AnatomyDiseasesChemicals and DrugsPhenomena and ProcessesInformation Science
VitronectinReceptors, VitronectinReceptors, CytoadhesinIntegrinsGlycoproteinsFibronectinsCell AdhesionIntegrin alphaVbeta3Plasminogen Activator Inhibitor 1Integrin alphaVReceptors, FibronectinReceptors, Urokinase Plasminogen ActivatorOligopeptidesHeparinIntegrin beta3Extracellular Matrix ProteinsPlatelet Membrane GlycoproteinsPlasminogen InactivatorsUrokinase-Type Plasminogen ActivatorReceptors, ImmunologicProtein BindingBlood ProteinsExtracellular MatrixFibrinogenAmino Acid SequenceMolecular Sequence DataLamininComplement Membrane Attack ComplexCells, CulturedAntithrombin IIICell MovementBinding SitesFibrinolysinThrombinIntegrin beta ChainsAntibodies, MonoclonalReceptors, Cell SurfaceThrombastheniaThrombospondins
FibrinogenIntegrinIntegrinsFibronectin and vitronectinBindsCD51ProteinsAffinityAdhesionOsteoclastsLamininIIIaBindOsteoclastVascularUrokinase receptorPlasminogen activationFactorGlycoproteinProteinInhibitsInhibitionPlatelet aggregationRANKLActivatorInteractionPlateletsDifferentiationGeneBoneFunctionalSequenceReductionComplexHumanCells
Fibrinogen7
  • Abciximab inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules to GPIIb/IIIa receptor sites on activated platelets. (nih.gov)
  • Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including α v β 3 . (nih.gov)
  • Research has also shown that the RGD motif in present in other proteins such as vitronectin, osteopontin, collagens, thrombospondin, fibrinogen and many other factors. (thomassci.com)
  • Human CD41 is a member of a major platelet transmembrane glycoprotein complex (CD41/CD61) which mediates platelet aggregation and adhesion by serving as the receptor for fibrinogen and von Willebrand factor, fibronectin and vitronectin. (ancell.com)
  • iv) αllbß3 binding to its ECM protein, fibrinogen and (v) αvß3 binding to the SARS-CoV-2 spike protein receptor binding domain. (bvsalud.org)
  • CD41 antigen acts as a receptor for fibrinogen, von Willebrand factor (vWf), fibrinectin and vitronectin and mediates platelet adhesion and aggregation. (gasyblog.com)
  • The platelet integrin GP IIb-IIIa (also referred to as α IIb-β) is a calcium-dependent heterodimer complex that can bind fibronectin, fibrinogen, vWF, and vitronectin. (medscape.com)
Integrin15
  • Vitronectin binds to integrin alpha-V beta-3 and thus promotes cell adhesion and spreading. (wikipedia.org)
  • The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. (medlineplus.gov)
  • Heterodimers of CD51 with several integrin β chains function as receptors for extracellular matrix proteins. (bdbiosciences.com)
  • General - Abciximab binds to the intact platelet GPIIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. (nih.gov)
  • Abciximab binds with similar affinity to the vitronectin receptor, also known as the α v β 3 integrin. (nih.gov)
  • The α v β 3 integrin is the most prominent receptor affecting tumor growth, tumor invasiveness, metastasis, tumor-induced angiogenesis, inflammation, osteoporosis, and rheumatoid arthritis ( 2-7 ). (nih.gov)
  • A Toll-like receptor 2-integrin beta(3) complex senses bacterial lipopeptides via vitronectin. (mpg.de)
  • The PAI-vitronectin complex binds to the Arg-Gly-Asp motif of αv integrins and inhibits the integrin-mediated cell migration [ 28 - 33 ]. (biomedcentral.com)
  • Receptors such as INTEGRIN ALPHAVBETA3 that bind VITRONECTIN with high affinity and play a role in cell migration. (nih.gov)
  • Second, there is a strong functional hypothesis: ITGAV encodes the protein α v (CD51 antigen) of the integrin family, which combines with β 3 to form the vitronectin receptor [ 3 ] and has a central role in angiogenesis [ 4 ]. (biomedcentral.com)
  • Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. (nih.gov)
  • Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C. This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. (nih.gov)
  • The alphav beta5 integrin is involved in adhesion to vitronectin. (nih.gov)
  • In the search for candidate receptors for the new embryo specific FN1 isoform, RNA expression analysis identified 5 α integrin subunits (ITGA2B, ITGA3, ITGA5, ITGA8, ITGAV) and 2 β integrin subunits (ITGB1 and ITGB3) with a similar or overlapping RNA expression pattern as compared to FN1. (biomedcentral.com)
