The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. (wikipedia.org)
10 20 30 40 50 60 Homeobox genes, and thus the homeodomain protein motif, are found in most eukaryotes. (wikipedia.org)
HD-Zip protein usually contain two highly conserved domains: homeodomain (HD) and leucine zipper (LZ) [ 1 ]. (biomedcentral.com)
The leucine zipper domain forms a dimer that is essential for HD-Zip protein recognition of DNA [ 3 ]. (biomedcentral.com)
A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. (gao-lab.org)
The Engrailed homeodomain protein is an 'active' or dominant transcriptional repressor in cultured cells. (biologists.com)
In contrast, the Fushi Tarazu homeodomain protein is an activator, both in cultured cells and in Drosophila embryos, where it activates several known target genes, including its own gene. (biologists.com)
The IB1cDNA encodes a 714 amino acid protein with a proline-rich region and a putative basic helix-loop-helix domain (bHLH). (justia.com)
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. (lookformedical.com)
loop_ _audit_author.name _audit_author.pdbx_ordinal 'Wen, H.' 1 'Li, J.Z.' 2 'Song, T.' 3 'Lu, M.' 4 'Lee, M.' 5 # _citation.id primary _citation.title 'Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. (rcsb.org)
Homeobox4
The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox). (wikipedia.org)
The homeodomain domain is generally composed of about 60 amino acids encoded homeobox, which form three alpha helices. (biomedcentral.com)
The WOX genes form a plant-specific subclade of the eukaryotic homeobox transcription factor superfamily, which is characterized by the presence of a conserved DNA-binding homeodomain. (gao-lab.org)
Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital. (gao-lab.org)
Motif1
This amino acid sequence folds into a "helix-turn-helix" (i.e. homeodomain fold) motif that is stabilized by a third helix. (wikipedia.org)
Genes1
Based on previous phylogenetic analyses in arabidopsis ( Arabidopsis thaliana ), our results showed that some tomato SL-ZH ( S. lycopersicum zinc-finger homeodomain) genes cluster into the same neighbor-joining (NJ) branch as arabidopsis, indicating that these genes may share similar structures and functions in these plants. (ashs.org)
Amino2
Contrary to previous predictions, the dimerization interface involves the carboxyl terminus of the DNA recognition helix of the homeodomain, which in an extended conformation interacts with specific residues at the amino terminus of helix alpha1 and in the loop between helices alpha3 and alpha4 of the POU-specific domain of the symmetry related monomer. (rcsb.org)
This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. (gao-lab.org)
Histone2
Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex. (nature.com)
The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism. (nature.com)
Transcription3
HD-Zips (Homeodomain-Leucine Zippers) are a class of plant-specific transcription factors that play multiple roles in plant growth and development. (biomedcentral.com)