered after antigen binding. (news-medical.net)
According to their results, the big surprise is that there is evidently no significant change in the receptor's spatial structure after antigen binding, as this was practically the same both with and without an antigen. (news-medical.net)
The remaining question is how antigen binding could instead lead to T-cell activation. (news-medical.net)
The co-receptor CD8 is known to approach the T-cell receptor after antigen binding and to stimulate the transfer of phosphate groups to its intracellular part. (news-medical.net)
The calibrators, controls and diluted patient samples are added to the wells and autoantibodies recognizing the tTG antigen bind during first incubation. (cdc.gov)
and that tightly bind to the antigen of an invader, tagging the invader for attack or directly neutralizing it. (msdmanuals.com)

Bispecific antibodies could bind to particular neoantigen targets found on tumor cells and recruit T-cells to destroy the cancer. (eurekalert.org)
The antibodies bind to the PF4-heparin complexes on the platelet surface and induce platelet activation by cross-linking FcγIIA receptors. (medscape.com)
Alternatively, HIT antibodies may recognize PF4 bound to platelet chondroitin sulfate. (medscape.com)
Some are monoclonal antibodies that specifically recognize and bind to VEGF . (cancer.gov)
These are sites where people's antibodies would bind to and inactivate the virus. (livescience.com)
But because of these deletions, many antibodies cannot recognize the virus. (livescience.com)
Following influenza virus infection or receipt of a flu vaccine, the body's immune system develops antibodies that recognize and bind to "antigenic sites," which are regions found on an influenza virus' surface proteins. (cdc.gov)
By binding to the HA antigenic sites, antibodies can neutralize influenza viruses, which prevents them from causing further infection. (cdc.gov)
Antibodies that bind to the NA antigenic sites can also reduce further spread. (cdc.gov)
The HI test works by measuring how well antibodies bind to the HA proteins and prevent them from "gluing" red blood cells together (i.e., hemagglutination inhibition). (cdc.gov)
HI test results can tell us whether antibodies developed after vaccination (or infection) with one virus can recognize and bind to other viruses, which means these other viruses are similar to the vaccine virus. (cdc.gov)
Scientists also use the HI test to compare the antigenic properties (i.e., the virus' ability to be recognized by antibodies) of currently circulating influenza viruses with those of influenza viruses that have circulated in the past. (cdc.gov)
Endomysial antibodies of the IgA subclass present in the serum bind to the reticulin component of the endomysium of the smooth muscle in monkey esophagus tissue and can be detected by indirect immunofluorescence. (cdc.gov)

On their surface, these special white blood cells carry a receptor that recognizes antigens . (news-medical.net)
The fact that this particular peptide was predicted not to bind to HLAs ( human leukocyte antigens ) by sequence-based methods highlights a blind spot in our current prediction capacity. (rice.edu)
Antigens" are molecular structures on the surface of viruses that are recognized by the immune system and are capable of triggering one kind of immune response known as antibody production. (cdc.gov)
Antigens are any substances that the immune system can recognize and that can thus stimulate an immune response. (msdmanuals.com)

The code determines the recognition of RNA molecules by a superfamily of RNA-binding proteins called pentatricopeptide repeat (PPR) proteins. (scitechdaily.com)
β2 integrins recognize signs of inflammation and attach (bind) to proteins called ligands on the lining of blood vessels. (medlineplus.gov)

The process of recognizing and targeting particles by binding with OPSONINS (e.g. (bvsalud.org)

Other angiogenesis inhibitors bind to VEGF and/or its receptor as well as to other receptors on the surface of endothelial cells or to other proteins in the downstream signaling pathways, blocking their activities. (cancer.gov)
That part of the peptide drawn from a SARS-CoV virus turned out to have an unexpected but significant influence on how it stably binds with a receptor central to the immune system's ability to attack diseased cells. (rice.edu)

By incorporating structural analysis, we can detect the contribution of these secondary interactions to peptide binding and stability, hopefully enabling us to find better targets for antiviral vaccine development and T-cell-based cancer immunotherapy," he said. (rice.edu)
Stable binding of a peptide and MHC is a prerequisite to the activation of T cells, which look for peptides not normally found in healthy cells. (rice.edu)