  • Analysis of the integrin expression could not identify the binding partner for the embryo specific FN1 transcript variant making further steps necessary for the identification of the FN1 receptor and the downstream effects of FN1-receptor binding. (biomedcentral.com)
Integrins4
  • Vitronectin contains an RGD (45-47) sequence, which is a binding site for membrane-bound integrins, e.g., the vitronectin receptor, which serve to anchor cells to the extracellular matrix. (wikipedia.org)
  • Based on this association between extracellular signals and intracellular protein kinase activity, we have chosen to include integrins in the 'Catalytic receptors' section of the database until more stringent criteria from NC-IUPHAR allows precise definition of their classification. (guidetopharmacology.org)
  • Integrins are heterodimeric entities, composed of α and β subunits, each 1TM proteins, which bind components of the extracellular matrix or counter-receptors expressed on other cells. (guidetopharmacology.org)
  • Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. (nih.gov)
Fibronectin and vitronectin2
  • The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins. (rupress.org)
  • Fn14 expression decreases cellular adhesion to extracellular matrix proteins fibronectin and vitronectin and reduces cell growth and migration. (enzolifesciences.com)
Binds5
  • The somatomedin B domain of vitronectin binds to plasminogen activator inhibitor-1 (PAI-1), and stabilizes it. (wikipedia.org)
  • It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl-heidelberg.de)
  • Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation. (nih.gov)
  • Abciximab also binds to the vitronectin (α v β 3 ) receptor found on platelets and vessel wall endothelial and smooth muscle cells. (nih.gov)
  • Abciximab also binds to the activated Mac-1 receptor on monocytes and neutrophils (2). (nih.gov)
CD512
  • A hybridoma cell line producing a monoclonal hamster antibody specific to mouse CD51 (vitronectin receptor, alpha chain) (clone H9.2B8) as described in J Exp Med. (nih.gov)
  • Both OCs and FBGCs expressed the alpha-chains of the vitronectin receptor (CD51) and of the VLA-2 (CDw49b) and VLA-4 (CDw49d) molecules as well as their respective beta-chains, gpIIIa (CD61) and CD29. (ox.ac.uk)
Proteins3
  • The complement system as understood today is a multimolecular system composed of more than 32 proteins and consisting of serum proteins, serosal proteins, and cell membrane receptors that bind to complement fragments. (medscape.com)
  • The complement system consists of 7 serum and 9 membrane regulatory proteins, 1 serosal regulatory protein, and 8 cell membrane receptors that bind complement fragments. (medscape.com)
  • Osteoclasts (OCs) and other cells of the mononuclear phagocyte system possess receptors for adhesive proteins present in the extracellular matrix. (ox.ac.uk)
Affinity3
  • 15. High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread. (nih.gov)
  • This ganglioside copurified with the glycoprotein receptor for vitronectin on affinity columns containing either an Arg-Gly-Asp-containing peptide, concanavalin A, or lentil lectin. (rupress.org)
  • Human PAI-1 Recombinant Stable Mutant Vitronectin Binding Reduced from Innovative Research has been recombinantly produced in E. coli and purified by affinity chromatography. (innov-research.com)
Adhesion4
  • Fibronectin and V-CAM adhesion receptor. (xenbase.org)
  • In in vitro studies, Abciximab and 7E3 IgG blocked Mac-1 receptor function as evidenced by inhibition of monocyte adhesion (3). (nih.gov)
  • In the presence of calcium, GD2, the major ganglioside of M21 cells, colocalized with this receptor on the surface of human melanoma cells and their focal adhesion plaques as demonstrated by double-label transmission immunoelectron microscopy and indirect immunofluorescence. (rupress.org)
  • Collectively, our data imply GAPDH as an important adhesion factor of M. hyrohinis and a receptor for hijacking host plasminogen to degrade ECM. (biomedcentral.com)
