• CD1a mediates the presentation of nonpeptide antigens to T cells, while langerin facilitates uptake of microbial fragments and perhaps their delivery to a specialized subcellular compartment. (jci.org)
  • The rate of BCR internalization, its movement to late endosomes, and efficiency of BCR-mediated Ag processing and presentation are significantly reduced in both xid and Btk inhibitor-treated B cells. (jimmunol.org)
  • We previously showed that ( a ) estrogen-related receptor α1 (ERRα1) down-modulates estrogen receptor (ER)-stimulated transcription in low ErbB2-expressing MCF-7 mammary carcinoma cells, and ( b ) ERRα and ErbB2 mRNA levels positively correlate in clinical breast tumors. (aacrjournals.org)
  • We show here that ERRα1 represses ERα-mediated activation in MCF-7 cells because it failed to recruit the coactivator glucocorticoid receptor interacting protein 1 (GRIP1) when bound to an estrogen response element. (aacrjournals.org)
  • ERRα1-activated transcription in BT-474 cells was inhibited by disruption of ErbB2/epidermal growth factor receptor signaling with trastuzumab or gefitinib or inactivation of downstream components of this signaling, MAPK kinase/MAPK, and phosphatidylinositol-3-OH kinase/Akt, with U0126 or LY294002, respectively. (aacrjournals.org)
  • Most therapies available to treat acute myelogenous leukemia target leukemia blast cells which are in general a later progenitor/precursor cell no longer capable of self-renewal and multipotential differentiation. (frontiersin.org)
  • Adoptive T cell transfer (ACT) using T cells genetically modified to express chimeric antigen receptors (CAR) against tumor-associated antigens (TAA) has shown great promise in the treatment of blood-borne malignant disease, but may be limited by the strong immunosuppressive environment within solid tumors. (aacrjournals.org)
  • Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. (medscape.com)
  • As a skin resident member of the DC family of APCs, Langerhans cells (LCs) initiate both innate and adaptive immune responses to skin-relevant antigens, thereby acting as immunological sentinels. (jci.org)
  • LCs employ I-A molecules for presentation of peptide antigens to CD4 T cells. (jci.org)
  • Lymphatic research denotes a field of new discovery in recent years largely because of the advancement of technology and the discovery of several lymphatic-specific molecules including lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). (arvojournals.org)
  • However, for stable-linker ADCs to be effective, they must be internalized and degraded, limiting potential targets to surface antigens that are trafficked to lysosomes. (bloodjournal.org)
  • For example, CD1b isoform is internalized in clathrin-coated pits via a tyrosine-based motif in its cytoplasmic tail (YXXΦ where Y is tyrosine, X is any amino acid, and Φ is a bulky hydrophobic residue), sorted to early endosomes, late endosomes/lysosomes, and MHC II-rich compartments (MIICs), and recycled back to the plasma membrane. (jci.org)
  • Diabetes mellitus was induced in Long Evans rats with streptozotocin, and an anti-α4 integrin/CD49d neutralizing antibody was injected 5 and 10 days later. (arvojournals.org)
  • 4 These interactions are transient and dynamic and allow the leukocytes to search for antigens, respond to inflammatory stimuli, extravasate, or adhere firmly to the endothelium to perform immune functions. (arvojournals.org)
  • The second mechanism involves an alteration of events following postreceptor occupancy without affecting receptor affinity, such as cell spreading and/or integrin clustering. (asm.org)
  • The cause of the hypofunction seemed to be multifactorial and was associated with upregulation of intrinsic T-cell inhibitory enzymes (diacylglycerol kinase and SHP-1) and the expression of surface inhibitory receptors (PD1, LAG3, TIM3, and 2B4). (aacrjournals.org)
  • Erythrocyte H antigens are absent, leading to expression of the Bombay (hh) phenotype. (medscape.com)
  • Structure, function and cellular expression of complement anaphylatoxin receptors. (medscape.com)
  • Likewise, regulation of the endogenous genes pS2, progesterone receptor , and ErbB2 by ERRα1 reflected the cell type-specific differences observed with our reporter plasmids. (aacrjournals.org)
  • Difference in the clustering of complement receptor type 1 (CR1) on polymorphonuclear leukocytes and erythrocytes: effect on immune adherence. (medscape.com)
  • 4 The treatment of chronic GVHD is limited by a number of factors, including late diagnosis, an inability to predict outcome or response to the therapy, and a poor understanding of the immune targets important for optimal therapy. (haematologica.org)
  • We have identified CD79, the signaling component of the B-cell receptor (BCR), as a promising ADC target for the treatment of NHL. (bloodjournal.org)