• This domain, which is known as the C-type lectin domain (CTL) or as the carbohydrate-recognition domain (CRD), consists of about 110 to 130 residues. (embl.de)
  • PPL1 has two tandem carbohydrate recognition domain (CRD) structures in its sequence which has sequence homology with rhamnose-binding lectins (RBLs) from various fish eggs and a galactose-binding lectin (SUEL) from sea urchin eggs [24]. (cancer-ecosystem.com)
  • The carbohydrate recognition domain (CRD) is responsible for the specificity of galectins for saccharides. (shengsci.com)
  • Galectins are a family of ß-galactoside-binding lectins characterized by a unique sequence motif in the carbohydrate recognition domain, and evolutionary and structural conservation from fungi to invertebrates and vertebrates, including mammals. (nsf.gov)
  • Sialic acids usually occur at the terminal positions of oligosaccharides and glycoconjugates, and they can act as ligands for receptor recognition (trans-interactions) or masking recognition sites on the same cell surface (cis-interactions). (glycopedia.eu)
  • Numerous intracellular pathogens exploit cell surface glycoconjugates for host cell recognition and entry. (unl.pt)
  • Such biological functions depend on their lectinic properties (recognition of N-acetyllactosamine sequences displayed on the cell surface, in the extracellular matrix, or intracellular glycoconjugates) ( Table 1 ). (encyclopedia.pub)
  • It is known that GSLs interact with both intracellular as well as exogenous proteins and are critical for membrane organisation, signalling, and recognition events. (springer.com)
  • Glycoconjugates are the classification family for carbohydrates - referred to as glycans - which are covalently linked with chemical species such as proteins, peptides, lipids, and other compounds. (wikipedia.org)
  • Using BLAST searches, we identify a family of MAR-containing proteins in enteroparasitic coccidians, a subclass of apicomplexans, including T. gondii, suggesting that all these parasites exploit sialylated glycoconjugates on host cells as determinants for enteric invasion. (unl.pt)
  • Lectins which are carbohydrate recognition proteins have been found in viruses bacteria fungi plants and animals. (cancer-ecosystem.com)
  • Galectins form a family of carbohydrate-binding proteins defined by their affinity for beta-galactosides containing glycoconjugates. (shengsci.com)
  • The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, the roles of glycans in complex biological systems, and their analysis and manipulation. (cshlpress.com)
  • At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
  • Strikingly, some viruses, bacteria, and protistan parasites take advantage of the aforementioned recognition roles of the vector/host galectins, for successful attachment and invasion. (nsf.gov)
  • A detailed understanding of the combining site of this antibody and the measurement of its binding to different ligands is of interest as this knowledge will have implications in the characterization of arabinofuranose-containing glycoconjugates that are increasingly recognized as important biological molecules. (uni-luebeck.de)
  • In mammals, they are found at the distal ends of cell surface glycoconjugates, and thus are major determinants of cellular recognition and adhesion events. (ubc.ca)
  • Lectin-carbohydrate interactions: different folds, common recognition principles. (embl.de)
  • They agglutinate cells and/or precipitate glycoconjugates specific interactions with sugar chains [25]. (cancer-ecosystem.com)
  • The Siglec family of receptors mediates cell surface interactions through recognition of sialylated glycoconjugates. (ox.ac.uk)
  • Les interactions sucres/protéines (enzymes, lectines) sont au cœur de la communication cellulaire tant extracellulaire (interactions cellule-cellule, cellule-matrice, hôte-pathogène) qu'intracellulaire (GlcNAcylation en tant que modification post-traductionnelle). (univ-nantes.fr)
  • The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. (fishersci.com)
  • Immunization with glycoconjugates successfully induced long term immune memory against carbohydrates antigens. (wikipedia.org)
  • Lectins can be found in many organisms and are involved in a multitude of cellular processes that depend on specific recognition of complex carbohydrates. (embl.de)
  • The Award will be presented to Prof. MOLINARO in recognition of his outstanding accomplishments toward the structural elucidation of complex carbohydrates from microbial world, in particular, in the study of structure and role of cell wall of microorganisms in the elicitation of innate immune response in plants and mammals. (eurocarb2023.com)
  • Description: This 1RNM44N monoclonal antibody recognizes mouse CD170, also known as Siglec F. Siglec F is a cell surface lectin belonging to the Ig superfamily that binds glycoconjugates containing sialic acids that are commonly found on various cell types. (fishersci.com)
  • All this may influence glycan recognition processes. (srcinhibitors.com)
  • Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
  • These complex carbohydrate structures and glycoconjugates are useful tools to study their interaction with the host immune system, as antigens and ligands for innate immune system cell receptors as well as to develop glycomimetic conjugates as vaccines against bacterial infections. (eurocarb2023.com)
  • Their biological roles, initially understood as limited to recognition of endogenous ("self") carbohydrate ligands in embryogenesis and early development, dramatically expanded in later years by the discovery of their roles in tissue repair, cancer, adipogenesis, and regulation of immune homeostasis. (nsf.gov)
  • Structural basis of lectin-carbohydrate recognition. (embl.de)
  • New glycopolymers as multivalent systems for lectin recognition. (univ-grenoble-alpes.fr)
  • In recognition of his outstanding accomplishments in the chemical and enzymatic synthesis of N -glycans and glycoproteins. (eurocarb2023.com)