Osteoclasts3
  • Endocr Rev 13: 66-80, 1992) through which osteoblastic/stromal cells stimulate osteoclast formation and resorption via a receptor RANK (TRANCER) located on osteoclasts and osteoclast precursors (Lacey et al. (justia.com)
  • Osteoblasts also secrete protein that strongly inhibits osteoclast formation called osteoprotegerin (OPG, also known as OCIF), which acts as a decoy receptor for the RANKL thus inhibiting the positive signal between osteoclasts and osteoblasts via RANK and RANKL. (justia.com)
  • Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells. (ox.ac.uk)
Laminin1
IIIa6
  • The mechanism of action is thought to involve steric hindrance and/or conformational effects to block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GPIIb/IIIa. (nih.gov)
  • 80% GPIIb/IIIa receptor blockade, but above the in vivo therapeutic range, Abciximab more effectively blocked the burst of thrombin generation that followed platelet activation than select comparator antibodies which inhibit GPIIb/IIIa alone (1). (nih.gov)
  • Pre-clinical experience- Maximal inhibition of platelet aggregation was observed when ≥ 80% of GPIIb/IIIa receptors were blocked by Abciximab. (nih.gov)
  • Doses of the murine version of 7E3 or Abciximab sufficient to produce high-grade (≥ 80%) GPIIb/IIIa receptor blockade prevented acute thrombosis and yielded lower rates of thrombosis compared with aspirin and/or heparin. (nih.gov)
  • Pharmacokinetics- Following intravenous bolus administration, free plasma concentrations of Abciximab decrease rapidly with an initial half-life of less than 10 minutes and a second phase half-life of about 30 minutes, probably related to rapid binding to the platelet GPIIb/IIIa receptors. (nih.gov)
  • Approximately 80,000 GP IIb-IIIa receptors are present on the surface of each platelet. (medscape.com)
Bind1
Osteoclast2
  • The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. (nih.gov)
  • Davies J, Warwick J, Totty N, Philp R, Helfrich M, Horton M: The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. (exbio.cz)
Vascular3
  • The vitronectin receptor mediates the procoagulant properties of platelets and the proliferative properties of vascular endothelial and smooth muscle cells. (nih.gov)
  • Novel vascular lesions in mice given a non-peptide vitronectin receptor antagonist. (southernbiotech.com)
  • The distinct but functionally related ανβ 5 receptor differs from ανβ 3 in a way that ανβ 3 plays a critical role in basic fibroblast growth factor (bFGF)-stimulated angiogenesis and ανβ 5 in vascular endothelial growth factor (VEGF)-induced angiogenesis [ 5 ]. (biomedcentral.com)
Urokinase receptor5
  • The Somatomedin B domain interacts with the urokinase receptor, and this interaction has been implicated in cell migration and signal transduction. (wikipedia.org)
  • High plasma levels of both PAI-1 and the urokinase receptor have been shown to correlate with a negative prognosis for cancer patients. (wikipedia.org)
  • 1. Inhibition of tumor growth and metastasis by ATF-Fc, an engineered antibody targeting urokinase receptor. (nih.gov)
  • 13. Vitronectin binding to urokinase receptor in human breast cancer. (nih.gov)
  • 18. Crystallization of soluble urokinase receptor (suPAR) in complex with urokinase amino-terminal fragment (1-143). (nih.gov)
Plasminogen activation1
Factor2
  • 11. Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice. (nih.gov)
  • Multiple myeloma [myeloma involves the mutation of white blood cells which causes alterations of the bone marrow] has recently been found to induce considerable imbalance in the newly identified system of osteoprotegerin (OPG), receptor activator of nuclear factor KB ligand (RANKL) and RANK[White blood cells have the ability to alter the OPG/RANKL gradient] . (heightquest.com)
Glycoprotein4
  • Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is synthesized and excreted by the liver, and abundantly found in serum, the extracellular matrix and bone. (wikipedia.org)
  • Vitronectin is a 54 kDa glycoprotein, consisting of 478 amino acid residues. (wikipedia.org)