A functional model is presented in which IHF favors the contact between the TodT activator, bound further upstream, and the alpha-subunit of RNA polymerase bound to the downstream promoter element. (nih.gov)
ITGB2 gene mutations that cause leukocyte adhesion deficiency type 1 lead to the production of a β2 subunit that cannot bind with other subunits to form β2 integrins. (medlineplus.gov)

That much was known from previous studies of the bound and unbound states of many such complexes," Kavrakisaid. (rice.edu)

Retinoic acid receptors (RARs) heterodimerize with retinoid X receptors (RXRs) and bind to RA response elements (RAREs) in the regulatory regions of their target genes. (nih.gov)

RNA binding proteins recognize these sequences and assemble with their mRNA target into mRNPs. (europa.eu)

Many surface receptors relay signals into the interior of the cell by changing their spatial structure after ligand binding. (news-medical.net)
Some of these signals, such as vascular endothelial growth factor (VEGF) , bind to receptors on the surface of normal endothelial cells. (cancer.gov)
When VEGF and other endothelial growth factors bind to their receptors on endothelial cells, signals within these cells are initiated that promote the growth and survival of new blood vessels. (cancer.gov)

RFX forms cooperative DNA binding complexes with x2bp and cbf/nf-y. (lu.se)

CO preferentially binds haemoglobin, which displaces oxygen and adversely affects the delivery of oxygen to the tissues. (cdc.gov)

TodS transphosphorylates TodT, which binds to two highly similar DNA binding sites at base pairs -107 and -85 of the promoter. (nih.gov)
Dendritic localisation of CaMKIIa-mRNA requires its 3'UTR harbouring binding sites for RBPs as FMRP and Staufen2, which are required for its correct localisation. (europa.eu)
Gck was predicted to contain two hexokinase domains, an ATP-binding domain and multiple functional sites, while G6pca.1 and G6pca.2 contained nine transmembrane helices, a PAP2 (type-2 phosphatidic acid phosphatase) domain and multiple functional amino acid sites. (bvsalud.org)

The Politicites didn't get the legally binding agreement they dream of, but what they got may turn out to be almost as good. (joannenova.com.au)
The Paris agreement is "politically" rather than "legally" binding in two ways. (joannenova.com.au)
We recognize that this is not a legally binding contract. (tmforum.org)
It is the first legally binding instrument with an internationally recognized definition of human trafficking. (unodc.org)

The Hines College is internationally recognized for bringing exceptional student work to the world stage. (uh.edu)

Comparison of HLA ligand elution data and binding predictions reveals varying prediction performance for the multiple motifs recognized by HLA-DQ2.5. (lji.org)
The analysis of the truncated variants of TodS reveals that toluene binds to the N-terminal input domain (Kd = 2.3 +/- 0.1 microM) but not to the C-terminal half. (nih.gov)

Integration host factor (IHF) plays a crucial role in the activation process and binds between the upstream TodT boxes and the -10 hexamer region. (nih.gov)

They are the primary pathogens associated with residue in an linkage (same binding site used for recog- shellfishborne outbreaks worldwide ( 3,4 ). (cdc.gov)
This binding leads to linkage (adhesion) of the leukocyte to the blood vessel wall. (medlineplus.gov)

Ponatinib binds the BRAF dimer and stabilizes a distinct αC-helix conformation through interaction with a previously unrevealed allosteric site. (nature.com)
The Constitution recognizes three distinct branches of government. (freerepublic.com)

As medicine has advanced, immunologists have discovered ways to engineer a person's T-cells, the white blood cells that fight and kill infected cells, to recognize and target cancer cells and eliminate them from the body. (eurekalert.org)
The other arm binds to T-cells," Weidanz said. (eurekalert.org)
A vaccine containing these molecules may help the immune system better recognize and destroy cancer cells. (healthline.com)
Immune cells are removed from the body and sent to a laboratory, where they're modified to recognize prostate cancer cells. (healthline.com)
bound to the surface of mast cells. (cdc.gov)

The new paper in PLOS Genetics describes for the first time how PPR proteins recognize their RNA targets via an easy-to-understand code. (scitechdaily.com)