  • In recent years, however, evidence has also accumulated to support the notion that galectins can bind ("non-self") glycans on the surface of potentially pathogenic microbes, and function as recognition and effector factors in innate immunity. (nsf.gov)
  • Lectins are responsible for cell surface sugar recognition in bacteria, animals, and plants. (embl.de)
  • By isolating glycoconjugates from Gram-negative bacteria and determining their 3D-structures using state of art NMR and MS methodologies and molecular mechanics and dynamics approaches, Antonio MOLINARO was able to elucidate the conformational behavior of the ligand alone and when interacting with a protein, determine its bioactive conformation and elucidate its epitope mapping. (eurocarb2023.com)
  • Thus, this evidence has established a newparadigm by which galectins can function not only as pattern recognition receptors but also as effector factors, by binding to the microbial surface and inhibiting adhesion and/or entry into the host cell, directly killing the potential pathogen by disrupting its surface structures, or by promoting phagocytosis, encapsulation, autophagy, and pathogen clearance from circulation. (nsf.gov)
  • Various members from all around the globe have focused their research and expertise on learning more and more about various biomolecules and use of Glycobiology, this is a best chance to meet the global participants in the wider arena of Glycobiology, to share information, meeting with current and expert researchers and receive name recognition in this two day premier event. (biochemistryconferences.com)
  • In recognition of his outstanding accomplishments in fundamental and clinical aspects of the glycobiology of the human opportunistic fungal pathogen Aspergillus fumigatus . (eurocarb2023.com)
  • it is a normal constituent of plasma and degrades a wide range of glycoconjugates containing β-linked N -acetylhexosaminyl residues. (medscape.com)
  • Isofagomine-type inhibitors are poor mimics of transition-state conformation, owing to the high energy barriers that must be crossed to attain mechanistically relevant conformations, however, these sugar-shaped heterocycles allow the acquisition of ternary complexes that span the active site, thus providing valuable insight into active-site residues involved in substrate recognition. (diamond.ac.uk)
  • Galactose recognition by the apicomplexan parasite Toxoplasma gondii. (expasy.org)
  • A synthesized MUC1 peptide was also used as a carrier for the chemoenzymatic Inhibitors,research,lifescience,medical synthesis of glycoconjugates (O-glycopeptides), on NHS-activated glass slides via amine group guaranteeing covalent and site-specific VE-822 datasheet attachment [23,25,63]. (srcinhibitors.com)
  • We report herein the encapsulation of a semisynthetic glycoconjugate (GC) composed of a synthetic tetrasaccharide mimicking theS. (univ-nantes.fr)
  • Aiming at a broad serotype coverage S. flexneri glycoconjugate vaccine, a non-natural lightly protected tetrasaccharide was designed for compatibility with (i) serotype-specific glucosylations and O-acetylations defining S. flexneri O-antigens, (ii) recognition by suitable α-transglucosylases, and (iii) programmed oligomerization following enzymatic α-d-glucosylation. (pasteur.fr)
  • Glycoconjugate-bearing polymers, which have been shown to bind to Bacillus spores, were tested for recognition and binding of protective antigen (PA), lethal factor (LF), and edema factor (EF) toxins. (listlabs.com)
  • Without glycoconjugate (GC) activation, murine macrophages were killed by Bacillus toxins. (listlabs.com)
  • This involves recognition of exposed glycoconjugates on damaged membranes, membrane repair, removal of membranes by autophagy, and replacement of membranous organelles through respective biogenesis programs. (glyco26.org)
  • Mechanisms for sugar recognition have evolved independently in diverse protein structural frameworks, but share some key features. (embl.de)
  • Little is known about the histochemistry of the glycoconjugates present in the epidermis of the species Eisenia foetida . (hindawi.com)
  • The stereochemical principles underlying the recognition process have been the subject of extensive biochemical and structural studies. (embl.de)
  • The structural basis for selective sugar recognition by members of all of these groups has been investigated by x-ray crystallography. (embl.de)
  • This array format is characterized by the addition of a carrier protein or polypeptide forming glycoconjugate-based epitopes. (srcinhibitors.com)
  • The aim of this study was to characterize the nature and regional distribution of the glycoconjugates secreted by epidermal mucous cells in Eisenia foetida (Annelida). (hindawi.com)
  • Histochemical staining properties of glycoconjugates in epidermal mucous cells were determined regionally. (hindawi.com)
  • The glycoconjugates, which are essential components of the glycocalyx of many cell types, take part in many functions, including osmoregulation, cell to cell recognition, binding of hormones, protection of cells from phagocytosis and dehydration, differentiation, defense, and ion transport [ 8 ]. (hindawi.com)
  • In some epithelial cells, which morphologically and functionally polarize in relation to different behaviours in ion transport [ 9 ], it is likely that a functional specialization of the glycoconjugates is observed on the basolateral surface. (hindawi.com)
  • Our recent findings on molecular basis of their Man recognition are also described. (go.jp)
  • This study provided comprehensive information about the regional distribution patterns of the glycoconjugates and an opportunity to compare their distributional patterns in other annelids. (hindawi.com)
  • The 2023 Emil Fischer Award is conferred to Prof. Jeroen CODÉE , professor in Organic Chemistry at Leiden University, The Netherlands, in recognition of his exceptional accomplishments and dedication to bio-organic chemistry in the field of Glycosciences. (eurocarb2023.com)
  • Glycoconjugate vaccines was introduced since the 1990s have yielded effective results against influenza and meningococcus. (wikipedia.org)