  • This report demonstrates that human melanoma cells (M21) synthesize and express a glycoprotein receptor that shares antigenic epitopes with the vitronectin receptor on human fibroblasts and is capable of specifically recognizing the Gly-Arg-Gly-Asp-Ser-Pro sequence. (rupress.org)
  • Chelation of this ion with EDTA caused the dissociation of GD2 from the receptor and rendered the remaining glycoprotein incapable of binding to an Arg-Gly-Asp-containing peptide. (rupress.org)
Protein5
  • On occasion, the protein is cleaved after arginine 379, to produce two-chain vitronectin, where the two parts are linked by a disulfide bond. (wikipedia.org)
  • T in the vitronectin ( VTN ) gene influences protein expression and functional aspects of encoded vitronectin, a human blood and extracellular matrix (ECM) protein. (nih.gov)
  • PAI-1 promoted the migration of microglial cells in culture via the low-density lipoprotein receptor-related protein (LRP) 1/Janus kinase (JAK)/signal transducer and activator of transcription (STAT)1 axis. (biomedcentral.com)
  • PAI-1 plays a dual role in the regulation of cell migration through differential interactions with its binding partners such as uPA, tPA, vitronectin, and low-density lipoprotein receptor-related protein (LRP)1. (biomedcentral.com)
  • the latter are ligands for several of the above matrix protein receptors. (ox.ac.uk)
Inhibits1
  • 3. Amino-terminal fragment of urokinase inhibits tumor cell invasion in vitro and in vivo: respective contribution of the urokinase plasminogen activator receptor-dependent or -independent pathway. (nih.gov)
Inhibition1
  • Inhibition of platelet function was temporary following a bolus dose, but receptor blockade could be sustained at ≥ 80% by continuous intravenous infusion. (nih.gov)
Platelet aggregation1
  • In non-human primates, Abciximab bolus doses of 0.25 mg/kg generally achieved a blockade of at least 80% of platelet receptors and fully inhibited platelet aggregation. (nih.gov)
RANKL2
  • Receptor activator for NF-κ B ligand (RANKL, also known as TRANCE, ODF and OPGL) is another signal (Suda et al. (justia.com)
  • OPG is a decoy circulating receptor for RANKL which blocks its binding to RANK. (heightquest.com)
Activator2
Interaction1
  • Reconstitution experiments demonstrated a requirement for calcium, and not magnesium, for receptor binding to Arg-Gly-Asp and indicated that addition of ganglioside can enhance this interaction. (rupress.org)
Platelets1
Differentiation1
  • For example, it was recently demonstrated that the chemokine CXCL12, which also is expressed in active multiple sclerosis lesions, is able to accelerate oligodendrocyte precursor cell differentiation via its receptor CXCR7 in the context of serum-containing differentiation medium (Gottle et al . (medscape.com)
Gene1
  • Abnormalities in either gene or in the assembly of the complex result in an abnormal or deficient receptor and, consequently, in disease. (medscape.com)
Bone1
Functional1
  • An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2. (rupress.org)
Sequence1
  • Many adhesive cell surface receptors recognize the RGD sequence for cell attachment. (thomassci.com)
Reduction1
  • This product modifes the stable mutant through Q123K point mutation to produce PAI-1 with a greatly extended half life that demonstrates a ten-fold reduction in vitronectin binding. (innov-research.com)
Complex1
  • the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)
Human2
  • Biochemical evidence is presented indicating that the vitronectin receptor on M21 human melanoma cells contains associated calcium and GD2. (rupress.org)
  • Select this product for Molecular Innovations name, Human PAI-1 (Vitronectin binding reduced stable mutant) and product number, CPAI-Q123K . (innov-research.com)
Cells2
  • This major Arg-Gly-Asp-directed receptor on M21 cells could be metabolically labeled with 45Ca2+. (rupress.org)
  • Included in these are IgE (both in its secreted type and on membranes of dedicated B cells), Compact disc21 (also called supplement receptor 2), Compact disc18/Compact disc11b and Compact disc18/Compact disc11c (supplement receptors 3 and 4, respectively), as well as the vitronectin receptor (1). (lavoixdesrroms.org)