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  • TGFBR2
  • By mating Fabpl(4xat-132) Cre mice with Tgfbr2(flx/flx) mice, we have generated a mouse model that is null for Tgfbr2 in the colonic epithelium, and in this model system, we have assessed the effect of loss of TGF-beta signaling in vivo on colon cancer formation induced by azoxymethane (AOM). (nih.gov)
  • We have observed a significant increase in the number of AOM-induced adenomas and adenocarcinomas in the Fabpl(4xat-132) Cre Tgfbr2(flx/flx) mice compared with Tgfbr2(flx/flx) mice, which have intact TGF-beta receptor type II (TGFBR2) in the colon epithelium, and we have found increased proliferation in the neoplasms occurring in the Fabpl(4xat-132) Cre Tgfbr2(flx/flx) mice. (nih.gov)
  • In a co-xenograft model, we show that Tgfbr2(FspKO) fibroblasts enhance mammary carcinoma growth and metastasis in mice while increasing hepatocyte growth factor (HGF) expression and c-Met signaling downstream pathways including signal transducers and activators of transcription 3 (Stat3) and p42/44 mitogen-activated protein kinase (MAPK). (nih.gov)
  • TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. (creativebiomart.net)
  • They bind to TGF-beta receptor type-2 (TGFBR2). (wikipedia.org)
  • TGFB
  • These experiments show that the TGFB-1 receptor plays a critical role in the function of the female reproductive tract. (wikipedia.org)
  • role of endogenous
  • Recently we confirmed the pro-apoptotic role of endogenous TGF-beta in the developing chick and mouse retina. (arvojournals.org)
  • To evaluate the role of endogenous TGF-betas in the growth and differentiation of the mammary gland in vivo, we have targeted expression of a truncated, kinase-defective TGF-beta type II receptor to mammary epithelial cells in transgenic mice using the mouse mammary tumor virus promoter/enhancer. (aacrjournals.org)
  • epithelial cells
  • The results show that TGF-beta signaling in fibroblasts suppresses tumor metastasis by antagonizing HGF/c-Met signaling within tumor epithelial cells. (nih.gov)
  • Exogenously added TGF-beta1, -beta2, and -beta3 have been shown to regulate growth and differentiation of mammary epithelial cells in vitro and in vivo. (aacrjournals.org)