Recombinant RAR-RXR binds these non-canonical spacings in vitro with comparable affinities to DR2 and DR5. (nih.gov)
Some of the mAbs tested enhanced the in vitro light chain activity of BoNT/B, suggesting that BoNT/B may undergo conformational change upon binding some mAbs. (cdc.gov)

Recognizes human SERPINH1. (biocheminfo.org)
Substrate-bound IgA antibody is identified with a fluorescein-conjugated anti-human IgA (Fab2-specific) conjugate. (cdc.gov)

In a study published by the Proceedings of the National Academy of Sciences , researchers at Rice University's Brown School of Engineering and the University of Texas MD Anderson Cancer Center revealed models at atomic resolution that detail not only the binding but also, for the first time, the unbinding mechanisms that underlie a key component of the immune system. (rice.edu)

The differential ability of RAR-RXR bound to DR0 compared to DR2, DR5, and DR8 to mediate RA-dependent transcriptional activation indicates that half-site spacing allosterically regulates RAR function. (nih.gov)
The downstream signal transduction toward Eda-A1 involves the canonical Wnt/β-catenin pathway (Clevers 2006 ) and requires lymphoid enhancer-binding factor-1 (Lef-1) for activation of the Ed1 ( Ta ) expression (Durmowicz et al. (springer.com)

This phase is known as `induction' The IgE is then recognize allergic disease as it arises. (cdc.gov)

The researchers modeled mutations of the MHC to see how they would influence binding and found they supported the importance of position 4 to the stability of the complex. (rice.edu)

This was recognized by the molecular-weight chemicals. (cdc.gov)

Those included the lack of officially recognized indigenous peoples, who were rather referred to as "marginalized communities", land rights, including for women, and the redistribution of land. (ohchr.org)

Marlo Lewis explains it may yet be politically binding on the target rich Western nations, which is all that really matters. (joannenova.com.au)

The FH domain is a winged helix DNA-binding domain. (nih.gov)

Recognize that the LoA is timeless, not time-bound. (stevepavlina.com)
Your thoughts/intentions are not time-bound. (stevepavlina.com)

On March 12, 2009, the U.S. House of Representatives passed a non-binding resolution (HRES 224),[4] recognizing March 14, 2009 as National Pi Day. (cdc.gov)

This specific half-site organization constitutes a previously unrecognized but frequent signature of RAR binding elements. (nih.gov)

Noroviruses are the most frequent cause of diarrhea analysis were performed to evaluate specific binding of outbreaks in all age groups ( 8,15 ). (cdc.gov)
Heterogeneous population of RNA granules serve as motile units to translocate, store, translate, and degrade mRNAs in the dendrites contain cis -elements and trans -acting factors such as RNA-binding proteins and microRNAs to convey stimulus-, transcript-specific local translation. (frontiersin.org)
Their secret is their versatility - they can find and bind a specific RNA molecule, and have the capacity to correct it if it is defective, or destroy it if it is detrimental. (scitechdaily.com)

There are the main, canonical anchors that people know, but there are these secondary interactions that contribute to the binding and the stability," Antunes said. (rice.edu)

recognizes lists where every element satisfies vl-bind-p . (utexas.edu)

She went on to say that "measurable metrics" should be developed for valuing non-billable contributions, recognizing that it is important to have "connectors" and "builders" as well as fee earners to provide the best services to clients. (canadianlawyermag.com)

RNA-binding PPR proteins could revolutionize the way we treat disease. (scitechdaily.com)

Anatomy22

Organisms17

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes80

Information Science3

Health Care1

Protein10

Antigen11

Antibodies13

Antigens4

Proteins called2

Particles1

Receptor2

Peptide2

Subunit2

Unbound1

Regulatory1

Sequences1

Receptors3

Complexes1

Tissues1

Sites3

Legally4

Internationally recognized1

Reveals2

Hexamer1

Linkage2

Distinct2

Cells5

Targets1

Vitro2

Human2

Atomic resolution1

Activation2

Induction1

Found1

Molecular1

Communities1

Target1

Domain1

Time2

Resolution1

Site1

Specific3

Secondary1

Element1

Important1

Disease1