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  • Antagonists
  • This article is about the discovery and development of antiandrogens, or androgen receptor (AR) antagonists. (wikipedia.org)
  • Rapid effects of aldosterone were found not be reversed by the MR antagonist spironolactone, indicating additional receptors besides just the classical MR. It has been estimated that as much as 50% of the rapid actions of aldosterone are mediated by mMRs that are not the classical MR, based on findings of insensitivity to classical mR antagonists. (wikipedia.org)
  • progestin
  • Phylogenetic and sequence analyses demonstrated that the mPRs belong to a larger, highly conserved family of proteins, termed progestin and adeponectin receptors (PAQRs). (endocrine-abstracts.org)
  • anabolic-androgenic steroid
  • Mibolerone, sold under the brand names Cheque Drops and Matenon, is a synthetic, orally active, and extremely potent anabolic-androgenic steroid (AAS) and a 17α-alkylated nandrolone (19-nortestosterone) derivative which was marketed by Upjohn for use as a veterinary drug. (wikipedia.org)
  • The drug has mixed progestogenic and antiprogestogenic activity - that is, it is a partial agonist of the PR or a selective progesterone receptor modulator (SPRM) - and is a weak agonist of the AR, or an anabolic-androgenic steroid (AAS). (wikipedia.org)
  • proteins
  • A consensus motif (LXXLL, where X is any amino acid) in SRC-1 and related proteins, which is necessary and sufficient for interaction with nuclear receptors, has been identified ( 16 ). (pnas.org)
  • Such receptors are closely related to chaperones (namely heat shock proteins hsp90 and hsp56), which are required to maintain their inactive (but receptive) cytoplasmic conformation. (wikipedia.org)
  • Unbound AR is mainly located in the cytoplasm, like a typical steroid receptor, and is associated with a complex of heat shock proteins (HSP) through interactions with LBD. (wikipedia.org)
  • Addition of such inhibitor causes proteosomal degradation of signaling proteins like steroid receptors, Raf kinase and Akt. (wikipedia.org)
  • estrogens
  • glucocorticoids and mineralocorticoids (corticosteroids) and androgens , estrogens , and progestogens (sex steroids). (wn.com)
  • Other contexts will include progestogens as a third class of sex steroids, distinct from androgens and estrogens. (wikipedia.org)
  • clinical
  • Recently, both clinical and experimental findings indicate the possible roles of sex steroids in the development and progression of desmoid tumors but detailed information is still ambiguous. (nii.ac.jp)
  • Leung YK, Lee MT, Lam HM, Tarapore P, Ho SM (2012) Estrogen receptor-beta and breast cancer: translating biology into clinical practice. (springer.com)