Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)
Since apoptosis can make autoantigens accessible for recognition by antibodies, and also create neo-epitopes by chemical modifications occurring naturally during this process, we sought to determine if CLL mAbs recognize autoantigens associated with apoptosis. (nih.gov)
Antibodies1
Consistent with this, tumor-derived antibodies are polyreactive and characterized by autoantigen recognition. (bvsalud.org)
Allergens3
Type I allergy is a classical Th2-driven hypersensitivity disease based on IgE recognition of environmental allergens. (drcalapai.com)
DCs are present in almost all tissues of the body and play cardinal roles in recognition of microbial agents, autoantigens, allergens and alloantigen. (zju.edu.cn)
Therefore, the development of strong immune responses against antigens from infectious agents could inhibit responses to 'weak' antigens such as autoantigens and allergens 4. (ombrelab.com)
Antigens2
However, problems with recognition of auto-antigens and the subsequent cell elimination are at the root of numerous autoimmune diseases. (umontreal.ca)
Particular IGHV and IGHV/D/J rearrangements contributed to autoantigen binding, although the presence and degree of reactivity varied based on specific structural elements. (nih.gov)
Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
Moreover, autoantigens that activate Th1-immune responses could contribute to chronic inflammation in allergy, thus linking allergy to autoimmunity. (drcalapai.com)
Protein7
The largest group of single strand RNA-binding protein is the eukaryotic RNA recognition motif (RRM) family that contains an eight amino acid RNP-1 consensus sequence. (wikipedia.org)
The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor appears to have two RRM-like domains with specialised features for protein recognition. (wikipedia.org)
The subcellular distribution of an RNA quality control protein, the Ro autoantigen, is regulated by noncoding Y RNA binding. (albany.edu)
This subgroup corresponds to the RRM of Raly, also termed autoantigen p542, or heterogeneous nuclear ribonucleoprotein C-like 2, or hnRNP core protein C-like 2, or hnRNP associated with lethal yellow protein homolog, an RNA-binding protein that may play a critical role in embryonic development. (nih.gov)
Thyroglobulin(Tg) - a heavily glycosylated, iodinated protein - is a major autoantigen in autoimmune thyroiditis. (johnshopkins.edu)
We will also analyze the peptides presented by dendritic cells from healthy donors expressing T1D-associated HLA alleles pulsed with b-cells protein extracts and/or soluble autoantigens. (uab.cat)
A subclass of receptor-like protein tryosine phosphatases that contain an extracellular RDGS-adhesion recognition motif and a single cytosolic protein tyrosine phosphate domain. (online-medical-dictionary.org)
Proteins2
Respect to the recognition of proteins by T cells, our approach, following our previous experience with T1D and other autoinmune diseases, is to find T cell ligands that are present in the periphery but are not found in the thymus. (uab.cat)
We review here the recent developments on the structural and functional characterization of this evolutionary ancient and important family of proteins, which can function as cytokine receptors (Toll in Drosophila) or pattern recognition receptors (TLR4 in mammals) and activate similar, albeit non identical signal transduction pathways, in flies and mammals. (cnrs.fr)
Intracellular1
Efficient uptake of dying cells and handling of their DNA is important for preventing intracellular autoantigens from coming into contact with the immune system. (lu.se)
Autoreactive1
In AIG, the gastric proton pump, H+/K+ ATPase, is the major autoantigen recognized by autoreactive T cells. (uniroma1.it)
Nucleic acids3
An important step in this process is the recognition of endogenous nucleic acids released from dying cells by various pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and other cytosolic receptors. (frontiersin.org)
TLR9 and the recognition of self and non-self nucleic acids. (umassmed.edu)
Lamphier MS, Sirois CM, Verma A, Golenbock DT, Latz E. TLR9 and the recognition of self and non-self nucleic acids. (umassmed.edu)
Structural3
Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen. (albany.edu)
Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity. (albany.edu)
A structural model for visualisation of TCR recognition was derived. (biomedcentral.com)
Bind2
RNA recognition motif, RNP-1 is a putative RNA-binding domain of about 90 amino acids that are known to bind single-stranded RNAs. (wikipedia.org)
Raly contains two distinct domains, an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal auxiliary domain that includes a unique glycine/serine-rich stretch. (nih.gov)
Tissue1
Immunofluorescence staining held a significant tissue imaging market share in 2019 and deploys cultured cell lines or tissue sections as a source of antigen and identifies particular recognition of autoantibodies to native autoantigens present on fixed tissue/cell. (globenewswire.com)
Chronic1
2017. Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease . (cardiff.ac.uk)
Cells6
Peripheral tolerance evolved to counteract autoantigen-recognizing T or B cells that escape central tolerance. (frontiersin.org)
Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)
As a result, the body mounts an immune response against the cells displaying these autoantigens. (drbonnie360.com)
Immune cells compete for cytokines, recognition for major histocompatibility complex (MHC)/self-peptide complexes, and growth factors necessary for the differentiation and proliferation of B and T cells during immune responses. (ombrelab.com)
Many molecules including complement are involved in the recognition of dying cells as shown by phenotype displayed by patients lacking complement component, for example deficiency of C1q leads in 95% cases to SLE. (lu.se)
First, the major histocompatibility complex (MHC) and T-cell receptor (TCR) contact residues were identified by analysis of single site substituted analogue peptides for HLA-DR4 binding and cognate T cell recognition using both T hybridomas and polyclonal T cells from peptide-immunized HLA-DR4 transgenic mice. (biomedcentral.com)
Cell1
Use of a selected MAb as a surrogate for the T-cell receptor suggests that a specific iodine- containing epitope is sometimes involved in recognition. (johnshopkins.edu)
Immune system1
The next wave of truly transformative therapeutics should aspire to provide a cure by selectively suppressing pathogenic autoantigen-specific immune responses while leaving the rest of the immune system intact to control infectious diseases and malignancies. (frontiersin.org)
Human1
In this work, we developed a user-friendly AAgAtlas portal (http://biokb.ncpsb.org.cn/aagatlas_portal/index.php#), which can be used to search for 8045 non-redundant autoantigens (AAgs) and 47 post-translationally modified AAgs against 1073 human diseases that are prioritized by a credential score developed by multisource evidence. (bvsalud.org)
Peptides1
Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases", CHEMISTRY & BIOLOGY , vol. 7, 2000, pp. 119-132. (uni-bielefeld.de)
Target1
For example, lupus is a systemic autoimmune disease where the autoantigen target may be the patient's own DNA! (drbonnie360.com)
State1
Immune tolerance co-evolved as a safety system that maintains a state of immune unresponsiveness to autoantigens and self-tissues ( 2 , 3 ). (frontiersin.org)